CN106075441A - A kind of preparation method of core hat nanostructure particle - Google Patents
A kind of preparation method of core hat nanostructure particle Download PDFInfo
- Publication number
- CN106075441A CN106075441A CN201610458370.9A CN201610458370A CN106075441A CN 106075441 A CN106075441 A CN 106075441A CN 201610458370 A CN201610458370 A CN 201610458370A CN 106075441 A CN106075441 A CN 106075441A
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- China
- Prior art keywords
- preparation
- core
- hat
- particle
- nanoparticle
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
Abstract
The invention discloses the preparation method of a kind of core hat nanostructure particle, belong to bio-nanotechnology field, concrete technical scheme is: nanoparticle is arranged in template subband structures film, by the method for physical deposition fast deposition layer of precious metal on this subband structures film, by ultrasonic vibration, particle is separated from template again, form single dispersing core hat nanostructure particle.Core hat nanostructure particle prepared by this method, not only has surface plasma resonance effect, and its wavelength can manually adjust by controlling the time acquisition of deposition of metal, solves the technical problem that wavelength tuning range is little；Preparation method is easy, efficiency is high；The particle of this core cap nanostructured can make medicine and focus molecule directly in conjunction with and heat, big with the specific surface area of focal contact, solve the technical problem of drug release difficulty.
Description
Technical field
The invention belongs to bio-nanotechnology field, relate to Nano medication or the nano junction of probe biomolecule label
Structure, is related specifically to the preparation method of a kind of core hat nanostructure particle.
Background technology
Core shell nanostructure particle gets most of the attention in life science in recent years, especially has noble metal nano shell
The particle on shape surface shows the application prospect of broadness especially in Nano medication with biomolecule image.Due to gold, silver, platinum etc.
Precious metal material has the surface plasma resonance effect of uniqueness in nanoscale scope, shows as at visible ray-near-infrared ripple
Section shows strong absorbent properties, and this character can absorb luminous energy and heat its medicine wrapped up, and the most also may be used
To carry out imaging, therefore in image technology, there is important using value at nanometer medicine.Existing noble metal hull shape nanometer
The nanostructured of capsule is the outside chemically grown last layer metal parcel shell at Nano capsule.In order to obtain uniform shell
Layer, the thickness of this shell is the biggest, and this not only limit the release of medicine and makes the peak absorbance of near infrared band
Acquisition becomes difficulty.Therefore, even structure, preparation is easy, be prone to the grain that medicine carries out heating Yu discharging near infrared band
Minor structure gets more and more people's extensive concerning with preparation method.
Summary of the invention
The invention provides the preparation method of a kind of core hat nanostructure particle, nanoparticle is arranged in by template
Subband structures film, by the method for physical deposition fast deposition layer of precious metal on this subband structures film, then by ultrasonic vibration by grain
Son separates from template, forms single dispersing core hat nanostructure particle.
The concrete technical scheme of the present invention comprises the following steps:
Step 1: nanoparticle is arranged in template subband structures film；
Step 2: plate thickness on the subband structures film that step 1 is formed less than nano particle diameter by physical deposition method
Layer of precious metal, in template formed core hat nanostructure particle；
Step 3: the core hat nanostructure particle in step 2 is separated from template by ultrasonic vibration method,
Form single dispersing core hat nanostructure particle.
Wherein, described nano particle diameter is more than 2 nanometers.Physical deposition method described in step 2 is evaporation or sputtering
Method.The material of described layer of precious metal is the noble metal with surface plasmon resonance effect.Described layer of precious metal be monolayer or
Multilamellar.
The invention has the beneficial effects as follows: core hat nanostructure particle prepared by this method, not only there is surface plasma
Resonance effect, and its wavelength can manually adjust by controlling the time acquisition of deposition of metal, solves wavelength and adjusts model
Enclose little technical problem；Preparation method is easy, efficiency is high；The particle of this core cap nanostructured can make medicine direct with focus molecule
In conjunction with and heat, big with the specific surface area of focal contact, solve the technical problem of drug release difficulty.
Accompanying drawing explanation
Accompanying drawing 1 is the preparation method schematic diagram of core hat nanostructure particle.
In figure: 1 particle is arranged as subband structures membrane structure in template；
2 on subband structures film physical deposition layer of precious metal；
3 core hat nanostructure particles are formed in template；
Particle is departed from from template by 4 by ultrasonic vibration；
5 single dispersing core hat nanostructure particles.
Detailed description of the invention
1 pair of preferred embodiment elaborates below in conjunction with the accompanying drawings.
Embodiment
A kind of preparation method of core hat nanostructure particle, the method comprises the following steps:
Step 1: nanoparticle is arranged in template subband structures film.
Step 2: plate thickness on the subband structures film that step 1 is formed less than nano particle diameter by physical deposition method
Layer of precious metal, in template formed core hat nanostructure particle.
Step 3: the core hat nanostructure particle in step 2 is separated from template by ultrasonic vibration method,
Form single dispersing core hat nanostructure particle.
Wherein, the material of described nanoparticle does not limits, structure does not limits, and particle diameter is more than 2 nanometers.Physics described in step 2
Deposition process is evaporation.The material of described layer of precious metal is the Precious Metals-Gold with surface plasmon resonance effect.Described expensive
Metal level is monolayer.
Claims (8)
1. the preparation method of a core hat nanostructure particle, it is characterised in that comprise the following steps:
Step 1: nanoparticle is arranged in template subband structures film；
Step 2: plate thickness on the subband structures film that step 1 is formed by physical deposition method and be less than the expensive of nano particle diameter
Metal level, forms core hat nanostructure particle in template；
Step 3: separated from template by the core hat nanostructure particle in step 2 by ultrasonic vibration method, is formed
Single dispersing core hat nanostructure particle.
The preparation method of a kind of core hat nanoparticle the most according to claim 1, it is characterised in that described physical deposition
Method is evaporation or sputtering method.
The preparation method of a kind of core hat nanoparticle the most according to claim 1 and 2, it is characterised in that described nanometer
Particle diameter is more than 2 nanometers.
The preparation method of a kind of core hat nanoparticle the most according to claim 1 and 2, it is characterised in that your gold described
The material belonging to layer is the noble metal with surface plasmon resonance effect.
The preparation method of a kind of core hat nanoparticle the most according to claim 3, it is characterised in that described layer of precious metal
Material be the noble metal with surface plasmon resonance effect.
6. according to the preparation method of a kind of core hat nanoparticle described in claim 1 or 2 or 5, it is characterised in that described expensive
Metal level is single or multiple lift.
The preparation method of a kind of core hat nanoparticle the most according to claim 3, it is characterised in that described layer of precious metal
For single or multiple lift.
The preparation method of a kind of core hat nanoparticle the most according to claim 4, it is characterised in that described layer of precious metal
For single or multiple lift.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610458370.9A CN106075441A (en) | 2016-06-23 | 2016-06-23 | A kind of preparation method of core hat nanostructure particle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610458370.9A CN106075441A (en) | 2016-06-23 | 2016-06-23 | A kind of preparation method of core hat nanostructure particle |
Publications (1)
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| CN106075441A true CN106075441A (en) | 2016-11-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610458370.9A Pending CN106075441A (en) | 2016-06-23 | 2016-06-23 | A kind of preparation method of core hat nanostructure particle |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101100000A (en) * | 2007-06-05 | 2008-01-09 | 暨南大学 | Core-shell structure composite nanometer material and preparation method thereof |
| CN101161378A (en) * | 2007-11-23 | 2008-04-16 | 暨南大学 | Silicon dioxide monocaryon bismuth-silver double cap shaped complex nanometer particle and its preparing method |
| CN103213938A (en) * | 2013-04-16 | 2013-07-24 | 上海大学 | Surface-enhanced Raman active substrate with gold nano cap array and preparation method thereof |
| CN105084307A (en) * | 2015-07-15 | 2015-11-25 | 西安交通大学 | Preparation method of metal nanostructure with adjustable resonance peak positions |
-
2016
- 2016-06-23 CN CN201610458370.9A patent/CN106075441A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101100000A (en) * | 2007-06-05 | 2008-01-09 | 暨南大学 | Core-shell structure composite nanometer material and preparation method thereof |
| CN101161378A (en) * | 2007-11-23 | 2008-04-16 | 暨南大学 | Silicon dioxide monocaryon bismuth-silver double cap shaped complex nanometer particle and its preparing method |
| CN103213938A (en) * | 2013-04-16 | 2013-07-24 | 上海大学 | Surface-enhanced Raman active substrate with gold nano cap array and preparation method thereof |
| CN105084307A (en) * | 2015-07-15 | 2015-11-25 | 西安交通大学 | Preparation method of metal nanostructure with adjustable resonance peak positions |
Non-Patent Citations (11)
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Application publication date: 20161109 |
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