CN106063894A - Traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle - Google Patents

Abstract

nullA kind of traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle，It is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II，Wherein: according to weight proportion，Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 9 11 parts、The Radix Astragali 26 parts、Pericarpium Citri Reticulatae 20 31 parts、Bulbus Fritillariae Uninbracteatae 11 14 parts、Fructus Evodiae 42 46 parts、Bulbus Allii Macrostemonis 48 parts、Cortex Cinnamomi 15 18 parts、Radix Codonopsis 40 45 parts、Radix Aconiti Lateralis Preparata 9 10 parts、Semen Coicis 20 27 parts、Flos Caryophylli 25 parts、8 10 parts of Radix Glycyrrhizae、Fructus Ligustri Lucidi 37 parts、Fragrant 8 12 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi)、Semen Raphani 79 parts and Herba Schizonepetae 38 parts，Traditional Chinese medicine reagent II is set to include Semen Raphani 10 14 parts、Semen Cassiae 59 parts、Fructus Crataegi 20 26 parts、Flos Chrysanthemi 8 13 parts、Endothelium Corneum Gigeriae Galli 33 37 parts、Semen Lepidii (Semen Descurainiae) 49 parts、Cortex Lycii 42 46 parts、The Rhizoma Pinelliae 26 parts、The Radix Angelicae Dahuricae 37 parts、Camphora 14 17 parts、Ghost 10 12 parts、Cortex Lycii 33 36 parts and Stigma Maydis 12 18 parts，Realize warming and recuperating the kidney-YANG，Promote the production of body fluid lung benefiting，Supplementing the kidney to control the nocturnal，Its muscles and bones strong，Blood circulation promoting and blood stasis dispelling，Clearing away heat-damp and promoting diuresis，Thus reach the therapeutic effect of traditional Chinese medical science treating both the principal and secondary aspects of a disease.

Description

Traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle

One, technical field

The present invention relates to a kind of traditional Chinese medicine reagent, a kind of traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle.

Two, background technology

Kleine-Levin syndrome is a kind of rare disease, and kleine-Levin syndrome combines also known as Ke Laienlaiwen Closing disease, be more common in teenager, hyperfunction with the diet of intermittent attack, snoozed and psychological and behavior disorder is characterized, and is commonly found in Male is juvenile, in periodical attack (interval several weeks or several months), continues 3～10 days every time, shows as drowsiness, voracious and behavior is different Often.The cause of disease and pathogenesis are unclear, may be caused by diencephalon particularly hypothalamus dysfunction or Focal encephalitis, this The reason planting disease is the most unclear, and some research worker suspects autoimmune, brain hypothalamus dysfunction, is considered same brain Interior control sleep is abnormal with the regional function of appetite the most relevant, causes Narcolepsy to eat by force the reason of disease, is also due to inferior colliculus Caused by the diseases such as brain rear portion tumor, inflammation or wound.Ke Laienlaiwen syndrome clinical manifestation, whole world patient is the most over thousands of People, after majority grow up, symptom eliminates.Medical circle does not knows the cause of disease so far, does not has specific short yet.Doctor can only combination of stimulation Class medicine and sleep medicine, on the one hand prevent patient from falling asleep without omen, on the one hand improves patient sleeps's mass, currently there are no one Kind for the traditional Chinese medicine reagent of the drowsiness voracious syndrome for the treatment of cycle, for improve kleine-Levin syndrome outbreak and Treatment.

Three, summary of the invention

The object of the present invention is a kind of traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle.

In order to overcome above-mentioned technical disadvantages, it is an object of the invention to provide a kind of comprehensive for the drowsiness voracity for the treatment of cycle The traditional Chinese medicine reagent levied, therefore improves the therapeutic effect to kleine-Levin syndrome and does not has side effects.

For reaching above-mentioned purpose, the present invention adopts the technical scheme that: be set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 9-11 part, Radix Astragali 2-6 part, Pericarpium Citri Reticulatae 20-31 part, Bulbus Fritillariae Uninbracteatae 11-14 part, Wu Zhu Cornel 42-46 part, Bulbus Allii Macrostemonis 4-8 part, Cortex Cinnamomi 15-18 part, Radix Codonopsis 40-45 part, Radix Aconiti Lateralis Preparata 9-10 part, Semen Coicis 20-27 part, Flos Caryophylli 2-5 part, Radix Glycyrrhizae 8-10 part, Fructus Ligustri Lucidi 3-7 part, fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) 8-12 part, Semen Raphani 7-9 part and Herba Schizonepetae 3-8 part,

Traditional Chinese medicine reagent II is set to include Semen Raphani 10-14 part, Semen Cassiae 5-9 part, Fructus Crataegi 20-26 part, Flos Chrysanthemi 8-13 part, chicken Endothelium corneum 33-37 part, Semen Lepidii (Semen Descurainiae) 4-9 part, Cortex Lycii 42-46 part, Rhizoma Pinelliae 2-6 part, Radix Angelicae Dahuricae 3-7 part, Camphora 14-17 part, ghost head 10- 12 parts, Cortex Lycii 33-36 part and Stigma Maydis 12-18 part.

Theory of Chinese medical science is stated: the morbidity of kleine-Levin syndrome is many because of deficiency of kidney-essence, and menses are double empty, daily life Not normal, and cause damp and hot interior life and accumulate the cloudy blood trouble of consumption for a long time, the most then hinder blood stasis to run, become silted up and hinder in network, for the disease of deficiency in origin and excess in superficiality.Control with temperature Kidney benefit essence is it, clearing away heat-damp and promoting diuresis simultaneously, blood circulation promoting and blood stasis dispelling, to turn round and look at the card of mark reality.The combination of the two kinds of Chinese medicine compositions passed through should With, it is achieved warming and recuperating the kidney-YANG, promote the production of body fluid lung benefiting, supplementing the kidney to control the nocturnal, by force its muscles and bones, blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, thus reaches traditional Chinese medical science specimen The double therapeutic effect controlled.

In we, Radix Calystegiae sepii, Cortex Cinnamomi, Radix Codonopsis and Semen Raphani, Endothelium Corneum Gigeriae Galli, Semen Lepidii (Semen Descurainiae) are monarch drug；The Radix Astragali, Flos Caryophylli, Radix Glycyrrhizae, Fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) and Semen Cassiae, Fructus Crataegi, Camphora, ghost head are ministerial drug；Bulbus Fritillariae Uninbracteatae, Fructus Evodiae, Bulbus Allii Macrostemonis, Semen Coicis, Pericarpium Citri Reticulatae and Cortex Lycii, the Rhizoma Pinelliae, Cortex Lycii is adjuvant drug；Radix Aconiti Lateralis Preparata, Fructus Ligustri Lucidi, Semen Raphani, Herba Schizonepetae and Flos Chrysanthemi, the Radix Angelicae Dahuricae, Stigma Maydis are for making medicine.Should by these drug regimens With, make various medicine produce effect synergism, thus reach best therapeutic effect.

The present invention devises, and is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 10 parts, the Radix Astragali 5 parts, Pericarpium Citri Reticulatae 30 parts, Bulbus Fritillariae Uninbracteatae 11 parts, Fructus Evodiae 43 parts, Bulbus Allii Macrostemonis 7 parts, Cortex Cinnamomi 17 parts, Radix Codonopsis 41 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 25 parts, Flos Caryophylli 3 parts, 9 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 3 parts, fragrant 11 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Raphani 8 parts and Herba Schizonepetae 6 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 11 parts, Semen Cassiae 8 parts, Fructus Crataegi 21 parts, Flos Chrysanthemi 13 parts, Endothelium Corneum Gigeriae Galli 36 parts, fourth Power 8 parts, Cortex Lycii 45 parts, the Rhizoma Pinelliae 3 parts, the Radix Angelicae Dahuricae 4 parts, Camphora 16 parts, ghost 10 parts, Cortex Lycii 34 parts and Stigma Maydis 12 parts.

In the technical program, Radix Calystegiae sepii: perennial herb.Herb is not by hair.Stem is wound around, and has thin rib.Leaf changeable, leaf Sheet triangular shape is avette or width egg shape, long 4-10cm, wide 2-6cm, and the tapering sharp point of tip, base halberd shape or heart, full edge or base portion are slightly It is stretched to the sliver that 2-3 canine tooth of tool lacks.Spend single leave axil；Bennet is up to 10cm, has thin rib or the most individual narrow wing；Bract 2, wide Avette, the sharp point of tip；Sepal 5, avette；Corolla generally white or sometimes pale red or purple, funnel-form, limb fine fisssure, stamen 5, filigree base portion expands, by little palea；Ovary is split without hair, stigma 2.Capsule is avette, be about 1cm be increase harbor bract and calyx Sheet is coated.Seed pitchy, is about 4mm, and there is little wart on surface.The month at florescence 6-7, really the phase 7-8 month.

In the technical program, the Radix Astragali: have another name called continuous stilbene.Perennial herb is high 50-100 centimetre.Main root is plump, wooden, often Branch, canescence.Stem is upright, and top multi-branched has thin rib, by white pubescence.Perennial herb is high 50-100 centimetre.Originate in The ground such as the Inner Mongol, Shanxi, Gansu, Heilungkiang.

In the technical program, Pericarpium Citri Reticulatae: for rutaceae orange Citrus reticulata BlancoAnd cultivation becomes The dry mature skin planted.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or low temperature is done Dry.

In the technical program, Bulbus Fritillariae Uninbracteatae: for herbaceos perennial, its bulb hyoscine, because its shape is gained the name, " book on Chinese herbal medicine Through focusing " say: " being similar to poly-Monetariamoneta (L.)(Monetariaannulus (L.)) ", and therefore named Bulbus Fritillariae Uninbracteatae, can relieving cough and resolving phlegm, the merit of heat clearing away eliminating stagnation.Another name: diligent mother, Herba Sonchi Oleracei, bitter colored, Empty grass, medicine is real.Originate in the ground such as Qinghai, Sichuan, Yunnan, Qinling-Bashan mountainous area, Gansu.

In the technical program, Fructus Evodiae: another name Fructus Evodiae, tea are peppery, paint spicy, smelly spicy tree, the pure deep and remote son of left power, rice spicy Deng.Generally divide several kinds such as Flos Caryophylli Fructus Evodiae, middle colored Fructus Evodiae and little Hua Fructus Evodiae.Dungarunga or shrub, high 3-5 rice is tender The dark violet redness of branch, with tender shoots with by sallow or red rust color fine hair, or thin undercoat.It is born in level land to 1500 meters of mountain region sparse woods of height above sea level Or in bushes, it is more common in hillside fields on the sunny side.Various places have little or plant in a large number.Tender fruit is i.e. Chinese medicine Wu Zhu after brewed airing Cornel, is called for short Fructus Evodiae, is bitter stomachic and analgesics, makees again lumbricide.^[2]Its hot bitter in the mouth of property is pungent, has dispersing cold for relieving pain, sending down the abnormal ascending QI The diseases such as the merit of preventing or arresting vomiting, headache for treating that liver insufficiency of stomach is cold, caused by cloudy turbid superinverse or gastralgia.In the technical program, Chinese onion White: another name Allium macrostemon, Bullbus Allii nipponici, bitter Bulbus Allii, little Bulbus Allii, little root vegetables, little root vegetables, big head, wild Bulbus Allii, Herba Allii prattii, open country.Latin literary fame Allium macrostemon Bunge. belongs to Liliaceae, allium.Li Shizhen (1518-1593 A.D.) is said: " its root is cooked, grain is hidden, vinegar soaks all suitable ". Gen Sebai, makees medicinal, name Bulbus Allii Macrostemonis.Bulb is the most spherical, bulb outer belt black, and papery or film quality do not rupture, but many in specimen The endothelium of white is only deposited because coming off.3-5 piece of leaf, semi-cylindrical, or it is three prismatic semi-cylindrical because rib prosperity is indulged at back, in Sky, upper mask groove, ovary is the most spherical, and ventral suture base portion has the depression honey cave of curtain；Style stretches out outside perianth.Flowering fruit bearing stage 5-7 Month.In addition to Xinjiang, Qinghai, national each provinces and regions are all produced.It is born on hillside, hills, mountain valley or the meadow of height above sea level less than 1500 meters, pole Minority area (Yunnan and Tibet) also has on the hillside of height above sea level 3000 meters.Also there are distribution in the Soviet Union, Korea and Japan.Bulb makees medicine With, it is possible to make vegetable and eat, cultivated in minority area.In the technical program, Cortex Cinnamomi: have another name called beautiful osmanthus, male osmanthus, cajaput, Great Gui, peppery osmanthus, safety tree, cassia, for the dry bark of canella Cortex Cinnamomi.Bark fragrance, can make spice, taste with originate from The Cortex cinnamomi japonici (Ramulus Cinnamomi) of Sri Lanka Cortex Cinnamomi is similar, but pepperyyer, delicious not as good as Cortex cinnamomi japonici (Ramulus Cinnamomi), and relatively Cortex cinnamomi japonici (Ramulus Cinnamomi) is thick.In North America then Cortex Cinnamomi powder pay no attention to from Chinese cinnamon presses down Sri Lanka Cortex Cinnamomi, does not sells together with all making any distinction between, and Cortex Cinnamomi strips from stem and branch, shelves dried, Curling rolling.Some kinds are then for scraping.Scraping taker thin and be azarin brown, the bark do not scraped is thick and is Lycoperdon polymorphum Vitt.Cortex Cinnamomi powder Light reddish brown color.In the fragrance of domestic Cortex Cinnamomi be slightly poorer than Vietnam and Indonesia product person, three all has fragrance, and taste is sweet and peppery.In The immature fruit adhesion of state Cortex Cinnamomi and male osmanthus (C. loureirii) is in firmly having in the taupe cup-shaped calyx of wrinkle, the longest 11 public (0.4, including calyx tube)；Footpath, top about 6 is public (0.25), and even calyx tube is taken to be dried and i.e. claimed Cortex Cinnamomi bud.Have like osmanthus The fragrance of skin and the sweet pungent of Cortex Cinnamomi, for foodstuff flavouring.

In the technical program, Radix Codonopsis: ovalize or the sheet of similar round, surface yellowish-brown or lark, tangent plane is yellow White or yellowish-brown, have crack or Flos Chrysanthemi stricture of vagina, and there are the faint yellow center of circle in central authorities.Periphery yellowish white puts yellowish-brown, has vertical wrinkle.Have Special aroma, taste is micro-sweet.Raw Radix Codonopsis sheet supplementing QI for promoting the production of body fluid power victory.It is usually used in gas Tianjin two to hinder or deficiency of both QI and blood.Radix Codonopsis sweet in the mouth, property is put down. Have invigorating the spleen and replenishing QI, quench the thirst, strengthening spleen and tonifying lung, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, dyspnea due to deficiency of coughing, insufficiency of vital energy and blood, face Color is sallow, shortness of breath and palpitation, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst.Lazy speech is losed heart, myasthenia of limbs, be off one's feed, the deficiency of vital energy, gas Tianjin two are empty, gas Blood is double to be lost and the disease such as blood deficiency and yellow complexion.But exterior syndrome does not solves and can not the using of the fullness in the epigastrium and abdomen domination of pathogen.This product effect is similar to Radix Ginseng, only medicine Power is weak.Control general deficiency syndrome, Radix Ginseng can be replaced to use；Collapse is heavily demonstrate,proved, and is the most still advisable with Radix Ginseng.Autumn excavates, and cleans, dries. In the woods limit, mountain region of place of production north of China height above sea level 1560-3100 rice and shrubbery.The Codonopsis plant whole world there are about 40 kinds, and China is about Having 39 kinds, medicinal have 21 kinds, 4 mutation.Radix Codonopsis is traditional tonic that China is conventional, the party that ancient times produce with area, Shangdang, Shanxi Ginseng, for top grade, has invigorating the spleen and replenishing QI, effect of strengthening spleen and tonifying lung.Modern study, Radix Codonopsis have enhancing immunity, expansion blood vessel, blood pressure lowering, Improve microcirculation, strengthen the effects such as hemopoietic function.In addition the leukopenia caused chemotherapy radiotherapy has castering action.

In the technical program, Radix Aconiti Lateralis Preparata: have another name called Aconitum carmichjaelii Debx. or Radix Aconiti Lateralis Preparata, another name: Radix Aconiti Kusnezoffii, the Radix Linderae, salt Aconitum carmichjaelii Debx., E Erhua, the ornamental work of iron, The five poisonous creatures: scorpion, viper, centipede, house lizard, toad, Latin literary fame: Aconitum carmichaeli Debx. Ranunculaceae, the processed goods of daughter root of aconitum plant.Main product In Sichuan, Hubei, the ground such as Hunan.Late June excavated to early August, removed parent root, fibrous root and silt, practises and claims " mud Radix Aconiti Lateralis Preparata ".Add Work is concocted as Radix Aconiti Lateralis Preparata, Radix Aconiti Lateralis Preparata (Radix Aconiti Lateralis Preparata), Radix Aconiti Lateralis Preparata, RADIX ACONITI LATERALIS PREPARATA, gun tab.Belong to drugs for dispelling internal cold." recuperating depleted YANG and rescuing the patient from collapse in Chinese medicine One product ".Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain.Controlling excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate Cold type of pain, the splenic diarrhea cold-dysentery, tinea pedis edema children's's intermittent infantile convulsion, anemofrigid-damp arthralgia, contracture, sexual impotence cold womb, carbuncle of yin nature skin ulcer is leaked and all are heavy cold The disease of syndrome of aversion to cold lasting day and night with cold limbs.

In the technical program, Semen Coicis: be a kind of frumentum just having from ancient times, originate in Vietnam, China be also referred to as Semen Coicis, Semen Coicis, Semen Coicis, Semen Coicis.It is described as " king of world grass ".In the technical program, Flos Caryophylli: also known as Syringa oblata Lindl. Belonging to, this platymiscium is machaka or dungarunga；Big portion is for viewing and admiring, and the flower of some kind can obtain through refining aromatic oil, is also nectar source Plant, timber is for building and furniture.Totally 35 kinds, do not include Natural hybrid, be distributed mainly on China, Korea, Himalaya Area, W. Asia, Japan, Afghanistan.China has the wild species of Genus Syringa 81%, is that the modern times of genus syringa divide Cloth center.The flower having many kinds in this genus is to extract essence, the raw material of preparation fine perfumery；The most with luxuriant foliage and spreading branches in leafy profusion, pattern is simple and elegant And delicate fragrance, therefore flower garden is widely cultivated for viewing and admiring, for the treasure in flower garden.American-European existing last 100 years that this genus is cross-breeding History, the most once selected hundreds of cultivars.This research has also been carried out in botanical garden, BeiJing, China, has cultivated into purple cloudSyringe oblateCv. " Ziyun ", sieve royal purpleSyringe oblataCv. " Luolanzi ", fragrant snowSyringe oblate" Xiangxue ", cv. spring pavilionSyringe vulgarisCv. the new varieties such as " Chun'ge "

In the technical program, Radix Glycyrrhizae: another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial grass This, root is sturdy with root stock, is a kind of tonification Chinese herbal medicine.A kind of medicine good to human body, medicinal part is root and rhizome, medical material Character root is cylinder, long 25～100 centimetres, diameter 0.6～3.5 centimetres.Crust degree of tightness differs, surface red brown or greyish brown Color.Rhizome is cylinder, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, eliminates the phlegm Cough-relieving, gastral cavity abdomen etc..Happiness is dark moist, sunshine the low dry climate of long temperature.Radix Glycyrrhizae is grown in desert arid, semiarid grass more Former, desert edge and loess hill area.Root and root stock hyoscine.

In the technical program, Fructus Ligustri Lucidi: another name Fructus Ligustri Lucidi reality, Fructus Ilicis Purpureae, wax tree, Mus Chinese catalpa, for Oleaceae plants Fructus Ligustri Lucidi The dry mature fruit of Ligustrum lucidum Ait..These product are avette, oval or kidney shape, and long 6～8.5mm, diameter 3.5～5.5mm.The black purple in surface or grey black, shrinkage is uneven, and base portion has carpopodium trace or tool Constellation calyx and short stalk.Body is light.Outer peel Thin, mesocarp is relatively soft, is easily peeled, and endocarp is wooden, yellowish-brown, the vertical rib of tool, breaks rear seed and is usually 1, and kidney shape is purple black Color, oiliness.Odorless, sweet in the mouth, micro-bitterness.Primary in the ground such as Yangtze River in China basin and south various places, Henan, Shaanxi, Gansu, the north Less cold place is also introduced a fine variety, and also has distribution in Korea south, India.

In the technical program, fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi): aiphyllium.Bark Lycoperdon polymorphum Vitt, smooth.Branch is close by yellow calm tax shape pubescence. Leaf is closely to raw or alternate；Petiole is close by yellow calm thin,tough silk shape pubescence；Blade ovum shape ellipse or ovum shape lanceolar, tip is gradually Point, base portion wedge shape or circle, completely, above bottle green, light.Inflorescence axil is raw, and close by yellow calm thin,tough silk shape pubescence, most end is divided Branch, has 3-5 flower, makees sympodium arrangement.Flower both sexes, faint yellow；Ovary is spherical, without hair, stigma plate-like.Fruit ellipse, blue Black；Hypocarp cup-shaped, tip is completely.The month at florescence 6-7, really the phase 8-10 month.It is grown in hillside, mountain valley evergreen broadleaf forest.

In the technical program, Semen Raphani: for crucifer Radix RaphaniRaphanus sativus L. drying and ripening kind Son.Tap plant during fruit maturation in summer, dry, rub seed, remove impurity, then dry.

In the technical program, Herba Schizonepetae: another name: fragrant Schizonepeta tenuifolia Briq, line shepherd's purse, Herba Schizonepetae, false Soviet Union, is that Labiatae, Nepeta are perennial Plant.Stem is strong, base portion lignifying, and multi-branched is high 40-150 centimetre, nearly four prismatics of base portion, blunt four prismatics in top, has shallow slot, By white pubescence.Enter medicinal its dry stem and leaf and spica.Fresh and tender bud children's is calm optimal, and balm leaf yellow green, stem is square micro- Band purple, cross section yellow-white, the most black purple yellow green of tassel.Taste is put down, and warm in nature, nontoxic, faint scent is dense.Herba Schizonepetae is diaphoresis, antipyretic Medicine, is one of conventional medical herbs of China, can town expectorant, dispel the wind, removing heat from blood.Control influenza, headache cold and heat diaphoresis, vomiting.In this technology In scheme, Semen Raphani: have another name called Semen Raphani, trailing plants white chessman, Semen Raphani etc., for the mature seed of crucifer Radix Raphani.In all parts of the country Generally cultivate.Entering spleen, stomach, lung meridian, can help digestion de-swelling, and effect is notable, has the title of " rush wall fall wall ".Can be used for for Therapeutic diet Stagnation, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots are breathed with cough.The pungent scattered gas consumption of this product, therefore the deficiency of vital energy is without food stagnation, expectorant, and stagnant person is careful With.Should not be with Radix Ginseng with using.

In the technical program, Semen Cassiae: be leguminous plant Semen Cassiae or the dry mature seed of little Semen Cassiae, have improving eyesight with it Merit and name it.Gather autumn mature fruit, dry, lay seed, remove impurity.Semen Cassiae bitter in the mouth, sweet, salty, cold nature, enter Liver, kidney, large intestine channel；Loosening bowel to relieve constipation, blood fat reducing improving eyesight, treatment constipation and hyperlipidemia, hypertension.Liver heat removing and eyesight improving, diuretic relieving constipation, have slow Rush down effect, reducing blood pressure and blood fat.

In the technical program, Fructus Crataegi: having another name called fruit, Fructus Pyri Pashiae in mountain, Rosaceae Crataegus, deciduous tree, height is up to 6 Rice.In Shandong, Shaanxi, Shanxi, Henan, Jiangsu, Zhejiang, Liaoning, Jilin, Heilungkiang, the Inner Mongol, the ground such as Hebei all have distribution. Stone fruit, caryoplasm is hard, and sarcocarp is thin, and taste is micro-sour and astringent.The most raw-eaten or make preserved fruit fruitcake, drying after can be used as medicine, be Chinese Special Some medicines fruit dual-purpose seeds, have the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, are also spleen benefiting and stimulating the appetite simultaneously, help digestion Changing stagnant, the good medicine of phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has good curative effect.Flavonoid in Fructus Crataegi Compound vitexin, is the medicine that a kind of antitumaous effect is stronger, and its extract is to suppressing internal growth of cancer cells, breeding and infiltrate Transfer all has certain effect.

In the technical program, Flos Chrysanthemi: be the perennial root herbaceous plant of Compositae, Chrysanthemum in Plant Taxonomy.Press Planting form is divided into the cultivated forms such as bull chrysanthemum, solely this chrysanthemum, Chrysanthemum morifolium Ramat, steep cliff chrysanthemum, skill chrysanthemum, Desk Chrysanthemum Applying；Have by the outward appearance of petal Form is divided into garden to embrace, move back embrace, anti-embrace, disorderly embrace, the dew heart is embraced, fly the noon cultivated form such as embraces.Flos Chrysanthemi in dissimilar is named again respectively Plant the variety name of various kinds.In the technical program, Endothelium Corneum Gigeriae Galli: for Phasianidae animal man chickenGallusgallusdomesticus The dry inner wall of sandbag of Brisson.After killing chicken, take out chicken gizzard, peel inwall, cleaning, drying immediately.In the technical program, Semen Lepidii (Semen Descurainiae): call hot food, has drug effect plant, cures mainly sputum and stops up stagnant, and productive cough is panted, the excess syndrome of cough with dyspnea failing to sleep due to dyspnea.

In the technical program, Cortex Lycii: another name: Chinese wolfberry skin, for Solanaceae, Lycium, is Fructus Lycii Lycium The root bark of chinense Mill..Can be used as medicine, have and bring down a fever except the effect of steaming, removing heat from blood is except effects such as steaming, lung heat clearing pathogenic fire reducing.Often it is born in mountain By slope, wasteland, hilly ground, salt-soda soil, roadside and limit, village residence, be distributed in China northeast, Hebei, Shanxi, Shaanxi, SOUTH OF GANSU with And each provinces and regions in southwest, Central China, south China and East China；Korea, Japan, there are cultivation or ease in Europe for wild.

In the technical program, the Rhizoma Pinelliae: have another name called ground literary composition, keep field etc., belong to Arales.It is distributed widely in Yangtze River in China basin And the area such as northeast, North China.Medicinal plants, has drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, and the life furuncle and phyma effect that disappears, veterinary is in order to control Cynanche Huang.Also distribution, height above sea level about 3000m is had in Tibet.In the technical program, the Radix Angelicae Dahuricae: perennial tall and big draft, high 1- 2.5 meters, root is cylindrical, 2-5 centimetre of basal part of stem footpath, a time pinnation of basal leaf, and universal umbel top is raw or side is raw, and fruit is long Circular to oval, it is used as medicine with root, the function such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, nose Scorching, toothache.The diseases such as leucorrhea with red and white discharge, bitterly furuncle and phyma poison, also can make spice.There is cultivation some provinces and regions in the north, market one's own products more, minority Adjust outside the province.Typically be born in by sylvan life, border, small stream, shrubbery and meadow, mountain valley.

In the technical program, Camphora: for the branch of canella Camphor tree, dry, leaf and root, through refining the graininess prepared Crystallization.Camphora has orifice opening, qi stagnation removing, wards off foul, effect of killing parasites for relieving itching, reducing swelling and alleviating pain, cures mainly scabies pruritus, traumatic injury wound Bitterly, the symptom such as toothache.It is mainly composed of gum camphor (d-Camphora) purely, is camphane compounds.

In the technical program, ghost head: releasing name office indocalamus, ghost taro, carbuncle pathogenic wind toxic (defibrination spreading), also controlling disappears exhausts.

In the technical program, Cortex Lycii: another name: Chinese wolfberry skin, for Solanaceae, Lycium, is Fructus Lycii Lycium The root bark of chinense Mill..Can be used as medicine, have and bring down a fever except the effect of steaming, removing heat from blood is except effects such as steaming, lung heat clearing pathogenic fire reducing.Often it is born in mountain By slope, wasteland, hilly ground, salt-soda soil, roadside and limit, village residence, be distributed in China northeast, Hebei, Shanxi, Shaanxi, SOUTH OF GANSU with And each provinces and regions in southwest, Central China, south China and East China；Korea, Japan, there are cultivation or ease in Europe for wild.

In the technical program, Stigma Maydis: Chinese medicine name.Style and post for grass Semen Maydis Zea mays L. Head.The whole nation is the most all produced.Summer, autumn fruit are collected when whom becoming, and remove impurity.Using fresh herb or dry raw use.

In the technical program, two kinds of traditional Chinese medicine reagent compositionss are important technical characteristic, drowsiness for treatment cycle In the technical field of the traditional Chinese medicine reagent of voracious syndrome, there is novelty, creativeness and practicality, the art in the technical program Language is all can to explain with patent documentation in the art and understand.

Four, detailed description of the invention

A kind of traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle, first embodiment, it is set to include Chinese medicine Reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 9 parts, the Radix Astragali 2 parts, Pericarpium Citri Reticulatae 20 parts, Bulbus Fritillariae Uninbracteatae 11 parts, Fructus Evodiae 42 parts, Bulbus Allii Macrostemonis 4 Part, Cortex Cinnamomi 15 parts, Radix Codonopsis 40 parts, Radix Aconiti Lateralis Preparata 9 parts, Semen Coicis 20 parts, Flos Caryophylli 2 parts, 8 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 3 parts, fragrant 8 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Lay Fu 7 parts and Herba Schizonepetae 3 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 10 parts, Semen Cassiae 5 parts, Fructus Crataegi 20 parts, Flos Chrysanthemi 8 parts, Endothelium Corneum Gigeriae Galli 33 parts, fourth Power 4 parts, Cortex Lycii 42 parts, the Rhizoma Pinelliae 2 parts, the Radix Angelicae Dahuricae 3 parts, Camphora 14 parts, ghost 10 parts, Cortex Lycii 33 parts and Stigma Maydis 12 parts.

Traditional Chinese medicine reagent I and traditional Chinese medicine reagent II are added water boil respectively, form the Chinese medicines of 200ml the most respectively Liquid, according to early, neutralizes and takes for three times on the one evening, and using ten days is a course for the treatment of, when occurring that condition of illness increases the weight of, stops Chinese medicine Taking of the medicinal liquid of reagent I, when needing according to early, neutralizing the late liquor taking carrying out traditional Chinese medicine reagent II for three times on the one, uses ten It is a course for the treatment of.

Second embodiment, is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 11 parts, the Radix Astragali 6 parts, Pericarpium Citri Reticulatae 31 parts, Bulbus Fritillariae Uninbracteatae 14 parts, Fructus Evodiae 46 parts, Bulbus Allii Macrostemonis 8 parts, Cortex Cinnamomi 18 parts, Radix Codonopsis 45 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 27 parts, Flos Caryophylli 5 parts, 10 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 7 parts, fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) 12 Part, Semen Raphani 9 parts and Herba Schizonepetae 8 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 14 parts, Semen Cassiae 9 parts, Fructus Crataegi 26 parts, Flos Chrysanthemi 13 parts, Endothelium Corneum Gigeriae Galli 37 parts, fourth Power 9 parts, Cortex Lycii 46 parts, the Rhizoma Pinelliae 6 parts, the Radix Angelicae Dahuricae 7 parts, Camphora 17 parts, ghost 12 parts, Cortex Lycii 36 parts and Stigma Maydis 18 parts.

3rd embodiment, is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 9-11 part, Radix Astragali 2-6 part, Pericarpium Citri Reticulatae 20-31 part, Bulbus Fritillariae Uninbracteatae 11-14 part, Wu Zhu Cornel 42-46 part, Bulbus Allii Macrostemonis 4-8 part, Cortex Cinnamomi 15-18 part, Radix Codonopsis 40-45 part, Radix Aconiti Lateralis Preparata 9-10 part, Semen Coicis 20-27 part, Flos Caryophylli 2-5 part, Radix Glycyrrhizae 8-10 part, Fructus Ligustri Lucidi 3-7 part, fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) 8-12 part, Semen Raphani 7-9 part and Herba Schizonepetae 3-8 part,

Traditional Chinese medicine reagent II is set to include Semen Raphani 10-14 part, Semen Cassiae 5-9 part, Fructus Crataegi 20-26 part, Flos Chrysanthemi 8-13 part, chicken Endothelium corneum 33-37 part, Semen Lepidii (Semen Descurainiae) 4-9 part, Cortex Lycii 42-46 part, Rhizoma Pinelliae 2-6 part, Radix Angelicae Dahuricae 3-7 part, Camphora 14-17 part, ghost head 10- 12 parts, Cortex Lycii 33-36 part and Stigma Maydis 12-18 part.

4th embodiment, is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 10 parts, the Radix Astragali 4 parts, Pericarpium Citri Reticulatae 25 parts, Bulbus Fritillariae Uninbracteatae 12 parts, Fructus Evodiae 44 parts, Bulbus Allii Macrostemonis 6 parts, Cortex Cinnamomi 16 parts, Radix Codonopsis 42 parts, Radix Aconiti Lateralis Preparata 9 parts, Semen Coicis 23 parts, Flos Caryophylli 3 parts, 9 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 5 parts, fragrant 10 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Raphani 8 parts and Herba Schizonepetae 5 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 12 parts, Semen Cassiae 7 parts, Fructus Crataegi 23 parts, Flos Chrysanthemi 10 parts, Endothelium Corneum Gigeriae Galli 35 parts, fourth Power 6 parts, Cortex Lycii 44 parts, the Rhizoma Pinelliae 4 parts, the Radix Angelicae Dahuricae 5 parts, Camphora 15 parts, ghost 11 parts, Cortex Lycii 34 parts and Stigma Maydis 15 parts.

5th embodiment, is set to include traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 10 parts, the Radix Astragali 5 parts, Pericarpium Citri Reticulatae 30 parts, Bulbus Fritillariae Uninbracteatae 11 parts, Fructus Evodiae 43 parts, Bulbus Allii Macrostemonis 7 parts, Cortex Cinnamomi 17 parts, Radix Codonopsis 41 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 25 parts, Flos Caryophylli 3 parts, 9 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 3 parts, fragrant 11 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Raphani 8 parts and Herba Schizonepetae 6 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 11 parts, Semen Cassiae 8 parts, Fructus Crataegi 21 parts, Flos Chrysanthemi 13 parts, Endothelium Corneum Gigeriae Galli 36 parts, fourth Power 8 parts, Cortex Lycii 45 parts, the Rhizoma Pinelliae 3 parts, the Radix Angelicae Dahuricae 4 parts, Camphora 16 parts, ghost 10 parts, Cortex Lycii 34 parts and Stigma Maydis 12 parts.

Clinical case is tested

1, sampling approach

It is diagnosed as the patient of kleine-Levin syndrome over nearly 10 years from institute of traditional Chinese medicine of Dongping County of Shandong Province, randomly selects 40 example patients, wherein, male 20 examples, female 20 example, age 12-50 year, clinical symptoms shows themselves in that periodically, ictal addicted to Sleep, pathologic is voracious and emotion, dystropy, neurolysis, the most drowsiness lazy speech, aversion to cold and cold limbs, and complexion is white all of a sudden, forgetful, quiet Crouch and be not tired of, big loose stool.It is randomly divided into matched group and treatment group, often organizes each 20 people.The data such as two groups of ages there was no significant difference, tool There is comparability.

2, test method

2.1 matched group patients take main formula Fuzi Lizhong Wan plus-minus.It is decocted in water for oral dose.By specification is taken, 20 days courses for the treatment of.

2.2 treatment groups are administered orally the present invention according to being embodied as traditional Chinese medicine reagent I and traditional Chinese medicine reagent II is decocted in water for oral dose, early, middle and late The most once.It within 10 days, it is 1 course for the treatment of, totally 3 courses for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterions of therapeutical effect:

Clinical recovery: the clinical symptoms of disorders of excessive sleepiness, sign disappear or substantially disappear；Effective: the clinical symptoms of disorders of excessive sleepiness, body Levy and be obviously improved；Effective: the clinical symptoms of disorders of excessive sleepiness, sign all take a favorable turn；Invalid: the clinical symptoms of disorders of excessive sleepiness, sign All it is not improved or increases the weight of.

3.2 therapeutic outcomes: in treatment group 20 example, clinical recovery 15 example (75%), effective 3 examples (15%), effective 2 examples (10%), invalid 0 example;In matched group 20 example, clinical recovery 8 example (40%), effective 3 examples (15%), effective 2 examples (10%), invalid 7 examples (35%).Two groups of differences statistically significant (P < 0.01), treatment group is more than matched group.Result shows, the Chinese medicine composition of the present invention Thing has extremely significant curative effect to treating drowsiness patient.

As can be seen here, use the present invention prescription prepare medicine can safely and effectively the drowsiness voracity for the treatment of cycle comprehensive Levy.

The model case of the 5th embodiment:

Liu, man, 17 years old, high school student, see that its spirit is seemingly slept like bright, mesh is stayed without language, checks diagnosis through The Central Hospital of Taian For neurasthenia.After taking Western medicine 7 days, do not feel any better, increase the weight of the most drowsiness on the contrary, anorexia, within three days, do not defecate, urine Huang Chi, dark tongue quality, tongue is the thickest greasy.Taking Chinese medicine composition of the present invention 7, drowsiness symptom alleviates, and every day, three meals can be on time Eating, following the service Chinese medicine composition of the present invention 15 days, symptom significantly improves.Following the service Chinese medicine composition of the present invention 2 months, the most extensive Answer normal, followed up a case by regular visits to after 1 year, without recurrence, there is good therapeutic effect.

Above-described embodiment is the traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle provided by the present invention A kind of way of realization, according to other deformation of scheme provided by the present invention, increases or reduces composition therein or step, or The present invention is used for other the technical field close with the present invention by person, belongs to protection scope of the present invention.

Claims (2)

1. for a traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle, it is characterized in that: be set to include Chinese medicine examination Agent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 9-11 part, Radix Astragali 2-6 part, Pericarpium Citri Reticulatae 20-31 part, Bulbus Fritillariae Uninbracteatae 11-14 part, Wu Zhu Cornel 42-46 part, Bulbus Allii Macrostemonis 4-8 part, Cortex Cinnamomi 15-18 part, Radix Codonopsis 40-45 part, Radix Aconiti Lateralis Preparata 9-10 part, Semen Coicis 20-27 part, Flos Caryophylli 2-5 part, Radix Glycyrrhizae 8-10 part, Fructus Ligustri Lucidi 3-7 part, fragrant Cortex cinnamomi japonici (Ramulus Cinnamomi) 8-12 part, Semen Raphani 7-9 part and Herba Schizonepetae 3-8 part,

Traditional Chinese medicine reagent II is set to include Semen Raphani 10-14 part, Semen Cassiae 5-9 part, Fructus Crataegi 20-26 part, Flos Chrysanthemi 8-13 part, chicken Endothelium corneum 33-37 part, Semen Lepidii (Semen Descurainiae) 4-9 part, Cortex Lycii 42-46 part, Rhizoma Pinelliae 2-6 part, Radix Angelicae Dahuricae 3-7 part, Camphora 14-17 part, ghost head 10- 12 parts, Cortex Lycii 33-36 part and Stigma Maydis 12-18 part.

Traditional Chinese medicine reagent for the drowsiness voracious syndrome for the treatment of cycle the most according to claim 1, is characterized in that: arrange For including traditional Chinese medicine reagent I and traditional Chinese medicine reagent II, wherein: according to weight proportion,

Traditional Chinese medicine reagent I is set to include Radix Calystegiae sepii 10 parts, the Radix Astragali 5 parts, Pericarpium Citri Reticulatae 30 parts, Bulbus Fritillariae Uninbracteatae 11 parts, Fructus Evodiae 43 parts, Bulbus Allii Macrostemonis 7 parts, Cortex Cinnamomi 17 parts, Radix Codonopsis 41 parts, Radix Aconiti Lateralis Preparata 10 parts, Semen Coicis 25 parts, Flos Caryophylli 3 parts, 9 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 3 parts, fragrant 11 parts of Cortex cinnamomi japonici (Ramulus Cinnamomi), Semen Raphani 8 parts and Herba Schizonepetae 6 parts,

Traditional Chinese medicine reagent II is set to include Semen Raphani 11 parts, Semen Cassiae 8 parts, Fructus Crataegi 21 parts, Flos Chrysanthemi 13 parts, Endothelium Corneum Gigeriae Galli 36 parts, fourth Power 8 parts, Cortex Lycii 45 parts, the Rhizoma Pinelliae 3 parts, the Radix Angelicae Dahuricae 4 parts, Camphora 16 parts, ghost 10 parts, Cortex Lycii 34 parts and Stigma Maydis 12 parts.