CN106109554A - A kind of compositions improving insulin resistant - Google Patents

A kind of compositions improving insulin resistant Download PDF

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Publication number
CN106109554A
CN106109554A CN201610638578.9A CN201610638578A CN106109554A CN 106109554 A CN106109554 A CN 106109554A CN 201610638578 A CN201610638578 A CN 201610638578A CN 106109554 A CN106109554 A CN 106109554A
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powder
radix astragali
sesamin
grifolan
total glycosides
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CN201610638578.9A
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Chinese (zh)
Inventor
雷红
刘末
苏安祥
薛梅
刘琴
胡秋辉
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Nanjing University of Finance and Economics
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Nanjing University of Finance and Economics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of compositions improving insulin resistant, be made up of sesamin powder, Radix Astragali total glycosides powder and grifolan powder mix homogeneously, wherein the mass ratio of sesamin, Radix Astragali total glycosides and grifolan is 1 2:1 2:1 2；Described sesamin powder is extracted by sesame seed meal, and wherein sesamin content is more than 50%；Described Radix Astragali total glycosides powder is extracted by the Radix Astragali, and wherein Radix Astragali total glycosides content is more than 50%；Described grifolan powder is extracted by Grifola Frondosa sporophore, and wherein grifolan content is more than 50%.The present invention has reduction Insulin Resistance Animal Model blood glucose, the effect of blood fat, can work in coordination with enhancing physiologically active, preferably improve respective function；Toxicological test shows, the compositions application safety of the present invention.The compositions of the present invention can be used for preparation auxiliary and improves health food and the medicine of insulin resistant, can improve the clinical symptoms caused by metabolic syndrome patients's hyperglycemia.

Description

A kind of compositions improving insulin resistant
Technical field
The invention belongs to biomedicine field, be specifically related to a kind of health food for improving insulin resistant.
Background technology
Along with raising and the living-pattern preservation of people's living standard, obesity, diabetes, hypertension, hyperlipemia etc. Metabolic disease is in ascendant trend year by year, and these diseases exist the most simultaneously, has common pathogenic basis, i.e. insulin resistant. Insulin resistant is caused by h and E factor, shows as the body tissue cell reactivity to insulin physiological function Reduce, mainly show as the tissues such as fat, liver, muscle and glucose is absorbed the chronic pathology mistake of obstacle, carbohydrate metabolism disturbance Journey, causes metabolic syndrome disease.Mechanism and the prevention and controls of inquiring into insulin resistant are always bioscience research Focus.Developing natural product by modern study means, exploitation effective ingredient comes from food and the health food of integration of edible and medicinal herbs Chinese medicine, Minimizing drug dose can be used by assistant chemical medicine, reduce toxic and side effects；Individually take and be applicable to patient with slight symptoms, can take for a long time With；To improving above metabolic disease patients symptomatic, reduction of patient misery has important social value.
Summary of the invention
The invention provides a kind of compositions improving insulin resistant, by sesamin powder, Radix Astragali total glycosides powder and ash Tree flower polysaccharide powder mix homogeneously, obtains having the compositions improving Insulin Resistance；Wherein sesamin, Radix Astragali total glycosides and The mass ratio of grifolan is 1-2:1-2:1-2, preferably 1:1:1.
Described sesamin powder is extracted by sesame seed meal, and sesamin content therein is more than 50%；Described Radix Astragali total glycosides powder Being extracted by the Radix Astragali, Radix Astragali total glycosides content therein is more than 50%；Described grifolan powder is carried by Grifola Frondosa sporophore Taking, grifolan content therein is more than 50%.Said composition can become oral formulations by known processes, such as granule Agent, tablet, capsule, soft capsule etc..
Containing oils and fats, protein, polysaccharide, trace element, vitamin, sesamin etc. in Semen Sesami, wherein sesamin is main Active component.Containing saponin, polysaccharide, flavone, aminoacid, phenols and trace element etc. in the Radix Astragali, wherein saponin and polysaccharide are Main active.Rich in the multiple nutrients compositions such as aminoacid, polysaccharide and trace element, ash therein in Grifola Frondosa sporophore Tree flower polysaccharide is main bioactive ingredients.
Pharmacological testing shows, the sesamin (SES) of the present invention, Radix Astragali total glycosides (AST) and grifolan (GFP) compositions There is reduction Insulin Resistance Animal Model blood glucose, the effect of blood fat, enhancing physiologically active can be worked in coordination with, preferably improve respective Function；Toxicological test shows, the compositions application safety of the present invention.The compositions of the present invention can be used for preparing auxiliary and improves islets of langerhans The health food of element opposing and medicine, can improve the clinical symptoms caused by metabolic syndrome patients's hyperglycemia.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1:
A kind of compositions improving insulin resistant is mixed all by sesamin powder, Radix Astragali total glycosides powder and grifolan powder Even composition, wherein the mass ratio of sesamin, Radix Astragali total glycosides and grifolan is 1:1:1.
Sesamin powder extraction process is as follows: by sesame seed meal grind into powder, the normal hexane adding about 2 times of volumes stirs Mixing defat, 3h during dimension, the normal hexane adding about 2 times of volumes after filtration carries out second time defat, 3h during dimension, air-dries.Accurately claim Take a certain amount of powder, add solid-liquid ratio 1:8.5(g/mL) ethanol of 93%, stirs, extraction time at bath temperature 55 DEG C 2.5h, repeats to extract once.Extracting solution filters, and filtrate steams part ethanol (residual volume < 25 on a rotary evaporator ML), concentrating under reduced pressure, and in 60 DEG C of vacuum drying, weigh, obtain sesamin powder, and measure the content (mg/g) of sesamin.This product Character is: light tan powder, and odorless is tasteless, has hygroscopicity, is dissolved in alcohol, water insoluble.
Sesamin assay: use HPLC method to be measured.The standard solution of sesamin 20-100 μ g/mL it Between, respective peaks area and sesamin mass concentration have significant linear relationship, have worked out standard curve.By dehydrated alcohol (chromatograph Pure) sesamin powder is dissolved, filter.At column temperature: room temperature；Flowing phase: methanol-water (8:2, v/v)；Flow velocity 0.8mL/min；Enter Sample amount: 20 μ L；Detection wavelength 290nm；Analysis time: measure sesamin content in this product under the conditions of 15min.Guarantor according to standard specimen Stay the time to carry out qualitative, calculate the content of sesamin by external standard method.This product sesamin content is 617.15mg/g.
Sesamin extraction process and content assaying method are public method.
The preparation technology of Radix Astragali total glycosides powder is as follows: Milkvetch Root, cuts the thick decoction pieces of about 0.5cm, adds 70% alcohol reflux and carry Take 2 times, add 10 times amount for the first time, extract 90min；Add 8 times amount for 2nd time, extract 60min, merge 70% ethanol extract, filter, Filtrate reduced in volume steams to the greatest extent ethanol, slight fever, adds water to 2000ml, places 12h, filters, and filtrate is by appropriate D101 macroporous absorption Resin, the filtrate adsorbed discards, and continues the D101 macroporous adsorbent resin after use water rinses absorption, can't check reducing sugar to washing liquid Till, discard water lotion, then with appropriate 30% alcohol flushing, discard 30% alcohol washing liquid, then use 70% ethanol elution, examine to eluent Till not going out astragaloside, concentrating under reduced pressure 70% ethanol elution, and in 60 DEG C of vacuum drying, weigh, obtain Radix Astragali total glycosides powder, And measure the content (mg/g) of Radix Astragali total glycosides.This product character is: chocolate brown powder, odorless, mildly bitter flavor, has hygroscopicity, is dissolved in alcohol And water.
Radix Astragali total glycosides assay: use spectrophotography: mensuration wavelength is 560nm, vanillin-high chlorine selected by developer Acid color development system, with astragaloside as reference substance, good in 50-250 μ g range internal linear relation.Take this product 10mg, accurate title Fixed, add water 10mL, and heating makes dissolving, extracts three times with water-saturated n-butanol, each 20mL, merges n-butyl alcohol liquid, steams with rotating Sending out instrument and reclaim n-butyl alcohol to dry, residue adds methanol and dissolves by several times, is quantitatively transferred in 10mL measuring bottle, adds methanol to scale, shakes up. The accurate 0.20mL that draws puts in tool plug test tube, volatilizes solvent in water-bath, and each precision adds 5% vanillin glacial acetic acid solution 0.2mL With perchloric acid 0.8mL, close plug, shake up, in 70 DEG C of water-baths, heat 20min, cool down with flowing water immediately after taking-up, add glacial acetic acid Solution 5.0mL, shakes up, and measures trap at 560nm wavelength.Read in need testing solution from standard curve and be equivalent to the Radix Astragali The amount of first glycosides, tries to achieve Radix Astragali total glycosides content.In Radix Astragali total glycosides powder, Radix Astragali total glycosides content is 590.52mg/g.
The preparation technology of Radix Astragali total glycosides powder and content assaying method are public method.
The extraction process of grifolan powder is as follows: by Grifola Frondosa sporophore grind into powder, add about 3 times of volumes 95% ethanol solution is stirred defat, 2h during dimension, and sucking filtration obtains precipitate.Accurately weigh a certain amount of precipitate, add solid-liquid ratio Distilled water 1:10(g/ml), high pressure extract 30min at 120 DEG C.Centrifugal, take supernatant, add 1:1 volume dehydrated alcohol and sink Shallow lake 12h.Centrifugal, take precipitation, in 60 DEG C of vacuum drying, weigh, obtain grifolan powder, and measure the content of grifolan (mg/g).This product character is: light tan powder, and odorless is tasteless, has hygroscopicity, is slightly soluble in water, ethanol insoluble in high concentration, Acetone and other organic solvent.
Grifolan assay: use Anthrone-sulfuricacid method to be measured.Draw standard curve, at 20 ~ 90 μ g ml-1In the range of absorbance and beta-dextran content be good linear relationship, standard curve equation is Y=0.0085X-0.0424 (R=0.9990).Take sample solution 0.5mL, moisturizing to 1mL, cool down in ice-water bath.Add anthrone sulphate reagent 4mL, shake up. Boiling water bath boils 10min.Ice-water bath cools down 10min again.With distilled water as blank, at 620nm, measure absorbance. In grifolan powder, Grifola frondosa polyoses content is 554.26mg/g.
The extraction process of grifolan powder and content assaying method are public method.
The preparation of granule: prepare granule by Preparation Technology of Granules.Every bag contains sesamin+Radix Astragali total glycosides+Grifola frondosa Polysaccharide is 40mg+40mg+40mg.
Embodiment 2:
A kind of compositions improving insulin resistant is mixed all by sesamin powder, Radix Astragali total glycosides powder and grifolan powder Even composition, wherein the mass ratio of sesamin, Radix Astragali total glycosides and grifolan is 1:2:1.
Sesamin powder, Radix Astragali total glycosides powder are purchased from Nanjing Ze Lang agricultural science and technology company limited.
Grifolan powder is purchased from the grand hundred million agricultural development company limiteies in Qingyuan County, Zhejiang.The preparation of tablet, by tablet system Standby technique prepares tablet.Every is 15mg+30mg+15mg containing sesamin+Radix Astragali total glycosides+grifolan.
The other the same as in Example 1.
Embodiment 3:
A kind of compositions improving insulin resistant is mixed all by sesamin powder, Radix Astragali total glycosides powder and grifolan powder Even composition, wherein the mass ratio of sesamin, Radix Astragali total glycosides and grifolan is 2:2:1.
Sesamin powder, Radix Astragali total glycosides powder are purchased from Nanjing Ze Lang agricultural science and technology company limited.
Grifolan powder is purchased from the grand hundred million agricultural development company limiteies in Qingyuan County, Zhejiang.
The preparation of capsule, prepares capsule by capsules preparation technique.Every containing sesamin+Radix Astragali total glycosides+grifolan is 24mg+24mg+12mg。
The other the same as in Example 1.
Embodiment 4:
The preparation of soft capsule, by soft capsule, preparation technology prepares soft capsule.Every contains sesamin+Radix Astragali total glycosides+grifolan For 20mg+20mg+20mg.
The other the same as in Example 1.
Every daily oral dose, counts sesamin+Radix Astragali total glycosides+grifolan as 240mg with active component composition.For Improving symptoms of insulin resistance, granule instructions of taking is every day 2 times, each 1 bag, warm boiled water；Tablets method is Every day 2 times, each 2；Capsule and soft capsule instructions of taking are every day 2 times, each 2.It within 3 months, it is a course for the treatment of.
Concrete animal experiment situation is as follows:
Experiment: the reducing blood sugar and blood fat effect to Insulin Resistance Animal Model KKay mice
KKay mice 50, weight range, at 40 ± 2g, is randomly divided into 5 groups:
Model group, sesamin (SES, 60mg kg-1·d-1), Radix Astragali total glycosides (AST, 60mg kg-1·d-1), grifolan (GFP, 60mg kg-1·d-1), SES+GFP+AST(20+20+20 mg kg-1·d-1, embodiment 1 prepares), often organize 10 Only, male and female half and half；Separately take 10 C57Mice is that Normal group is (because of C57Genetic background mice for KKay).
Every day gastric infusion, every day 2 times, Normal group and model group gavage isometric(al) CMC-Na, successive administration 2 weeks. After being administered first 1 day (d0), being administered 4,8,12 days, after mice fasting 4h, tail point took blood, measures blood glucose value by blood glucose meter.With Kit measurement blood fat (triglyceride, T-CHOL, free fatty) and serum insulin levels.Result of the test is shown in Table 1, table 2。
Table 1 result shows, within the 4th, 8,12 days, KKay mice fasting glucose can be made to be decreased obviously in being administered, illustrate that the present invention has There is the effect reducing Insulin Resistance Animal Model KKay mice fasting glucose.Table 2 result shows, within the 12nd day, can make in being administered KKay lipid of mice level and serum insulin levels are decreased obviously, and illustrate that the present invention has reduction Insulin Resistance Animal Model KKay lipid of mice level and the effect improving insulin resistant.SES+AST+GFP three's combination is substantially better than alone, has association Same-action.
The table 1 hypoglycemic activity to Insulin Resistance Animal Model KKay mice
Table 2 is to the blood fat reducing of Insulin Resistance Animal Model KKay mice and the effect that improves insulin resistant
The present invention shows through the acute toxicity tests, and mouse stomach to SES+AST+GFP mono-day maximum dosage-feeding (MTD) is 19.3g/kg, is equivalent to effective dose 120 times；There is not any untoward reaction in animal.Product safety of the present invention is described, almost without Toxicity.

Claims (6)

1. the compositions improving insulin resistant, it is characterised in that: by sesamin powder, Radix Astragali total glycosides powder and Grifola frondosa Polysaccharide powder mix homogeneously forms, and wherein the mass ratio of sesamin, Radix Astragali total glycosides and grifolan is 1-2:1-2:1-2.
A kind of compositions improving insulin resistant the most according to claim 1, it is characterised in that: described sesamin powder Being extracted by sesame seed meal, wherein sesamin content is more than 50%.
A kind of compositions improving insulin resistant the most according to claim 1, it is characterised in that: described Radix Astragali total glycosides powder End is extracted by the Radix Astragali, and wherein Radix Astragali total glycosides content is more than 50%.
A kind of compositions improving insulin resistant the most according to claim 1, it is characterised in that: described grifolan Powder is extracted by Grifola Frondosa sporophore, and wherein grifolan content is more than 50%.
5. according to a kind of compositions improving insulin resistant described in any one of claim 1-4, it is characterised in that: described sesame The mass ratio of fiber crops element, Radix Astragali total glycosides and grifolan is 1:1:1.
6. according to a kind of compositions improving insulin resistant described in any one of claim 1-4, it is characterised in that: by Semen Sesami Element powder, Radix Astragali total glycosides powder and grifolan powder mix homogeneously make granule, tablet, capsule or soft capsule.
CN201610638578.9A 2016-08-08 2016-08-08 A kind of compositions improving insulin resistant Pending CN106109554A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106912904A (en) * 2017-03-15 2017-07-04 福建农林大学 A kind of preparation method of grifola frondosus full agonist and products thereof
CN115039882A (en) * 2022-06-27 2022-09-13 华中农业大学 Polysaccharide composition for reducing postprandial blood sugar and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102204871A (en) * 2011-06-01 2011-10-05 王青 Composition for weight loss
CN102356837A (en) * 2011-09-23 2012-02-22 合肥工业大学 Combined food for reducing blood sugar
CN102356872A (en) * 2011-09-23 2012-02-22 合肥工业大学 Blood lipid-lowering composite food
CN103432192A (en) * 2013-09-15 2013-12-11 王青 Composition with slimming function

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102204871A (en) * 2011-06-01 2011-10-05 王青 Composition for weight loss
CN102356837A (en) * 2011-09-23 2012-02-22 合肥工业大学 Combined food for reducing blood sugar
CN102356872A (en) * 2011-09-23 2012-02-22 合肥工业大学 Blood lipid-lowering composite food
CN103432192A (en) * 2013-09-15 2013-12-11 王青 Composition with slimming function

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106912904A (en) * 2017-03-15 2017-07-04 福建农林大学 A kind of preparation method of grifola frondosus full agonist and products thereof
CN106912904B (en) * 2017-03-15 2020-09-08 福建农林大学 Preparation method of full active substance of grifola frondosa and product thereof
CN115039882A (en) * 2022-06-27 2022-09-13 华中农业大学 Polysaccharide composition for reducing postprandial blood sugar and application thereof
CN115039882B (en) * 2022-06-27 2024-01-26 华中农业大学 Polysaccharide composition for reducing postprandial blood sugar and application thereof

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