CN106074340A - 一种柔发组合物及其制备方法 - Google Patents

一种柔发组合物及其制备方法 Download PDF

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CN106074340A
CN106074340A CN201610538841.7A CN201610538841A CN106074340A CN 106074340 A CN106074340 A CN 106074340A CN 201610538841 A CN201610538841 A CN 201610538841A CN 106074340 A CN106074340 A CN 106074340A
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CN106074340B (zh
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王立
周力
张晓倩
吕明飞
杨帆
李欣然
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Shanghai Zhengxin Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988Honey; Royal jelly, Propolis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/02Preparations for cleaning the hair
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • A61Q5/12Preparations containing hair conditioners

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Birds (AREA)
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  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cosmetics (AREA)

Abstract

本发明涉及一种柔发组合物及其制备方法,属于化妆品领域,其采用桑葚提取物5‑15份,葛根提取物3‑8份,覆盆莓提取物6‑10份,PEG‑26甘油醚5‑10份,丝肽蛋白1‑4份,硬脂酰胺丙基甜菜碱12‑18份,经蜡硬脂醇/PEG‑20硬脂酸酯10‑20份,乳酸壳聚糖4‑8份,水杨酸锌4‑9份,维生素E 2‑9份,蜂胶2‑7份,二甲基硅油18‑36份,柠檬醛0.02‑0.04份,尼泊金甲酯0.01‑0.03份,尼泊金乙酯0.02‑0.04份,精制水余量的配方,柔发效果显著。

Description

一种柔发组合物及其制备方法
技术领域
本发明涉及化妆品领域,具体涉及一种柔发组合物及其制备方法。
背景技术
桑葚,又叫桑果,为桑科落叶乔木桑树的成熟果实,性味甘、酸,寒。桑葚果实中含有丰富的活性蛋白、维生素、氨基酸、胡萝卜素、矿物质等成分,营养是苹果的5-6倍,是葡萄的4倍,具有多种功效,被医学界誉为“二十一世纪的最佳保健果品”,其具有显著的提高人体免疫力,具有延缓衰老,嫩白肌肤,美容养颜的功效。
葛根为豆科植物野葛的干燥根,习称野葛。秋、冬二季采挖,趁鲜切成厚片或小块;干燥。甘、辛,凉。有解肌退热,透疹,生津止渴,升阳止泻之功。常用于表证发热,项背强痛,麻疹不透,热病口渴,阴虚消渴,热泻热痢,脾虚泄泻。葛根含有20多种异黄酮成分(如葛根素Puerarin、大豆黄酮daidzein等)、葛根甙类、三萜类及其它活性成分,另外还含有丰富的淀粉。葛根异黄酮具有清除氧自由基及抗脂质过氧化之功效,可显著抑制氧化损伤引起的红细胞溶血,抑制对微粒体的活性氧类造成的过氧化反应发生发展,并提高体内SOD活性强度,调节体内氧自由基与自由基清除剂的平衡,所以说葛根有较好的抗衰老作用。葛根的异黄酮成分对人类皮肤黑色素的发生与形成也具有抑制作用。
覆盆莓为蔷薇科植物华东覆盆子Rubus chingii Hu的干燥果实,其与山莓类似,富含有机酸、糖类及少量维生素C,果实中还含有三萜成分、覆盆子酸、鞣花酸和β-谷甾醇,具有优异的嫩白肌肤和抗衰老功效。
发明内容
本发明的目的是提供一种效果显著的柔发组合物,其组成按重量份配比如下
桑葚提取物5-15份
葛根提取物3-8份
覆盆莓提取物6-10份
PEG-26甘油醚5-10份
丝肽蛋白1-4份
硬脂酰胺丙基甜菜碱12-18份
鲸蜡硬脂醇/PEG-20硬脂酸酯10-20份
乳酸壳聚糖4-8份
水杨酸锌4-9份
维生素E 2-9份
蜂胶2-7份
二甲基硅油18-36份
柠檬醛0.02-0.04份
尼泊金甲酯0.01-0.03份
尼泊金乙酯0.02-0.04份
精制水余量。
所述桑葚提取物、葛根提取物和覆盆莓提取物可以通过本领域的常规方法进行制备,例如:
所述桑葚提取物的制备方法为:将桑葚打浆,按料液比1:15-20加入蒸馏水,浸提2h,混合物进行抽滤,滤液浓缩,用95%乙醇醇析,沉淀离心,干燥,即得。
所述葛根提取物的制备方法为:将葛根粉碎过80目,至于10-15倍量的蒸馏水中,超声提取后过滤,3000r/min离心1-2h,浓缩,干燥,即得。
所述覆盆莓提取物的制备方法为:将覆盆莓打浆,按料液比1:10-20加入95%乙醇,用超声波辅助提取3次,每次1h,过滤,收集合并滤液,减压浓缩,干燥即得。
本发明的柔发组合物可以采用本领域洗发露的常规方法进行制备。
本发明的柔发组合物通过将桑葚提取物、葛根提取物和覆盆莓提取物进行复配组合,产生了预料不到的柔发效果。
具体实施方式
实施例1
将桑葚打浆,按料液比1:18加入蒸馏水,浸提2h,混合物进行抽滤,滤液浓缩,用95%乙醇醇析,沉淀离心,干燥,即得桑葚提取物;
将葛根粉碎过80目,至于12倍量的蒸馏水中,超声提取后过滤,3000r/min离心2h,浓缩,干燥,即得葛根提取物;
将覆盆莓打浆,按料液比1:15加入95%乙醇,用超声波辅助提取3次,每次1h,过滤,收集合并滤液,减压浓缩,干燥即得覆盆莓提取物。
实施例2
按如下组成取原料:
实施例1的桑葚提取物5份
实施例1的葛根提取物3份
实施例1的覆盆莓提取物6份
PEG-26甘油醚5份
丝肽蛋白2份
硬脂酰胺丙基甜菜碱12份
鲸蜡硬脂醇/PEG-20硬脂酸酯10份
乳酸壳聚糖4份
水杨酸锌5份
维生素E 3份
蜂胶3份
二甲基硅油18份
柠檬醛0.02份
尼泊金甲酯0.01份
尼泊金乙酯0.02份
精制水余量
按本领域常规方法制备成乳液。
实施例3
按如下组成取原料:
实施例1的桑葚提取物10份
实施例1的葛根提取物5份
实施例1的覆盆莓提取物8份
PEG-26甘油醚8份
丝肽蛋白3份
硬脂酰胺丙基甜菜碱15份
鲸蜡硬脂醇/PEG-20硬脂酸酯15份
乳酸壳聚糖6份
水杨酸锌6份
维生素E 6份
蜂胶5份
二甲基硅油25份
柠檬醛0.03份
尼泊金甲酯0.02份
尼泊金乙酯0.03份
精制水余量
按本领域常规方法制备成乳液。
实施例4
按如下组成取原料:
实施例1的桑葚提取物15份
实施例1的葛根提取物8份
实施例1的覆盆莓提取物10份
PEG-26甘油醚10份
丝肽蛋白4份
硬脂酰胺丙基甜菜碱18份
鲸蜡硬脂醇/PEG-20硬脂酸酯20份
乳酸壳聚糖8份
水杨酸锌9份
维生素E 9份
蜂胶6份
二甲基硅油36份
柠檬醛-0.04份
尼泊金甲酯0.03份
尼泊金乙酯0.04份
精制水余量
按本领域常规方法制备成乳液。
实施例5
柔发效果试验:
选取120名志愿者进行试验,男女各半,试验者测试前2个月没有使用过皮肤外用药物,皮肤无外伤。随机分成4组,试验组1-3使用本发明实施例2-4的柔发组合物,对照组使用市售普通洗发露,进行双盲对比试验,随机试用头发的柔顺程度,分别记录洗后第3分钟,第10分钟,第30分钟头发的柔顺情况,用分值来记录,分值从1-10分,分数越高则头发越柔顺。试验结果如表1所示:
表1柔发效果试验
组别 样本数 洗发后15min 洗发后30min
对照组 30 3.78±1.23 4.34±1.87
实施例2组 30 7.01±1.23 8.35±1.54
实施例3组 30 6.99±1.34 8.98±1.43
实施例4组 30 7.43±2.01 9.01±1.32
结果显示,本发明的柔发组合物柔顺效果明显,叫对照组(普通市售洗发露)具有明显提高,效果显著。

Claims (4)

1.一种柔发组合物,其特征在于,其组成按重量份配比如下
桑葚提取物 5-15份
葛根提取物 3-8份
覆盆莓提取物 6-10份
PEG-26甘油醚 5-10份
丝肽蛋白 1-4份
硬脂酰胺丙基甜菜碱 12-18份
鲸蜡硬脂醇/PEG-20硬脂酸酯 10-20份
乳酸壳聚糖 4-8份
水杨酸锌 4-9份
维生素E 2-9份
蜂胶 2-7份
二甲基硅油 18-36份
柠檬醛 0.02-0.04份
尼泊金甲酯 0.01-0.03份
尼泊金乙酯 0.02-0.04份
精制水余量。
2.根据权利要求1所述的柔发组合物,其特征在于,所述桑葚提取物的制备方法为:将桑葚打浆,按料液比1:15-20加入蒸馏水,浸提2h,混合物进行抽滤,滤液浓缩,用95%乙醇醇析,沉淀离心,干燥,即得。
3.根据权利要求1所述的柔发组合物,其特征在于,所述葛根提取物的制备方法为:将葛根粉碎过80目,至于10-15倍量的蒸馏水中,超声提取后过滤,3000r/min离心1-2h,浓缩,干燥,即得。
4.根据权利要求1所述的柔发组合物,其特征在于,所述覆盆莓提取物的制备方法为:将覆盆莓打浆,按料液比1:10-20加入95%乙醇,用超声波辅助提取3次,每次1h,过滤,收集合并滤液,减压浓缩,干燥即得。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101422423A (zh) * 2008-12-08 2009-05-06 浙江理工大学 含有人发水解物的护发素及其制作工艺
CN105534819A (zh) * 2016-01-25 2016-05-04 柳州三农科技有限公司 一种洗护合一中药洗发精华

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101422423A (zh) * 2008-12-08 2009-05-06 浙江理工大学 含有人发水解物的护发素及其制作工艺
CN105534819A (zh) * 2016-01-25 2016-05-04 柳州三农科技有限公司 一种洗护合一中药洗发精华

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王建新主编: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 *

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Denomination of invention: A hair softening composition and its preparation method

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