CN106038477A - Method for preparing vagina gel containing tioconazole - Google Patents
Method for preparing vagina gel containing tioconazole Download PDFInfo
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- CN106038477A CN106038477A CN201610412369.2A CN201610412369A CN106038477A CN 106038477 A CN106038477 A CN 106038477A CN 201610412369 A CN201610412369 A CN 201610412369A CN 106038477 A CN106038477 A CN 106038477A
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- tioconazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a method for preparing a vagina gel containing tioconazole. The particle size of tioconazole is regulated to a designated scope so as to promote a medicine release effect of tioconazole; water is added to hydroxyethyl cellulose and hydroxyethyl cellulose is heated to manufacture a gel substrate; and a catechin component is added. The retention effect in the vagina is good when the gel is used, there is no foreign body sensation in the vagina, medicines are release completely and are easy to clean, clothes are not polluted easily, patients' medicine using compliance can be improved, and a cellulose material is unfavorable for growth of various pathogenic bacteria.
Description
Technical field
The invention belongs to field of medicaments, relate to the preparation method of a kind of vagina gel containing tioconazole.
Background technology
Tioconazole, chemistry entitled 1,2-(2-chloro-3-thienyl) methoxyl group-2-(double chlorphenyl) ethyl-1H-imidazoles, be
The imidazoles antifungal agent of a new generation, strong drug action, has a broad antifungal spectrum.The compound that Pfizer proposed tioconazole in 1975 is special
Profit application, Patent No. MS4062966；The patent of tioconazole compositions has been applied for again in 1985, Patent No. MS717423,
This patent relate to the oral tablet of 100mg, the emulsifiable paste of 1% and 2% content, the ointment of 6.5% and the vaginal tablet of 100mg；In 1986
On December 30, the tioconazole vaginal ointments (trade name VAGISTAT) of Pfizer's local tioconazole 6.5% passes through
FDA new drug certification (NDA19 ~ 355), the prescription of this ointment is by white vaseline (white, soft paraffin), aluminium-magnesium silicate
(aluminum magnesium silicate) and butylated hydroxyanisole (BHA) (BHA) form.
Patent CN101057844A, CN1630509A and CN102462658A disclose a kind of vagina containing tioconazole
Using ointment machin its preparation method, the substrate of ointment is made up of oleaginous bases such as vaseline, but at vagina when oiliness ointment uses
Interior anelasticity pollution clothes poor, easy.
Application number CN102123736A discloses the pharmaceutical composition of a kind of antibacterial and prebiotics to monilial vagina
Scorching Therapeutic Method, and disclose a kind of gel containing tioconazole, have employed lactulose, oligosaccharide, oligomeric galactose, gather
The oligosaccharides gel rubber materials such as xylose, are simultaneously introduced probiotic bacteria, utilize oligosaccharide to promote the growth of probiotic bacteria；The shortcoming of this invention
Impurity for oligosaccharide and other sugar therein can promote the growth of other pathogenic microorganism.
Summary of the invention
The invention provides the preparation method of a kind of vagina gel containing tioconazole, this preparation method uses ethoxy
Cellulose adds water heated gel-type vehicle of making, and by tioconazole size controlling to appointment scope, and adds the catechin of 1ppm,
Promote the absorption of medicine, improve the stability of medicine.When gel prepared by this preparation method uses, intravaginal retention effect is good,
Intravaginal foreign sense, release completely, are easily cleaned, are difficult to pollution clothes, can improve the medication compliance of patient, and catechu
Element and cellulose material are unfavorable for the growth of all kinds of pathogenic bacterium.
The invention provides the preparation method of a kind of vagina gel containing tioconazole, carry out in accordance with the following steps:
1) by tioconazole raw material pulverizing to particle diameter less than 40 μm, by catechin raw material pulverizing to particle diameter less than 100 μm；
2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 1 ~ 5 ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, it is molten that preparation obtains gel-type vehicle
Liquid；
3) purified water of residue recipe quantity being heated to 60-70 DEG C, add the tioconazole after step (1) is pulverized, dispersed with stirring is equal
Even, preparation obtains pastille feed liquid；
4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
In preferred embodiments, in described step 1), tioconazole particle size range is 20 ~ 35 μm.
In preferred embodiments, 1-40 weight portion pharmaceutically acceptable can also be added in described step 3) increase
Solvent；
In an even more preferred embodiment, 5-30 weight portion pharmaceutically acceptable solubilising can also be added in described step 3)
Agent；
In an even more preferred embodiment, described step 3) can also add 0.05-1 weight portion pharmaceutically acceptable to press down
Microbial inoculum.
In an even more preferred embodiment, described step 3) can also add 0.1-1 weight portion pharmaceutically can accept
Antibacterial.
In an even more preferred embodiment, described solubilizing agent is sorbester p17, octanoic acid certain herbaceous plants with big flowers acid glyceride (Labrasol), diethyl
Glycol list ethyletherOne or more in M1944CS.
In an even more preferred embodiment, described antibacterial is Benzalkonii Chloridum, benzalkonium bromide, thimerosal, chlorobutanol
With one or more in sorbic acid.
The present invention provides the preparation method of another kind of tioconazole vaginal jellies, and it includes step:
(1) by tioconazole raw material pulverizing to 20 ~ 35 μm；By catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 1 ~ 5 ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, it is molten that preparation obtains gel-type vehicle
Liquid；
(3) purified water of residue recipe quantity being heated to 60-70 DEG C, add the tioconazole after step (1) is pulverized, dispersed with stirring is equal
Even, preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
The pharmaceutically acceptable solubilizing agent of 1-40 weight portion can also be added in described step (3)；
0.05-1 weight pharmaceutically acceptable antibacterial can also be added in described step (3).
A kind of vagina gel prepared by any of the above-described method.
Detailed description of the invention
" scope " disclosed herein is with lower limit and the form of the upper limit.One or more lower limit, and one can be respectively
Or the multiple upper limit.Given range is defined by a selected lower limit and a upper limit.Selected lower limit and upper limit limit
Determine the border of special scope.All scopes that can be defined by this way comprise and can be combined, the most any lower limit
A scope can be formed with the combination of any upper limit.Such as, list the scope of 60-120 and 80-110 for special parameter,
It is interpreted as that the scope of 60-110 and 80-120 also expects.If additionally, the minimum zone value 1 and 2 listed, and if
List maximum magnitude value 3,4 and 5, then scope below can all expect: 1-3,1-4,1-5,2-3,2-4 and
2-5.
In the present invention, unless otherwise indicated, between content range and its preferred scope of each component of compositions
Can be mutually combined and form new technical scheme.
In the present invention, unless otherwise indicated, " a combination thereof " represents the multicomponent mixture of described each element, such as two
Kind, three kinds, four kinds and until the multicomponent mixture of maximum possible.
In the present invention, unless otherwise indicated, all " part " and percent (%) all refers to percetage by weight.
In the present invention, unless otherwise indicated, in all compositionss, the percent sum of each component is 100%.
In the present invention, unless otherwise indicated, numerical range " a-b " represents the contracting of any real combinings between a to b
Sketch form shows, wherein a and b is real number.Such as numerical range " 0-5 " expression the most all lists between " 0-5 "
All real numbers, " 0-5 " is that the breviary of these combinations of values represents.
In the present invention, unless otherwise indicated, integer numerical range " a-b " represents the arbitrary integer combination between a to b
Breviary represent, wherein a and b is integer.Such as integer numerical range " 1-N " represents 1,2 ... N, wherein N is integer.
Without particularly pointing out, the term " a kind of " used by this specification refers to " at least one ".
Without particularly pointing out, the benchmark of percent of the present invention (including percetage by weight) is all described combination
The gross weight of thing.
In this article, except as otherwise noted, ratio or the weight of each component all refers to dry weight.
In the present invention, without particularly explanation, all embodiments mentioned in this article and the side of being preferable to carry out
Formula can be mutually combined and form new technical scheme.
In the present invention, without particularly explanation, all technical characteristics mentioned in this article and preferred feature can
New technical scheme is formed to be mutually combined.
In the present invention, without particularly explanation, mentioned in this article can sequentially carry out in steps, it is also possible to
Carry out at random, but the most sequentially carry out.Such as, described method includes step (a) and (b), represents that described method can be wrapped
Include step (a) and (b) that order is carried out, it is also possible to include step (b) and (a) sequentially carried out.Such as, described side is mentioned described in
Method may also include step (c), represents that step (c) can join described method with random order, and such as, described method can include
Step (a) and (b) and (c), it is possible to include step (a), (c) and (b), it is also possible to include step (c), (a) and (b) etc..
In the present invention, without particularly explanation, " including " mentioned in this article represents open, it is also possible to be envelope
Enclosed.Such as, described " including " can expression can also comprise other elements do not listed, it is also possible to only includes the unit listed
Part.
The invention provides the preparation method of a kind of vagina gel containing tioconazole, carry out in accordance with the following steps:
1) by tioconazole raw material pulverizing to particle diameter less than 40 μm；
2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin of 1 ~ 5 ppm, be heated to 60-70 DEG C of stirring and dissolving, preparation obtains gel-type vehicle solution；
3) purified water of residue recipe quantity being heated to 60-70 DEG C, add the tioconazole after step (1) is pulverized, dispersed with stirring is equal
Even, preparation obtains pastille feed liquid；
4) the pastille feed liquid step 3) joined adds to step 2) the gel-type vehicle solution prepared collects, stirs,
It is cooled to room temperature；
5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
In a preferred embodiment, in described step 1), tioconazole particle size range is 20 ~ 35 μm.
In a preferred embodiment, 1-40 weight portion pharmaceutically acceptable solubilising can also be added in described step 3)
Agent；
In more preferred embodiment, described step 3) can also add 5-30 weight portion pharmaceutically acceptable solubilising
Agent；
In more preferred embodiment, described step 3) can also add 0.05-1 weight portion pharmaceutically acceptable antibacterial
Agent.
In more preferred embodiment, method as claimed in claim 5, it is characterised in that: also may be used in described step 3)
To add 0.1-1 weight portion pharmaceutically acceptable antibacterial.
In more preferred embodiment, described solubilizing agent is sorbester p17, octanoic acid certain herbaceous plants with big flowers acid glyceride (Labrasol), diethyl two
Alcohol list ethyletherOne or more in M1944CS.
In more preferred embodiment, described antibacterial be Benzalkonii Chloridum, benzalkonium bromide, thimerosal, chlorobutanol and
One or more in sorbic acid.
The invention provides a kind of method preparing tioconazole gel, it includes step:
(1) it is 20 ~ 35 μm by tioconazole raw material pulverizing to particle size range, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 1 ~ 5 ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, it is molten that preparation obtains gel-type vehicle
Liquid；
(3) purified water of residue recipe quantity being heated to 60-70 DEG C, add the tioconazole after step (1) is pulverized, dispersed with stirring is equal
Even, preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
In a preferred embodiment, 1-40 weight portion pharmaceutically acceptable can also be added in described step (3) increase
Solvent；
In more preferred embodiment, described step (3) can also add 0.05-1 weight portion pharmaceutically acceptable and press down
Microbial inoculum.
Further describe the present invention below by specific embodiment, but do not limit the scope of the invention.
Embodiment 1
The prescription of tioconazole vaginal jellies 1
| Preparation prescription forms | Component content in every 100 grams of gels |
| Tioconazole | 6.5 gram |
| Hydroxyethyl cellulose | 10 grams |
| Catechin | 1ppm |
| Purified water | Add to 100 grams |
Preparation process:
(1) it is 40 μm by tioconazole raw material pulverizing to particle diameter, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 1ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, preparation obtains gel-type vehicle solution；
(3) it is heated to after 60-70 DEG C adding the tioconazole after step (1) is pulverized, dispersed with stirring by the purified water of residue recipe quantity
Uniformly, preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
Embodiment 2
The prescription of tioconazole vaginal jellies
Preparation method
(1) it is 35 μm by tioconazole raw material pulverizing to particle diameter, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 2ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, preparation obtains gel-type vehicle solution；
(3) purified water of residue recipe quantity is heated to 60-70 DEG C, adds the TC of recipe quantityAdding the tioconazole after step (1) is pulverized after stirring and dissolving, dispersed with stirring is uniform, and preparation obtains containing spice
Liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
Embodiment 3
The prescription of tioconazole vaginal jellies 3
(1) by tioconazole raw material pulverizing to particle diameter 20 μm, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 4ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, preparation obtains gel-type vehicle solution；
(3) purified water of residue recipe quantity is heated to 60-70 DEG C, adds the TC of recipe quantityWith sad certain herbaceous plants with big flowers acid glyceride (Labrasol) stirring and dissolving of recipe quantity, add step (1) pulverize after
Tioconazole, dispersed with stirring is uniform, and preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
Embodiment 4
The prescription of tioconazole vaginal jellies 4
Preparation method:
(1) it is 30 μm by tioconazole raw material pulverizing to particle diameter, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 5ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, preparation obtains gel-type vehicle solution；
(3) purified water of residue recipe quantity is heated to 60-70 DEG C, adds the TC of recipe quantityThe sad certain herbaceous plants with big flowers acid glyceride (Labrasol) of recipe quantity and the Benzalkonii Chloridum stirring and dissolving of recipe quantity, then add
Entering the tioconazole after step (1) is pulverized, dispersed with stirring is uniform, and preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
By aseptic experiment, Example 1 ~ 4 sample spreads upon in LB culture medium, cultivates 24h, does not finds that visible colonies is raw
Long.Example 1 ~ 4 sample is placed on simulated humanbody skin, after 3 ~ 10 hours, in different time points different parts sampling ginseng
According to Tioconazole Cream detection method of content in British Pharmacopoeia BP2013, detecting through HPLC, the skin surface of tioconazole is residual
Stay percentage rate prolongation in time and gradually decrease；And find that its retention performance is effective compared with conventional gel；Institute of the present invention is described
External residual quantity after gel topical is provided, can be as the reference of research body absorption amount.In experimentation, invention
People finds that this gel also has easily cleaning, is difficult to the characteristic of pollution clothes.
The foregoing is only presently preferred embodiments of the present invention, be not limited to the substantial technological content model of the present invention
Enclosing, the substantial technological content of the present invention is broadly to be defined in the right of application, any technology that other people complete
Entity or method, if with the right of application defined in identical, also or the change of a kind of equivalence, all by
It is considered to be covered by among this right.
The all documents mentioned in the present invention are incorporated as reference the most in this application, just as each document by individually
It is incorporated as with reference to like that.In addition, it is to be understood that after the foregoing having read the present invention, those skilled in the art can be right
The present invention makes various changes or modifications, and these equivalent form of values fall within the application appended claims limited range equally.
Claims (9)
1. the preparation method of vagina gel containing tioconazole, it is characterised in that described method includes step:
(1) by tioconazole raw material pulverizing to particle diameter less than 40 μm, by catechin raw material pulverizing to particle diameter less than 100 μm；
(2) adding the hydroxyethyl cellulose of recipe quantity in the purified water of recipe quantity 30-50%, 20-25 DEG C of abundant moistening is swelling
After, adding the catechin after 1～5ppm step (1) is pulverized, be heated to 60-70 DEG C of stirring and dissolving, it is molten that preparation obtains gel-type vehicle
Liquid；
(3) purified water of residue recipe quantity being heated to 60-70 DEG C, add the tioconazole after step (1) is pulverized, dispersed with stirring is equal
Even, preparation obtains pastille feed liquid；
(4) pastille feed liquid step (3) joined adds the gel-type vehicle solution prepared to step (2) and collects, and stirring is all
Even, it is cooled to room temperature；
(5) fill is in vagina administration apparatus, seals, obtains tioconazole vaginal jellies.
2. the method for claim 1, it is characterised in that: in described step (1), tioconazole particle size range is 20-35 μm.
3. the method for claim 1, it is characterised in that: 1-40 weight portion medicine can also be added in described step (3)
Acceptable solubilizing agent on.
4. method as claimed in claim 3, it is characterised in that: 5-30 weight portion medicine can also be added in described step (3)
Acceptable solubilizing agent on.
5. the method for claim 1, it is characterised in that: 0.05-1 weight portion can also be added in described step (3)
Pharmaceutically acceptable antibacterial.
6. method as claimed in claim 5, it is characterised in that: 0.1-1 weight portion medicine can also be added in described step (3)
Acceptable antibacterial on.
7. the method as described in claim 3 or 4, it is characterised in that: described solubilizing agent is sorbester p17, octanoic acid certain herbaceous plants with big flowers acid glyceride
(Labrasol), TC (P TC),In M1944CS
One or more.
8. the method as described in claim 5 or 6, it is characterised in that: described antibacterial is Benzalkonii Chloridum, benzalkonium bromide, sulfur
One or more in willow hydrargyrum, chlorobutanol and sorbic acid.
9. the vagina gel prepared by method described in any claim in claim 1～6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610412369.2A CN106038477A (en) | 2016-06-14 | 2016-06-14 | Method for preparing vagina gel containing tioconazole |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610412369.2A CN106038477A (en) | 2016-06-14 | 2016-06-14 | Method for preparing vagina gel containing tioconazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106038477A true CN106038477A (en) | 2016-10-26 |
Family
ID=57170922
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610412369.2A Pending CN106038477A (en) | 2016-06-14 | 2016-06-14 | Method for preparing vagina gel containing tioconazole |
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| Country | Link |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1726032A (en) * | 2002-12-18 | 2006-01-25 | 菲尔若国际公司 | Pharmaceutical compositions of sertaconazole for vaginal use |
| CN1832760A (en) * | 2003-08-08 | 2006-09-13 | 米法有限公司 | Bioadhesive gel based on hydroxyethylcellulose |
| CN101721353A (en) * | 2009-07-08 | 2010-06-09 | 济南宏瑞创博医药科技开发有限公司 | Stable thermosensitive gelatin composite |
| CN105232526A (en) * | 2015-10-15 | 2016-01-13 | 王孝仓 | Application of medicine containing catechin to preparation of antibacterial medicines |
-
2016
- 2016-06-14 CN CN201610412369.2A patent/CN106038477A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1726032A (en) * | 2002-12-18 | 2006-01-25 | 菲尔若国际公司 | Pharmaceutical compositions of sertaconazole for vaginal use |
| CN1832760A (en) * | 2003-08-08 | 2006-09-13 | 米法有限公司 | Bioadhesive gel based on hydroxyethylcellulose |
| CN101721353A (en) * | 2009-07-08 | 2010-06-09 | 济南宏瑞创博医药科技开发有限公司 | Stable thermosensitive gelatin composite |
| CN105232526A (en) * | 2015-10-15 | 2016-01-13 | 王孝仓 | Application of medicine containing catechin to preparation of antibacterial medicines |
Non-Patent Citations (1)
| Title |
|---|
| 崔德福: "《药剂学》", 30 November 2006 * |
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Application publication date: 20161026 |
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