CN106094224A - A kind of turnover spectrophotometric unit and endoscopic optical imaging system, formation method - Google Patents
A kind of turnover spectrophotometric unit and endoscopic optical imaging system, formation method Download PDFInfo
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- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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Abstract
The invention discloses a kind of turnover spectrophotometric unit and endoscopic optical imaging system, formation method, this turnover spectrophotometric unit is for making the imaging focal plane position consistency of the light of two kinds of different wave lengths；This imaging system includes: optical signal launch unit, light signal collection unit and image unit, optical signal launch unit is to tissue emissions visible ray to be detected and near-infrared excitation light, light signal collection unit collection is through the visible ray of Tissue reflectance to be detected and is excited the near-infrared fluorescent sent, image unit receives two kinds of light that light signal collection unit gathers, and makes the imaging focal plane position consistency of two kinds of light.This formation method includes: to tissue emissions visible ray to be detected and near-infrared excitation light；Gather the visible ray of Tissue reflectance to be detected and the near-infrared fluorescent sent that is stimulated；Light is closed in two kinds of light light splitting again, makes the imaging focal plane position consistency of two kinds of light.Present configuration is simple, volume is little, cost of manufacture is low；Can export colour and fluoroscopic image, the computing to software requires low simultaneously.
Description
Technical field
The present invention relates to less invasive techniques field, particularly to one turnover spectrophotometric unit and endoscopic optical imaging system,
Formation method.
Background technology
In recent years, along with near infrared fluorescent contrast agent ICG (indocyanine green) is for ocular angiogenesis especially choroidal artery
Research, the diagnosis of malignant tumor, the determination of borderline tumor and tumor sentinel lymph node detection etc., Wicresoft diagnosis and operation
Field is rapidly developed, and meanwhile, also matching used medical endoscope is proposed new requirement.Existing medical endoscope one
As use visible light (400nm-700nm) more, in this spectral region, endoscopic system can meet blur-free imaging want
Ask.But near-infrared fluorescent radiography uses near-infrared fluorescent spectrum (820nm-850nm) imaging, to make two kinds of spectrum lead to
Remaining to blur-free imaging after crossing endoscopic system, need to solve the chromatism of position problem that two kinds of spectrum introduce, i.e. visible ray is with the reddest
Outer fluorescence imaging position of focal plane is inconsistent, typically has the deviation of 0.3mm-0.5mm.So, or by complicated optical system
Color difference eliminating, or need doctor in diagnosis or operation process, two kinds of spectrum to be focused repeatedly, visible ray could be obtained
Picture rich in detail with near-infrared fluorescent.But the former cost is high, and structure and size are not easy to miniaturization；The latter repeatedly focuses and have impact on
Operation, reduces efficiency.
In order to solve visible light and the most confocal problem of near-infrared fluorescent light spectrum image-forming, Publication No.: US
The United States Patent (USP) of 8773756 B2 discloses a kind of for correcting visible ray and near-infrared fluorescent light spectrum image-forming in endoscope apparatus
The optical coupler of out of focus.This optical coupler is made up of remote burnt prism assemblies and imaging optical system, wherein, and remote burnt prism group
Part is made up of the prism of different refractivity, is coated with spectro-film so that visible ray separates with near-infrared fluorescent between prism.By dividing
Not Jiao Zheng visible ray and the light path of near-infrared fluorescent, reach the purpose that both imagings are confocal.But, the prism that this mode uses
Number is many, and volume is big, and assembly precision is required height.
The Chinese patent of Publication No.: CN 104905759 A discloses the core optical system of a kind of endoscope.This is
Unite by optimizing object lens, field lens between image rotation assembly, and object lens and image rotation assembly so that the out of focus of system is minimum with the curvature of field
Change, the problem solving visible ray and near-infrared fluorescence imaging out of focus.But, the eyeglass number of this kind of method use is more, material
Material complexity, and be difficult to optimize.
The United States Patent (USP) of Publication No.: US 6293911 B1 and US 9173554 B2 all discloses a kind of visible ray with near
Infrared fluorescence imaging system, described imaging system uses colour splitting prism and (or) dichroic mirror by glimmering to visible ray and near-infrared
Light is divided into red, green, blue, four wave bands of fluorescence process respectively, is the most each imaged on red, green, blue, four imageing sensors of fluorescence
On, by the method for software processes, export again after synthesis colour and fluoroscopic image.Although the method avoids visible ray and the reddest
Problem the most confocal during the imaging simultaneously of outer fluorescence, and improve the resolution of image, but four imageing sensor costs are high, need
Exporting after colour to be synthesized and fluoroscopic image, the computing to software requires height, and huge structure, complexity again.
Summary of the invention
The present invention is directed to above-mentioned problems of the prior art, propose one turnover spectrophotometric unit and endoscopic optical becomes
As system, formation method, use turnover spectrophotometric unit make visible ray (400nm～700nm) and near-infrared fluorescent (820nm～
Imaging focal plane position consistency 850nm), it is possible to obtain visible ray and the picture rich in detail of near-infrared fluorescent, turnover spectrophotometric unit letter
Singly being easy to do, system structure is simple, volume is little, cost of manufacture is low；And colour and fluoroscopic image can be exported simultaneously, need not first synthesize
Visible ray exports after near-infrared fluorescent image again, and the computing to software requires low.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of turnover spectrophotometric unit, and it is for carrying out incident first wave length light and second wave length light point
Light closes light again, makes first wave length light different with the light path of second wave length light, and then makes becoming of first wave length light and second wave length light
As position of focal plane is consistent；
First wave length light is different with the wavelength of second wave length light.
It is preferred that turnover spectrophotometric unit includes: isosceles right-angle prism and plate glass, wherein,
Described plate glass be arranged in parallel with the inclined-plane of described isosceles right-angle prism；
Described first wave length light and described second wave length light are transmitted into institute from a right-angle surface of described isosceles right-angle prism
State isosceles right-angle prism, then through the inclined-plane light splitting of described isosceles right-angle prism, be divided into described first wave length light and described second
Wavelength light；Described first wave length light is through the slant reflection of described isosceles right-angle prism；Described second wave length light is straight through described isosceles
The inclined-plane of angle prism transmits described isosceles right-angle prism, enters from the face of the close described isosceles right-angle prism of described plate glass
Penetrate, through the another side reflection of described plate glass, sequentially pass through the face of the close described isosceles right-angle prism of described plate glass
And the inclined-plane of described isosceles right-angle prism is transmitted into described isosceles right-angle prism；Last described first wave length and described second
Wavelength transmits described isosceles right-angle prism from another right-angle surface of described isosceles right-angle prism.
It is preferred that two right-angle surface of described isosceles right-angle prism are coated with anti-reflection film, it is used for making described first wave length light and institute
State second wave length light transmission；
The inclined-plane of described isosceles right-angle prism is coated with dichroic film, is used for making described first wave length luminous reflectance, makes described
Two wavelength light transmissions；
The one side of the close described isosceles right-angle prism of described plate glass is coated with anti-reflection film, is used for making described second wave length
Light transmission, the another side of described plate glass is coated with reflectance coating or semi-transparent semi-reflecting film, is used for making described second wave length luminous reflectance.
It is preferred that described isosceles right-angle prism and described plate glass are glued together by optical cement.
The present invention also provides for a kind of endoscopic optical imaging system, comprising: optical signal launch unit, light signal collection list
Unit and image unit；Wherein,
Described optical signal launch unit is used for certain field emission visible ray and the near-infrared excitation light to tissue to be detected,
So that described tissue to be detected by visible reflectance and makes the near-infrared fluorescent group of described tissue to be detected by described near-infrared
Excitation launches near-infrared fluorescent；
Described light signal collection unit for gather through the visible ray of described Tissue reflectance to be detected and launch near
Infrared fluorescence；
Described image unit includes: optical signal processing unit and imageing sensor；
Visible ray and near-infrared that described optical signal processing unit gathers for receiving described light signal collection unit are glimmering
Light, and it is processed, so that described visible ray is consistent with the imaging focal plane of described near-infrared fluorescent；Described optical signal prosessing
Unit includes: turnover spectrophotometric unit, described turnover spectrophotometric unit is turnover spectrophotometric unit described above；
Described imageing sensor is for receiving the visible ray after described optical signal processing unit processes and near-infrared
Fluorescence.
It is preferred that described visible ray, described near-infrared excitation light and described near-infrared fluorescent are from described isosceles right-angled edge
One right-angle surface of mirror is transmitted into described isosceles right-angle prism, then through the inclined-plane light splitting of described isosceles right-angle prism；Described can
See the light slant reflection through described isosceles right-angle prism；Described near-infrared excitation light and described near-infrared fluorescent are through described isosceles
The inclined-plane of corner cube prism transmits described isosceles right-angle prism, from the face of the close described isosceles right-angle prism of described plate glass
Incidence, described near-infrared fluorescent reflects through the another side of described plate glass, and described near-infrared excitation light is through described plate glass
Another side transmission, described near-infrared fluorescent sequentially pass through the close described isosceles right-angle prism of described plate glass face and
The inclined-plane of described isosceles right-angle prism is transmitted into described isosceles right-angle prism；Last described visible ray and described near-infrared fluorescent
Described isosceles right-angle prism is transmitted from another right-angle surface of described isosceles right-angle prism；Further,
The one side away from described isosceles right-angle prism of described plate glass is semi-transparent semi-reflecting film, is used for making described near-infrared
Fluorescent reflection, makes described near-infrared excitation light transmission.
It is preferred that described optical signal processing unit also includes: optical coupler, described visible ray and near-infrared fluorescent are first
Through described optical coupler, then through described turnover spectrophotometric unit；
Described optical coupler include one or more lens, described optical coupler be used for eliminating described visible ray and
The aberration of described near-infrared fluorescent.
It is preferred that endoscopic optical imaging system also includes: optical signal conversion unit, described optical signal conversion unit is used for
The described visible ray received by described imageing sensor and described near-infrared fluorescent are converted to the signal of telecommunication of correspondence, and process
Become video data.
It is preferred that endoscopic optical imaging system also includes: graphics processing unit, described graphics processing unit is used for receiving
And process the described video data that described optical signal conversion unit obtains；Further,
Also including: image-display units, described image-display units is used for receiving the process of described graphics processing unit and obtains
Video data, obtain visible images or there is the fluoroscopic image of color background, and showing in real time, when described video data is
During the video data of visible ray, obtain for visible images, when the video data that described video data is near-infrared fluorescent,
Obtain is the fluoroscopic image with color background.
It is preferred that endoscopic optical imaging system also includes: optical signal control unit, described optical signal control unit is used for
Control described optical signal launch unit and launch visible ray and near-infrared excitation light；
Described optical signal control unit is additionally operable to control described graphics processing unit and receives and process the video counts of visible ray
According to or the video data of near-infrared fluorescent, when described graphics processing unit receive for the video data of visible ray time, not to institute
State video data to process, when described graphics processing unit receive for the video data of near-infrared fluorescent time, to described video
Data are done lateral shift and are processed so that it is with the location overlap of the video data of visible ray, and mark fluorescent region, for non-fluorescence
Region is done color background and is processed.
The present invention also provides for a kind of endoscopic optical formation method, and it comprises the following steps:
S11: utilize visible ray and near-infrared excitation light to irradiate certain region of tissue to be detected so that described to be detected group
Knit described visible reflectance and make described tissue to be detected be gone out near-infrared fluorescent by described near-infrared excitation light excitation-emission；
S12: gather through the visible ray of described Tissue reflectance to be detected and the near-infrared fluorescent launched, and utilize turnover
It is processed by spectrophotometric unit, so that described visible ray is consistent with the imaging focal plane of described near-infrared fluorescent；
S13: utilize imageing sensor to receive described visible ray after treatment and described near-infrared fluorescent.
It is preferred that also include after described step S13:
S14: the described visible ray received by described imageing sensor and described near-infrared fluorescent are converted to correspondence
The signal of telecommunication, and it is processed into video data；
S15: select the video data of the visible ray received or the video data of near-infrared fluorescent to be processed, when connecing
Receive for the video data of visible ray time, video data is not processed, when selecting the video for near-infrared fluorescent that receives
During data, then video data is done lateral shift and processes so that it is with the location overlap of the video data of visible ray, and mark fluorescent
Region, does color background for non-fluorescence region and processes；
S16: obtain visible images according to described video data or there is the fluoroscopic image of color background, and it is real-time
Display, when the video data that described video data is visible ray, obtain for visible images, when described video data is near
During the video data of Infrared fluorescence, obtain is the fluoroscopic image with color background.
Compared to prior art, the invention have the advantages that
(1) present invention provide turnover spectrophotometric unit and endoscopic optical imaging system, formation method, use turnover light splitting
Unit carries out light splitting to visible ray and near-infrared fluorescent and closes light again, changes the light path of two kinds of wavelength light, and then makes two kinds of light
Imaging focal plane position consistency, it is thus achieved that visible ray and the picture rich in detail of near-infrared fluorescent；And turnover spectrophotometric unit simple in construction, required
Number of prisms few, assembling is simple, convenient, cost of manufacture is low；
(2) present invention can export colour and fluoroscopic image simultaneously, i.e. need not first synthesizing visible light and near-infrared fluorescent
Image after export again, the computing of software is required low；
(3) out of focus of visible ray and near-infrared fluorescent is corrected by the present invention to by turnover spectrophotometric unit, can be straight
Connecing the image of output visible ray and near-infrared fluorescent, doctor, without repeatedly focusing two kinds of spectrum, can directly observe, not change
Become the existing operating habit of doctor, simple to operate；
(4) as long as the present invention selects the plate glass of respective thickness according to the defocusing amount of different optical systems, can fit
Visible ray and near-infrared fluorescent optical system for different defocusing amounts.
Certainly, the arbitrary product implementing the present invention it is not absolutely required to reach all the above advantage simultaneously.
Accompanying drawing explanation
Below in conjunction with the accompanying drawings embodiments of the present invention are described further:
Fig. 1 is the structural representation of the turnover spectrophotometric unit of embodiments of the invention 1；
Fig. 2 is the structural representation of the endoscopic optical imaging system of embodiments of the invention 2；
Fig. 3 is the structural representation of the endoscopic optical imaging system of embodiments of the invention 3；
Fig. 4 is the schematic diagram of the image unit of the endoscopic optical imaging system of embodiments of the invention 4；
Fig. 5 a be the near-infrared fluorescent that receives of the imageing sensor of embodiments of the invention 4 through plate glass reflection and
Schematic diagram without plate glass reflection；
Fig. 5 b is that the near-infrared fluorescent that the imageing sensor of embodiments of the invention 4 receives reflects also through plate glass
Schematic diagram after lateral shift；
Fig. 6 is the schematic diagram of the image unit of the endoscopic optical imaging system of embodiments of the invention 5；
Fig. 7 is the structural representation of the endoscopic optical imaging system of embodiments of the invention 6；
Fig. 8 is the structural representation of the endoscopic optical imaging system of embodiments of the invention 7.
Label declaration: 1-isosceles right-angle prism, 2-plate glass, 3-first wave length light, 4-second wave length light；
11-mono-right-angle surface, another right-angle surface of 12-, 13-inclined-plane；
21-front surface, 22-rear surface；
Certain region of 100-tissue to be detected, 101-optical signal launch unit, 102-light signal collection unit, 103-images
Unit, 104-optical signal conversion unit, 105-optical signal control unit, 106-graphics processing unit, 107-image-display units；
1011-VISIBLE LIGHT EMISSION unit, 1012-near-infrared excitation light transmitter unit；
1021-object lens, 1022-transfer unit, 1023-eyepiece；
1031-transfers spectrophotometric unit, 1032-imageing sensor, 1033-optical coupler；
Detailed description of the invention
Elaborating embodiments of the invention below, the present embodiment is carried out under premised on technical solution of the present invention
Implement, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following enforcement
Example.
Embodiment 1: turnover spectrophotometric unit
In conjunction with Fig. 1, the turnover spectrophotometric unit of the present invention is described in detail by the present embodiment, and it is for incident two kinds
The light of different wave length: first wave length light and second wave length light carry out light splitting and closes light again, makes first wave length light and second wave length light
Light path is different, and then makes the imaging focal plane position consistency of first wave length light and second wave length light.Specifically, its structural representation is such as
Shown in Fig. 1, comprising: isosceles right-angle prism 1 and plate glass 2, the front surface of plate glass 2 and isosceles right-angle prism 1
Inclined-plane is glued together, in different embodiments, it is possible to be fixed by other means.First wave length light 3 and second wave length light 4
It is transmitted in isosceles right-angle prism 1 through a right-angle surface 11 of isosceles right-angle prism 1, is made simultaneously incident to isosceles right-angle prism 1
On inclined-plane 13, first wave length light 3 through inclined-plane transmission, incides the front surface 21 of plate glass through slant reflection, second wave length light 4
(i.e. near the one side of isosceles right-angle prism), in then transmission enters plate glass 2, then reflects through the rear surface 22 of plate glass,
Sequentially pass through inclined-plane 13 transmission of plate glass 2 and isosceles right-angle prism 1, be again introduced in isosceles right-angle prism 1, finally,
First wave length light 3 and second wave length light 4 all transmit from another right-angle surface 12 of isosceles right-angle prism 1.The thickness of plate glass 2
Defocusing amount according to relative first wave length light 3 image space of second wave length light 4 selects, after turnover spectrophotometric unit,
The imaging focal plane position consistency of first wave length light 3 and second wave length light 4, can the most all blur-free imagings, but two
Certain transverse positional displacement d can be there is, as shown in Figure 1 between kind.
In preferred embodiment, two right-angle surface 11 and 12 of isosceles right-angle prism 1 are all plated and are set anti-reflection film so that first wave length light
Enter or transmit isosceles right-angle prism 1 with second wave length light transmission, inclined-plane 13 plating of isosceles right-angle prism 1 is provided with dichroic film,
Enable to first wave length light and second wave length light be divided into two-beam, first wave length light to reflect through inclined-plane 13 when inclined-plane 13,
Second wave length light is through inclined-plane 13 transmission；Front surface 21 plating of plate glass 2 is provided with anti-reflection film so that the second wave length light after transmission
Entering in plate glass 2 through front surface 21 transmission of plate glass 2, rear surface 22 plating of plate glass 2 is provided with reflectance coating, it is possible to make
Second wave length light reflects in the rear surface 22 of plate glass 2, then sequentially passes through front surface and the isosceles right-angled edge of plate glass 2
Inclined-plane 13 transmission of mirror 1；Finally, first wave length light and second wave length light are all through another right-angle surface 12 of isosceles right-angle prism 1
Transmit isosceles right-angle prism 1.
In preferred embodiment, what the plating of the rear surface 22 of plate glass 2 set can be semi-transparent semi-reflecting film, when initially incidence not
Only include: first wave length light and two kinds of light of second wave length light, it is also possible to include that the light of its commplementary wave length, semi-transparent semi-reflecting film can make
Two wavelength light reflections, and make the light transmission of its commplementary wave length.
Embodiment 2: endoscopic optical imaging system
In conjunction with Fig. 2, the endoscope optical system of the present invention is described in detail by the present embodiment, its structural representation such as figure
Shown in 2, comprising: optical signal launch unit 101, light signal collection unit 102 and image unit 103.Wherein, optical signal is sent out
Penetrate unit 101 for launching visible ray (400nm～700nm) and near-infrared excitation light to certain region 100 of tissue to be detected
(such as 808nm near-infrared laser), certain region 100 of tissue to be detected by visible reflectance, and by near-infrared excitation light excite send out
Injection near-infrared fluorescent (820nm～850nm), it is seen that light, near-infrared fluorescent and near-infrared excitation light all enter optical signal and adopt
In collection unit 102, three kinds of light are processed, such as by light signal collection unit 102: eliminate aberration, change optical path direction to required
Direction, image unit 103 is for receiving the light processed through optical signal processing unit 102, and image unit 103 includes: turnover
Spectrophotometric unit 1031 and imageing sensor 1032, turnover spectrophotometric unit 1031 is for carrying out visible ray and near-infrared fluorescent
Closing light after first light splitting, the light path making two kinds of light is different, makes near-infrared fluorescent walk a part of light path than visible ray more, and then makes two kinds
The imaging focal plane position consistency of light；Imageing sensor 1032 for receive the visible ray from turnover spectrophotometric unit 1031 outgoing and
Near-infrared fluorescent.
Embodiment 3: endoscopic optical imaging system
The present embodiment is the improvement done on the basis of embodiment 2, and it is to add optical signal on the basis of embodiment 2
Converting unit 104, optical signal control unit 105, graphics processing unit 106 and image-display units 107, its structural representation
As it is shown on figure 3, wherein, optical signal conversion unit 104 is glimmering for visible ray and the near-infrared received by image tactility apparatus 1032
Light is converted to the corresponding signal of telecommunication, and is processed into video data；Graphics processing unit 106 is used for receiving optical signal conversion unit
104 video datas obtained；Optical signal control unit 105 is used for controlling optical signal launch unit 101 and launches visible ray and near
Infrared excitation light, is additionally operable to arrange visible mode or near-infrared fluorescent pattern, and graphics processing unit 106 is according to optical signal control
The pattern that unit 105 is arranged, selects to the video data of the visible ray received or the video data of near-infrared fluorescent
Reason, when for the video data of visible ray, does not processes video data, when the video data for near-infrared fluorescent, the most right
Video data does lateral shift and processes (translation d) so that it is with the location overlap of the video data of visible ray, and mark fluorescent district
Territory, does color background for non-fluorescence region and processes；Image-display units 107 is used for receiving graphics processing unit 106 and processes
The video data arrived, obtains visible images or has the fluoroscopic image of color background, and showing in real time, when video data is can
When seeing light data, obtain for visible images, when video data is near-infrared fluorescent data, obtain for having the colored back of the body
The fluoroscopic image of scape.
Embodiment 4: endoscopic optical imaging system
The present embodiment is on the basis of embodiment 2 or embodiment 3, to the image unit in embodiment 2 or embodiment 3
Structure is described in detail, and image unit includes: optical signal processing unit and imageing sensor 1032, structural representation such as figure
Shown in 4.Optical signal processing unit includes: the turnover spectrophotometric unit 1031 in embodiment 1, imageing sensor 1032 and turnover light splitting
The exit facet of unit 1031 is parallel, for receiving the visible ray from another right-angle surface 12 outgoing of isosceles right-angle prism 1 and near
Infrared fluorescence.
Turnover spectrophotometric unit 1031 is identical with the turnover spectrophotometric unit in embodiment 1, unique except for the difference that plate glass 2
Rear surface plating set as semi-transparent semi-reflecting film, be used for making near-infrared fluorescent reflect, make near-infrared excitation light transmission.
The operation principle of the endoscopic optical imaging system of the present embodiment is: owing to visible ray (400nm～700nm) is with near
The wavelength of Infrared fluorescence (820nm～850nm) is different, causes its imaging focal plane position inconsistent, it is impossible to pass at same image
Obtaining the blur-free imaging of two kinds of light on sensor, the light path of near-infrared fluorescent is changed by the present invention so that it is with visible ray simultaneously
Light path different, by the thickness of plate glass 2 is set accordingly so that the imaging focal plane position consistency of two kinds of light,
The blur-free imaging of two kinds of light can be obtained on same imageing sensor simultaneously, as anti-in Fig. 5 a illustrates without plate glass
The imaging containing fluorescing fractions 01 penetrated (a, b) and through the imaging 01 ' (a ', b ') containing fluorescing fractions of plate glass reflection,
As can be seen from Figure 01 ' (a ', b ') than 01 (a, hot spot b) is bigger, it is known that tissue to be detected is placed exactly in its imaging focal plane,
Imaging is apparent, but 01 ' (a ', b ') is relative to 01 as can be seen from Figure (a, b) transverse translation d, as long as by 01 ' (a ',
B ') mobile d, i.e. move to 01 (a, b) corresponding position, can with the picture registration of visible ray to together with, as shown in Figure 5 b.
Embodiment 5: endoscopic optical imaging system
The present embodiment is the improvement done on the basis of embodiment 4, and the optical signal processing unit 103 of the present embodiment also wraps
Include: optical coupler 1033, before optical coupler 1033 is positioned at turnover spectrophotometric unit 1031, for light signal collection unit
The residual aberration (such as spherical aberration, astigmatism etc.) of 102 compensates.In the present embodiment, optical coupler 1033 includes three lens, but
Being to be not limited thereto, the form of lens and quantity can require to carry out different settings according to optimizing.
Embodiment 6: endoscopic optical imaging system
The present embodiment is on the basis of embodiment 5, gives a kind of tool of light signal collection unit 102 (i.e. endoscope)
Body example, this light signal collection unit 102 includes: object lens 1021, transfer unit 1022 and the eyepiece 1023 being arranged in order, as
Shown in Fig. 7, wherein, object lens 1021 include four lens units, and transfer unit 1022 includes that odd number group rod-like mirror, eyepiece 1023 wrap
Include two lens units, but be not limited thereto, in different embodiments, light signal collection unit 102 not necessarily include this three
Part, form of lens and the quantity of every part carry out different setting also dependent on needs.
Embodiment 7: endoscopic optical imaging system
The present embodiment is on the basis of embodiment 5, gives the instantiation of a kind of endoscopic imaging system, gives
Each unit position is specifically set, as shown in Figure 8, optical signal launch unit is divided into two parts to its structural representation, is positioned at phase
To both sides, launch visible ray and near-infrared excitation light, light signal collection to certain region 100 of tissue to be detected respectively from both sides
Unit 102 includes three lens units.The present embodiment has been merely given as the mode of a kind of concrete setting, is not to the present invention's
Limiting, the position of unit and form can be configured as required.
Embodiment 8: endoscopic optical formation method
The endoscopic optical formation method of the present invention is described in detail by the present embodiment, and it can use above-described embodiment
Any one endoscopic imaging system realize, it comprises the following steps:
S11: utilize visible ray and near-infrared excitation light to irradiate certain region of tissue to be detected so that tissue to be detected will
Visible reflectance and make tissue to be detected be gone out near-infrared fluorescent by near-infrared excitation light excitation-emission；
S12: the visible ray gathering Tissue reflectance to be detected and the near-infrared fluorescent launched, and utilize turnover light splitting list
It is processed, so that visible ray is consistent with the imaging focal plane of near-infrared fluorescent by unit；
S13: utilize imageing sensor to receive visible ray after treatment and near-infrared fluorescent.
In preferred embodiment, also include after step S13:
S14: the visible ray received by imageing sensor and near-infrared fluorescent are converted to the signal of telecommunication of correspondence, and process
Become video data；
S15: select the video data of the visible ray received or the video data of near-infrared fluorescent to be processed, when connecing
Receive for the video data of visible ray time, video data is not processed, when selecting the video for near-infrared fluorescent that receives
During data, then video data is done lateral shift and processes so that it is with the location overlap of the video data of visible ray, and mark fluorescent
Region, does color background for non-fluorescence region and processes；
S16: obtain visible images according to video data or there is the fluoroscopic image of color background, and it is shown in real time
Show, when the video data that video data is visible ray, obtain for visible images, when video data is near-infrared fluorescent
During video data, obtain is the fluoroscopic image with color background.
Disclosed herein is only the preferred embodiments of the present invention, and this specification is chosen and specifically described these embodiments, is
In order to preferably explain the principle of the present invention and actual application, it it is not limitation of the invention.Any those skilled in the art
The modifications and variations done in the range of description, all should fall in the range of the present invention is protected.
Claims (12)
1. a turnover spectrophotometric unit, it is characterised in that described turnover spectrophotometric unit is for incident first wave length light and the
Two wavelength light carry out light splitting and close light again, make first wave length light different with the light path of second wave length light, so make first wave length light and
The imaging focal plane position consistency of second wave length light；
First wave length light is different with the wavelength of second wave length light.
Turnover spectrophotometric unit the most according to claim 1, it is characterised in that including: isosceles right-angle prism and plate glass,
Wherein,
Described plate glass be arranged in parallel with the inclined-plane of described isosceles right-angle prism；
Described first wave length light and described second wave length light are transmitted into described etc. from a right-angle surface of described isosceles right-angle prism
Waist corner cube prism, then through the inclined-plane light splitting of described isosceles right-angle prism, is divided into described first wave length light and described second wave length
Light；Described first wave length light is through the slant reflection of described isosceles right-angle prism；Described second wave length light is through described isosceles right-angled edge
The inclined-plane of mirror transmits described isosceles right-angle prism, incident from the face of the close described isosceles right-angle prism of described plate glass,
Through described plate glass another side reflect, sequentially pass through the close described isosceles right-angle prism of described plate glass face and
The inclined-plane of described isosceles right-angle prism is transmitted into described isosceles right-angle prism；Last described first wave length and described second wave length
Described isosceles right-angle prism is transmitted from another right-angle surface of described isosceles right-angle prism.
Turnover spectrophotometric unit the most according to claim 2, it is characterised in that two right-angle surface platings of described isosceles right-angle prism
There is anti-reflection film, be used for making described first wave length light and described second wave length light transmission；
The inclined-plane of described isosceles right-angle prism is coated with dichroic film, is used for making described first wave length luminous reflectance, makes described second ripple
Long light transmission；
The one side of the close described isosceles right-angle prism of described plate glass is coated with anti-reflection film, is used for making described second wave length light saturating
Penetrating, the another side of described plate glass is coated with reflectance coating or semi-transparent semi-reflecting film, is used for making described second wave length luminous reflectance.
Turnover Amici prism the most according to claim 1, it is characterised in that described isosceles right-angle prism and described flat board glass
Glass is glued together by optical cement.
5. an endoscopic optical imaging system, it is characterised in that including: optical signal launch unit, light signal collection unit with
And image unit；Wherein,
Described optical signal launch unit is used for certain field emission visible ray and the near-infrared excitation light to tissue to be detected, so that
Described tissue to be detected is by visible reflectance and makes the near-infrared fluorescent group of described tissue to be detected be excited by described near-infrared
Light excitation-emission goes out near-infrared fluorescent；
Described light signal collection unit is for gathering through the visible ray of described Tissue reflectance to be detected and the near-infrared launched
Fluorescence；
Described image unit includes: optical signal processing unit and imageing sensor；
Described optical signal processing unit is used for receiving visible ray and the near-infrared fluorescent that described light signal collection unit gathers, and
It is processed, so that described visible ray is consistent with the imaging focal plane of described near-infrared fluorescent；Described optical signal processing unit
Including: turnover spectrophotometric unit, described turnover spectrophotometric unit is the turnover spectrophotometric unit as described in any one of Claims 1-4；
Described imageing sensor is for receiving the visible ray after described optical signal processing unit processes and near-infrared fluorescent.
Endoscopic optical imaging system the most according to claim 5, it is characterised in that when described turnover spectrophotometric unit is such as
During turnover spectrophotometric unit described in claim 2, described visible ray, described near-infrared excitation light and described near-infrared fluorescent from
One right-angle surface of described isosceles right-angle prism is transmitted into described isosceles right-angle prism, then oblique through described isosceles right-angle prism
Face light splitting；Described visible ray is through the slant reflection of described isosceles right-angle prism；Described near-infrared excitation light and described near-infrared
Fluorescence transmits described isosceles right-angle prism through the inclined-plane of described isosceles right-angle prism, close described etc. from described plate glass
The face of waist corner cube prism is incident, and described near-infrared fluorescent reflects through the another side of described plate glass, described near-infrared excitation light
Through the another side transmission of described plate glass, the close described isosceles that described near-infrared fluorescent sequentially passes through described plate glass are straight
The face of angle prism and the inclined-plane of described isosceles right-angle prism are transmitted into described isosceles right-angle prism；Last described visible ray and
Described near-infrared fluorescent transmits described isosceles right-angle prism from another right-angle surface of described isosceles right-angle prism；Further,
When described spectrophotometric unit of turning back is for turnover spectrophotometric unit as claimed in claim 3, described plate glass away from institute
The one side stating isosceles right-angle prism is semi-transparent semi-reflecting film, is used for making described near-infrared fluorescent reflect, makes described near-infrared excitation light
Transmission.
Endoscopic optical imaging system the most according to claim 5, it is characterised in that described optical signal processing unit also wraps
Including: optical coupler, described visible ray and near-infrared fluorescent first pass through described optical coupler, then through described turnover light splitting
Unit；
Described optical coupler includes that one or more lens, described optical coupler are used for eliminating described visible ray and described
The aberration of near-infrared fluorescent.
Endoscopic optical imaging system the most according to claim 5, it is characterised in that also include: optical signal conversion unit,
Described optical signal conversion unit turns for described visible ray and the described near-infrared fluorescent received by described imageing sensor
It is changed to the signal of telecommunication of correspondence, and is processed into video data.
Endoscopic optical imaging system the most according to claim 8, it is characterised in that also include: graphics processing unit, institute
State graphics processing unit for receiving the described video data that described optical signal conversion unit obtains；Further,
Also include: image-display units, described image-display units for receive described graphics processing unit process obtain regard
Frequency evidence, obtains visible images or has the fluoroscopic image of color background, and showing in real time, when described video data is visible
During the video data of light, obtain for visible images, when the video data that described video data is near-infrared fluorescent, obtain
Be that there is the fluoroscopic image of color background.
Endoscopic optical imaging system the most according to claim 9, it is characterised in that also include: optical signal controls single
Unit, described optical signal control unit is used for controlling described optical signal launch unit and launches visible ray and near-infrared excitation light；
Described optical signal control unit be additionally operable to control described graphics processing unit receive and process visible ray video data or
The video data of near-infrared fluorescent, when described graphics processing unit receive for the video data of visible ray time, do not regard described
Frequency according to processing, when described graphics processing unit receive for the video data of near-infrared fluorescent time, to described video data
Do lateral shift to process so that it is with the location overlap of the video data of visible ray, and mark fluorescent region, for non-fluorescence region
Do color background to process.
11. 1 kinds of endoscopic optical formation methods, it is characterised in that comprise the following steps:
S11: utilize visible ray and near-infrared excitation light to irradiate certain region of tissue to be detected so that described tissue to be detected will
Described visible reflectance and make described tissue to be detected be gone out near-infrared fluorescent by described near-infrared excitation light excitation-emission；
S12: gather through the visible ray of described Tissue reflectance to be detected and the near-infrared fluorescent launched, and utilize turnover light splitting
It is processed by unit, so that described visible ray is consistent with the imaging focal plane of described near-infrared fluorescent；
S13: utilize imageing sensor to receive described visible ray after treatment and described near-infrared fluorescent.
12. endoscopic optical formation methods according to claim 11, it is characterised in that also wrap after described step S13
Include:
S14: the described visible ray received by described imageing sensor and described near-infrared fluorescent are converted to the telecommunications of correspondence
Number, and it is processed into video data；
S15: select the video data of the visible ray received or the video data of near-infrared fluorescent are processed, when receive
During for the video data of visible ray, video data is not processed, when selecting the video data for near-infrared fluorescent that receives
Time, then video data is done lateral shift and processes so that it is with the location overlap of the video data of visible ray, and mark fluorescent district
Territory, does color background for non-fluorescence region and processes；
S16: obtain visible images according to described video data or there is the fluoroscopic image of color background, and it is shown in real time
Show, when the video data that described video data is visible ray, obtain for visible images, when described video data is the reddest
During the video data of outer fluorescence, obtain is the fluoroscopic image with color background.
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