CN106083967A - Containing galactoside structure triazole norcantharidin derivative and preparation method and application - Google Patents
Containing galactoside structure triazole norcantharidin derivative and preparation method and application Download PDFInfo
- Publication number
- CN106083967A CN106083967A CN201610392600.6A CN201610392600A CN106083967A CN 106083967 A CN106083967 A CN 106083967A CN 201610392600 A CN201610392600 A CN 201610392600A CN 106083967 A CN106083967 A CN 106083967A
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- Prior art keywords
- galactoside
- methanol
- room temperature
- reaction
- norcantharidin derivative
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610392600.6A CN106083967B (en) | 2016-06-06 | 2016-06-06 | Triazole norcantharidin derivative of structure containing Arabinoside and the preparation method and application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610392600.6A CN106083967B (en) | 2016-06-06 | 2016-06-06 | Triazole norcantharidin derivative of structure containing Arabinoside and the preparation method and application thereof |
Publications (2)
Publication Number | Publication Date |
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CN106083967A true CN106083967A (en) | 2016-11-09 |
CN106083967B CN106083967B (en) | 2018-10-23 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201610392600.6A Active CN106083967B (en) | 2016-06-06 | 2016-06-06 | Triazole norcantharidin derivative of structure containing Arabinoside and the preparation method and application thereof |
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CN (1) | CN106083967B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108752404A (en) * | 2018-07-03 | 2018-11-06 | 山东省科学院生物研究所 | A kind of berberine salt derivative and its preparation method and application that triazole is sugar-modified |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101717411A (en) * | 2009-11-19 | 2010-06-02 | 绍兴文理学院 | Methyl-removal cantharidin derivative phosphate disodium salt and synthesis method and application thereof |
CN101812066A (en) * | 2010-03-04 | 2010-08-25 | 绍兴文理学院 | Pyrazolo N-substituted dehydronorcantharidin imide derivative as well as synthesis method, activity test method and application thereof |
CN102276673A (en) * | 2011-06-21 | 2011-12-14 | 中国科学院成都生物研究所 | Preparation method of 2-deoxy-beta-D-glucopyranosyl triazole compound |
CN104817605A (en) * | 2015-04-14 | 2015-08-05 | 湖北工程学院 | 2-(1',2',3'-triazole-4'-benzyloxy)-1,3,4,6-O-acetyl-D-glucose and preparation method and application thereof |
-
2016
- 2016-06-06 CN CN201610392600.6A patent/CN106083967B/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101717411A (en) * | 2009-11-19 | 2010-06-02 | 绍兴文理学院 | Methyl-removal cantharidin derivative phosphate disodium salt and synthesis method and application thereof |
CN101812066A (en) * | 2010-03-04 | 2010-08-25 | 绍兴文理学院 | Pyrazolo N-substituted dehydronorcantharidin imide derivative as well as synthesis method, activity test method and application thereof |
CN102276673A (en) * | 2011-06-21 | 2011-12-14 | 中国科学院成都生物研究所 | Preparation method of 2-deoxy-beta-D-glucopyranosyl triazole compound |
CN104817605A (en) * | 2015-04-14 | 2015-08-05 | 湖北工程学院 | 2-(1',2',3'-triazole-4'-benzyloxy)-1,3,4,6-O-acetyl-D-glucose and preparation method and application thereof |
Non-Patent Citations (6)
Title |
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LIPING DENG,等: "Disodium Phosphate of Norcantharidin Analogues: Design, Synthesis and their Anticancer Evaluation", 《LETTERS IN DRUG DESIGN & DISCOVERY》 * |
LIPING DENG,等: "Novel 1, 2, 3-Triazole-Linked Norcantharidin Analogues: Synthesis and Evaluation of Growth Inhibition in a Panel of Selected Tumor-Cell Lines", 《LETTERS IN DRUG DESIGN & DISCOVERY》 * |
PERUMAL RAJAKUMAR,等: "Synthesis and In-vitro anti-inflammatory activity of novel glycodendrimers with benzene 1,3,5 carboxamide core and triazole as branching unit", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
RAM JANAM SINGH: "1, 2, 3-TRIAZOLE DERIVATIVES AS POSSIBLE ANTIINFLAMMATORY AGENTS", 《RASAYAN J.CHEM.》 * |
赵岩,等: "去甲斑蝥素主动肝靶向性药物设计研究进展", 《环球中医药》 * |
高建德,等: "《物理药剂学及应用》", 31 May 2014 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108752404A (en) * | 2018-07-03 | 2018-11-06 | 山东省科学院生物研究所 | A kind of berberine salt derivative and its preparation method and application that triazole is sugar-modified |
Also Published As
Publication number | Publication date |
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CN106083967B (en) | 2018-10-23 |
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Effective date of registration: 20191129 Address after: No. 99, Changli Road, Wuzhong District, Suzhou, Jiangsu 215100 Patentee after: SUZHOU CITY WUZHONG TECHNOLOGY INNOVATION PARK MANAGEMENT CO.,LTD. Address before: 312000, No. 508 West Ring Road, Yuecheng District, Zhejiang, Shaoxing Patentee before: Shaoxing University |
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Effective date of registration: 20221109 Address after: 271000 west head of peitianmen street, high tech Industrial Development Zone, Tai'an City, Shandong Province Patentee after: JEWIM PHARMACEUTICAL (SHANDONG) CO.,LTD. Address before: 215100 99 Changli Road, Wuzhong District, Suzhou City, Jiangsu Province Patentee before: SUZHOU CITY WUZHONG TECHNOLOGY INNOVATION PARK MANAGEMENT CO.,LTD. |
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Effective date of registration: 20230320 Address after: 271000 west head of peitianmen street, high tech Industrial Development Zone, Tai'an City, Shandong Province Patentee after: JEWIM PHARMACEUTICAL (SHANDONG) CO.,LTD. Patentee after: Shandong Ruishun Pharmaceutical Co.,Ltd. Address before: 271000 west head of peitianmen street, high tech Industrial Development Zone, Tai'an City, Shandong Province Patentee before: JEWIM PHARMACEUTICAL (SHANDONG) CO.,LTD. |