CN106092848B - Dialyzer ultrafiltration performance test fluid - Google Patents
Dialyzer ultrafiltration performance test fluid Download PDFInfo
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- CN106092848B CN106092848B CN201610163783.4A CN201610163783A CN106092848B CN 106092848 B CN106092848 B CN 106092848B CN 201610163783 A CN201610163783 A CN 201610163783A CN 106092848 B CN106092848 B CN 106092848B
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- test fluid
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- dialyzer
- albumin
- ultrafiltration performance
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- 238000000108 ultra-filtration Methods 0.000 title claims abstract description 40
- 239000012530 fluid Substances 0.000 title claims abstract description 24
- 238000011056 performance test Methods 0.000 title claims abstract description 15
- 238000012360 testing method Methods 0.000 claims abstract description 32
- 239000002504 physiological saline solution Substances 0.000 claims abstract description 15
- 108010088751 Albumins Proteins 0.000 claims abstract description 12
- 102000009027 Albumins Human genes 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 229920001503 Glucan Polymers 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 4
- 108010071390 Serum Albumin Proteins 0.000 claims description 3
- 102000007562 Serum Albumin Human genes 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 210000002966 serum Anatomy 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 24
- 239000008280 blood Substances 0.000 abstract description 23
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 2
- 238000009472 formulation Methods 0.000 abstract 1
- 239000002002 slurry Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 11
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 7
- 229940098773 bovine serum albumin Drugs 0.000 description 7
- 210000002381 plasma Anatomy 0.000 description 7
- 239000012510 hollow fiber Substances 0.000 description 6
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 5
- 229940050526 hydroxyethylstarch Drugs 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000004695 Polyether sulfone Substances 0.000 description 4
- 229920002492 poly(sulfone) Polymers 0.000 description 4
- 229920006393 polyether sulfone Polymers 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 101100004287 Caenorhabditis elegans best-6 gene Proteins 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N2015/086—Investigating permeability, pore-volume, or surface area of porous materials of films, membranes or pellicules
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
A kind of dialyzer ultrafiltration performance test fluid, is related to haemodialyser testing field, is mixed by the raw material comprising following proportion by weight：1000 parts of physiological saline, 19 parts of albumin, 30 80 parts of glucide；The viscosity of test fluid is 2~6 millipascal seconds.Inventive formulation is simple, simple for production, and performance is stable, of low cost, and test data precision is high, is starched instead of ox blood of the prior art.
Description
Technical field
The present invention relates to haemodialyser testing fields, and it is that one kind can substitute ox blood slurry, be formulated simple, making to elaborate
Simplicity, performance is stable, of low cost, the high dialyzer ultrafiltration performance test fluid of test data precision.
Background technology
Ultrafiltration rate is one of performance of hollow fiber dialyzer, the main water-scavenging capability for reflecting hollow fiber dialyzer,
It is the important performance indexes for evaluating hollow fiber dialyzer.In external performance evaluation, the prior art is to starch to test using ox blood
The ultrafiltration rate of hollow fiber dialyzer.With the production-scale continuous expansion of China's dialyzer, also exist to the demand of ox blood slurry
It is continuously increased.But ox blood slurry in use there is it is many problem of, for example, ox blood slurry quality influenced by Niu Zishen
It is bigger, the particularity of having differences property, blood plasma itself between different batches blood plasma, can not multigelation use, can only be primary
Property use, blood plasma for a long time exposure in air and and dialyzer membrane material it can all be generated certain influence and then
Interference is generated to test result, the accurate data degree of test is low.In addition, due to the limitation in ox blood slurry source, the cost of ox blood slurry
Compare high, according to the quotation of largest domestic ox blood slurry manufacturing enterprise Guangzhou stamen spy, the market quotes that every liter of ox blood is starched is up to 1000 yuan
Left and right.And ox blood is starched inevitably there are Carried bacteria and the risk of virus during production and use, and
It is also relative complex in the processing of ox blood slurry after use.
Invention content
The present invention provides the test fluids that a kind of alternative ox plasma solutions carry out ultrafiltration rate test, it is intended to solve above-mentioned ox
The deficiency of blood plasma in use.Testing cost can be reduced by carrying out the evaluation of ultrafiltration rate using solution provided by the invention, be ensured
Measuring accuracy, while also avoid pollution of the discharge of ox blood slurry to environment.
The test fluid that the invention provides is suitable for field of blood purification small throughput, low pass efficient, high throughput, ultra-high throughput etc.
The performance evaluation of hemodialysis membrane.
Technical solution is used by the present invention solves above-mentioned the deficiencies in the prior art：
A kind of dialyzer ultrafiltration performance test fluid, it is characterised in that：It is mixed by the raw material comprising following proportion by weight
It is made：1000 parts of physiological saline, 1-9 parts of albumin, 30-80 parts of glucide.
Raw material preferred mass part of heretofore described dialyzer ultrafiltration performance test fluid matches：Physiological saline 1000
Part, 2-5 parts of albumin, 40-60 parts of glucide.
The viscosity of heretofore described dialyzer ultrafiltration performance test fluid is 2~6 millipascal seconds；Preferably 2.5-5.5 millis
Pa/second.
Heretofore described glucide is at least one of glucan, hydroxyethyl starch.
Heretofore described albumin is bovine serum albumin(BSA), human serum albumins, in porcine serum albumin at least
It is a kind of.
Preparation method is：Physiological saline, glucide and albumin are weighed by proportion by weight, by glucide and in vain
Albumen and physiological saline are put into container, are stirred evenly, until dissolving to get finished product.
Dialyzer ultrafiltration performance test fluid finished product produced by the present invention needs matching while using, prepares the finished product of completion in room temperature
Under used in best 6 hours, be otherwise affected to test result, test errors or failure even occur.
In the use of the present invention, test the super of hollow fiber dialyzer according to the method for 5.6.3.2 in ISO8637-2010
Filter performance.
Compared with prior art, technical advantage of the invention is：
（1）Data stabilization.Due to using only commercialized albumin, carbohydrate and physiological saline in solution process for preparation,
Ingredient is simple for the composition of ox blood slurry, ratio is precisely controllable, and performance is stable, the influence to test result is small, surveys
The accurate data degree obtained is high.
（2）It is of low cost.The price of one liter of ox blood slurry is at 1000 yuan or so, and price prepared by the present invention is only 150 yuan
Left and right, it is of low cost.
（3）Environmental protection.Inevitably there are Carried bacteria and the wind of virus during production and use for ox blood slurry
Danger, and it is also relative complex in the processing of ox blood slurry after use；The present invention overcomes ox bloods to starch these shortcomings.
Description of the drawings
Fig. 1 is the polyether sulfone product for selecting company A in the market, is used according to the method for 5.6.3.2 in ISO8637-2010
The test fluid that ox blood is starched and prepared by embodiment 1 carries out the result table of comparisons that the test of ultrafiltration rate performance obtains;
Fig. 2 is the polyether sulfone product for selecting company A in the market, is used according to the method for 5.6.3.2 in ISO8637-2010
The test fluid that ox blood is starched and prepared by embodiment 2 carries out the result table of comparisons that the test of ultrafiltration rate performance obtains;
Fig. 3 is the polysulfones product for selecting B companies in the market, and ox is used according to the method for 5.6.3.2 in ISO8637-2010
Test fluid prepared by blood plasma and embodiment 3 carries out the result table of comparisons that the test of ultrafiltration rate performance obtains;
Fig. 4 is the polysulfones product for selecting C companies in the market, and ox is used according to the method for 5.6.3.2 in ISO8637-2010
Test fluid prepared by blood plasma and embodiment 4 carries out the result table of comparisons that the test of ultrafiltration rate performance obtains.
Specific embodiment
A kind of dialyzer ultrafiltration performance test fluid, it is characterised in that：It is mixed by the raw material comprising following proportion by weight
It is made：40-60 parts of 1000 parts of physiological saline, 2-5 parts of bovine serum albumin(BSA), glucan and hydroxyethyl starch；Dialyzer obtained
The viscosity of ultrafiltration performance test fluid is 4-5.5 millipascal seconds.
Preparation method is：Physiological saline, hydroxyethyl starch and bovine serum albumin(BSA) are weighed by proportion by weight, by hydroxyl second
Base starch and bovine serum albumin(BSA) are put into physiological saline, are stirred evenly, until dissolving to get finished product.It dialyses to hollow fibre
When device is tested, its ultrafiltration performance is tested according to the method for 5.6.3.2 in ISO8637-2010.
The measure of existing three kinds of haemodialysers progress ultrafiltration performance on the market is selected below, compares ox blood slurry ultrafiltration rate
With the consistency for substituting solution ultrafiltration rate data.
Embodiment one
30 parts of glucans and 8 parts of porcine serum albumin are weighed by proportion by weight, are dissolved in 1000 parts of physiological saline
In, stirring is until be completely dissolved；The polyether sulfone product of company A in the market is selected, according to the side of 5.6.3.2 in ISO8637-2010
The test that method carries out ultrafiltration rate performance obtains that the results are shown in Table 1.
The product ultrafiltration performance contrast table of 1 company A of table
Embodiment two
40 parts of hydroxyethyl starch and 5 parts of bovine serum albumin(BSA)s are weighed by proportion by weight, are dissolved in 1000 parts of physiology
In brine, stirring is until be completely dissolved；The polyether sulfone product of company A in the market is selected, according to 5.6.3.2 in ISO8637-2010
Method carry out the test of ultrafiltration rate performance and obtain that the results are shown in Table 2.
The product ultrafiltration performance contrast table of 2 company A of table
Embodiment three
60 parts of glucans, 3 parts of bovine serum albumin(BSA)s are weighed by proportion by weight, are dissolved in 1000 parts of physiological saline
In, stirring is until be completely dissolved；The polysulfones product of B companies in the market is selected, according to the method for 5.6.3.2 in ISO8637-2010
The test for carrying out ultrafiltration rate performance obtains that the results are shown in Table 3.
The product ultrafiltration performance contrast table of 3 B companies of table
Example IV
40 parts of glucans, 40 parts of hydroxyethyl starch, 1 part of bovine serum albumin(BSA) and 1 part of Swine serum are weighed by proportion by weight
Albumin is dissolved in 1000 parts of physiological saline, and stirring is until be completely dissolved；The polysulfones product of C companies in the market is selected,
The test that method according to 5.6.3.2 in ISO8637-2010 carries out ultrafiltration rate performance obtains that the results are shown in Table 4.
The product ultrafiltration performance contrast table of 4 C companies of table
Analyzing above-mentioned experimental data can obtain, and the hollow fiber dialyzer ultrafiltration rate experimental data measured using the present invention is with making
The ultrafiltration rate experimental data of like products measured with ox blood slurry differs very little, in the range of data error permission.Therefore, originally
Invention can replace ox blood slurry to test dialyzer ultrafiltration performance completely, and simple, simple for production with being formulated, and performance is steady
It is fixed, of low cost, the advantages that test data precision is high.
Claims (5)
1. a kind of dialyzer ultrafiltration performance test fluid, it is characterised in that：It mixes system by the raw material comprising following proportion by weight
Into：1000 parts of physiological saline, 1-9 parts of albumin, 30-80 parts of glucide；The glucide is glucan, ethoxy forms sediment
At least one of powder.
2. dialyzer ultrafiltration performance test fluid according to claim 1, it is characterised in that the albumin is cow's serum
At least one of albumin, human serum albumins, porcine serum albumin.
3. dialyzer ultrafiltration performance test fluid according to claim 2, it is characterised in that：The dialyzer ultrafiltration performance
The viscosity of test fluid is 2~6 millipascal seconds.
4. dialyzer ultrafiltration performance test fluid according to claim 3, it is characterised in that：The dialyzer ultrafiltration performance
The viscosity of test fluid is preferably 2.5-5.5 millipascal seconds.
5. the preparation method of dialyzer ultrafiltration performance test fluid according to claim 1, it is characterised in that：Match by mass parts
Than weighing physiological saline, carbohydrate and albumin, carbohydrate and albumin are put into physiological saline, stirred evenly, until dissolving, i.e.,
Obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610163783.4A CN106092848B (en) | 2016-03-22 | 2016-03-22 | Dialyzer ultrafiltration performance test fluid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610163783.4A CN106092848B (en) | 2016-03-22 | 2016-03-22 | Dialyzer ultrafiltration performance test fluid |
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| Publication Number | Publication Date |
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| CN106092848A CN106092848A (en) | 2016-11-09 |
| CN106092848B true CN106092848B (en) | 2018-07-06 |
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| CN201610163783.4A Active CN106092848B (en) | 2016-03-22 | 2016-03-22 | Dialyzer ultrafiltration performance test fluid |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107153037B (en) * | 2017-05-17 | 2019-11-26 | 自然资源部天津海水淡化与综合利用研究所 | A kind of ultrafiltration membrane rejection detection method based on narrow ditribution chitosan |
| CN108645597A (en) * | 2018-05-30 | 2018-10-12 | 威海威高血液净化制品有限公司 | dialyzer pressure drop performance test liquid |
| CN108760233A (en) * | 2018-05-30 | 2018-11-06 | 威海威高血液净化制品有限公司 | dialyzer pressure drop performance test liquid |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127476A (en) * | 1993-06-04 | 1996-07-24 | 生物时间公司 | Plasma-like solution |
| US5589197A (en) * | 1993-10-04 | 1996-12-31 | Baxter International, Inc. | Low sodium peritoneal dialysis solution |
| CN101991595A (en) * | 2009-08-26 | 2011-03-30 | 温州医学院 | Plasma substitute and preparation method thereof |
| CN102065926A (en) * | 2008-02-04 | 2011-05-18 | 纽约市哥伦比亚大学理事会 | Fluid separation devices, systems and methods |
| JP2013031835A (en) * | 2011-07-01 | 2013-02-14 | Japan Organo Co Ltd | Method of evaluating filter |
| CN103418249A (en) * | 2012-10-31 | 2013-12-04 | 上海理工大学 | Ultrafiltration rate measurement device of hollow fiber hemodialyzer |
-
2016
- 2016-03-22 CN CN201610163783.4A patent/CN106092848B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1127476A (en) * | 1993-06-04 | 1996-07-24 | 生物时间公司 | Plasma-like solution |
| US5589197A (en) * | 1993-10-04 | 1996-12-31 | Baxter International, Inc. | Low sodium peritoneal dialysis solution |
| CN102065926A (en) * | 2008-02-04 | 2011-05-18 | 纽约市哥伦比亚大学理事会 | Fluid separation devices, systems and methods |
| CN101991595A (en) * | 2009-08-26 | 2011-03-30 | 温州医学院 | Plasma substitute and preparation method thereof |
| JP2013031835A (en) * | 2011-07-01 | 2013-02-14 | Japan Organo Co Ltd | Method of evaluating filter |
| CN103418249A (en) * | 2012-10-31 | 2013-12-04 | 上海理工大学 | Ultrafiltration rate measurement device of hollow fiber hemodialyzer |
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| CN106092848A (en) | 2016-11-09 |
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Address after: No.20, Xingshan Road, Weihai Torch hi tech Industrial Development Zone, Weihai City, Shandong Province, 264210 Patentee after: Shandong Weigao blood purification products Co.,Ltd. Address before: 264200 Weigao Industrial Park, No.20 Xingshan Road, chucun Town, torch hi tech Development Zone, Weihai City, Shandong Province Patentee before: WEIHAI WEIGAO BLOOD PURIFICATION PRODUCTS Co.,Ltd. |
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