CN106074358A - A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof - Google Patents

A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof Download PDF

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CN106074358A
CN106074358A CN201610471348.8A CN201610471348A CN106074358A CN 106074358 A CN106074358 A CN 106074358A CN 201610471348 A CN201610471348 A CN 201610471348A CN 106074358 A CN106074358 A CN 106074358A
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林春梅
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof.It is made up of following steps: decanedioic acid and ethylene glycol are mixed by (1), high-speed stirred reaction at temperature 160 170 DEG C；(2) temperature is cooled to 120 125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol stirring reaction；(3) temperature is risen to 180 185 DEG C and continues reaction；(4) cooling the temperature to 160 165 DEG C, dropping trimethylolpropane allyl ether reacts 60 70 minutes；(5) temperature is risen to 180 185 DEG C and continues reaction；(6) polylactic acid, lauryl methacrylate and ethyl acetate stirring are added；(7) adding lauroyl peroxide, N, N methylene-bisacrylamide, sodium peroxydisulfate and ascorbic acid at room temperature carry out solidifying and get final product.The Thermosensitive Material Used for Controlled Releasing of Medicine of the present invention has higher water absorption rate, and hydrophilic is good, and degradation rate is very fast simultaneously.

Description

A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof
Technical field
The present invention relates to medical material field, be specifically related to a kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof.
Background technology
Drug controlled release usually utilizes polymers as carrier or the medium of medicine, makes certain dosage form, control Pharmacy thing rate of release in human body, make medicine according to design dosage, by certain speed in the time range required The most slowly discharge, to reach the purpose effectively treated.Preferably controlled drug delivery system can give full play to drug effect, makes blood The valid density of liquid Chinese medicine keeps constant, improves stability and the effective rate of utilization of medicine, reduces times for spraying, make medicine have There is Targeting delivery function, alleviate patient suffering, farthest reduce the medicine toxic and side effects to health, reach optimal treatment Effect.And the realization of drug delivery system function relies on the huge progress of synthetic macromolecular material, novel degradable with The slow-release material that absorbs the drug is biodegradable, will not be detained in vivo, medicine can be protected not to be biodegradable, table Reveal the great potential as pharmaceutical carrier, the most all have in clinical practice or medicine and pharmacology and be of great significance.
Summary of the invention
Solve the technical problem that: it is an object of the invention to provide a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, there is higher water absorption rate, Hydrophilic is good, and degradation rate is very fast simultaneously.
Technical scheme: a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 10-15 part, the last of the ten Heavenly stems Diacid 2-5 part, fumaric acid 12-15 part, trimethylolpropane allyl ether 5-8 part, lauroyl peroxide 1-3 part, N, N-Asia Bisacrylamide 2-4 part, Polyethylene Glycol 3-6 part, phosphoamide 2-4 part, sodium peroxydisulfate 1-3 part, ascorbic acid 2-4 part, first Base lauryl acrylate 2-5 part, ethylene glycol 10-20 part, diethylene glycol 1-2 part, ethyl acetate 5-10 part.
It is further preferred that described a kind of Thermosensitive Material Used for Controlled Releasing of Medicine, following component it is prepared from weight portion: polylactic acid 11-14 part, decanedioic acid 3-4 part, fumaric acid 13-14 part, trimethylolpropane allyl ether 6-7 part, lauroyl peroxide 1.5-2.5 part, N,N methylene bis acrylamide 2.5-3.5 part, Polyethylene Glycol 4-5 part, phosphoamide 2.5-3.5 part, persulfuric acid Sodium 1.5-2.5 part, ascorbic acid 2.5-3.5 part, lauryl methacrylate 3-4 part, ethylene glycol 12-18 part, diethylene glycol 1.1- 1.7 parts, ethyl acetate 6-9 part.
The preparation method of said medicine slow-release material comprises the following steps:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 160-170 DEG C, high-speed stirred is reacted 60-80 minute；
(2) temperature is cooled to 120-125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 60- 80 minutes；
(3) temperature is risen to 180-185 DEG C, continue reaction 40-60 minute；
(4) cooling the temperature to 160-165 DEG C, dropping trimethylolpropane allyl ether reacts 60-70 minute；
(5) temperature is risen to 180-185 DEG C, continue reaction 30-50 minute；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 20-40 minute；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
It is further preferred that temperature is 165 DEG C in step (1), mixing time is 65-75 minute.
It is further preferred that temperature is 121-124 DEG C in step (2), mixing time is 65-75 minute.
It is further preferred that temperature is 181-184 DEG C in step (3), the response time is 45-55 minute.
It is further preferred that temperature is 161-164 DEG C in step (4), the response time is 65 minutes.
It is further preferred that temperature is 181-184 DEG C in step (5), the response time is 35-45 minute.
It is further preferred that mixing time is 25-35 minute in step (6).
Beneficial effect: the Thermosensitive Material Used for Controlled Releasing of Medicine of the present invention has higher water absorption rate, reaches as high as 45.6%, and hydrophilic is good, Degradation rate is very fast, and after soaking 30 days in phosphate buffer, its degradation rate can reach 76.9%.
Detailed description of the invention
Embodiment 1
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 10 parts, decanedioic acid 2 parts, fumaric acid 12 Part, trimethylolpropane allyl ether 5 parts, lauroyl peroxide 1 part, N,N methylene bis acrylamide 2 parts, Polyethylene Glycol 3 parts, phosphoamide 2 parts, sodium peroxydisulfate 1 part, 2 parts of ascorbic acid, lauryl methacrylate 2 parts, ethylene glycol 10 parts, diethylene glycol 1 Part, ethyl acetate 5 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 160 DEG C, high-speed stirred is reacted 60 minutes；
(2) temperature is cooled to 120 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 60 minutes；
(3) temperature is risen to 180 DEG C, continue reaction 40 minutes；
(4) cooling the temperature to 160 DEG C, dropping trimethylolpropane allyl ether reacts 60 minutes；
(5) temperature is risen to 180 DEG C, continue reaction 30 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 20 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
Embodiment 2
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 11 parts, decanedioic acid 3 parts, fumaric acid 13 Part, trimethylolpropane allyl ether 6 parts, lauroyl peroxide 1.5 parts, N,N methylene bis acrylamide 2.5 parts, poly-second Glycol 4 parts, phosphoamide 2.5 parts, sodium peroxydisulfate 1.5 parts, 2.5 parts of ascorbic acid, lauryl methacrylate 3 parts, ethylene glycol 12 Part, diethylene glycol 1.1 parts, ethyl acetate 6 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 165 DEG C, high-speed stirred is reacted 65 minutes；
(2) temperature is cooled to 121 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 65 minutes；
(3) temperature is risen to 181 DEG C, continue reaction 45 minutes；
(4) cooling the temperature to 161 DEG C, dropping trimethylolpropane allyl ether reacts 65 minutes；
(5) temperature is risen to 181 DEG C, continue reaction 35 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 25 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
Embodiment 3
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 12.5 parts, decanedioic acid 3.5 parts, rich horse Acid 13.5 parts, trimethylolpropane allyl ether 6.5 parts, lauroyl peroxide 2 parts, N,N methylene bis acrylamide 3 parts, Polyethylene Glycol 4.5 parts, phosphoamide 3 parts, sodium peroxydisulfate 2 parts, 3 parts of ascorbic acid, lauryl methacrylate 3.5 parts, ethylene glycol 15 parts, diethylene glycol 1.5 parts, ethyl acetate 7.5 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 165 DEG C, high-speed stirred is reacted 70 minutes；
(2) temperature is cooled to 122 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 70 minutes；
(3) temperature is risen to 182 DEG C, continue reaction 50 minutes；
(4) cooling the temperature to 162 DEG C, dropping trimethylolpropane allyl ether reacts 65 minutes；
(5) temperature is risen to 182 DEG C, continue reaction 40 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 30 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
Embodiment 4
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 14 parts, decanedioic acid 4 parts, fumaric acid 14 Part, trimethylolpropane allyl ether 7 parts, lauroyl peroxide 2.5 parts, N,N methylene bis acrylamide 3.5 parts, poly-second Glycol 5 parts, phosphoamide 3.5 parts, sodium peroxydisulfate 2.5 parts, 3.5 parts of ascorbic acid, lauryl methacrylate 4 parts, ethylene glycol 18 Part, diethylene glycol 1.7 parts, ethyl acetate 9 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 165 DEG C, high-speed stirred is reacted 75 minutes；
(2) temperature is cooled to 124 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 75 minutes；
(3) temperature is risen to 184 DEG C, continue reaction 55 minutes；
(4) cooling the temperature to 164 DEG C, dropping trimethylolpropane allyl ether reacts 65 minutes；
(5) temperature is risen to 184 DEG C, continue reaction 45 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 35 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
Embodiment 5
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 15 parts, decanedioic acid 5 parts, fumaric acid 15 Part, trimethylolpropane allyl ether 8 parts, lauroyl peroxide 3 parts, N,N methylene bis acrylamide 4 parts, Polyethylene Glycol 6 parts, phosphoamide 4 parts, sodium peroxydisulfate 3 parts, 4 parts of ascorbic acid, lauryl methacrylate 5 parts, ethylene glycol 20 parts, diethylene glycol 2 Part, ethyl acetate 10 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 170 DEG C, high-speed stirred is reacted 80 minutes；
(2) temperature is cooled to 125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 80 minutes；
(3) temperature is risen to 185 DEG C, continue reaction 60 minutes；
(4) cooling the temperature to 165 DEG C, dropping trimethylolpropane allyl ether reacts 70 minutes；
(5) temperature is risen to 185 DEG C, continue reaction 50 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 40 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
Comparative example 1
The present embodiment is not contain lauroyl peroxide and N,N methylene bis acrylamide with the difference of embodiment 5.Specifically Ground is said and is:
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: polylactic acid 15 parts, decanedioic acid 5 parts, fumaric acid 15 Part, trimethylolpropane allyl ether 8 parts, Polyethylene Glycol 6 parts, phosphoamide 4 parts, sodium peroxydisulfate 3 parts, 4 parts of ascorbic acid, first Base lauryl acrylate 5 parts, ethylene glycol 20 parts, diethylene glycol 2 parts, ethyl acetate 10 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 170 DEG C, high-speed stirred is reacted 80 minutes；
(2) temperature is cooled to 125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 80 minutes；
(3) temperature is risen to 185 DEG C, continue reaction 60 minutes；
(4) cooling the temperature to 165 DEG C, dropping trimethylolpropane allyl ether reacts 70 minutes；
(5) temperature is risen to 185 DEG C, continue reaction 50 minutes；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 40 minutes；
(7) add sodium peroxydisulfate and ascorbic acid at room temperature carries out solidifying and get final product.
Comparative example 2
The present embodiment is not contain polylactic acid and ethyl acetate with the difference of embodiment 5.Specifically:
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine, is prepared from weight portion by following component: decanedioic acid 5 parts, fumaric acid 15 parts, trihydroxy methyl Propane diallyl ether 8 parts, lauroyl peroxide 3 parts, N,N methylene bis acrylamide 4 parts, Polyethylene Glycol 6 parts, phosphoamide 4 Part, sodium peroxydisulfate 3 parts, 4 parts of ascorbic acid, lauryl methacrylate 5 parts, ethylene glycol 20 parts, diethylene glycol 2 parts.
The preparation method of said medicine slow-release material is:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 170 DEG C, high-speed stirred is reacted 80 minutes；
(2) temperature is cooled to 125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 80 minutes；
(3) temperature is risen to 185 DEG C, continue reaction 60 minutes；
(4) cooling the temperature to 165 DEG C, dropping trimethylolpropane allyl ether reacts 70 minutes；
(5) temperature is risen to 185 DEG C, continue reaction 50 minutes；
(6) add lauryl methacrylate, stir 40 minutes；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
The embodiment of material of the present invention and the partial properties index of comparative example see table, it will be seen that material of the present invention Material has higher water absorption rate, reaches as high as 45.6%, and hydrophilic is good, and degradation rate is very fast, soaks 30 days in phosphate buffer Its degradation rate rear can reach 76.9%.
The partial properties index of table 1 Thermosensitive Material Used for Controlled Releasing of Medicine
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Comparative example 1 Comparative example 2
Water absorption rate (%) 45.2 45.3 45.5 45.6 45.4 45.1 44.4
Degradation rate (%) 76.8 76.8 76.9 76.9 76.6 75.3 73.7
Note: being determined as of degradation rate is soaked in phosphate buffer 30 days.

Claims (9)

1. a Thermosensitive Material Used for Controlled Releasing of Medicine, it is characterised in that: it is prepared from weight portion by following component: polylactic acid 10-15 part, the last of the ten Heavenly stems Diacid 2-5 part, fumaric acid 12-15 part, trimethylolpropane allyl ether 5-8 part, lauroyl peroxide 1-3 part, N, N-Asia Bisacrylamide 2-4 part, Polyethylene Glycol 3-6 part, phosphoamide 2-4 part, sodium peroxydisulfate 1-3 part, ascorbic acid 2-4 part, first Base lauryl acrylate 2-5 part, ethylene glycol 10-20 part, diethylene glycol 1-2 part, ethyl acetate 5-10 part.
A kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 1, it is characterised in that: by following component with weight portion preparation Become: polylactic acid 11-14 part, decanedioic acid 3-4 part, fumaric acid 13-14 part, trimethylolpropane allyl ether 6-7 part, peroxidating Lauroyl 1.5-2.5 part, N,N methylene bis acrylamide 2.5-3.5 part, Polyethylene Glycol 4-5 part, phosphoamide 2.5-3.5 part, Sodium peroxydisulfate 1.5-2.5 part, ascorbic acid 2.5-3.5 part, lauryl methacrylate 3-4 part, ethylene glycol 12-18 part, two sweet Alcohol 1.1-1.7 part, ethyl acetate 6-9 part.
3. the preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine described in any one of claim 1 to 2, it is characterised in that: include following Step:
(1) decanedioic acid and ethylene glycol being mixed, at temperature 160-170 DEG C, high-speed stirred is reacted 60-80 minute；
(2) temperature is cooled to 120-125 DEG C, adds fumaric acid, Polyethylene Glycol, phosphoamide and diethylene glycol, stirring reaction 60- 80 minutes；
(3) temperature is risen to 180-185 DEG C, continue reaction 40-60 minute；
(4) cooling the temperature to 160-165 DEG C, dropping trimethylolpropane allyl ether reacts 60-70 minute；
(5) temperature is risen to 180-185 DEG C, continue reaction 30-50 minute；
(6) add polylactic acid, lauryl methacrylate and ethyl acetate, stir 20-40 minute；
(7) add lauroyl peroxide, N,N methylene bis acrylamide, sodium peroxydisulfate and ascorbic acid at room temperature to carry out Solidify and get final product.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (1) Temperature is 165 DEG C, and mixing time is 65-75 minute.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (2) Temperature is 121-124 DEG C, and mixing time is 65-75 minute.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (3) Temperature is 181-184 DEG C, and the response time is 45-55 minute.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (4) Temperature is 161-164 DEG C, and the response time is 65 minutes.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (5) Temperature is 181-184 DEG C, and the response time is 35-45 minute.
The preparation method of a kind of Thermosensitive Material Used for Controlled Releasing of Medicine the most according to claim 3, it is characterised in that: in described step (6) Mixing time is 25-35 minute.
CN201610471348.8A 2016-06-27 2016-06-27 A kind of Thermosensitive Material Used for Controlled Releasing of Medicine and preparation method thereof Pending CN106074358A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101072817A (en) * 2004-12-10 2007-11-14 株式会社日本触媒 Method for surface-treatment of water absorbent resin
CN101293955A (en) * 2007-04-26 2008-10-29 湖南大学 Degradable unsaturated polyester amide urea copolymer and synthesizing method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101072817A (en) * 2004-12-10 2007-11-14 株式会社日本触媒 Method for surface-treatment of water absorbent resin
CN101293955A (en) * 2007-04-26 2008-10-29 湖南大学 Degradable unsaturated polyester amide urea copolymer and synthesizing method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
童旭卿: "生物降解高吸水性树脂的研究进展", 《广东化工》 *
高鹏: "新型不饱和树脂基亲水性药物缓释材料的制备", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 *

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