CN106124008A - A kind of micro-simply supported beam device weighing DNA molecular quality - Google Patents
A kind of micro-simply supported beam device weighing DNA molecular quality Download PDFInfo
- Publication number
- CN106124008A CN106124008A CN201610414068.3A CN201610414068A CN106124008A CN 106124008 A CN106124008 A CN 106124008A CN 201610414068 A CN201610414068 A CN 201610414068A CN 106124008 A CN106124008 A CN 106124008A
- Authority
- CN
- China
- Prior art keywords
- simply supported
- supported beam
- micro
- dna molecular
- superimposed layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G3/00—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances
- G01G3/12—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the weighing element is in the form of a solid body stressed by pressure or tension during weighing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
Abstract
The invention discloses a kind of micro-simply supported beam device weighing DNA molecular quality, belong to detection and the weighing field of organic macromolecule quality.It includes that fixed hinge, moveable hinge, two ends are installed in fixed hinge and the compound micro-simply supported beam on moveable hinge, DNA molecular module to be weighed and the microstrain sensor being installed in the middle part of compound micro-simply supported beam on bottom surface respectively；Compound micro-simply supported beam include superimposed layer, lower lamination, couple superimposed layer and lower lamination without slide surface.The present invention is micro-simply supported beam device that a kind of flexural deformation is notable, can accurately measure DNA molecular quality.
Description
Technical field
The invention mainly relates to detection and the weighing field of organic macromolecule quality, refer in particular to a kind of weighing DNA molecular quality
Micro-simply supported beam device.
Background technology
Measure DNA molecular quality rapidly and accurately to have great importance, this is because DNA molecular to be chromosome main
Constituent, is also central genetic material simultaneously.The infection of the various diseases of the mankind, majority can be from corresponding DNA molecular
Embody in structure and quality.But, it is less that DNA molecular compares macro object, and its difficult quality accurately measures, therefore,
Design a kind of device that can quickly, accurately detect DNA molecular quality and there is certain practical value.
Summary of the invention
The present invention need to solve the technical problem that: the technical problem existed for prior art, and the present invention provides a kind of curved
Bent deformation is notable, can accurately measure micro-simply supported beam device of DNA molecular quality.
In order to solve the problems referred to above, the solution that the present invention proposes is: a kind of micro-simply supported beam weighing DNA molecular quality
Device, it includes that fixed hinge, moveable hinge, two ends are installed in described fixed hinge and being combined on described moveable hinge respectively
Micro-simply supported beam, DNA molecular module to be weighed and the microstrain sensing being installed in the middle part of described compound micro-simply supported beam on bottom surface
Device；Described compound micro-simply supported beam include superimposed layer, lower lamination, couple described superimposed layer and described lower lamination without slide surface.
The middle part of the superimposed layer of the present invention begins with DNA pit, and described DNA pit can be placed with described DNA molecular module；
Described microstrain sensor checks that precision is 0.1 micron；The thickness of described superimposed layer is the half of described lower laminated thickness；Described
Superimposed layer uses silicon wafer to manufacture, and thickness is 5-15 micron；Described lower lamination uses liquid crystal elastomer to make.
The present invention compared with prior art, has the advantage that and beneficial effect:
(1) a kind of micro-simply supported beam device weighing DNA molecular quality of the present invention, is provided with 5-15 micron silicon chip high with liquid crystal
The composite beam that body makes, can occur significant flexural deformation under DNA molecular effect；
(2) a kind of micro-simply supported beam device weighing DNA molecular quality of the present invention, is additionally provided with the micro-of 0.1 micrometer resolution
Strain transducer, by detecting the microstrain of composite beam, and then can identify DNA molecular quality, and certainty of measurement is high.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of micro-simply supported beam device weighing DNA molecular quality of the present invention.
Fig. 2 is the weighing schematic diagram of a kind of micro-simply supported beam device weighing DNA molecular quality of the present invention.
In figure, 11 fixed hinges；12 moveable hinge；2 micro-simply supported beams；20 without slide surface；21 superimposed layers；
22 times laminations；23 DNA pits；3 DNA molecular models；4 microstrain sensors.
Detailed description of the invention
Below with reference to the drawings and specific embodiments, the present invention is described in further detail.
Seeing shown in Fig. 1 and Fig. 2, a kind of micro-simply supported beam device weighing DNA molecular quality of the present invention, including fixing hinge
Chain 11, moveable hinge 12, two ends are installed in fixed hinge 11 and the compound micro-simply supported beam on moveable hinge 12, to be weighed respectively
DNA molecular module 3 and the microstrain sensor 4 being installed in the middle part of compound micro-simply supported beam on bottom surface；Compound micro-simply supported beam includes
Superimposed layer 21, lower lamination 22, couple superimposed layer 21 and lower lamination 22 without slide surface 20；The middle part of superimposed layer 21 begins with DNA
Pit 23, DNA pit 23 can be placed with DNA molecular module 3；Microstrain sensor 4 checks that precision is 0.1 micron；Superimposed layer 21
The half that thickness is lower lamination 22 thickness；Superimposed layer 21 uses silicon wafer to manufacture, and thickness is 5-15 micron；Lower lamination 22 uses liquid
Brilliant elastomer makes.
See shown in Fig. 1 and Fig. 2, it is assumed that compound micro-simply supported beam, when acting on without DNA molecular module 3, occurs the least curved
Bent deformation (such as Fig. 1), now the reading of microstrain sensor 4 is x0；DNA molecular module 3 is positioned in DNA pit 23, by
In the weight effect of DNA molecular module 3, there is significant flexural deformation (such as Fig. 2) in compound micro-simply supported beam, now microstrain senses
The reading of device 4 is x1；Then X1-X0 is the additional strain that DNA molecular module 3 effect produces, according to superimposed layer 21 and lower lamination 22
The pattern of equivalent can obtain the elastic module E of compound micro-simply supported beam；Flexural deformation formula is utilized to can get DNA molecular model 3
Quality.
Claims (1)
1. the micro-simply supported beam device weighing DNA molecular quality, it is characterised in that: include fixed hinge (11), moveable hinge
(12), two ends are installed in described fixed hinge (11) and the compound micro-simply supported beam on described moveable hinge (12) respectively, wait to weigh
DNA molecular module (3) and the microstrain sensor (4) that is installed in the middle part of described compound micro-simply supported beam on bottom surface；Described multiple
Close micro-simply supported beam to include superimposed layer (21), lower lamination (22), couple the described superimposed layer (21) the nothing cunning with described lower lamination (22)
Shifting face (20)；The middle part of described superimposed layer (21) begins with DNA pit (23), and described DNA pit (23) can be placed with described DNA
Molecular modules (3)；Described microstrain sensor (4) checks that precision is 0.1 micron；The thickness of described superimposed layer (21) be described under
The half of lamination (22) thickness；Described superimposed layer (21) uses silicon wafer to manufacture, and thickness is 5-15 micron；Described lower lamination (22) is adopted
Make of liquid crystal elastomer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610414068.3A CN106124008A (en) | 2016-06-13 | 2016-06-13 | A kind of micro-simply supported beam device weighing DNA molecular quality |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610414068.3A CN106124008A (en) | 2016-06-13 | 2016-06-13 | A kind of micro-simply supported beam device weighing DNA molecular quality |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106124008A true CN106124008A (en) | 2016-11-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610414068.3A Pending CN106124008A (en) | 2016-06-13 | 2016-06-13 | A kind of micro-simply supported beam device weighing DNA molecular quality |
Country Status (1)
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Citations (7)
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|---|---|---|---|---|
| CN1844897A (en) * | 2006-05-18 | 2006-10-11 | 张青川 | Method and apparatus for monitoring interaction of probe molecule and target molecule on micro-cantilever |
| JP2007500846A (en) * | 2003-07-28 | 2007-01-18 | エイビービー インコーポレイテッド | System and method for measuring features such as web basis weight by using beta rays with web modification |
| CN101477029A (en) * | 2009-01-16 | 2009-07-08 | 中国科学院上海微系统与信息技术研究所 | Surface stress sensitization method for improving resonance type ultra-thin cantilever beam transducer sensitivity |
| CN101717066A (en) * | 2009-11-24 | 2010-06-02 | 天津大学 | Method and nano balance for weighing viruses |
| CN101963564A (en) * | 2010-08-20 | 2011-02-02 | 中国科学院苏州纳米技术与纳米仿生研究所 | Chiral sensor and preparation method thereof |
| CN103667039A (en) * | 2012-09-10 | 2014-03-26 | 中国科学院上海微系统与信息技术研究所 | Quality sensor for gene detection as well as preparation method and application of quality sensor |
| CN104569369A (en) * | 2015-01-13 | 2015-04-29 | 中国科学院上海微系统与信息技术研究所 | Resonant cantilever beam biochemical sensor for liquid phase detection and preparation method of resonant cantilever beam biochemical sensor |
-
2016
- 2016-06-13 CN CN201610414068.3A patent/CN106124008A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007500846A (en) * | 2003-07-28 | 2007-01-18 | エイビービー インコーポレイテッド | System and method for measuring features such as web basis weight by using beta rays with web modification |
| CN1844897A (en) * | 2006-05-18 | 2006-10-11 | 张青川 | Method and apparatus for monitoring interaction of probe molecule and target molecule on micro-cantilever |
| CN101477029A (en) * | 2009-01-16 | 2009-07-08 | 中国科学院上海微系统与信息技术研究所 | Surface stress sensitization method for improving resonance type ultra-thin cantilever beam transducer sensitivity |
| CN101717066A (en) * | 2009-11-24 | 2010-06-02 | 天津大学 | Method and nano balance for weighing viruses |
| CN101963564A (en) * | 2010-08-20 | 2011-02-02 | 中国科学院苏州纳米技术与纳米仿生研究所 | Chiral sensor and preparation method thereof |
| CN103667039A (en) * | 2012-09-10 | 2014-03-26 | 中国科学院上海微系统与信息技术研究所 | Quality sensor for gene detection as well as preparation method and application of quality sensor |
| CN104569369A (en) * | 2015-01-13 | 2015-04-29 | 中国科学院上海微系统与信息技术研究所 | Resonant cantilever beam biochemical sensor for liquid phase detection and preparation method of resonant cantilever beam biochemical sensor |
Non-Patent Citations (3)
| Title |
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| 吴森: "基于AFM的一维纳米材料操纵及力学特性测试技术", 《中国博士学位论文全文数据库 工程科技I辑》 * |
| 姜馨 等: "液晶高弹体的光致变形与弯曲行为研究", 《力学季刊》 * |
| 孟玮烈 等: "微悬臂梁DNA生物传感器纳米力学分析的重力模型及其应用", 《传感技术学报》 * |
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Application publication date: 20161116 |
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| RJ01 | Rejection of invention patent application after publication |