CN106075593A - A kind of preparation method of wear-resisting artificial joint coating material - Google Patents

A kind of preparation method of wear-resisting artificial joint coating material Download PDF

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CN106075593A
CN106075593A CN201610447919.4A CN201610447919A CN106075593A CN 106075593 A CN106075593 A CN 106075593A CN 201610447919 A CN201610447919 A CN 201610447919A CN 106075593 A CN106075593 A CN 106075593A
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artificial joint
wear
solution
coating material
preparation
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林春梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/24—Materials or treatment for tissue regeneration for joint reconstruction

Abstract

The invention discloses the preparation method of a kind of wear-resisting artificial joint coating material, concretely comprise the following steps: 1) artificial joint matrix is polished, clean the artificial joint matrix obtained through polishing；2) hemoglobin, myogen, xylan, allantoin are added to the water, add sodium alginate, regulate pH, stir to obtain solution A；3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added to the water, stir to obtain solution B；4) the artificial joint matrix through polishing is immersed in solution A as anode, electro-deposition；5) being transferred to solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, peace and quiet and get final product.Artificial joint coating material prepared by the present invention, wearability is good, good biocompatibility, infection and the bond strength height with matrix, contributes to it and effectively implants use, can meet tightened up application demand, have a extensive future.

Description

A kind of preparation method of wear-resisting artificial joint coating material
Technical field
The invention belongs to medical material tech field, be specifically related to the preparation side of a kind of wear-resisting artificial joint coating material Method.
Background technology
Along with the increase of the joint damage that aggravation and the various damages of aged tendency of population cause, often lead on articulation structure Changing, simple use Drug therapy cannot improve function of joint, and its effective solution is by artificial joint operation, So can obvious orthotic joint deformity, recover joint normal function, or can also be performed the operation by prosthetic replacement, according to system Meter, the whole world there are about more than 100 ten thousand person-times every year and accepts artificial joint replacement surgery, and in the trend increased year by year.
Metal, pottery and macromolecular material are three big medical artificial joint materials now, and three-type-person's work joint material is respectively arranged with Its pluses and minuses: metal and pottery are widely used at negative load medical field, but metal is easy to wear and corrosion, and Pottery then fragility is big, and both are also high to requirement on machining accuracy simultaneously, and cost is high；Though macromolecular material cost performance ratio and pliability Good, but biocompatibility, wearability；Antibiotic property and hardness are poor.For the artificial joint material that metal material is made, people After internal long service, the abrasive dust produced because of friction can produce some adverse effects to the tissue of implant site, such as induction office Portion's tissue inflammation, intoxicating, carcinogenic or teratogenesis, shorten the service life of artificial joint material.In order to solve this problem, can be to manually Joint material surface is coated biocompatible coating, improves wearability and the biocompatibility of artificial joint material.But Along with the demand of artificial joint gets more and more, the properties to artificial joint, such as biocompatibility, intensity, antibiotic property, boundary Face adhesion, corrosion resistance are had higher requirement.Therefore it provides the wear-resisting artificial joint coating of a kind of performance Optimal improvements Material is significant.
Summary of the invention
At least one of present invention prior art problem to be solved, it is provided that the system of a kind of wear-resisting artificial joint coating material Preparation Method.
In order to solve above-mentioned technical problem, the present invention is achieved by the following technical solutions:
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 3.5-5, stirs 12-24 hour, stands 24 hours, obtains solution A；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, Stirring and dissolving at 30-50 DEG C, and it is stirred continuously 25-80min, it is cooled to be that room temperature obtains solution B；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, at 15-60V constant potential voltage Lower deposition 10-80min, is then turned off power supply, and keeps 2-5 hour at solution system temperature is 37 DEG C ± 1 DEG C, take out, and Clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7-8, and Keep 5-10 hour under the conditions of 37 DEG C ± 1 DEG C, take out and clean up, obtain wear-resisting artificial joint coating material.
Preferably, described calcium salt is calcium chloride, calcium hydroxide, calcium nitrate, calcium oxalate, calcium nitrate tetrahydrate, two hydration chlorine Change at least two in calcium.
Preferably, during described microcosmic salt is sodium phosphate, sodium polyphosphate, sodium pyrophosphate, Diammonium phosphate (DAP), disodium hydrogen phosphate extremely Few two kinds.
Preferably, hemoglobin, myogen, xylan, allantoin, sodium alginate and deionized water in described solution A The amount of material is than being (0.5-1.5): (0.3-2): 1.2:3.5:2:(50-80).
Preferably, calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine in described solution B It is (3-6) with the amount ratio of the material of deionized water: (2-5): 2:1:1.5:0.4:1.2:(80-100).
Preferably, step 2) described in regulate pH value of solution be 4.2, stir 15 hours.
Preferably, described in step 3) at 45 DEG C stirring and dissolving, and be stirred continuously 30min.
Preferably, under 36V constant potential voltage, 25min is deposited described in step 4).
Preferably, described artificial joint matrix is artificial knee joint or the artificial hip joint or artificial of metal or alloy material Shoulder joint.
Owing to have employed above technical scheme, the invention have the benefit that
Wear-resisting artificial joint coating material prepared by the present invention, wearability is good, good biocompatibility, infection and the knot with matrix Conjunction intensity is high, contributes to it and effectively implants use, can meet tightened up application demand；The preparation method of the present invention is reasonable simultaneously Feasible, can industrialized production, have a extensive future.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail.Following example are used for the present invention is described, But it is not limited to the scope of the present invention.
Embodiment 1
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；Described artificial joint matrix is the people of metal or alloy material Work knee joint or artificial hip joint or artificial shoulder joint；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 3.5, stirs 12 hours, stands 24 hours, obtain solution A；Hemoglobin, myogen, wood in described solution A The amount of the material of polysaccharide, allantoin, sodium alginate and deionized water is than for 0.5:0.3:1.2:3.5:2:50；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, 30 Stirring and dissolving at DEG C, and it is stirred continuously 25min, it is cooled to be that room temperature obtains solution B；
Described calcium salt be mass ratio be the mixture of the calcium chloride of 3:5:1, calcium hydroxide, calcium nitrate；
Described microcosmic salt be mass ratio be the mixture of the sodium phosphate of 3:5:1, sodium polyphosphate, sodium pyrophosphate；
Calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in described solution B The amount of material is than for 3:2:2:1:1.5:0.4:1.2:80；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, sink at 15V constant potential voltage Long-pending 80min, is then turned off power supply, and keeps 2 hours at solution system temperature is 37 DEG C ± 1 DEG C, take out, and clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7, and 37 DEG C ± 1 DEG C under the conditions of keep 5 hours, take out and clean up, obtain wear-resisting artificial joint coating material.
The wearability of wear-resisting artificial joint coating material prepared by the present embodiment is good, by the friction-wear test of the industry Record its wear rate less than 10-11.Additionally, osteocyte is planted the present embodiment containing wear-resisting artificial joint coating material matrix On, after cell is cultivated 5 days, to observe osteocyte and grow in the surface attachment of matrix material, adhesiveness is good, shows this wear-resisting manually The biocompatibility that joint coating material is good.Recording the bond strength between coating and matrix material by scarification is 45.6N, also shows preferable bond strength high, contributes to it and effectively implant use.
Embodiment 2
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；Described artificial joint matrix is the people of metal or alloy material Work knee joint or artificial hip joint or artificial shoulder joint；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 3.5-5, stirs 12-24 hour, stands 24 hours, obtains solution A；Hemoglobin, flesh egg in described solution A In vain, the amount of the material of xylan, allantoin, sodium alginate and deionized water is than for 1:1.1:1.2:3.5:2:65；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, 40 Stirring and dissolving at DEG C, and it is stirred continuously 52min, it is cooled to be that room temperature obtains solution B；
Described calcium salt be mass ratio be the mixture of the calcium chloride of 3:1:1:2, calcium nitrate, calcium oxalate, CALCIUM CHLORIDE DIHYDRATE；
Described microcosmic salt be mass ratio be the mixing of the sodium polyphosphate of 2:5:2:1, sodium pyrophosphate, Diammonium phosphate (DAP), disodium hydrogen phosphate Thing；
Calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in described solution B The amount of material is than for 4.5:3.5:2:1:1.5:0.4:1.2:90；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, sink at 38V constant potential voltage Long-pending 45min, is then turned off power supply, and keeps 3.5 hours at solution system temperature is 37 DEG C ± 1 DEG C, take out, and cleans dry Only；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7.5, and Keep 7.5 hours under the conditions of 37 DEG C ± 1 DEG C, take out and clean up, obtain wear-resisting artificial joint coating material.
The wearability of wear-resisting artificial joint coating material prepared by the present embodiment is good, by the friction-wear test of the industry Record its wear rate less than 10-11.Additionally, osteocyte is planted the present embodiment containing wear-resisting artificial joint coating material matrix On, after cell is cultivated 5 days, to observe osteocyte and grow in the surface attachment of matrix material, adhesiveness is good, shows this wear-resisting manually The biocompatibility that joint coating material is good.Recording the bond strength between coating and matrix material by scarification is 48.2N, also shows preferable bond strength high, contributes to it and effectively implant use.
Embodiment 3
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；Described artificial joint matrix is the people of metal or alloy material Work knee joint or artificial hip joint or artificial shoulder joint；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 5, stirs 24 hours, stands 24 hours, obtain solution A；In described solution A, hemoglobin, myogen, wood gather The amount of the material of sugar, allantoin, sodium alginate and deionized water is than for 1.5:2:1.2:3.5:2:80；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, 50 Stirring and dissolving at DEG C, and it is stirred continuously 80min, it is cooled to be that room temperature obtains solution B；
Described calcium salt be mass ratio be the mixture of the calcium nitrate of 2:2:1, calcium oxalate, calcium nitrate tetrahydrate, CALCIUM CHLORIDE DIHYDRATE；
Described microcosmic salt be mass ratio be the mixture of the sodium pyrophosphate of 4:1:2, Diammonium phosphate (DAP), disodium hydrogen phosphate；
Calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in described solution B The amount of material is than for 6:5:2:1:1.5:0.4:1.2:100；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, sink at 15 constant potential voltages Long-pending 10min, is then turned off power supply, and keeps 5 hours at solution system temperature is 37 DEG C ± 1 DEG C, take out, and clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 8, and 37 DEG C ± 1 DEG C under the conditions of keep 10 hours, take out and clean up, obtain wear-resisting artificial joint coating material.
The wearability of wear-resisting artificial joint coating material prepared by the present embodiment is good, by the friction-wear test of the industry Record its wear rate less than 10-11.Additionally, osteocyte is planted the present embodiment containing wear-resisting artificial joint coating material matrix On, after cell is cultivated 5 days, to observe osteocyte and grow in the surface attachment of matrix material, adhesiveness is good, shows this wear-resisting manually The biocompatibility that joint coating material is good.Recording the bond strength between coating and matrix material by scarification is 50.4N, also shows preferable bond strength high, contributes to it and effectively implant use.
Embodiment 4
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；Described artificial joint matrix is the people of metal or alloy material Work knee joint or artificial hip joint or artificial shoulder joint；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 4.2, stirs 15 hours, stands 24 hours, obtain solution A；Hemoglobin, myogen, wood in described solution A The amount of the material of polysaccharide, allantoin, sodium alginate and deionized water is than for 1.2:0.8:1.2:3.5:2:75；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, 45 Stirring and dissolving at DEG C, and it is stirred continuously 30min, it is cooled to be that room temperature obtains solution B；
Described calcium salt be mass ratio be the mixture of the calcium hydroxide of 4:1:2:1, calcium nitrate, calcium oxalate, calcium nitrate tetrahydrate；
Described microcosmic salt be mass ratio be the mixture in the sodium phosphate of 3:2:1:4, sodium pyrophosphate, Diammonium phosphate (DAP), disodium hydrogen phosphate；
Calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in described solution B The amount of material is than for 4.8:3.6:2:1:1.5:0.4:1.2:96；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, sink at 36V constant potential voltage Long-pending 25min, is then turned off power supply, and keeps 4 hours at solution system temperature is 37 DEG C ± 1 DEG C, take out, and clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7.6, and Keep 8 hours under the conditions of 37 DEG C ± 1 DEG C, take out and clean up, obtain wear-resisting artificial joint coating material.
The wearability of wear-resisting artificial joint coating material prepared by the present embodiment is good, by the friction-wear test of the industry Record its wear rate less than 10-11.Additionally, osteocyte is planted the present embodiment containing wear-resisting artificial joint coating material matrix On, after cell is cultivated 5 days, to observe osteocyte and grow in the surface attachment of matrix material, adhesiveness is good, shows this wear-resisting manually The biocompatibility that joint coating material is good.Recording the bond strength between coating and matrix material by scarification is 54.5N, also shows preferable bond strength high, contributes to it and effectively implant use.
Embodiment 5
The preparation method of a kind of wear-resisting artificial joint coating material, concretely comprises the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；Described artificial joint matrix is the people of metal or alloy material Work knee joint or artificial hip joint or artificial shoulder joint；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 4.5, stirs 18 hours, stands 24 hours, obtain solution A；Hemoglobin, myogen, wood in described solution A The amount of the material of polysaccharide, allantoin, sodium alginate and deionized water is than for 0.8:1.7:1.2:3.5:2:72；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, 48 Stirring and dissolving at DEG C, and it is stirred continuously 60min, it is cooled to be that room temperature obtains solution B；
Described calcium salt be mass ratio be in the calcium hydroxide of 3:2:1:1, calcium nitrate, calcium nitrate tetrahydrate, CALCIUM CHLORIDE DIHYDRATE Mixture；
Described microcosmic salt be mass ratio be the mixture of the sodium phosphate of 1:3:4:2, sodium polyphosphate, Diammonium phosphate (DAP), disodium hydrogen phosphate；
Calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in described solution B The amount of material is than for 5:4:2:1:1.5:0.4:1.2:85；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, sink at 45V constant potential voltage Long-pending 75min, is then turned off power supply, and keeps 4 hours at solution system temperature is 37 DEG C ± 1 DEG C, take out, and clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7.4, and Keep 7 hours under the conditions of 37 DEG C ± 1 DEG C, take out and clean up, obtain wear-resisting artificial joint coating material.
The wearability of wear-resisting artificial joint coating material prepared by the present embodiment is good, by the friction-wear test of the industry Record its wear rate less than 10-11.Additionally, osteocyte is planted the present embodiment containing wear-resisting artificial joint coating material matrix On, after cell is cultivated 5 days, to observe osteocyte and grow in the surface attachment of matrix material, adhesiveness is good, shows this wear-resisting manually The biocompatibility that joint coating material is good.Recording the bond strength between coating and matrix material by scarification is 52.1N, also shows preferable bond strength high, contributes to it and effectively implant use.

Claims (9)

1. the preparation method of a wear-resisting artificial joint coating material, it is characterised in that concretely comprise the following steps:
1) artificial joint matrix is polished with 1000 mesh abrasive paper for metallograph, bruting process is constantly added the alumina powder of 500 mesh End；Then it is respectively placed in acetone, 20wt% dilute nitric acid solution and deionized water and replaces ultrasonic cleaning 5 times successively, and the most ultrasonic Scavenging period is 10min, obtains the artificial joint matrix through polishing；
2) hemoglobin, myogen, xylan, allantoin are added in deionized water, stirring and dissolving, add sodium alginate, Regulation pH value of solution is 3.5-5, stirs 12-24 hour, stands 24 hours, obtains solution A；
3) calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine are added in deionized water, Stirring and dissolving at 30-50 DEG C, and it is stirred continuously 25-80min, it is cooled to be that room temperature obtains solution B；
4) the artificial joint matrix through polishing obtained above is immersed in solution A as anode, at 15-60V constant potential voltage Lower deposition 10-80min, is then turned off power supply, and keeps 2-5 hour at solution system temperature is 37 DEG C ± 1 DEG C, take out, and Clean up；
5) being transferred to after cleaning up in solution B, ultrasonic disperse limit, limit is added dropwise over ammonia, and the pH of regulation system is 7-8, and Keep 5-10 hour under the conditions of 37 DEG C ± 1 DEG C, take out and clean up, obtain wear-resisting artificial joint coating material.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that described calcium salt is At least two in calcium chloride, calcium hydroxide, calcium nitrate, calcium oxalate, calcium nitrate tetrahydrate, CALCIUM CHLORIDE DIHYDRATE.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that described microcosmic salt is At least two in sodium phosphate, sodium polyphosphate, sodium pyrophosphate, Diammonium phosphate (DAP), disodium hydrogen phosphate.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that described solution A The amount of the material of middle hemoglobin, myogen, xylan, allantoin, sodium alginate and deionized water is than being (0.5-1.5): (0.3-2):1.2:3.5:2:(50-80)。
5. according to the preparation method of the wear-resisting artificial joint coating material described in claim 1 or 2 or 3, it is characterised in that described The amount of the material of calcium salt, microcosmic salt, strontium carbonate, Sodium Citrate, usp, Dihydrate Powder, cerous nitrate, Disilver carbonate, lysine and deionized water in solution B Than being (3-6): (2-5): 2:1:1.5:0.4:1.2:(80-100).
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that step 2) in institute Stating regulation pH value of solution is 4.2, stirs 15 hours.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that institute in step 3) State stirring and dissolving at 45 DEG C, and be stirred continuously 30min.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that institute in step 4) State deposition 25min under 36V constant potential voltage.
The preparation method of wear-resisting artificial joint coating material the most according to claim 1, it is characterised in that described artificial pass Save artificial knee joint or artificial hip joint or artificial shoulder joint that matrix is metal or alloy material.
CN201610447919.4A 2016-06-21 2016-06-21 A kind of preparation method of wear-resisting artificial joint coating material Pending CN106075593A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824290A (en) * 2005-12-23 2006-08-30 上海大学 Therapeutic compound joint synovia and its preparation method
CN101862269A (en) * 2010-05-17 2010-10-20 杭州伟智生物医药科技有限公司 Preparation of nano-coating micropore surface implant having regeneration activity and antibacterial property

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1824290A (en) * 2005-12-23 2006-08-30 上海大学 Therapeutic compound joint synovia and its preparation method
CN101862269A (en) * 2010-05-17 2010-10-20 杭州伟智生物医药科技有限公司 Preparation of nano-coating micropore surface implant having regeneration activity and antibacterial property

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Application publication date: 20161109