CN106109549A - 一种含地锦草和诺氟沙星的畜禽用复方药物 - Google Patents
一种含地锦草和诺氟沙星的畜禽用复方药物 Download PDFInfo
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- 229960001180 norfloxacin Drugs 0.000 title claims abstract description 26
- 239000003814 drug Substances 0.000 title claims abstract description 21
- 244000144977 poultry Species 0.000 title claims abstract description 15
- 150000001875 compounds Chemical class 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 4
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- 235000013594 poultry meat Nutrition 0.000 description 10
- 241000287828 Gallus gallus Species 0.000 description 9
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- 210000002429 large intestine Anatomy 0.000 description 3
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- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
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- 238000003745 diagnosis Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 229960003760 florfenicol Drugs 0.000 description 1
- 229960004273 floxacillin Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
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- 239000008155 medical solution Substances 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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Abstract
本发明涉及一种含地锦草和诺氟沙星的畜禽用复方药物，由诺氟沙星和地锦草组成，诺氟沙星和地锦草的重量比为1:5‑1:10。本发明还要求保护由上述畜禽用复方药物所制备成的复方制剂。本发明具备的有益效果是：经试验研究证明，诺氟沙星与地锦草以特定的重量比例联合使用，具有协同作用明显，疗效快，成本低等优点。
Description
技术领域
本发明属于畜禽用复方药物技术领域，尤其涉及一种含地锦草和诺氟沙星的畜禽用复方药物，用于治疗畜禽由大肠埃希氏菌感染引起的疾病。
背景技术
畜禽受大肠埃希氏菌感染后，可致急性败血症、腹膜炎、肝炎、肺炎、肠炎等多部位严重感染，给畜禽养殖造成巨大的经济损失。诺氟沙星、氟苯尼考等是防治此类疾病的常用西药，随着用药愈来愈泛滥，其耐药菌株愈来愈多，用药成本也越来越大，但是治疗效果及耐药情况并没有得到好转，反而每况日下。
经检索，没有查询到将地锦草和诺氟沙星联合用于治疗畜禽由大肠埃希氏菌感染引起的疾病的相关报道。
发明内容
本发明要解决的技术问题是提供一种含地锦草和诺氟沙星的畜禽用复方药物，其协同作用明显，能够消除大肠埃希氏菌对诺氟沙星的耐药性，提高治疗效果。
为解决以上技术问题，本发明采用以下技术方案：一种含地锦草和诺氟沙星的畜禽用复方药物，由诺氟沙星和地锦草组成，诺氟沙星和地锦草的重量比为1:5-1:10。
本发明还要求保护由上述畜禽用复方药物所制备成的复方制剂。
本发明具备的有益效果是：经试验研究证明，诺氟沙星与地锦草以特定的重量比例联合使用，具有协同作用明显，疗效快，成本低等优点。
具体实施方式
下面结合具体实施例对本发明的技术方案及有益效果做进一步说明，除特殊声明外，本发明所述的地锦草重量均为地锦草的干重。
一、地锦草对诺氟沙星的耐药消除作用的测定
1.测定方法
按照重量比为1:1、1:3、1:5、1:10、1:30、1:50分别配制地锦草与各种西药的混合药液；选取对西药耐药的菌株作为试验对象，利用平板稀释法进行传代培养，测定各处理药液对耐药菌株的MIC变化情况；同时设不加地锦草的西药为阳对照，设不加地锦草及西药作为阴对照。
上述处理分别连续培养4代。
2.试验结果
连续培养4代后，阴对照的处理平板是长菌的，其他各药剂及混合药液对于大肠埃希氏菌的MIC的结果统计如表1所示：
由上表可知，当诺氟沙星与地锦草的重量比为1:5和1:10时，诺氟沙星对耐药大肠埃希氏菌的最小抑菌浓度均减小32倍以上，可见，耐药大肠埃希氏菌对诺氟沙星的耐药性明显降低。
而当诺氟沙星与地锦草的重量比为1:1、1:3、1:30和1:50时，诺氟沙星对耐药大肠埃希氏菌的最小抑菌浓度与不加地锦草的阳对照相比，没有明显变化。
二、诺氟沙星与地锦草联合使用的体外实验
将诺氟沙星和地锦草(粉)按照重量比为1:5混合，制成散剂，作为试验组；另设诺氟沙星单剂及地锦草单剂作为对照组1和对照组2。
试验对象为确诊感染了鸡大肠埃希氏菌疾病的鸡群。
将发病鸡群分成3组给药。试验组按照1g/kg饲料的添加量给药，对照组1用诺氟沙星单剂按照0.2g/kg饲料的添加量给药，对照组2用地锦草单剂按照1g/kg饲料的添加量给药；各组均持续用药5天。
试验结果：试验组的病鸡采食量有所增加，无死亡，使用5天后鸡群即可痊愈；对照组1的鸡群大多数仍呈病态，有4％的病鸡死亡；对照组2的鸡群大多数也是仍呈病态，有8％的病鸡死亡。
Claims (2)
1.一种含地锦草和诺氟沙星的畜禽用复方药物，其特征在于，由诺氟沙星和地锦草组成，诺氟沙星和地锦草的重量比为1:5-1:10。
2.由权利要求1所述的畜禽用复方药物所制备成的复方制剂。
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| CN106620058A (zh) * | 2016-12-16 | 2017-05-10 | 范明忠 | 一种含地锦草、四方藤和诺氟沙星的畜禽用复方药物 |
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| CN103977088A (zh) * | 2014-05-14 | 2014-08-13 | 广西大学 | 一种含有赤芍和氟喹诺酮类抗菌药的畜禽用复方药物 |
| CN103989730A (zh) * | 2014-05-28 | 2014-08-20 | 广西大学 | 一种含有含珠草和氟喹诺酮类抗菌药的畜禽用复方药物 |
| CN104027369A (zh) * | 2013-06-13 | 2014-09-10 | 广西南宁市桃源兽药厂 | 一种含有白花丹和诺氟沙星的畜禽用复方组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104027369A (zh) * | 2013-06-13 | 2014-09-10 | 广西南宁市桃源兽药厂 | 一种含有白花丹和诺氟沙星的畜禽用复方组合物 |
| CN103977088A (zh) * | 2014-05-14 | 2014-08-13 | 广西大学 | 一种含有赤芍和氟喹诺酮类抗菌药的畜禽用复方药物 |
| CN103989730A (zh) * | 2014-05-28 | 2014-08-20 | 广西大学 | 一种含有含珠草和氟喹诺酮类抗菌药的畜禽用复方药物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620058A (zh) * | 2016-12-16 | 2017-05-10 | 范明忠 | 一种含地锦草、四方藤和诺氟沙星的畜禽用复方药物 |
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