CN106135895A - A kind of supplementary - Google Patents
A kind of supplementary Download PDFInfo
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- CN106135895A CN106135895A CN201510191495.5A CN201510191495A CN106135895A CN 106135895 A CN106135895 A CN 106135895A CN 201510191495 A CN201510191495 A CN 201510191495A CN 106135895 A CN106135895 A CN 106135895A
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- supplementary
- methopterin
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- magnesium oxide
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Abstract
The present invention relates to a kind of supplementary, including following components: L methopterin or L methopterin salt, described supplementary also includes that following two component is made: arginine and magnesium oxide.The invention have the benefit that the present invention uses arginine, magnesium oxide and L methopterin or three kinds of components of L methopterin salt, described three kinds of components pass through synergism, strengthen human body constitution, make people away from sub-health state, meanwhile, to preventing primary cerebral infarction to have certain effect.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of supplementary.
Background technology
Sub-health state due to inherited genetic factors and/or environmental factors cause physiological function low or uncomfortable, be situated between
In healthy and unhealthy between physiological status, the chronic fatigue syndrome that i.e. it has often been said.Owing to it can not
Lay the blame on morbid state, so being typically referred to as sub-health state.
Along with the progress of science discloses: cause one major reason of sub-health state to be exactly genetic flaw and lead
Cause important bioactive substance to produce or lack, thus result in human body and be in sub-health state, if
This sub-health state is corrected not in time, it is likely that can be transformed into intractable pathological changes and cause disease.
The corporality symptom of sub-health population embodies a concentrated expression of: 1, hypomnesis, absent minded；2、
Slowness of thinking, bradykinesia, dreaminess of sleeping, asthenia；3, long unhealthy emotion, energy declines, waist
Acid backache, is short of physical strength.Modern medicine investigation display, the incidence rate of male's subhealth state has reached 65.70%.
Women occur more some unknown causes anxious state of mind, sleepy weak, go down, irritable, palpitation and short breath,
Soreness of waist and ache in legs, dizziness headache etc., though wherein most patient is without organic disease, but the health index of body
Being decreased obviously, its physiological status is in " subhealth state " state.Research data is had to show: China's main flow city
White collar (social elite stratum) subhealth state 76%, truly healthy less than 3%.It is strong that science sets up Asia
Health-caring, is to improve the thing that China's health care system must urgently solve, and significance of times is strong.
Subhealth state is the functional disorder of physiological equilibrium, if develops into serious organic disease and has uncertain
Property.But, the problem that subhealth state inherently needs to solve.This is the common recognition of medical circle.
It addition, in addition to subhealth state, primary cerebral infarction also has significant threat to the health of people.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides a kind of supplementary, be used for
Improve the sub-health state of human body, and to preventing primary cerebral infarction to have certain effect.
The technical solution adopted in the present invention is: a kind of supplementary, including following components: L methyl leaf
Acid or L methopterin salt, described supplementary also includes that following two component is made: arginine and oxidation
Magnesium.
Preferably, described supplementary includes the component of following weight portion: L methopterin 1～20 parts or L
Methopterin salt 1～20 parts, described supplementary also includes that the component of following weight portion is made: arginine
10～500 parts and magnesium oxide 10～500 parts.
Preferably, described supplementary includes the component of following weight portion: L methopterin 3～15 parts or L
Methopterin salt 3～15 parts, described supplementary also includes that the component of following weight portion is made: arginine
50～400 parts and magnesium oxide 50～400 parts.
Preferably, described supplementary includes the component of following weight portion: L methopterin 9 parts or L first
Base folate 9 parts, described supplementary also includes that the component of following weight portion is made: arginase 12 20 parts
With magnesium oxide 220 parts.
Further, described L methopterin salt is L methopterin calcium or L methopterin magnesium.
A kind of preparation method for preparing any of the above-described described supplementary, by described component mix homogeneously
?.
The invention also discloses, described supplementary improves medicine or the guarantor of sub-health state in preparation
Application in strong product.
The invention also discloses, described supplementary prevents the medicine of primary cerebral infarction in preparation
Or the application in health product.
The present invention can make pharmaceutically acceptable any preparation, uses existing technological means all can solve
Certainly, just repeat no more at this.
Below to the one in three kinds of compositions in the present invention, i.e. L methopterin or L methopterin salt, essence
Propylhomoserin and magnesium oxide are further elaborated.
L methopterin or L methopterin salt existence form in vivo are the same, say, that both
The effect played in supplementary is identical, in order to describe conveniently, the present invention when narration acts on,
Unified use L methopterin is expressed.
L methopterin also known as (6s)-5-methyltetrahydrofolate, be activity in man's folic acid be primarily present form,
Folic acid just has physiological function after being transformed into methopterin.Folic acid could be turned by 4 physiological metabolism steps
Turning to have bioactive L methopterin, L methopterin can pass through blood brain barrier, and cross-film carries, and enters
And play physiological function.4 physiological metabolism steps are:
1) in intestinal absorption and during transporting to perienchyma, folic acid is reduced by dihydrofolate reductase
For dihydrofoilic acid；
2) dihydrofoilic acid continues to be become tetrahydrofolic acid by dihydrofolate reductase reduction；
3) tetrahydrofolic acid is converted into 5,10-methylene tetrahydrofolate；
4) 5,10-methylene tetrahydrofolate is finally in the catalysis of Methylene tetrahydrofolate reductase (MTHFR)
Effect is lower forms L methopterin.
Wherein, in step 4) in, 5,10-CH2-THFA during being converted into L methopterin,
Needing two conditions, one is the catalysis of Methylene tetrahydrofolate reductase (MTHFR), and another is to need
The transmission of methyl to be carried out.
And in above-mentioned metabolic process, the transmission of methyl is completed by homocysteine metabolism, with
Type cysteine is converted into methionine by twice methylation；Thus complete the transmission of methyl, same
Type transforms cysteine is in the metabolic process of methionine, needs the cooperation of MTRR enzyme, and MTRR enzyme can
The methionine synthetase of inactivation is reduced into activated state, to maintain the unimpeded of methyl transmission path, once
The activity of internal MTRR enzyme is abnormal, the activity reduction of MTRR enzyme, will cause the resistance of the transmission path of methyl
Plug, and then have influence on the synthesis of L methopterin.
Methylene tetrahydrofolate reductase and MTRR enzyme are respectively by mthfr gene and two genes of MTRR
Control, and in crowd, the occupation rate population of disappearance or defect at least one gene above-mentioned is about
18%, the locally district occurred frequently crowd up to 40%, up to 70% in specific crowd (such as depression),
Can not effectively utilize folic acid to change into and there is bioactive L methopterin, say, that for this portion
For dividing crowd, direct Supplement of folic acid can not effectively play its physiological function.
After the mechanism of action that further investigation is above-mentioned, what inventor was creative directly uses the replacement of L methopterin
Conventional use of folic acid, thus got around above-mentioned folic acid and changed into the step of L methopterin in vivo, especially
It is for the people of said gene defect, it is necessary to supplementing L methopterin, the present invention can directly supplement body
Possess bioactive L methopterin needed for body, which greatly enhances the scope of application and effectively of the present invention
Rate.
It should be strongly noted that the probability that the person state of excessive drinking is in sub-health state is wanted than common people
Greatly, reason is that the human body of excessive drinking is interior general lack of L methopterin, and the supplementary that the present invention provides is to changing
The sub-health state of kind excessive drinking crowd has good effect.
In addition to the effect of anti-sub-health state, L methopterin still participates in many body weight for humans and wants physiology mistake
The bioactive substance of journey, one of them main effect is to safeguard endotheliocyte normal function, it is ensured that human body
Sanguimotor normal operation, so, there is certain effect to preventing primary cerebral infarction.
Arginine is half necessary aminoacid, is to safeguard nervous system and the necessary biology of blood circulation normal function
Active substance.Arginine be synthesis NO (nitric oxide) direct precursor, arginine be maintain and ensure in
The main matter that chrotoplast normally works, can improve, blood circulation promoting, reaches to release sub-health state not
The effect of suitable disease.Research shows to increase arginine supply, not only helps increase NO and produces and protect, change
Kind inner skin cell function；And contribute to increasing the activity of NO synzyme, and NO dyssynthesis is with many
Disease has Close relation, and especially relevant with endothelial dysfunction disease has important being correlated with
Property.
Endothelial dysfunction is the important pathology root that numerous disease occurs, especially with disturbance of blood circulation
Class disease is closely related, such as: cardiovascular and cerebrovascular disease, diabetic complication, and old amentia is sick, and these
The form of expression of the initial symptoms of disease is all the sub-health state of body.
In addition to the impact of precursor, endotheliocyte NO synzyme also has large effect to the synthesis of NO,
And endotheliocyte NO synthase activity is closely related with the cofactor of this enzyme, the cofactors having now been found that
In just have L methopterin, so, arginine in the present invention and L methopterin are with the use of, Ke Yibao
The smooth synthesis of card NO, and then in body, play due physiological function, beneficially body keeps preferably
State.
The function of magnesium oxide: magnesium is the necessary composition of multiple enzyme, and enzyme the manufacture of protein, lipid metabolism,
And play very important effect during the duplication of hereditary material DNA etc.；On the other hand, magnesium is still
Internal help absorbs and utilizes calcareous poising agent, it is possible to promotes the cell absorption to calcium, strengthens immunity simultaneously
System.At present, the domestic uneven problem that supplements the nutrients that there is unilateral simple " whole people replenish the calcium ", therefore lead
Cause the shortage of calcium absorption auxiliary agent magnesium.Magnesium oxide in the present invention, on the one hand can with the activity of reinforcement endoenzyme,
On the other hand may also help in absorption calcareous, to improve the sub-health state of human body.
In addition to above-mentioned major function, magnesium also has other functions following, improves the sub-health state of human body: 1,
Help blood circulation and calm nerves, maintain normal muscle (including cardiac muscle) and neural activity.There is guarantor
Protecting the function of nerve, magnesium deficiency can become irritated, nervous, to sound sensitive, excitement, impulsion etc.；2, may be used
Reduce liver, gallbladder, renal calculus formed, and the calcification chance 3 of soft tissue, be skeleton another composition
Composition, health invigorating；4, there is defecating feces excretion.
This is because magnesium has more beneficial functions, the present invention using the magnesium oxide of food stage as the one of component
Kind, match with described L methopterin and arginine, it is possible to play the effect being obviously improved sub-health state
Really.
The invention have the benefit that the present invention uses L methopterin, arginine and three kinds of components of magnesium oxide,
Described three kinds of components pass through synergism, strengthen human body constitution, hence it is evident that improve sub-health state, meanwhile, right
Primary cerebral infarction is prevented to have certain effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is done a progressive elaboration.
Embodiment 1
A kind of supplementary, the component including following weight makes: L methopterin 1 milligram, arginine
10 milligrams；Magnesium oxide 10 milligrams.
The preparation method of described supplementary, by described component mix homogeneously.
Embodiment 2
A kind of supplementary, the component including following weight makes: L methopterin 20 milligrams, arginine
500 milligrams；Magnesium oxide 500 milligrams.
The preparation method of described supplementary, by described component mix homogeneously.
Embodiment 3
A kind of supplementary, the component including following weight makes: L methopterin calcium 3 milligrams, essence ammonia
Acid 50 milligrams；Magnesium oxide 50 milligrams.
The preparation method of described supplementary, by described component mix homogeneously.
Embodiment 4
A kind of supplementary, the component including following weight makes: L methopterin calcium 15 milligrams, essence ammonia
Acid 400 milligrams；Magnesium oxide 400 milligrams.
The preparation method of supplementary described above, by described component mix homogeneously.
Embodiment 5
A kind of supplementary, the component including following weight makes: 9 milligrams of L methopterin magnesium, essence ammonia
Acid 220 milligrams；Magnesium oxide 220 milligrams.
The preparation method of supplementary described above, by described component mix homogeneously.
Above-described embodiment 1～5 all can be made pharmaceutically acceptable any preparation and use, and uses existing skill
Art means all can solve the problem that, just repeats no more at this.
In three kinds of compositions in the present invention:
L methopterin or L methopterin salt can directly supplement health needed for possess bioactive L first
Base folic acid, which greatly enhances the scope of application and the effective percentage of the present invention；
Arginine is half necessary aminoacid, is to safeguard nervous system and the necessary biology of blood circulation normal function
Active substance, L methopterin is with the use of the smooth synthesis of, it is ensured that NO, and then sends out in body
Wave due physiological function, beneficially body and keep preferable state；
Magnesium is the necessary composition of multiple enzyme, and enzyme is at manufacture, lipid metabolism and the hereditary material of protein
Very important effect is played during the duplication of DNA etc.；On the other hand, magnesium or internal help absorption
With utilize calcareous poising agent, it is possible to promote the cell absorption to calcium, strengthen immune system simultaneously, except this it
Outward, magnesium may also help in blood circulation and calm nerves, maintains normal muscle (including cardiac muscle) and nerve
Movable.
The present invention is carried out clinical trial, in the clinical trial of 187 example subhealth state discomfort crowds, effectively
174 examples, account for the 93.0% of total number of persons；Wherein significant 42 examples of effect, account for the 22.5% of total number of persons；Nothing
13 examples of effect, account for the 7.0% of total number of persons；It can be seen that the present invention is in the side improving human body sub-health status
, there is remarkable result in face.
The part use case of the present invention:
1) Wang, 42 years old, certain enterprise boss；Owing to fighting for many years, there is insomnia problem, during fashion always
Bad.Owing to workload strengthens, cause tired weak, frequent urination at night, it is difficult to after getting up in the night to urinate fall asleep again.Therefore daytime
Headache syndromes occur, memory is felt worse and worse.Take medicine as flu problem always, lose symptom and alleviate.
Taking the supplementary of the present invention, within first week, nocturia problem disappears, and sensation is easily fallen asleep, and readme sleep is stepped on
Real, headache disappears.After taking two weeks, hence it is evident that sensation muscle power strengthens, and memory is recovered substantially.
2) Liu, 38 years old, paperwork；Enterprise participates in a certain comparation and assessment in the recent period, and unexpected workload increases.
Owing to its personality is sought to prevail over others, overtime work is to the late into the night often, be overworked for a very long period appearance insomnia, headache syndromes,
And then constipation, weak fatiguability occur, to such an extent as to before sitting on computer, feel huge heavy burden, even occur
Dizzy phenomenon, thinks and has suffered from Meniere's syndrome, can not make a definite diagnosis to examination in hospital.Through taking the battalion of the present invention
After supporting supplement a period of time, dizzy anesthesia, cause spirit emotion to recover positive state, other are uncomfortable
Sensation disappears therewith.
3) often certain, 37 years old, pregnant first tire；The discomforts such as pregnancy period agitation, cramp in the leg occur, hospital outputs
Medicine of replenishing the calcium has been eaten and could not have been alleviated discomfort, through referring physician always, it is believed that the nutrition that can supplement the present invention is mended
Filling agent, after taking the supplementary one week of the present invention, the described pregnancy period is irritated, the transference cure of cramp in the leg.
4) in certain, female, 52 years old；Retirement, over 2 years, often feels palpitation and short breath, and often can feel
Unknown agitation, always worries that what to occur, can not find the most again reason.Think oneself as climacteric
Phase problem, has eaten much Chinese medicine, but DeGrain.Take the supplementary one of the present invention upon somebody's introduction
Zhou Hou, feels the comfortable many of health, and through taking 2 months, symptom disappears substantially.
5) Wang, female, 62 years old；There is diabetic history 7 years, constipation problem often occurs, be in use in the past
Medicine rush down leaf relieving constipation, but diarrhoea situation occurs the most again, two kinds of discomforts are alternately present, and symptom is unstable.Warp
Take the supplementary one month of the present invention, transference cure.Adhere to taking 3 months, and more feel body
Body taediumvitae disappears, and brains more feels clear-headed, and legs and feet are convenient more energetic.
6) Ma, man, 56 years old, small business owner；Due to often dinner party, the most drunk and return.Nearly 1 year
Come, left side arm, numbness of hand wood situation occur.Through taking the supplementary 15 days of the present invention, getting up early is felt
Health more easily, brains the most limpid much, adhere to taking 3 months, arm, numbness of hand wood transference cure.
7) Zheng, female, 70 years old；Being sensation of forgetting things for many years, memory go fromes bad to worse, and has a hunch oneself
Obtain senile dementia, and often doubted to get up, just think that life is hopeless, be sick of the affairs of human life.Take the present invention's
Supplementary 6 months, thinks that memory is constantly being recovered, and life is also cheered up.Chat according to children
State that " we are old, and mother's memory is better than us, some TV news, the even newsmaker, and it is good to have broadcasted
For a long time, she also can remember.Some foreigners occur in screen frequently, she can know last time this
It is individual that certain so-and-so be not exactly how, how personage squares with.”.
8) Lee, man, 53 years old, civil servant；Not only be busy with one's work, and old man, family, child bear
Carrying on a shoulder pole the heaviest, overwork is worried about result and is usually had a sleepless night, and getting up early thinks that brain is in heavy not waking state always, on
One day class tired must being not desired to of coming back home is moved again, often arrive hospital and see a doctor, and eats of the kidney invigorating, sleeps peacefully and sleep
Medicine, but effect is the most bad, bad during symptom fashion, this kind of state more than 10 year.Through taking the present invention
3 months symptoms of supplementary substantially disappear.Conscious health is increasingly strongr, and working unit is the most
Busy, but conscious have muscle power, have patience.
9) temperature certain, man, 47 years old, handicraftsman；It is addicted to drink history, readme is tired, drowsiness, weak all over,
Poor memory, brain is the most murky, is in less waking state, the most vexed, and manual work stops,
Almost life is lost interest.Through taking the supplementary 2 months of the present invention, have one's head in the clouds anesthesia.
Continuing to take 6 months, be addicted to drink and controlled, uncomfortable sensation disappears substantially, antisecosis, continues to pull
Work alive.
Case is it can be seen that the present invention is improving the aspect of human body sub-health status from the section above, has notable
Effect.
The invention have the benefit that the present invention uses L methopterin, arginine and three kinds of components of magnesium oxide,
Described three kinds of components pass through synergism, strengthen human body constitution, make people away from sub-health state, meanwhile,
Certain effect is had to preventing primary cerebral infarction.
The present invention is not limited to above-mentioned preferred forms, and anyone can draw it under the enlightenment of the present invention
His various forms of products, no matter but in its shape or structure, make any change, every have and the application
Technical scheme as same or like, within all falling within protection scope of the present invention.
Claims (10)
1. a supplementary, it is characterised in that include following components: L methopterin or L methyl
Folate, described supplementary also includes that following two component is made: arginine and magnesium oxide.
Supplementary the most according to claim 1, it is characterised in that include the group of following weight portion
Point: L methopterin 1～20 parts or L methopterin salt 1～20 parts, described supplementary also includes following
The component of weight portion is made: arginine 10～500 parts and magnesium oxide 10～500 parts.
Supplementary the most according to claim 1, it is characterised in that include the group of following weight portion
Point: L methopterin 3～15 parts or L methopterin salt 3～15 parts, described supplementary also includes following
The component of weight portion is made: arginine 50～400 parts and magnesium oxide 50～400 parts.
Supplementary the most according to claim 1, it is characterised in that include the group of following weight portion
Point: 9 parts or L methopterin salt of L methopterin 9 parts, described supplementary also includes following weight portion
Component make: arginase 12 20 parts and magnesium oxide 220 parts.
5. according to the arbitrary described supplementary of Claims 1 to 4, it is characterised in that described L methyl leaf
Hydrochlorate is L methopterin calcium or L methopterin magnesium.
6. the preparation method preparing the arbitrary described supplementary of Claims 1 to 4, it is characterised in that
By described component mix homogeneously.
7. the preparation method preparing supplementary described in claim 5, it is characterised in that by institute
State component mix homogeneously.
8. according to the purposes of the arbitrary described supplementary of Claims 1 to 4, it is characterised in that described battalion
Support supplement application in preparing the medicine or health product improving sub-health state.
9. according to the purposes of the arbitrary described supplementary of Claims 1 to 4, it is characterised in that described battalion
Support supplement application in the medicine or health product of the preparation primary cerebral infarction of prevention.
The purposes of supplementary the most according to claim 5, it is characterised in that described nutritional supplementation
Agent application in preparing the medicine or health product improving sub-health state.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510191495.5A CN106135895A (en) | 2015-04-21 | 2015-04-21 | A kind of supplementary |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510191495.5A CN106135895A (en) | 2015-04-21 | 2015-04-21 | A kind of supplementary |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106135895A true CN106135895A (en) | 2016-11-23 |
Family
ID=58058658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510191495.5A Pending CN106135895A (en) | 2015-04-21 | 2015-04-21 | A kind of supplementary |
Country Status (1)
| Country | Link |
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| CN (1) | CN106135895A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108714153A (en) * | 2018-07-17 | 2018-10-30 | 李健 | Treat pharmaceutical composition, preparation method and the application of coronary heart disease coronary stenosis |
| CN112007163A (en) * | 2019-08-06 | 2020-12-01 | 连云港金康和信药业有限公司 | Pharmaceutical composition for treating African swine fever and application thereof |
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| CN101043906A (en) * | 2004-07-29 | 2007-09-26 | 埃弗雷特实验室公司 | Compositions and methods for nutrition supplementation |
| CN103096735A (en) * | 2010-05-26 | 2013-05-08 | 杰奎琳·M·赫伯特 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore |
| CN104116744A (en) * | 2014-08-08 | 2014-10-29 | 淄博维克勋医药技术有限公司 | Pharmaceutical composition for treating depressive disorder |
| CN104138389A (en) * | 2014-08-08 | 2014-11-12 | 淄博维克勋医药技术有限公司 | Pharmaceutical composition for treating blood circulation disturbance diseases |
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2015
- 2015-04-21 CN CN201510191495.5A patent/CN106135895A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101043906A (en) * | 2004-07-29 | 2007-09-26 | 埃弗雷特实验室公司 | Compositions and methods for nutrition supplementation |
| CN103096735A (en) * | 2010-05-26 | 2013-05-08 | 杰奎琳·M·赫伯特 | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore |
| CN104116744A (en) * | 2014-08-08 | 2014-10-29 | 淄博维克勋医药技术有限公司 | Pharmaceutical composition for treating depressive disorder |
| CN104138389A (en) * | 2014-08-08 | 2014-11-12 | 淄博维克勋医药技术有限公司 | Pharmaceutical composition for treating blood circulation disturbance diseases |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108714153A (en) * | 2018-07-17 | 2018-10-30 | 李健 | Treat pharmaceutical composition, preparation method and the application of coronary heart disease coronary stenosis |
| CN112007163A (en) * | 2019-08-06 | 2020-12-01 | 连云港金康和信药业有限公司 | Pharmaceutical composition for treating African swine fever and application thereof |
| CN114340609A (en) * | 2019-08-06 | 2022-04-12 | 连云港金康和信药业有限公司 | Pharmaceutical composition for producing safe amount of nitric oxide and use thereof |
| CN112007163B (en) * | 2019-08-06 | 2023-07-28 | 连云港金康和信药业有限公司 | Pharmaceutical composition for treating African swine fever and application thereof |
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| CB03 | Change of inventor or designer information |
Inventor after: Li Ping Inventor after: Li Chenxi Inventor before: Li Ping |
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| CB03 | Change of inventor or designer information | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170515 Address after: 255000, No. 12, building 701, East Garden, Nanjing Road, Zhangdian District, Shandong, Zibo Applicant after: Li Jian Address before: 255000, No. 12, building 701, East Garden, Nanjing Road, Zhangdian District, Shandong, Zibo Applicant before: ZIBO WEIKEXUN MEDICAL TECHNOLOGY Co.,Ltd. |
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