CN106083707B - A kind of synthetic method of asymmetric heteroaryl thioether - Google Patents

A kind of synthetic method of asymmetric heteroaryl thioether Download PDF

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CN106083707B
CN106083707B CN201610381700.9A CN201610381700A CN106083707B CN 106083707 B CN106083707 B CN 106083707B CN 201610381700 A CN201610381700 A CN 201610381700A CN 106083707 B CN106083707 B CN 106083707B
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reaction
heteroaryl
chloro
thiocarbamide
asymmetric
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CN106083707A (en
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徐清
马献涛
苏陈良
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Wenzhou University
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

The invention discloses a kind of synthetic method of asymmetric heteroaryl thioether, technical solution is that heteroaryl halides, aminothio amide compound and alcohol directly heat under the conditions of without any extra catalyst and asymmetric heteroaryl sulfide compound can be obtained by the reaction the present invention provides a kind of any outer plus without the green synthesis method for preparing expense unsymmetrical heteroaryl thio-ether type compounds under catalysts conditions by heteroaryl halides, aminothio amide compound and alcohol.This method is alkylating reagent using alcohols that is cheap and easy to get, deriving from a wealth of sources, stablize low toxicity, the use of common aminothio amides compound is that the directly reaction synthesis under without any extra catalyst, condition of no solvent of sulphur source and heteroaryl halides cheap and easy to get obtains asymmetric heteroaryl thio-ether type compounds.This method reaction condition is simple, is not necessarily to inert gas shielding, is not necessarily to solvent, is easily operated, and the requirement to reaction condition is relatively low.

Description

A kind of synthetic method of asymmetric heteroaryl thioether
Technical field
The invention belongs to the field of chemical synthesis, and in particular to a kind of synthetic method of asymmetric heteroaryl thioether, the synthesis Method be by without under the conditions of any extra catalyst heteroaryl halide close object, aminothio amide compound with alcohol the system of reacting It is standby, it is a kind of green method.
Background technology
Asymmetric heteroaryl sulfide based structural is largely present in natural products and pharmaceutically active compounds, thus be drug, Important structural unit in natural products and pesticide synthesis.And sulfide based structural can also be further converted to sulfoxide or sulfone in turn As important synthesis material.Therefore, the synthesis of heteroaryl alkyl sulfide compound causes more and more organic chemists Attention.
In known synthetic method, asymmetric heteroaryl alkyl sulfide compound can pass through heteroaryl thiophenol and halogenated hydrocarbons It synthesizes, can also be replaced by the aryl nucleophilic of heteroaryl halides and alkyl hydrosulfide under alkaline condition under alkaline condition It reacts to synthesize.But which kind of method no matter is used, it all inevitably needs using with foul odour and being more toxic Thiophenol or mercaptan compound, and convert thiophenol or mercaptan to the stronger sulphur anion of nucleophilicity using large excess of alkali and join With react, cause also to will produce a large amount of waste in processing procedure after the reaction.First method also needs to big using toxicity, steady The alkyl halide compound of qualitative difference is primarily adapted for use in primary halogenated hydrocarbons as alkylating reagent, under alkaline condition this method, because Secondary halogenated hydrocarbons and tertiary halogenated hydrocarbons are easy to happen the competitive reaction of elimination and have to the target product of low yield, therefore the scope of application It is in fact very limited.
Therefore, synthesis asymmetric heteroaryl alkyl thioether of the new green method using one step of raw material for stablizing low toxicity is found Compound is all significantly to study for organic synthesis, biochemistry and Pharmaceutical Chemist.The present invention is directed to develop one kind Under the conditions of any extra catalyst, using the alcohol of green as alkylating reagent, to stablize the aminothio amide compound of free from extraneous odour New method of the object as the reaction one-step synthesis heteroaryl alkyl sulfide compound of sulphur source and heteroaryl halides.
Invention content
The purpose of the invention is to overcome shortcoming and defect of the existing technology, and provide a kind of asymmetric heteroaryl The synthetic method of thioether, this method are alkylating reagent using deriving from a wealth of sources, being cheap and easy to get, stablizing the alcohols of low toxicity, are appointed in nothing What extra catalyst, auxiliary agent or additive and it is solvent-free under the conditions of, realize heteroaryl halides, aminothio amide compound Object is reacted with alcohol.
To achieve the above object, the technical scheme is that heteroaryl halides, aminothio amide compound and alcohol Asymmetric heteroaryl sulfide compound can be obtained by the reaction by being directly heated under the conditions of without any extra catalyst, and reaction temperature is 100~180 DEG C, the reaction time is 6~60 hours, and reaction equation is：
X=Cl, Br, I
R1、R2For various substituent groups.
It is the pyridine that various functional groups are substituted in 3-, 4-, 5- or 6- that further setting, which is the heteroaryl halides,.
It is various functional group's substituted heteroaryl compounds, the heteraryl that further setting, which is the heteroaryl halides, Conjunction object is quinoline, benzothiazole, pyrimidine, pyrazine or pyridazine.
Further setting is R1For alkyl, aryl, amino, substituted-amino, amide groups or thioamides base.
Further setting be alcohol be alkyl primary alcohol, various functional groups replace benzyl alcohol, various functional groups substitution it is miscellaneous The cinnamyl alcohol that aryl methanol, various functional groups replace, the secondary alcohols such as various substituted diarylcarbinols and aryl alkyl methanol, or Various substituted tertiary alcohols.
Further setting is that the reaction is carried out in the case where having solvent or condition of no solvent.
Further setting is that the reaction carries out under inert gas protection or under air.
It is 120~160 DEG C that further setting, which is the reaction temperature, and the reaction time is 12~48 hours.
Further setting is that the reaction is not necessarily to any extra catalyst, auxiliary agent or additive.
It is an advantage of the invention that：Compared with prior art, this method can be used it is cheap and easy to get, derive from a wealth of sources, stablize low toxicity, The alcohol compound of green is alkylating reagent, does not use any catalyst, ligand, auxiliary agent or additive, and reaction is not necessarily to inertia Gas shield can be carried out directly under air, not use organic solvent, easily operated.Therefore, this method wants reaction condition Ask the relatively low, scope of application wider, it is with the obvious advantage compared with known method, have and potential is widely applied foreground.
The present invention is described further With reference to embodiment.
Specific implementation mode
The present invention is specifically described below by embodiment, is served only for that invention is further explained, no It can be interpreted as limiting the scope of the present invention, the technician in the field can be according to the content of foregoing invention to the present invention Make some nonessential modifications and adaptations.
Embodiment 1
2- bromopyridines, thiocarbamide and benzyl alcohol prepare 2- pyridyl group thioanisoles
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) with benzyl alcohol (64.8mg, 0.60mmol, 1.2equiv.), directly seal under air and then in solvent-free item 140 DEG C of reactions are heated under part for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 83%.1H NMR(500MHz,CDCl3) δ 8.45 (d, J=4.5Hz, 1H), 7.45 (t, J=7.5Hz, 1H), 7.40 (d, J=7.5Hz, 2H), 7.29 (t, J=7.5Hz, 2H), 7.23 (d, J=7.5Hz, 1H), 7.15 (d, J=8.0Hz, 1H), 6.97 (t, J= 6.0Hz,1H),4.43(s,2H)；13C NMR(125MHz,CDCl3)δ158.8,149.4,138.0,136.0,129.0, 128.5,127.1,122.1,119.6,34.5。
Embodiment 2
2- bromopyridines, thiocarbamide and 4- methoxy benzyl alcohols prepare 2- pyridyl groups (4- methoxyl groups)-thioanisole
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (76.0mg, 1.0mmol, 2.0equiv.) and 4- methoxy benzyl alcohols (82.8mg, 0.60mmol, 1.2equiv.), directly under air sealing then 140 DEG C of reactions are heated under condition of no solvent for 24 hours.After the reaction was complete, product is purified with pillar layer separation for TLC monitorings, and separation is received Rate 58%.1H NMR(500MHz,CDCl3) δ 8.38 (d, J=4.0Hz, 1H), 7.38 (t, J=7.5Hz, 1H), 7.25 (d, J= 8.5Hz, 2H), 7.07 (d, J=8.0Hz, 1H), 6.99-6.88 (m, 1H), 6.75 (d, J=8.5Hz, 2H), 4.31 (s, 2H), 3.70(s,3H)；13C NMR(125MHz,CDCl3)δ159.0,158.7,149.4,136.0,130.1,129.8,122.1, 119.6,113.9,55.3,34.0。
Embodiment 3
2- bromopyridines, thiocarbamide and 4- methoxy benzyl alcohols prepare 2- pyridyl groups (4- bromines)-thioanisole
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv., 4- bromobenzene methanol (111.6mg, 0.60mmol, 1.2equiv.) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 78%.1H NMR(500MHz,CDCl3) δ 8.43 (d, J=4.0Hz, 1H), 7.52-7.41 (m, 1H), 7.38 (d, J=8.5Hz, 2H), 7.27 (d, J=8.5Hz, 2H), 7.13 (d, J=8.0Hz, 1H),7.02–6.91(m,1H),4.37(s,2H)；13C NMR(125MHz,CDCl3)δ158.2,149.4,137.4,136.1, 131.6,130.7,122.2,120.9,119.8,33.6。
Embodiment 4
2- bromopyridines, thiocarbamide and 2- methylbenzyl alcohols prepare 2- pyridyl groups (2- methyl)-thioanisole
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) with 2- methylbenzyl alcohols (73.2mg, 0.60mmol, 1.2equiv.), directly seal under air and then in nothing 140 DEG C of reactions are heated under solvent condition for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 71%.1H NMR(500MHz,CDCl3) δ 8.38 (d, J=4.5Hz, 1H), 7.48-7.20 (m, 2H), 7.10-7.01 (m, 4H), 6.88 (dd, J=6.5,5.5Hz, 1H), 4.36 (s, 2H), 2.33 (s, 3H)；13C NMR(125MHz,CDCl3)δ159.2, 149.4,137.0,135.9,135.4,130.5,130.0,127.5,126.1,122.2,119.5,32.7,19.4。
Embodiment 5
2- bromopyridines, thiocarbamide and 2- chlorobenzene methanols prepare 2- pyridyl groups (2- chlorine)-thioanisole
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), 2- chlorobenzene methanols (85.2mg, 0.60mmol, 1.2equiv.) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 75%.1H NMR(500MHz,CDCl3) δ 8.46 (dd, J=5.0, 0.5Hz,1H),7.60–7.47(m,1H),7.46–7.42(m,1H),7.37–7.34(m,1H),7.18–7.07(m,3H), 7.00–6.95(m,1H),4.57(s,2H)；13C NMR(125MHz,CDCl3)δ158.3,149.4,136.01,135.99, 134.3131.1,129.6,128.5,126.8,122.3,119.7,31.9。
Embodiment 6
2- bromopyridines, thiocarbamide and 1- naphthalene methanol prepare 2- pyridyl group 1- naphthalene methyl sulfides
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) and 1- naphthalenes methanol (94.8mg, 0.60mmol, 1.2equiv.)) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 74%.1H NMR(500MHz,CDCl3)δ8.50–8.39(m,1H), 8.06 (d, J=8.5Hz, 1H), 7.75 (d, J=7.5Hz, 1H), 7.66 (d, J=8.5Hz, 1H), 7.49 (d, J=7.0Hz, 1H), 7.44-7.23 (m, 4H), 7.03 (d, J=8.0Hz, 1H), 6.95-6.81 (m, 1H), 4.83 (s, 2H)；13C NMR (125MHz,CDCl3)δ159.1,149.5,136.0,134.0,133.3,131.8,128.8,128.3,127.6,126.3, 125.9,125.5,124.0,122.3,119.7,32.3。
Embodiment 7
2- bromopyridines, thiocarbamide and 2- thenyl alcohols prepare 2- pyridyl group 2- thiophene methyl sulfides
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (76.0mg, 1.0mmol, 2.0equiv.) directly sealed under air and then without molten with 2- thenyl alcohols (68.4mg, 0.60mmol, 1.2equiv.) 120 DEG C of reactions are heated under the conditions of agent for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 40%.1H NMR(500MHz,CDCl3) δ 8.48 (dd, J=5.0,0.5Hz, 1H), 7.56-7.39 (m, 1H), 7.22-7.11 (m, 2H), 7.07-6.96 (m, 2H), 6.89 (dd, J=5.0,3.5Hz, 1H), 4.65 (s, 2H)；13C NMR(125MHz, CDCl3)δ158.0,149.4,141.2,136.1,126.7,126.4,124.9,122.4,119.8,28.9。
Embodiment 8
2- bromopyridines, thiocarbamide and cinnamyl alcohol prepare 2- pyridyl group Chinese cassia tree thioethers
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) directly sealed under air and then in solvent-free item with cinnamyl alcohol (80.4mg, 0.60mmol, 1.2equiv.) 140 DEG C of reactions are heated under part for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 59%.1H NMR(500MHz,CDCl3) δ 8.47 (d, J=4.5Hz, 1H), 7.52-7.48 (m, 1H), 7.41-7.13 (m, 6H), 7.01 (dd, J=6.5,5.5Hz, 1H), 6.63 (d, J=15.5Hz, 1H), 6.34 (dt, J=15.5,7.5Hz, 1H), 4.04 (d, J =7.5Hz, 2H)；13C NMR(125MHz,CDCl3)δ158.4,149.1,136.8,136.4,132.9,128.5,127.6, 126.4,125.1,122.6,119.7,32.9。
Embodiment 9
2- bromopyridines, thiocarbamide and 1- octanols prepare the pungent thioethers of 2- pyridyl groups 1-
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) with 1- octanols (130.0mg, 1.0mmol, 2.0equiv.), directly seal under air and then in solvent-free item 140 DEG C of reactions are heated under part for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 46%.1H NMR(500MHz,CDCl3) δ 8.42 (d, J=4.0Hz, 1H), 7.45 (t, J=7.5Hz, 1H), 7.16 (d, J=8.0Hz, 1H), 7.04-6.77 (m, 1H), 3.15 (t, J=7.5Hz, 2H), 1.75-1.65 (m, 2H), 1.50-1.40 (m, 2H), 1.39- 1.19 (m, 8H), 0.88 (t, J=6.0Hz, 3H)；13C NMR(125MHz,CDCl3)δ159.6,149.4,135.8,122.1, 119.1,31.8,30.1,29.3,29.2,29.0,22.6,14.1。
Embodiment 10
2- bromopyridines, thiocarbamide and benzohydrol prepare 2- pyridyl group diphenylmethyl thioethers
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), benzohydrol (110.4mg, 0.60mmol, 1.2equiv.) and toluene (1.0mL), nitrogen protection sealing, It is then heated to 140 DEG C of reactions for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 60%.1H NMR(500MHz,CDCl3) δ 8.36 (d, J=4.5Hz, 1H), 7.46 (d, J=7.5Hz, 4H), 7.39-7.34 (m, 1H), 7.27 (t, J=7.5Hz, 4H), 7.19 (t, J=7.5Hz, 2H), 7.08 (d, J=8.0Hz, 1H), 6.98-6.83 (m, 1H), 6.33(s,1H)；13C NMR(125MHz,CDCl3)δ158.4,149.5,141.4,136.1,128.6,128.5,127.1, 122.3,119.8,52.7。
Embodiment 11
2- bromopyridines, thiocarbamide and 1- benzyl carbinols prepare 2- pyridyl group 1- ethyl phenyl sulfides
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) with 1- benzyl carbinols (73.2mg, 0.60mmol, 1.2equiv.), directly seal under air and then solvent-free Under the conditions of be heated to 120 DEG C reaction for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 48% 。1H NMR(500MHz,CDCl3) δ 8.37 (dd, J=5.0,1.0Hz, 1H), 7.46-7.30 (m, 3H), 7.22 (t, J= 7.5Hz, 2H), 7.19-7.12 (m, 1H), 7.03 (d, J=8.0Hz, 1H), 6.89 (ddd, J=7.5,5.0,1.0Hz, 1H), 5.05 (q, J=7.0Hz, 1H), 1.66 (d, J=7.0Hz, 3H)；13C NMR(125MHz,CDCl3)δ158.8,149.2, 143.2,136.3,128.5,127.4,127.2,123.0,119.8,43.8,22.7。
Embodiment 12
2- bromopyridines, thiocarbamide and the tert-butyl alcohol prepare the tertiary butyl sulfide of 2- pyridyl groups
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), tertiary butyl alcohol (74.0mg, 1.0mmol, 2.0equiv.) is directly sealed and then under air in solvent-free item 140 DEG C of reactions are heated under part for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 31%.1H NMR(500MHz,CDCl3) δ 8.52 (d, J=4.5Hz, 1H), 7.52 (t, J=8.0Hz, 1H), 7.34 (d, J=8.0Hz, 1H), 7.08 (t, J=6.0Hz, 1H), 1.51 (s, 9H)；13C NMR(125MHz,CDCl3)δ158.5,149.5,136.0, 127.5,120.8,47.6,31.1。
Embodiment 13
2- bromopyridines, thiocarbamide and 1- adamantanols prepare 2- pyridyl group 1- Buddha's warrior attendant thioethers
Sequentially add 2- bromopyridines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), 1- adamantanols (91.2mg, 0.60mmol, 1.2equiv.) and water (9.0mg, 0.50mmol, 1.0equiv.), it directly seals under air, be then heated to 140 DEG C of reactions for 24 hours.TLC monitorings are after the reaction was complete, product column Chromatographic purification, separation yield 39%.8.47 (d, J=4.0Hz, 1H), 7.47 (t, J=7.0Hz, 1H), 7.32 (d, J= 8.0Hz,1H),7.12–6.97(m,1H),2.00(s,6H),1.98(s,3H),1.62(s,6H)；13C NMR(125MHz, CDCl3)δ156.7,149.6,136.0,129.1,121.4,50.1,43.6,36.3,30.1。
Embodiment 14
2- chloro-3-fluoropyridines, thiocarbamide and benzyl alcohol prepare 2- (3- fluorine)-pyridyl group thioanisole
2- chloro-3-fluoropyridines (78.6mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 76%.1H NMR(500MHz,CDCl3) δ 8.19 (d, J=4.5Hz, 1H), 7.33 (d, J=7.5Hz, 2H), 7.25-7.14 (m, 2H), 7.20-7.08 (m, 2H), 6.91 (dt, J=8.5,4.5Hz, 1H),4.39(s,2H)；13C NMR(125MHz,CDCl3) δ 156.1 (d, J=255.9Hz), 147.4 (d, J=17.7Hz), 144.8 (d, J=5.1Hz), 137.7,129.1,128.5,127.2,121.1 (d, J=17.9Hz), 120.1 (d, J= 2.9Hz), 33.2 (d, J=2.1Hz).
Embodiment 15
2,3- dichloropyridines, thiocarbamide and benzyl alcohol prepare 2- (3- chlorine)-pyridyl group thioanisole
2,3- dichloropyridines (88.2mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 80%.1H NMR(500MHz,CDCl3) δ 8.35 (d, J=4.5, 1.0Hz, 1H), 7.51 (dd, J=8.0,1.0Hz, 1H), 7.42 (d, J=7.5Hz, 2H), 7.29 (t, J=7.5Hz, 2H), 7.23 (t, J=7.5Hz, 1H), 6.94 (dd, J=8.0,4.5Hz, 1H), 4.45 (s, 2H)；13C NMR(125MHz,CDCl3)δ 157.2,146.9,137.6,135.9,129.2,128.8,128.5,127.2,119.9,34.6。
Embodiment 16
The chloro- 4- picolines of 2-, thiocarbamide and benzyl alcohol prepare 2- (4- methyl)-pyridyl group thioanisole
The chloro- 4- picolines (76.2mg, 0.60mmol, 1.2equiv.) of 2-, thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.) and benzyl alcohol (54.0mg, 0.50mmol) directly seal and then under air in nothings 140 DEG C of reactions are heated under solvent condition for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 68%.1H NMR(500MHz,CDCl3) δ 8.23 (d, J=5.0Hz, 1H), 7.31 (d, J=7.5Hz, 2H), 7.20 (t, J= 7.5Hz, 2H), 7.16-7.10 (m, 1H), 6.90 (s, 1H), 6.72 (d, J=5.0Hz, 1H), 4.35 (s, 2H), 2.16 (s, 3H)；13C NMR(125MHz,CDCl3)δ158.6,149.1,147.2,138.1,129.0,128.5,127.1,123.3, 121.1,34.5,20.9。
Embodiment 17
The chloro- 4- cyanopyridines of 2-, thiocarbamide and benzyl alcohol prepare 2- (4- cyano)-pyridyl group thioanisole
The chloro- 4- cyanopyridines (82.8mg, 0.60mmol, 1.2equiv.) of 2-, thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 75%.1H NMR(500MHz,CDCl3) δ 8.49 (d, J=5.0Hz, 1H), 7.42-7.12 (m, 6H), 7.06 (d, J=5.0Hz, 1H), 4.35 (s, 2H)；13C NMR(125MHz,CDCl3)δ 161.2,150.2,137.1,129.0,128.7,127.5,123.7,120.33,120.27,116.3,34.5。
Embodiment 18
2- chloro-5-methoxyls pyridine, thiocarbamide and benzyl alcohol prepare 2- (5- methoxyl groups)-pyridyl group thioanisole
2- chloro-5-methoxyls pyridine (85.8mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.) and benzyl alcohol (54.0mg, 0.50mmol) directly seal and then under air in nothings 170 DEG C of reactions are heated under solvent condition for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 46%.1H NMR(500MHz,CDCl3)δ8.20(s,1H),7.40–7.32(m,2H),7.30–7.21(m,3H),7.16–6.98 (m,2H),4.36(s,2H),3.82(s,3H)；13C NMR(125MHz,CDCl3)δ153.7,149.2,138.2,136.6, 128.9,128.4,127.0,123.3,122.4,55.8,35.7。
Embodiment 19
2- chloro-5-nitropyridines, thiocarbamide and benzyl alcohol prepare 2- (5- nitros)-pyridyl group thioanisole
2- chloro-5-nitropyridines (94.8mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 85%.1H NMR(500MHz,CDCl3) δ 9.18 (d, J=2.0Hz, 1H), 8.13 (dd, J=9.0,2.5Hz, 1H), 7.33 (d, J=7.5Hz, 2H), 7.24 (t, J=7.5Hz, 2H), 7.22- 7.12(m,2H),4.43(s,2H)；13C NMR(125MHz,CDCl3)δ167.3,145.0,141.3,136.7,130.4, 129.0,128.7127.6121.3,34.8。
Embodiment 20
The chloro- 5- cyanopyridines of 2-, thiocarbamide and benzyl alcohol prepare 2- (5- cyano)-pyridyl group thioanisole
The chloro- 5- cyanopyridines (82.8mg, 0.60mmol, 1.2equiv.) of 2-, thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 72%.1H NMR(500MHz,CDCl3)δ8.68(s,1H),7.76– 7.60 (m, 1H), 7.39 (d, J=7.5Hz, 2H), 7.31 (t, J=7.5Hz, 2H), 7.26 (d, J=7.5Hz, 1H), 7.21 (d, J=8.5Hz, 1H), 4.46 (s, 2H)；13C NMR(125MHz,CDCl3)δ164.9,152.2,137.8,136.9, 129.0,128.7,127.5,121.6,117.1,104.9,34.4。
Embodiment 21
2,5- dichloropyridines, thiocarbamide and benzyl alcohol prepare 2- (5- chlorine)-pyridyl group thioanisole
2,5- dichloropyridines (88.2mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 72%.1H NMR(500MHz,CDCl3) δ 8.41 (d, J=2.5Hz, 1H), 7.42 (dd, J=8.5,2.5Hz, 1H), 7.38 (d, J=7.5Hz, 2H), 7.30 (d, J=7.0Hz, 1H), 7.24 (d, J =7.5Hz, 2H), 7.08 (d, J=8.5Hz, 1H), 4.40 (s, 2H)；13C NMR(125MHz,CDCl3)δ157.0,148.1, 137.7,135.9,129.0,128.6,128.0,127.3,122.7,34.7。
Embodiment 22
The chloro- 5- bromopyridines of 2-, thiocarbamide and benzyl alcohol prepare 2- (5- bromines)-pyridyl group thioanisole
The chloro- 5- bromopyridines (114.6mg, 0.60mmol, 1.2equiv.) of 2-, thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 73%.1H NMR(500MHz,CDCl3) δ 8.50 (dd, J=2.5, 0.5Hz, 1H), 7.55 (dd, JJ=8.5,2.5Hz, 1H), 7.48-7.33 (m, 2H), 7.34-7.27 (m, 2H), 7.27-7.20 (m, 1H), 7.04 (dd, JJ=8.5,0.5Hz, 1H), 4.39 (s, 2H)；13C NMR(125MHz,CDCl3)δ157.6,150.2, 138.5,137.7,129.0,128.5,127.2,123.2,116.2,34.6。
Embodiment 23
The chloro- 6- picolines of 2-, thiocarbamide and benzyl alcohol prepare 2- (6- methyl)-pyridyl group thioanisole
The chloro- 6- picolines (82.8mg, 0.60mmol, 1.2equiv.) of 2-, thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.) and benzyl alcohol (54.0mg, 0.50mmol) directly seal and then under air in nothings 170 DEG C of reactions are heated under solvent condition for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 38%.1H NMR(500MHz,CDCl3) δ 7.33 (d, JJ=7.5Hz, 2H), 7.25 (t, JJ=7.5Hz, 1H), 7.20 (t, JJ =7.5Hz, 2H), 7.16-7.11 (m, 1H), 6.86 (d, JJ=8.0Hz, 1H), 6.74 (d, JJ=7.5Hz, 1H), 4.34 (s, 2H),2.44(s,3H)；13C NMR(125MHz,CDCl3)δ158.4,157.7,138.4,136.3,129.0,128.4, 127.0,119.0,118.9,34.5,24.4。
Embodiment 24
4- iodine pyridines, thiocarbamide and benzyl alcohol prepare 4- pyridyl group thioanisoles
Sequentially add 4- bromopyridine hydrochlorides (96.5mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) and benzyl alcohol (64.8mg, 0.60mmol, 1.2equiv.) directly under air sealing then 140 DEG C of reactions are heated under condition of no solvent for 24 hours.After the reaction was complete, product is purified with pillar layer separation for TLC monitorings, and separation is received Rate 63%.1H NMR(500MHz,CDCl3) δ 8.36 (d, J=6.0Hz, 2H), 7.39 (d, J=7.5Hz, 2H), 7.32 (t, J= 7.5Hz, 2H), 7.28 (d, J=7.5Hz, 1H), 7.10 (d, J=6.0Hz, 2H), 4.19 (s, 1H)；13C NMR(125MHz, CDCl3)δ149.3,149.0,135.6,128.8,128.7,127.7,120.8,35.7。
Embodiment 25
2- chloroquinolines, thiocarbamide and benzyl alcohol prepare 2- quinolyl thioanisoles
Sequentially add 2- chloroquinolines (97.8mg, 0.60mmol, 1.2equiv.) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.5mmol, 1.0equiv.) are direct It seals under air, be then heated to 140 DEG C of reactions for 24 hours.After the reaction was complete, product is purified with pillar layer separation for TLC monitorings, point From yield 62%.1H NMR(500MHz,CDCl3) δ 7.98 (d, J=8.5Hz, 1H), 7.84 (d, J=8.5Hz, 1H), 7.72- 7.59 (m, 2H), 7.48 (d, J=7.5Hz, 2H), 7.43-7.39 (m, 1H), 7.28 (t, J=7.5Hz, 2H), 7.21 (t, J= 7.5Hz, 1H), 7.16 (d, J=8.5Hz, 1H), 4.61 (s, 2H)；13C NMR(125MHz,CDCl3)δ158.8,148.3, 138.4,135.5,129.7,129.2,128.5,128.1,127.7,127.1,126.1,125.3,120.8,34.0。
Embodiment 26
2- chloro benzothiazoles, thiocarbamide and benzyl alcohol prepare 2-[4-morpholinodithio base thioanisole
2- chloro benzothiazoles (101.4mg, 0.60mmol, 1.2equiv.), thiocarbamide are sequentially added in tubular reactor (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) directly seals under air and then be heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings have been reacted Quan Hou, product are purified with pillar layer separation, separation yield 75%.1H NMR(500MHz,CDCl3) δ 7.82 (d, J=8.0Hz, 1H), 7.65 (d, J=8.0Hz, 1H), 7.47-7.28 (m, 3H), 7.30-7.05 (m, 4H), 4.51 (s, 2H)；13C NMR (125MHz,CDCl3)δ166.5,153.2,136.2,135.4,129.2,128.7,127.8,126.1,124.3,121.6, 121.0,37.8。
Embodiment 27
2- chloropyrazines, thiocarbamide and benzyl alcohol prepare 2- pyrazinyl thioanisoles
Sequentially add 2- chloropyrazines (68.4mg, 0.60mmol, 1.2equiv.) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.) and benzyl alcohol (54.0mg, 0.50mmol) directly under air sealing then in condition of no solvent Under be heated to 140 DEG C reaction for 24 hours.TLC monitorings are after the reaction was complete, and product is purified with pillar layer separation, separation yield 62%.1H NMR(500MHz,CDCl3) δ 8.43 (s, 1H), 8.37 (s, 1H), 8.20 (d, J=2.5Hz, 1H), 7.39 (d, J=7.5Hz, 2H), 7.30 (t, J=7.5Hz, 2H), 7.24 (t, J=7.5Hz, 1H), 4.42 (s, 2H)；13C NMR(125MHz,CDCl3)δ 156.7,143.9,143.8,139.6,137.2,129.0,128.6,127.4,34.0。
Embodiment 28
2- Bromopyrimidines, thiocarbamide and benzyl alcohol prepare 2- pyrimidine radicals thioanisoles
Sequentially add 2- Bromopyrimidines (79.0mg, 0.50mmol) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (64.8mg, 0.60mmol, 1.2equiv) and water (9.0mg, 0.50mmol, 1.0equiv.) are direct It seals under air and then is heated to 140 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings are after the reaction was complete, product column Chromatographic purification, separation yield 52%.1H NMR(500MHz,CDCl3) δ 8.44 (d, J=5.0Hz, 2H), 7.36 (d, J= 7.5Hz, 2H), 7.22 (t, J=7.5Hz, 2H), 7.16 (t, J=7.5Hz, 1H), 6.88 (t, J=5.0Hz, 1H), 4.34 (s, 2H)；13C NMR(125MHz,CDCl3)δ172.2,157.3,137.5,129.1,128.5,127.2,116.6,35.3。
Embodiment 29
3- chlorine pyridazine, thiocarbamide and benzyl alcohol prepare 3- pyridazinyl thioanisoles
Sequentially add 3- chlorine pyridazine (68.4mg, 0.60mmol, 1.2equiv.) in tubular reactor, thiocarbamide (45.6mg, 0.60mmol, 1.2equiv.), benzyl alcohol (54.0mg, 0.50mmol) and water (9.0mg, 0.50mmol, 1.0equiv.) are direct It seals under air and then is heated to 100 DEG C of reactions under solvent-free conditions for 24 hours.TLC monitorings are after the reaction was complete, product column Chromatographic purification, separation yield 24%.1H NMR(500MHz,CDCl3) δ 8.94 (s, 1H), 7.44 (d, J=7.5Hz, 2H), 7.38–7.20(m,5H),4.60(s,2H)；13C NMR(125MHz,CDCl3)δ162.9,148.1,136.8,129.2, 128.6,127.5,126.4,125.9,34.5。

Claims (5)

1. a kind of synthetic method of asymmetric heteroaryl thioether, it is characterised in that：
Heteroaryl halides, aminothio amide compound and alcohol are directly heated under the conditions of without any extra catalyst and can be reacted Asymmetric heteroaryl sulfide compound is obtained, reaction temperature is 100~180 DEG C, and the reaction time is 6~60 hours, and reaction equation is：
X=Cl, Br, I
It is describedFor thiocarbamide, R2- OH be benzyl alcohol, 4- methoxy benzyl alcohols, 2- methylbenzyl alcohols, 2- chlorobenzene methanols, 1- naphthalenes methanol, 2- thenyl alcohols, cinnamyl alcohol, 1- octanols, benzohydrol, 1- benzyl carbinols, the tert-butyl alcohol or 1- adamantanols；
The heteroaryl halides be 2- bromopyridines, 2- chloro-3-fluoropyridines, 2,3- dichloropyridines, the chloro- 4- picolines of 2-, The chloro- 4- cyanopyridines of 2-, 2- chloro-5-methoxyls pyridine, 2- chloro-5-nitropyridines, the chloro- 5- cyanopyridines of 2-, 2,5- dichloro pyrroles Pyridine, the chloro- 5- bromopyridines of 2-, the chloro- 6- picolines of 2-, 4- iodine pyridines, 2- chloroquinolines, 2- chloro benzothiazoles, 2- chloropyrazines, 2- bromines Pyrimidine or 3- chlorine pyridazines.
2. a kind of synthetic method of asymmetric heteroaryl thioether according to claim 1, it is characterised in that：The reaction It is carried out in the case where having solvent or condition of no solvent.
3. a kind of synthetic method of asymmetric heteroaryl thioether according to claim 1, it is characterised in that：The reaction It carries out under inert gas protection or under air.
4. a kind of synthetic method of asymmetric heteroaryl thioether according to claim 1, it is characterised in that：The reaction temperature Degree is 120~160 DEG C, and the reaction time is 12~48 hours.
5. a kind of synthetic method of asymmetric heteroaryl thioether according to claim 1, it is characterised in that：The reaction nothing Need any extra catalyst, auxiliary agent or additive.
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US20080039625A1 (en) * 2004-11-05 2008-02-14 Mark Lautens Screening Methods
EP2272846A1 (en) * 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidine derivatives as fungicide
JP5844456B2 (en) * 2011-05-20 2016-01-20 グラクソスミスクライン、インテレクチュアル、プロパティー、ナンバー２、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｎｏ．２ Ｌｉｍｉｔｅｄ Novel compounds as diacylglycerol acyltransferase inhibitors
CN103087050A (en) * 2011-10-28 2013-05-08 山东轩竹医药科技有限公司 Aryl kinase inhibitor
ES2410704B1 (en) * 2011-11-28 2014-04-29 Universitat De Barcelona FLUORATED INDOLENINS USEFUL FOR THE TREATMENT OF CANCER.
LT3013337T (en) * 2013-06-26 2019-01-10 Abbvie Inc. Primary carboxamides as btk inhibitors
WO2016068099A1 (en) * 2014-10-28 2016-05-06 塩野義製薬株式会社 Heterocyclic derivative having ampk activating effect
CN105523986A (en) * 2015-12-30 2016-04-27 江汉大学 Synthetic method of efflux pump inhibitor N-hydrogen-2-arylindol and derivatives thereof

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