CN106137774B

CN106137774B - Pit and fissure sealant based on tooth surface hydrophobization concept

Info

Publication number: CN106137774B
Application number: CN201610642503.8A
Authority: CN
Inventors: 李晓东; 罗巧洁
Original assignee: Zhejiang University ZJU
Current assignee: Zhejiang University ZJU
Priority date: 2016-08-08
Filing date: 2016-08-08
Publication date: 2020-04-17
Anticipated expiration: 2036-08-08
Also published as: CN106137774A

Abstract

The invention provides a pit and fissure sealant based on a tooth surface hydrophobization concept, which consists of a single-component pit and fissure sealant and a double-component pit and fissure sealant, wherein the necessary components comprise a hydrophobization reagent, a solvent, a hydrophobic polymerization monomer, a photopolymerization initiator and a filler. The invention relates to a pit and trench sealing agent, which solves the problems of poor sealing property, easy falling off and the like of the pit and trench sealing agent. Compared with the traditional pit and fissure sealant, the invention carries out hydrophobic modification on the surface of the tooth body in the pit and fissure sealing process, changes the hydrophilicity of the tooth surface and makes the tooth surface change from hydrophilic to hydrophobic; the method has the effects and benefits that the wettability of the socket and furrow closing agent on the tooth surface is enhanced, a uniform and stable tooth-socket and furrow closing agent interface is finally formed, the sealing property and durability of socket and furrow closing are improved, and the interface leakage rate is reduced.

Description

Pit and fissure sealant based on tooth surface hydrophobization concept

Technical Field

The invention belongs to the field of medical biomaterials, and relates to a pit and fissure sealant based on a tooth surface hydrophobization concept.

Background

Pit and furrow sealing is a method for preventing pit and furrow caries, and the caries preventing effect of pit and furrow sealing depends on the complete retention of sealing agent and the sealing property of sealing material and tooth surface. Despite the continual improvement in pit and trench sealing materials and techniques, the incidence of sealant sloughing and microleakage remains high. Therefore, it is of practical significance to improve the caries preventing effect of pit and fissure sealing by improving the permeability of the sealing agent and the adhesion to the tooth surface. The traditional pit and fissure sealant is generally composed of synthetic organic polymer resin, a diluent, an initiator and a plurality of auxiliary agents (solvents, fillers, fluorides, coatings and the like), has poor wettability on the surfaces of teeth after acid etching, cleaning and blow-drying, causes defects to exist on the interface between the pit and fissure sealant and the surfaces of the teeth, particularly the bottoms of the pits and furrows, and leads to caries due to the fact that food is easily accumulated to participate and bacteria are accumulated on the local defects; in addition, the existence of interface defects is also a main reason for the closed and detached pit and groove.

Disclosure of Invention

The invention aims to provide a pit and fissure sealant based on the concept of tooth surface hydrophobization, which can be a single-component pit and fissure sealant and a double-component pit and fissure sealant.

The pit and fissure sealant based on the tooth surface hydrophobization concept consists of a single-component pit and fissure sealant and a double-component pit and fissure sealant,

(1) the two-component pit and trench sealing agent comprises the following necessary components of a component A and a component B, wherein the component A comprises: a hydrophobizing agent (a) and a solvent (b); and (B) component: a hydrophobic polymerizable monomer (c), a photopolymerization initiator (d), and a filler (e) as essential components.

(2) The one-component pit and trench sealing agent comprises the essential components of a hydrophobizing agent (a), a hydrophobic polymerized monomer (c), a photopolymerization initiator (d) and a filler (e).

The hydrophobizing agent (a) in component A can be chlorosilane or methoxysilane or ethoxysilane, including alkylchlorosilane, fluorochlorosilane, functionalized chlorosilane, alkylmethoxysilane, functionalized methoxysilane, fluoromethoxysilane, alkylethoxysilane, functionalized ethoxysilane, fluoroethoxysilane (including but not limited to the agents provided in tables 1 to 25 which can perform hydrophobizing modification on the tooth surface, see attached tables 1 to 25), and a mixture of two or more different silanes in any proportion; the solvent (b) includes, but is not limited to, ethanol, diethyl ether, toluene, acetone, and a mixed solvent of two or more of the above solvents in any ratio. Wherein the total concentration of the hydrophobizing agent in the component A is 0.001 (V/V)% -100 (V/V)%.

The hydrophobic polymerized monomer (c) in the component B is a polymerized monomer which is hydrophobic, does not have a hydrophilic group and has at least two functional groups capable of initiating polymerization by free radicals in the molecule, and the polymerized monomers are mutually polymerized to endow the mechanical strength of the pit and fissure sealant. Generally, the dental hydrophobic polymerizable monomers may be used alone or in combination of two or more kinds thereof at an arbitrary ratio, and include, but are not limited to, aromatic methacrylates such as bisphenol a dimethacrylate, bisphenol a diglycidyl methacrylate, ethoxylated bisphenol a glycidyl dimethacrylate, 2-bis (4-methacryloyloxyethoxybenzyl) propane and the like, and polyfunctional methacrylates such as ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, neopentyl glycol dimethacrylate, trimethylolpropane trimethacrylate, urethane methacrylate and the like. Wherein the total content of the hydrophobic polymeric monomer is 1wt% -70 wt%.

The photopolymerization initiator (c) in component B may be a photopolymerization initiator commonly used in dentistry, including but not limited to α -diketones (camphorquinone, benzil, etc.), ketals (benzyldimethylaldehyde acetophenone, benzyldiethylaldehyde acetophenone, etc.), thioxanthones (2-chlorothioxanthone, 2, 4-diethylthioxanthone, etc.), acylphosphine oxides, coumarins, etc. the initiator may be used alone, or two or more initiators may be used in any ratio, the total content of the photopolymerization initiator is 0.01wt% to 10 wt%.

The filler (e) can be any type of filler for dental use, and can be an inorganic filler or an organic filler, one filler can be added, and a mixture of two or more fillers in any ratio can be added. Organic fillers include, but are not limited to, polymethyl methacrylate, polyethyl methacrylate, polyamides, polyvinyl chloride, nitrile butadiene rubber, styrene butadiene rubber, and the like; inorganic fillers include, but are not limited to, silica, ceramics, glass, alumina, calcium carbonate, sodium fluoride, potassium fluoride, hydroxyapatite, titanium oxide, zirconium oxide, calcium phosphate, and the like. The filler may be added directly, or may be added after surface hydrophobization pretreatment with the aforementioned silane agent or fluoride pretreatment. The total content of the filler is 1wt% -45 wt%.

The filler (e) has an average particle size of 10nm to 400nm, wherein the content of filler having a particle size of more than 400nm is less than 10wt% of the total amount of filler.

The ranges of the hydrophobizing agent (a), the hydrophobic polymerized monomer (c), the photopolymerization initiator (d) and the filler (e) of the one-component socket closure agent are consistent with the ranges of the hydrophobizing agent (a), the hydrophobic polymerized monomer (c), the photopolymerization initiator (d) and the filler (e) of the two-component socket closure agent.

In addition, in the present invention, a fluorine ion releasing substance may be added to the two-component system or the single-component system, and the fluorine ion releasing substance may be a pure substance or a mixture, including but not limited to fluorine glass such as fluoroaluminosilicate glass, and metal fluoride such as sodium fluoride and potassium fluoride. A fluoride ion releasing material may be added, or a mixture of two or more of them in any ratio, wherein the total fluoride ion releasing material content is less than 10wt% (the fluoride pretreated filler is not included).

In addition, no matter a two-component system or a single-component system, on the basis of necessary components, a stabilizer, a coloring agent, a fluorescent agent, an ultraviolet absorbent, a polymerization accelerator and the like can be added, and the content of each component is respectively less than 5 wt%.

In addition, in the present invention, no matter a two-component system or a single-component system, on the basis of necessary components, an antibacterial substance may be added, one antibacterial substance may be added, or a mixture of two or more antibacterial substances in any proportion, including but not limited to methacryloxy decammonium chloride, triclosan, etc., wherein the total content of the antibacterial substances is less than 10 wt%.

In addition, in the present invention, on the basis of necessary components, a monofunctional polymerizable monomer may be introduced to adjust the viscosity of the adhesive, one monofunctional polymerizable monomer may be introduced, or a mixture of two or more monofunctional polymerizable monomers in any ratio may be introduced, and the monofunctional polymerizable monomer includes, but is not limited to, methyl methacrylate, ethyl methacrylate, isopropyl methacrylate, 2, 3-dibromopropyl methacrylate, and the like. Wherein the content of the monofunctional polymerization monomer is less than 40 wt%.

In addition, the two-component system component B can introduce an amphiphilic polymerization monomer on the basis of necessary components, can add one amphiphilic polymerization monomer, and can also be a mixture composed of two or more amphiphilic polymerization monomers in any proportion. Amphiphilic polymeric monomers include, but are not limited to, 2 hydroxyethyl methacrylate, 3-hydroxypropyl methacrylate, 2-hydroxypropyl methacrylate, 1, 3-dihydroxypropyl methacrylate, 2-trimethylammonium ethyl methacryloyl chloride, polyethylene glycol dimethacrylate. Wherein the total content of amphiphilic polymeric monomers is less than 20 wt%.

In addition, in the present invention, no matter the two-component system component (B) or the one-component system, on the basis of the necessary components, a solvent including, but not limited to, ethanol, diethyl ether, toluene, acetone, and a mixed solvent of two or more of the above solvents in any ratio may be added, wherein the total content of the solvent is less than 30 wt%.

The invention aims to provide a pit and fissure sealant based on the concept of tooth surface hydrophobization, and solves the problems of poor adhesion, easy falling and the like of the pit and fissure sealant. Compared with the traditional pit and fissure sealant, the invention carries out hydrophobic modification on the surface of the tooth body in the pit and fissure sealing process, changes the hydrophilicity of the tooth surface and makes the tooth surface change from hydrophilic to hydrophobic; the method has the effects and benefits that the wettability of the socket and furrow closing agent on the tooth surface is enhanced, a uniform and stable tooth-socket and furrow closing agent interface is finally formed, the sealing property and durability of socket and furrow closing are improved, and the interface leakage rate is reduced.

Drawings

FIG. 1 Effect of treatment with a hydrophobicizing component of a pit and fissure sealant according to the invention on the hydrophilicity of enamel.

Figure 2 test of adhesion of pit sealer to enamel.

Detailed Description

The present invention will be further described with reference to the following drawings and examples, but the present invention is not limited to these examples.

Example one

1. The component A is as follows: 0.1% (V/V)% of alkyltrichlorosilane (see attached Table 1 for details, octadecyltrichlorosilane for example) in diethyl ether.

2. And (B) component: 20wt% of bisphenol A diglycidyl methacrylate, 40wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 30wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 1wt% of camphorquinone and 9 wt% of silane-treated silica powder, and mixing them.

Example two

1. The component A is as follows: 1 (V/V)% of fluorotrichlorosilane (see the attached Table 2 in detail) in ethanol.

EXAMPLE III

1. The component A is as follows: 1 (V/V)% of a functionalized trichlorosilane (see attached Table 3 for details) in ethanol.

Example four

1. The component A is as follows: 1 (V/V)% of an alcoholic solution of alkyltrimethoxysilane (see Table 4).

EXAMPLE five

1. The component A is as follows: 1 (V/V)% of a fluorotrimethoxysilane (see the attached Table 5 in detail) in ethanol.

EXAMPLE six

1. The component A is as follows: 1 (V/V)% of a solution of functionalized trimethoxysilane (see Table 6).

EXAMPLE seven

1. The component A is as follows: 1 (V/V)% of alkyltriethoxysilane (see Table 7 for details) in ethanol.

Example eight

1. The component A is as follows: 1 (V/V)% of fluorotriethoxysilane (see Table 8 for details) in ethanol.

Example nine

1. The component A is as follows: 1 (V/V)% of a functionalized triethoxysilane (see Table 9 for details) in ethanol.

Example ten

1. The component A is as follows: 1 (V/V)% of alkyldichlorosilane (see the attached Table 10 for details) in ethanol.

EXAMPLE eleven

1. The component A is as follows: 1 (V/V)% fluorodichlorosilane (see attached Table 11 for details) in ethanol.

Example twelve

1. The component A is as follows: 1 (V/V)% of a functionalized dichlorosilane (see Table 12 for details) in ethanol.

EXAMPLE thirteen

1. The component A is as follows: 1 (V/V)% of an alkyldimethoxysilane (see Table 13 for details) in ethanol.

Example fourteen

1. The component A is as follows: 1 (V/V)% of a fluorodimethoxysilane (see the attached Table 14 for details) in ethanol.

Example fifteen

1. The component A is as follows: 1 (V/V)% of a functionalized dimethoxysilane (see Table 15 for details) in ethanol.

Example sixteen

1. The component A is as follows: 1 (V/V)% of an alkyldiethoxysilane (see Table 16 for details) in ethanol.

Example seventeen

1. The component A is as follows: 1 (V/V)% of a fluorodiethoxysilane (see the attached Table 17 for details) in ethanol.

EXAMPLE eighteen

1. The component A is as follows: 1 (V/V)% of a functionalized diethoxysilane (see Table 18 for details) in ethanol.

Example nineteen

1. The component A is as follows: 1 (V/V)% of an alcoholic solution of alkylmonochlorosilane (see Table 19 for details).

Example twenty

1. The component A is as follows: 1 (V/V)% of fluoromonochlorosilane (see attached Table 20 for details) in ethanol.

Example twenty one

1. The component A is as follows: 1 (V/V)% of functionalized monochlorosilane (see attached Table 21 for details) in ethanol.

Example twenty two

1. The component A is as follows: 1 (V/V)% of an alcoholic solution of alkylmonomethoxysilane (see Table 22 for details).

Example twenty three

1. The component A is as follows: 1 (V/V)% of fluoromethoxy silane (see attached Table 23 for details) in ethanol.

Example twenty-four

1. The component A is as follows: 1 (V/V)% functionalized monomethoxysilane (see Table 24 for details) in ethanol.

Example twenty-five

1. The component A is as follows: 1 (V/V)% of an alkylmonoethoxysilane (see Table 25 for details) in ethanol.

Example twenty-six

1. The component A is as follows: 0.5 (V/V)% of octadecyl trichlorosilane, 1 (V/V)% of propyl trichlorosilane and ethanol solvent.

Example twenty-seven

1. The component A is as follows: 0.5 (V/V)% octadecyl trichlorosilane, 0.5 (V/V)% propyl trichlorosilane, 1 (V/V)% trifluoropropyl trichlorosilane and ethanol solvent.

Example twenty-eight

1. The component A is as follows: 1 (V/V)% of a trimethoxysilaneacetone solution.

Example twenty-nine

1. The component A is as follows: 1 (V/V)% trimethoxy silane, 50 (V/V)% acetone, 49 (V/V)% ethanol.

Example thirty

1. The component A is as follows: 1 (V/V)% trimethoxy silane, 0.5 (V/V)% methyltrimethoxy silane, 49.5 (V/V)% acetone,

49 (V/V)% ethanol.

Example thirty one

30wt% of bisphenol A diglycidyl methacrylate, 35 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 20wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 9 wt% of silane-treated silica powder, 1wt% of camphorquinone, 5wt% of ethanol, and 2% by volume of octadecyl trichlorosilane, and mixing the components to prepare the nano-composite material.

Example thirty-two

1. The component A is as follows: 0.1 (V/V)% octadecyl trichlorosilane in ether.

2. And (B) component: 20wt% of bisphenol A diglycidyl methacrylate, 40wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 30wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 0.9 wt% of camphorquinone, 9 wt% of silane-treated silica powder, and 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, and mixing them.

Example thirty-three

2. And (B) component: 20wt% of bisphenol A diglycidyl methacrylate, 39 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 30wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 0.9 wt% of camphorquinone, 9 wt% of silane-treated silica powder, 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, and 1wt% of methyl methacrylate, and mixing them.

Example thirty-four

30wt% of bisphenol A diglycidyl methacrylate, 35 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 20wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 9 wt% of silane-treated silica powder, 0.9 wt% of camphorquinone, 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, 5wt% of ethanol, and 2% of total volume of octadecyl trichlorosilane, and mixing the components to prepare the modified epoxy resin.

Example thirty-five

30wt% of bisphenol A diglycidyl methacrylate, 35 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 20wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 9 wt% of silane-treated silica powder, 0.9 wt% of camphorquinone, 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, 4 wt% of ethanol, 1wt% of methyl methacrylate, and 2% of octadecyltrichlorosilane in total volume, and mixing them to prepare the composition.

Example thirty-six

30wt% of bisphenol A diglycidyl methacrylate, 35 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 20wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 9 wt% of silane-treated silica powder, 0.9 wt% of camphorquinone, 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, 4 wt% of acetone, 1wt% of methyl methacrylate, and 2% by volume of octadecyltrichlorosilane, and mixing them to prepare the composition.

Example thirty-seven

2. And (B) component: 20wt% of bisphenol A diglycidyl methacrylate, 39 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 29 wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 1wt% of camphorquinone, 9 wt% of fluoride silicon dioxide powder, 1wt% of methyl methacrylate and 1wt% of triclosan, and mixing the components to prepare the adhesive.

Example thirty-eight

29 wt% of bisphenol A diglycidyl methacrylate, 35 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 20wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 9 wt% of silane-treated silica powder, 0.9 wt% of camphorquinone, 0.1 wt% of 2, 6-di-tert-butyl-4-methylphenol, 4 wt% of acetone, 1wt% of methyl methacrylate, 1wt% of triclosan, and 2% by volume of octadecyltrichlorosilane in total, and mixing them to prepare the composition.

Example thirty-nine

2. And (B) component: 20wt% of bisphenol A diglycidyl methacrylate, 37 wt% of 10 ethoxylated bisphenol A glycidyl dimethacrylate, 29 wt% of 4 ethoxylated bisphenol A glycidyl dimethacrylate, 1wt% of camphorquinone, 9 wt% of fluoride silica powder, 1wt% of methyl methacrylate, 1wt% of triclosan, and 2 wt% of 2 hydroxyethyl methacrylate, and mixing them.

Example forty provides a method of use

The tooth surface was treated with 1.37% phosphoric acid gel for 30s and rinsed thoroughly.

2. And (3) drying the tooth surface, coating the double-component socket sealant component A for 20s, and slightly blowing for 10 s.

3. Coating the two-component pit and fissure sealant component B, illuminating for 15s, and checking occlusion.

Example forty one provides a method of use

2. Drying the tooth surface, coating the single-component pit and fissure sealant, slightly blowing for 10s, illuminating for 15s, and checking occlusion.

Example forty two

Bovine labial enamel was polished, treated with 35% phosphoric acid gel for 30s, rinsed thoroughly and dried, and treated with example part a for various times to measure the contact angle of the enamel surface (fig. 1).

Example forty-three

Treating bovine labial enamel with 35% phosphoric acid gel for 30s, coating a thin layer of 3M pit and fissure sealant, slightly blowing for 10s, irradiating for curing, stacking 3M resin, and cutting into strips (control group); the adhesion of pit and fissure sealants to enamel was tested using the sample of example one, stacked with 3M resin, and cut strips (experimental group) as provided in example forty (figure 2).

TABLE 1 Alkyltrichlorosilane

TABLE 2 Fluorotrichlorosilane

Name of Chinese	Molecular formula	CAS
			Trifluoropropyl trichlorosilane	C₃H₄Cl₃F₃Si	592-09-6
1H,1H,2H, 2H-perfluorooctyltrichlorosilane	C₈H₄Cl₃F₁₃Si	78560-45-9
			Perfluorododecyl trichlorosilane	C₁₀H₄Cl₃F₁₇Si	78560-44-8
1H,1H,2H, 2H-perfluorododecyl trichlorosilane	C₁₂H₄Cl₃F₂₁Si	102488-49-3

TABLE 3 functionalized trichlorosilane

Name of Chinese	Molecular formula	CAS
			Vinyl trichlorosilane	C₂H₃Cl₃Si	75-94-5
Propenyl trichlorosilane	C₃H₅Cl₃Si	107-37-9
			Trichloro-1-propenylsilanes	C₃H₅Cl₃Si	18083-37-9
(E) -2-butene trichlorosilane	C₄H₇Cl₃Si	52885-13-9
			5-hexenyltrichlorosilane	C₆H₁₁Cl₃Si	18817-29-3
7-octyl-1-alkynyltrichlorosilane	C₈H₁₅Cl₃Si	52217-52-4
			Octenyl trichlorosilane	C₈H₁₅Cl₃Si	153447-97-3
3, 7-dimethyl-2, 6-dioctenethiosilane	C₁₀H₁₇Cl₃Si	28333-49-5
			10-alkenylundecyltrichlorosilane	C₁₁H₂₁Cl₃Si	17963-29-0

TABLE 4 Alkyltrimethoxysilane

TABLE 5 Fluorotrimethoxysilane

TABLE 6 functionalized trimethoxysilane

Name of Chinese	Molecular formula	CAS
			Vinyl trimethoxy silane	C₅H₁₂O₃Si	2768-02-7
Allyl trimethoxy silane	C₆H₁₄O₃Si	2551-83-9
			7-octenyltrimethoxysilane	C₁₁H₂₄O₃Si	52217-57-9
10-alkenylundecyltrimethoxysilane	C₁₄H₃₀O₃Si	872575-06-9
			11-allyloxy-undecyltrimethoxysilane	C₁₇H₃₆O₄Si	1196453-35-6

TABLE 7 Alkyltriethoxysilane

Name of Chinese	Molecular formula	CAS
			Triethoxy silane	C₆H₁₆O₃Si	998-30-1
Methyltriethoxysilane	C₇H₁₈O₃Si	2031-67-6
			Triethoxyethylsilane	C₈H₂₀O₃Si	78-07-9
Propyltriethoxysilane	C₉H₂₂O₃Si	2550-02-9
			N-butyl triethoxy silane	C₁₀H₂₄O₃Si	4781-99-1
Isobutyl triethoxy silane	C₁₀H₂₄O₃Si	17980-47-1
			Triethoxypentylsilane	C₁₁H₂₆O₃Si	2761-24-2
(3, 3-dimethylbutyl) triethoxysilane	C₁₂H₂₈O₃Si	41966-94-3
			N-hexyl triethoxy silane	C₁₂H₂₈O₃Si	18166-37-5
N-octyl triethoxysilane	C₁₄H₃₂O₃Si	2943-75-1
			N-decyl triethoxysilane	C₁₆H₃₆O₃Si	2943-73-9
N-decyl triethoxysilane	C₁₈H₄₀O₃Si	18536-91-9
			Hexadecyl triethoxy silane	C₂₂H₄8O₃Si	16415-13-7
Triethoxy octadecane silane	C₂₄H₅₂O₃Si	7399-00-0
			Docosyltriethoxysilane	C₂₈H₆₀O₃Si	330457-44-8

TABLE 8 Fluorotriethoxysilane

TABLE 9 functionalized triethoxysilanes

Name of Chinese	Name of English	Molecular formula	CAS
				Vinyl triethoxy silane	Triethoxyvinylsilane	C₈H₁₈O₃Si	78-08-0
Allyl triethoxy silane	Allyltriethoxysilane	C₉H₂₀O₃Si	2550-04-1
				3-butenyl triethoxysilane	3-Butenyltriethoxysilane	C₁₀H₂₂O₃Si	57813-67-9
5-hexenyltriethoxysilane	5-hexenyltriethoxysilane	C₁₂H₂₆O₃Si	52034-14-7

Dichloro (methoxy, ethoxy) silane:

TABLE 10 Alkyldichlorosilanes

Name of Chinese	Molecular formula	CAS
			Methyldichlorosilane	CH₄Cl₂Si	75-54-7
Ethyldichlorosilane	C₂H₆Cl₂Si	1789-58-8
			Dichlorodimethylsilane	C₂H₆Cl₂Si	75-78-5
Methyl ethyl dichlorosilane	C₃H₈Cl₂Si	4525-44-4
			Tert-butyldichlorosilane	C₄H₁₀Cl₂Si	85121-42-2
Dichlorodiethylsilane	C₄H₁₀Cl₂Si	1719-53-5
			Isopropyl methyl dichlorosilane	C₄H₁₀Cl₂Si	5926-38-5
Isopropyl methyl dichlorosilane	C₄H₁₀Cl₂Si	18236-89-0
			dichloromethyl-N-propylsilane	C₄H₁₀Cl₂Si	4518-94-9
Dichloroisobutyl methylsilane	C₅H₁₂Cl₂Si	18028-96-1
			Tert-butyl methyl dichlorosilane	C₅H₁₂Cl₂Si	18147-18-7
N-butylmethyl silicon dichloride	C₅H₁₂Cl₂Si	18147-23-4
			N-hexyl dichlorosilane	C₆H₁₄Cl₂Si	871-64-7
Dichloromethylpentyl silane	C₆H₁₄Cl₂Si	13682-99-0
			Di-n-propyldichlorosilane	C₆H₁₄Cl₂Si	2295-24-1
Diisopropyl di (isopropyl) benzeneChlorosilane compounds	C₆H₁₄Cl₂Si	7751-38-4
			Hexylmethyldichlorosilane	C₇H₁₆Cl₂Si	14799-94-1
Di-tert-butylchlorosilane	C₈H₁₈Cl₂Si	18395-90-9
			Heptyl methyl dichlorosilane	C₈H₁₈Cl₂Si	18395-93-2
Dibutyldichlorosilane	C₈H₁₈Cl₂Si	3449-28-3
			Dichloromethyl octyl silane	C₉H₂₀Cl₂Si	14799-93-0
Diamyl dichlorosilane	C₁₀H₂₂Cl₂Si	18037-39-3
			Methyldecyl dichlorosilane	C₁₁H₂₄Cl₂Si	18051-88-2
Dichlorodihexyl silane	C₁₂H₂₆Cl₂Si	18204-93-8
			Methyldodecyldichlorosilane	C₁₃H₂₈Cl₂Si	18407-07-3
Di-n-octyl dichlorosilane	C₁₆H₃₄Cl₂Si	18416-07-4
			Bis (2-ethylhexyl) dichlorosilane	C₁₆H₃₄Cl₂Si	1089687-03-5
Bis (2-ethylhexyl) dichlorosilane	C₁₆H₃₄Cl₂Si	1089687-03-5
			Methyloctadecyl dichlorosilane	C₁₉H₄₀Cl₂Si	5157-75-5
Behenylmethyl dichlorosilane	C₂₃H₄₈Cl₂Si	67892-56-2
			Didodecyl dichlorosilane	C₂₄H₅₀Cl₂Si	18768-06-4

TABLE 11 Fluorodichlorosilanes

Name of Chinese	Molecular formula	CAS
			(3,3, 3-trifluoropropyl) dichloromethylsilane	C₄H₇C_l2F₃Si	675-62-7
Methyl (3,3,4,4,5,5,6,6, 6-nonafluorohexyl) dichlorosilane	C₇H₇Cl₂F₉Si	38436-16-7
			1H,1H,2H, 2H-perfluorooctylmethyldichlorosilane	C₉H₇Cl₂F₁₃Si	73609-36-6
1H,1H,2H, 2H-perfluorodecylmethyldichlorosilane	C₁₁H₇Cl₂F₁₇Si	3102-79-2

TABLE 12 functionalized dichlorosilanes

Name of Chinese	Molecular formula	CAS
			Vinyl dichlorosilane	C₂H₄Cl₂Si	18076-99-8
Allyl dichlorosilane	C₃H₆Cl₂Si	3937-28-8
			Methyl vinyl dichlorosilane	C₃H₆Cl₂Si	124-70-9
Allyl dichloromethylsilane	C₄H₈Cl₂Si	1873-92-3
			1-propenyl methyldichlorosilane	C₄H₈Cl₂Si	18142-37-5
Vinyl ethyl dichlorosilane	C₄H₈Cl₂Si	10138-21-3
			Divinyldichlorosilane	C₄H₆Cl₂Si	1745-72-8
Butenyl dichloromethylsilane	C₅H₁₀Cl₂Si	15983-86-5
			Diallyl dichlorosilane	C₆H₁₀Cl₂Si	3651-23-8
Allylhexyldichlorosilane	C₉H₁₈Cl₂Si	168270-62-0
			Vinyl dichlorononane silane	C₁₀H₂₀Cl₂Si	211985-85-2

TABLE 13 Alkyldimethoxysilanes

Name of Chinese	Molecular formula	CAS
			Dimethoxysilane	C₃H₁₀O₂Si	16881-77-9
Dimethyldimethoxysilane	C₄H₁₂O₂Si	1112-39-6
			Dimethoxymethylpropylsilane	C₆H₁₆O₂Si	18173-73-4
Methyl tert-butyl dimethoxysilane	C₇H₁₈O₂Si	18293-81-7
			N-butyl methyl dimethoxy silane	C₇H₁₈O₂Si	18294-08-1
Isobutyl (methyl) dimethoxysilane	C₇H₁₈O₂Si	18293-82-8
			Tert-butyl (ethyl) dimethoxysilane	C₈H₂₀O₂Si	129880-07-5
Diisopropyl dimethoxysilane	C₈H₂₀O₂Si	18230-61-0
			Tert-butyl propyl dimethoxy silane	C₉H₂₂O₂Si	150176-63-9
Tert-butyl isopropyl dimethoxy silane	C₉H₂₂O₂Si	109144-59-4
			Isobutyl isopropyl dimethoxysilane	C₉H₂₂O₂Si	111439-76-0
Di-n-butyldimethoxysilane	C₁₀H₂₄O₂Si	18132-63-3
			Diisobutyldimethoxysilane	C₁₀H₂₄O₂Si	17980-32-4
Octyl methyl dimethoxy silane	C₁₁H₂₆O₂Si	85712-15-8
			Octadecyl methyl dimethoxy silane	C₂₁H₄₆O₂Si	70851-50-2

TABLE 14 Fluorodimethoxysilanes

Name of Chinese	Molecular formula	CAS
			3,3, 3-Trifluoropropylmethyldimethoxysilane	C₆H₁₃F₃O₂Si	358-67-8
1H,1H,2H, 2H-perfluorooctylmethyldimethoxysilane	C₁₁H₁₃F₁₃O₂Si	85857-17-6
			Dodecafluoroheptyl-propyl-methyl-dimethoxy-silane	C₁₃H₁₈F₁₂O₂Si	1374604-19-9

TABLE 15 functionalized dimethoxysilanes

Name of Chinese	Molecular formula	CAS
			Allyl dimethoxy silane	C₅H₁₂O₂Si	18147-35-8
Methyl vinyl dimethoxy silane	C₅H₁₂O₂Si	16753-62-1
			Allyl methyl dimethoxy silane	C₆H₁₄O₂Si	67681-66-7

TABLE 16 Alkyldiethoxysilanes

Name of Chinese	Molecular formula	CAS
			Methyldiethoxysilane	C₅H₁₄O₂Si	2031-62-1
Diethoxydimethylsilane	C₆H₁₆O₂Si	78-62-6
			Diethyl diethoxysilane	C₈H₂₀O₂Si	5021-93-2
Diisobutyl diethoxysilane	C₁₂H₂₈O₂Si	18297-14-8
			Di-n-hexyl diethoxysilane	C₁₆H₃₆O₂Si	18407-13-1
Dialkylmethyldiethoxysilane	C₁₇H₃₈O₂Si	60317-40-0
			Methyloctadecyldiethoxysilane	C₂₃H₅₀O₂Si	67859-75-0

TABLE 17 Fluorodiethoxysilanes

TABLE 18 functionalized diethoxysilanes

Name of Chinese	Molecular formula	CAS
			Methyl vinyl diethoxysilane	C₇H₁₆O₂Si	5507-44-8

Monochloro (methoxy, ethoxy) silane:

TABLE 19 Alkylmonochlorosilanes

TABLE 20 Fluoromonochlorosilane

Name of Chinese	Molecular formula	CAS
			Chlorodimethyl-3, 3, 3-fluoropropylsilane	C₅H₁₀ClF₃Si	1481-41-0
Nonafluorohexyldimethylchlorosilane	C₈H₁₀ClF₉Si	119386-82-2
			1H,1H,2H, 2H-perfluorooctyldimethylchlorosilane	C₁₀H₁₀ClF₁₃Si	102488-47-1
1H,1H,2H, 2H-perfluoroheptadecadimethylchlorosilane	C₁₂H₁₀ClF₁₇Si	74612-30-9

TABLE 21 functionalized monochlorosilanes

Name of Chinese	Molecular formula	CAS
			5-hexenyldimethylchlorosilane	C₈H₁₉ClSi	30102-73-9
1-alkenylundecyldimethylchlorosilane	C₁₃H₂₇ClSi	18406-97-8
			Dimethylvinylchlorosilane	C₄H₉ClSi	1719-58-0
Allyl dimethylchlorosilane	C₅H₁₁ClSi	4028-23-3

TABLE 22 Alkylmonomethoxysilanes

Name of Chinese	Molecular formula	CAS
			Dimethyl methoxy-N-propyl silane	C₆H₁₆OSi	18182-14-4
N-butyl dimethyl methoxysilane	C₇H₁₈OSi	64712-50-1
			Triethyl methoxysilane	C₇H₁₈OSi	2117-34-2

TABLE 23 fluoro-methoxy silanes

Name of Chinese	Molecular formula	CAS
			Dimethylmethoxy (3,3, 3-fluoropropyl) silane	C₆H₁₃F₃OSi	4852-13-5

TABLE 24 functionalized Monomethoxysilanes

Name of Chinese	Molecular formula	CAS
			Dimethylvinylmethoxysilane	C₅H₁₂OSi	16546-47-7
Triallylmethoxysilanes	C₁₀H₁₈OSi	17984-83-7

TABLE 25 Alkylethoxysilanes

Name of Chinese	Molecular formula	CAS
			Dimethylethoxysilane	C₄H₁₂OSi	14857-34-2

Claims

1. A pit and fissure sealant based on the idea of hydrophobization of the surface of a tooth is characterized by consisting of a single-component pit and fissure sealant or a double-component pit and fissure sealant,

(1) the two-component pit and trench sealant consists of a component A and a component B, wherein the component A: a hydrophobizing agent (a) and a solvent (b); and (B) component: a hydrophobic polymerizable monomer (c), a photopolymerization initiator (d), and a filler (e);

(2) the one-component pit and trench blocking agent consists of a hydrophobization reagent (a), a hydrophobization polymerization monomer (c), a photopolymerization initiator (d) and a filler (e);

the solvent (b) is selected from ethanol, ether, toluene, acetone and a mixed solvent of two or more than two;

the hydrophobization reagent (a) in the component A is chlorosilane, methoxysilane or ethoxysilane, and alkyl chlorosilane, fluoro-chlorosilane, functionalized chlorosilane, alkyl methoxysilane, functionalized methoxysilane, fluoro-methoxysilane, alkyl ethoxysilane, functionalized ethoxysilane, fluoro-ethoxysilane and a mixture of two or more different silanes are selected; the volume ratio total concentration of the hydrophobization reagent in the component A is 0.001% -100%;

the hydrophobic polymerized monomer (c) in the component B has no hydrophilic group and at least two functional groups for initiating polymerization by free radicals in the molecule, the polymerized monomers are mutually polymerized and are independently used, or two or more polymerized monomers are used in combination, and aromatic methacrylates of bisphenol A dimethacrylate, bisphenol A diglycidyl methacrylate, ethoxylated bisphenol A glycidyl dimethacrylate, 2-bis (4-methacryloyloxyethoxybenzyl) propane, ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, neopentyl glycol dimethacrylate, trimethylolpropane trimethacrylate and polyfunctional methacrylates of urethane methacrylate are selected and not limited, wherein the total content of the hydrophobic polymerized monomers is 1-70 wt%;

the photopolymerization initiator (c) in the component B is selected from α -diketones, ketals, thioxanthones, acylphosphine oxides and coumarins, which are used independently or in a mixture of two or more, the total content of the photopolymerization initiator is 0.01-10 wt%, the α -diketones are camphorquinone or benzil, the ketals are benzyl dimethyl acetal acetophenone and benzyl diethyl acetal acetophenone, and the thioxanthones are 2-chlorothioxanthone and 2, 4-diethylthioxanthone;

the filler (e) is an inorganic filler or an organic filler, which is used singly or in a mixture of two or more, and the organic filler is selected from but not limited to polymethyl methacrylate, polyethyl methacrylate, polyamide, polyvinyl chloride, nitrile rubber and styrene butadiene rubber; the inorganic filler is selected from but not limited to silicon dioxide, ceramics, glass, alumina, calcium carbonate, sodium fluoride, potassium fluoride, hydroxyapatite, titanium oxide, zirconium oxide and calcium phosphate, the total content of the filler is 1wt% -45 wt%, the average grain size of the filler (e) is 10 nm-400 nm, wherein the content of the filler with the grain size of more than 400nm is less than 10wt% of the total content of the filler;

wherein the definition and the range of the hydrophobization agent (a), the hydrophobic polymerization monomer (c), the photopolymerization initiator (d) and the filler (e) of the single-component pit and trench blocking agent are consistent with the definition and the range of the hydrophobization agent (a), the hydrophobic polymerization monomer (c), the photopolymerization initiator (d) and the filler (e) in the two-component pit and trench blocking agent.

2. The socket closure agent based on the concept of tooth surface hydrophobization of claim 1, wherein a stabilizer, a coloring agent, a fluorescent agent, an ultraviolet absorbent and a polymerization accelerator are added into the two-component socket closure agent, and the contents of the components are respectively less than 5 wt%;

the single-component pit and trench sealing agent is added with a stabilizer, a coloring agent, a fluorescent agent, an ultraviolet absorbent, a polymerization accelerator and the like, and the content of each component is less than 5wt% respectively.

3. The socket closure agent based on the tooth surface hydrophobization concept as claimed in claim 1, wherein the two-component socket closure agent is added with fluoride ion releasing substances, which are pure substances or mixtures, selected from but not limited to fluoroaluminosilicate glass, sodium fluoride, potassium fluoride metal fluoride, one kind of fluoride ion releasing substances, or mixtures of two or more kinds of combination, wherein the total content of the fluoride ion releasing substances is less than 10 wt%;

the single-component pit and trench sealing agent is a pure substance or a mixture, is prepared by adding fluorine ion releasing substances, is a fluorine glass of fluorine-aluminum silicate glass, sodium fluoride and potassium fluoride metal fluorides, is added with one fluorine ion releasing substance or a mixture of two or more than two fluorine ion releasing substances, and the total content of the fluorine ion releasing substances is less than 10 wt%.

4. The socket closure agent based on the concept of tooth surface hydrophobization of claim 1, wherein the two-component socket closure agent is prepared by adding antibacterial substances, adding an antibacterial substance, or a mixture of two or more antibacterial substances, such as but not limited to methacryloxy decyl ammonium chloride and triclosan, wherein the total content of the antibacterial substances is less than 10 wt%;

the single-component pit and fissure sealant is prepared by adding an antibacterial substance, adding an antibacterial substance or a mixture of two or more antibacterial substances, and selecting but not limited to methacryloxy decyl ammonium chloride and triclosan, wherein the total content of the antibacterial substances is less than 10 wt%;

in the two-component pit and trench sealing agent, a single-functional polymerized monomer is introduced, one single-functional polymerized monomer or a mixture of two or more single-functional polymerized monomers is introduced, and methyl methacrylate, ethyl methacrylate, isopropyl methacrylate and 2, 3-dibromopropyl methacrylate are selected and not limited, wherein the content of the single-functional polymerized monomer is less than 40 wt%;

the single-component pit and trench sealing agent is prepared by introducing a monofunctional polymerization monomer, or introducing a mixture of two or more monofunctional polymerization monomers, and selecting but not limited to methyl methacrylate, ethyl methacrylate, isopropyl methacrylate and 2, 3-dibromopropyl methacrylate, wherein the content of the monofunctional polymerization monomer is less than 40 wt%;

introducing an amphiphilic polymerization monomer into the two-component pit and trench sealing agent, adding one amphiphilic polymerization monomer or a mixture consisting of two or more amphiphilic polymerization monomers, and selecting but not limited to 2 hydroxyethyl methacrylate, 3-hydroxypropyl methacrylate, 2-hydroxypropyl methacrylate, 1, 3-dihydroxypropyl methacrylate, 2-trimethylammonium ethyl methacryloyl chloride and polyethylene glycol dimethacrylate, wherein the total content of the amphiphilic polymerization monomers is less than 20 wt%;

the single-component pit and trench sealing agent is prepared by introducing an amphiphilic polymerization monomer, adding one amphiphilic polymerization monomer or a mixture of two or more amphiphilic polymerization monomers, and selecting but not limited to 2 hydroxyethyl methacrylate, 3-hydroxypropyl methacrylate, 2-hydroxypropyl methacrylate, 1, 3-dihydroxypropyl methacrylate, 2-trimethylammonium ethyl methacryloyl chloride and polyethylene glycol dimethacrylate, wherein the total content of the amphiphilic polymerization monomers is less than 20 wt%;

adding a solvent into the two-component pit and trench sealing agent, wherein the solvent is selected from but not limited to ethanol, diethyl ether, toluene, acetone or a mixed solvent of two or more of the solvents, and the total content of the solvent is less than 30 wt%;

the single-component pit and trench sealing agent is added with a solvent, and the solvent is selected from but not limited to ethanol, diethyl ether, toluene, acetone or a mixed solvent of two or more of the solvents, wherein the total content of the solvent is less than 30 wt%.