CN106113513A - 3D prints method and the 3D printing medicine shell of medicine - Google Patents
3D prints method and the 3D printing medicine shell of medicine Download PDFInfo
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- CN106113513A CN106113513A CN201610809066.4A CN201610809066A CN106113513A CN 106113513 A CN106113513 A CN 106113513A CN 201610809066 A CN201610809066 A CN 201610809066A CN 106113513 A CN106113513 A CN 106113513A
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- medicine
- spheroid
- positive tetrahedron
- geometric center
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of 3D and print the method for medicine and 3D prints medicine shell, medicine shell includes four axis angles cylindrical cavity of 109.47 ° each other；Four axial length are equal, and one end of described four axis is connected in same point, and this point is the geometric center of positive tetrahedron, and described four axis are the line at this center and described four summits of positive tetrahedron；Described cylinder is located in spheroid, and the centre of sphere of described spheroid is same point with described geometric center, connects described positive tetrahedron in described spheroid.The inventive method is simple and reliable, and obtained pill is applicable to controlled release drug and medicine stability requires high occasion.
Description
Technical field
The present invention relates to the field of controlled release drug, a kind of 3D prints method and the 3D printing medicine shell of medicine.
Background technology
One of controlled release drug emphasis being always pharmacokinetic, to a certain extent, controlled release drug can be very big
The utilization ratio of medicine is improved in degree.In Modern Pharmaceutics and clinical practice, controlled release drug has wide utilization prospect.
A lot of scholar and producer is had to have substantial amounts of achievement in research in this field both at home and abroad.And general along with hardware of increasing income of 3D printing technique
And increasingly become the representative of advanced productivity.3D prints this increasing material manufacture that can generate labyrinth and controlled release medicine
Thing intersection is used, and is customized the release characteristics of medicine according to patient's particular requirement, and it has a extensive future.
One of controlled release drug emphasis being always pharmacokinetic, it can improve the utilization of medicine largely
Rate.In Modern Pharmaceutics and clinical practice, controlled release drug has wide utilization prospect.There are a lot of scholar and producer both at home and abroad
Substantial amounts of achievement in research is had in this field.And 3D printing technique increasingly becomes advanced productivity along with the universal of hardware of increasing income
Representative, this increasing material manufacture that can generate labyrinth and controlled release drug intersect and use, and customize according to patient requests
The release characteristics of medicine, has a extensive future.
In existing achievement in research, foreign study person uses the printer of FDM type to print multiple different characteristic
Controlled release drug.Including the medicine that release profiles is convex function (being abroad referred to as concave, its definition is contrary with domestic),
May be used for impact treatment；Release profiles is the medicine of concave function (convex), uses to the patient producing drug resistance；Release
Put the medicine that curve is linear function, long equivalent can be used in and eliminate occasion.In some are studied, multicomponent is used to beat
The medicine of multiple heterogeneity is printed as a tablet by print machine.Also have some researchs by customizing the surface area body of mathematical model
The release printing medicine is planned by long-pending ratio in advance.
The release profiles speedup that a lot of achievements in research all control medicine is constant, but also has a lot of deficiency among this,
Such as step is too much, and printed medicine must be high temperature resistant, does not give full play to the 3D printing technique advantage etc. for labyrinth,
3D prints still has very high potential not excavate for pharmaceutical technology.Food and Drug Administration (FDA) has had been approved by 3D and has beaten
The list marketing of print medicine.Along with progress and the passage 3D of time of technology print controlled release drug and surely can play a greater role.
The rate of release of conventional medicine is divided into Zero order release and first-order release (i.e. constant eliminates and constant proportion elimination).Zero level is released
When putting, medicine concentration in blood is always maintained at stable, and beneficially medicine acts on human body always.Release at long medicine
In putting, that can effectively reduce that patient eats takes number of times and frequency, greatly facilitates patient and takes medicine and doctor is administered.Simultaneously
Can use medicine more efficiently, reduce medicine and discharge the burden that body metabolism is caused the most in a large number.And on the market
Controlled release drug general strength is relatively low, easily bursts apart, mode of production underaction, it is impossible to look after the situation of all patients.
Summary of the invention
The technical problem to be solved is, not enough for prior art, it is provided that a kind of 3D prints the method for medicine
And 3D prints medicine shell.
For solving above-mentioned technical problem, the technical solution adopted in the present invention is: a kind of 3D prints the method for medicine, including
Following steps:
1) one positive tetrahedron of structure, finds the geometric center of positive tetrahedron, does spheroid with described center for the centre of sphere, connect in spheroid
The four of positive tetrahedron angles are connected by positive tetrahedron with the geometric center of positive tetrahedron, formed four have same summit and
The angle straight line of 109.47 ° each other, generates four straight line intersection in a summit by this angle, and four straight line angles two-by-two are identical,
Later stage spatially keeps uniform with the cylinder that this framework generates；It is axle center according to these four straight lines, generates four cylinders,
Spheroid and all cylinders are carried out Boolean calculation so that the geometric center of the entity that described four cylinders are formed and spheroid
Geometric center overlaps, and obtains medicine shell model, medicine shell saves as the medicine shell model of STL form；
2) import to Slice Software calculates by the mathematical model of STL form, generate G code；
3) to FDM 3D printer identification and being printed by described G code, in print procedure, FDM3D printer head is by thawing
Polyvinyl alcohol wire rod is piled up according to the G code path of described medicine shell model generation；
4) pva powder and drug powder are mixed, more mixed powder is mixed with water, all of powder and water
Weight ratio is that 6:4 or 5:5 is sufficiently stirred for as gel；
5) described gel is at the uniform velocity expelled to medicine shell from the syringe needle of 0.5mm to 0.7mm internal diameter；
6) dry whole pill, dry 8 to 10 hours at 70 to 80 DEG C, obtain a shell hard, the pill that core is dried.
In step 1), described positive tetrahedron be turned into 10mm.
In step 1), described radius of sphericity is 12.4mm.
Step 2) in, the parameter of Slice Software is set to: floor height 0.15mm；Jet diameters 0.3mm；Hott bed temperature 70 C；
Nozzle temperature 180 DEG C；Print speed 80mm/s.
Polyvinyl alcohol wire rod be purity be the 1.75mm diameter wire rod of 95%.
The 3D that present invention also offers a kind of Drug controlled release constant airspeed prints medicine shell, including four axis folders
The angle cylinder of 109.47 ° each other；Four axial length are equal, and one end of described four axis is connected in same point, and should
Point is the geometric center of positive tetrahedron, and described four axis are the line of this point and described four summits of positive tetrahedron；Described circle
Cylinder is located in spheroid, and the centre of sphere of described spheroid is same point with described geometric center, and the length of described axis is equal to spheroid
Radius.
Compared with prior art, the had the beneficial effect that present invention of the present invention is simple to operate, highly reliable.Hollow
Shell one-shot forming.Drug controlled release constant airspeed, the medicine of compatible various non-refractories, drug model can be according to actual feelings
Condition scaling meets the requirement of different patient, and customization is strong.
Accompanying drawing explanation
Fig. 1 is that Boolean calculation models schematic diagram.
Detailed description of the invention
3D of the present invention prints medicine shell can be with Drug controlled release constant airspeed, and its structure is four axle center folders
The angle spheroid of cylindrical cavity of 109.47 ° each other；Described printed material is polyvinyl alcohol wire rod；Described application scenario controlled release medicine
Thing and the occasion high to medicine stability requirement；Described effective ingredient speed when release is constant；Described manufacture is
FDM type 3D printer is used to print.
First the digital modeling of shell is carried out.Using CAD computer aided drawing software to set up a length of side is 10mm's
Positive tetrahedron.Find the geometric center of positive tetrahedron.Doing spheroid with this geometric center for the centre of sphere, diameter is about 12.4mm, this
Time positive tetrahedron in be connected to this ball.The four of positive tetrahedron angles are connected with its geometric center, form four and have same top
Point and the angle straight line of 109.47 ° each other.It is axle center according to these four straight lines, generates the cylinder of four a diameter of 3mm.By spheroid
Carrying out Boolean calculation with four cylinders, spheroid is emptied the spheroid (such as Fig. 1) for including irregular cavity.Model is saved as
The mathematical model of STL form.
Import to Slice Software calculates by the model of STL form, generate G code (control path) in case next step
Import in printer.During this, the parameter of Slice Software is floor height 0.15mm；Jet diameters 0.3mm；Hott bed temperature 70
℃；Nozzle temperature 180 DEG C；Print speed 80mm/s.Polyvinyl alcohol is the 1.75mm diameter wire rod of 95% purity.Previous step is led
The G code gone out is to FDM 3D printer identification and prints.After in print procedure, the polyvinyl alcohol wire rod melted is melted by shower nozzle
Pile up in a predetermined manner, form quality after cooling harder.
Pva powder and drug powder are mixed, then it is mixed with water, the most all of powder and the weight of water
Amount ratio is 6:4, and medicine ratio in the powder determines according to real needs, is finally sufficiently stirred for as gel.Use 1ml injection
Gel is at the uniform velocity expelled to medicine shell by device from the syringe needle of 0.5mm internal diameter.
Dry whole pill.Baking box is dried 8 hours at 70 DEG C.
Finally obtaining a shell hard, the pill that core is dried, when release, the surface area that four cylinders expose is not
Becoming, rate of release is constant.
Being used in the occasion of constant release, such as ibuprofen, patient once takes medicine and can maintain that blood drug level is constant is up to 6
Hour, effectively reduce dosage frequency, in the unit interval, release dose maintains a stable value, persistently eliminates pain.Simultaneously
Medicine size can be customized by 3D printing technique for the patient of the different scale of constructions, with satisfied different demands.
Claims (6)
1. the method that a 3D prints medicine, it is characterised in that comprise the following steps:
1) one positive tetrahedron of structure, finds the geometric center of positive tetrahedron, does spheroid with described center for the centre of sphere, connect in spheroid
The four of positive tetrahedron angles are connected by positive tetrahedron with the geometric center of positive tetrahedron, formed four have same summit and
The angle straight line of 109.47 ° each other, generates four straight line intersection in a summit by this angle, and four straight line angles two-by-two are identical,
Later stage spatially keeps uniform with the cylinder that this framework generates；It is axle center according to these four straight lines, generates four cylinders,
Spheroid and all cylinders are carried out Boolean calculation so that the geometric center of the entity that described four cylinders are formed and spheroid
Geometric center overlaps, and obtains medicine shell model, this medicine shell model saves as the medicine shell numeral mould of STL form
Type；
2) import to Slice Software calculates by the mathematical model of STL form, generate G code；
3) to FDM 3D printer identification and being printed by described G code, in print procedure, FDM 3D printer head will melt
Polyvinyl alcohol wire rod according to described medicine shell model generation G code path pile up, obtain print medicine shell；
4) pva powder and drug powder are mixed, more mixed powder is mixed with water, all of powder and water
Weight ratio is that 6:4 or 5:5 is sufficiently stirred for as gel；
5) described gel is at the uniform velocity expelled to the medicine shell printed from the syringe needle of 0.5mm to 0.7mm internal diameter；
6) dry whole pill, dry 8 to 10 hours at 70 to 80 DEG C, obtain a shell hard, the pill that core is dried.
3D the most according to claim 1 prints the method for pill, it is characterised in that in step 1), described positive tetrahedron
It is turned into 10mm.
3D the most according to claim 2 prints the method for pill, it is characterised in that in step 1), described radius of sphericity is
12.4mm。
3D the most according to claim 1 prints the method for pill, it is characterised in that step 2) in, the parameter of Slice Software
It is set to: floor height 0.15mm；Jet diameters 0.3mm；Hott bed temperature 70 C；Nozzle temperature 180 DEG C；Print speed 80mm/s.
3D the most according to claim 4 print pill method, it is characterised in that polyvinyl alcohol wire rod be purity be 95%
1.75mm diameter wire rod.
6. the 3D of a Drug controlled release constant airspeed prints medicine shell, it is characterised in that include that four axis angles are mutual
It it is the cylinder of 109.47 °；Four axial length are equal, and one end of described four axis is connected in same point, and this point is
The geometric center of positive tetrahedron, described four axis are the line of this point and described four summits of positive tetrahedron；Described cylinder
Being located in spheroid, and the centre of sphere of described spheroid is same point with described geometric center, the length of described axis is equal to radius of sphericity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610809066.4A CN106113513B (en) | 2016-09-08 | 2016-09-08 | The method and 3D printing medicine shell of 3D printing medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610809066.4A CN106113513B (en) | 2016-09-08 | 2016-09-08 | The method and 3D printing medicine shell of 3D printing medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106113513A true CN106113513A (en) | 2016-11-16 |
| CN106113513B CN106113513B (en) | 2018-02-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610809066.4A Active CN106113513B (en) | 2016-09-08 | 2016-09-08 | The method and 3D printing medicine shell of 3D printing medicine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
Citations (5)
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| CN103877053A (en) * | 2014-03-13 | 2014-06-25 | 浙江大学 | Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method |
| CN104337754A (en) * | 2013-08-02 | 2015-02-11 | 厦门塔斯曼生物工程有限公司 | Method for designing and manufacturing biochemistry medicament product based on 3D printing technology |
| CN204364481U (en) * | 2014-11-24 | 2015-06-03 | 黑龙江福和华星制药集团股份有限公司 | Sheet in lansoprazole Sodium Bicarbonate Tablets |
| CN105362320A (en) * | 2015-12-02 | 2016-03-02 | 广东药学院 | Method of preparing quick-acting jiuxin orally disintegrating tablet through 3D printing |
| CA2974167A1 (en) * | 2015-01-21 | 2016-07-28 | Bayer Oy | Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing |
-
2016
- 2016-09-08 CN CN201610809066.4A patent/CN106113513B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104337754A (en) * | 2013-08-02 | 2015-02-11 | 厦门塔斯曼生物工程有限公司 | Method for designing and manufacturing biochemistry medicament product based on 3D printing technology |
| CN103877053A (en) * | 2014-03-13 | 2014-06-25 | 浙江大学 | Multifunctional composite medicine table preparation method based on three-dimensional printing and product prepared by using method |
| CN204364481U (en) * | 2014-11-24 | 2015-06-03 | 黑龙江福和华星制药集团股份有限公司 | Sheet in lansoprazole Sodium Bicarbonate Tablets |
| CA2974167A1 (en) * | 2015-01-21 | 2016-07-28 | Bayer Oy | Drug delivery system comprising a non-steroidal anti-inflammatory (nsaid) and a progestogenic compound and methods for manufacturing |
| CN105362320A (en) * | 2015-12-02 | 2016-03-02 | 广东药学院 | Method of preparing quick-acting jiuxin orally disintegrating tablet through 3D printing |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11724486B2 (en) | 2019-07-09 | 2023-08-15 | Kyndryl, Inc. | Printing customized medication based on current user data and medical records of the user |
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| Publication number | Publication date |
|---|---|
| CN106113513B (en) | 2018-02-06 |
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