CN106037617A - Endoscope probe and novel inherent fluorescence tumor diagnostic apparatus - Google Patents
Endoscope probe and novel inherent fluorescence tumor diagnostic apparatus Download PDFInfo
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- CN106037617A CN106037617A CN201610618392.7A CN201610618392A CN106037617A CN 106037617 A CN106037617 A CN 106037617A CN 201610618392 A CN201610618392 A CN 201610618392A CN 106037617 A CN106037617 A CN 106037617A
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- Prior art keywords
- fluorescence
- tumor
- light output
- probe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/303—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the vagina, i.e. vaginoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
- A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
Abstract
The invention provides an endoscope probe. The endoscope probe comprises a light-guide fiber probe. A camera shooting channel, a fluorescence-excited light output channel, a white light output channel and a biopsy channel are arranged in the light-guide fiber probe. A camera is installed in the camera shooting channel, and a white light source is installed in the white light output channel. A camera signal output port, a fluorescence-excited light output interface, a power interface and a biopsy channel inlet are formed in the rear end of the light-guide fiber probe. Novel inherent fluorescence tumor diagnostic apparatus comprises the endoscope probe and a base. A displayer is arranged on the upper surface of the base, an inherent fluorescence generator and a fluorescence-excited light output end are arranged on the side face of the base, the fluorescence-excited light output interface is connected with the fluorescence-excited light output end, and the camera signal output port is connected with the displayer through a guide wire. According to the diagnostic apparatus, a former diagnosis method is abandoned, through perfect combination with a hysteroscope, precancerous lesions can be diagnosed earlier, and precancerous lesion tissue can be accurately found and taken out through the biopsy channel.
Description
Technical field
The present invention relates to Medical Instruments, be specifically related to a kind of endoscopic probe and novel primary fluorescence diagnostic meter for tumor.
Background technology
The material particle that a kind of human normal tissue is comprised from abnormal structure is different, and different material particle produces under fluorescence
By different color and lusters, the fluorescence of raw different color and luster, i.e. can determine whether whether tested tissue has pathological changes, before early discovery tumor or cancer
Pathological changes (such as CIN I CIN II).Instruct biopsy to position, find pathological changes when the non-ulceration of mucosa.Primary fluorescence is with molecular biosciences
The angle learned is by microscopic lesions macroscopic view.
Original primary fluorescence diagnostic meter for tumor diagnostic method (Patent No. 02112880.4) is that this is for cervix uteri table
The examination of the mucosal pattern tumor such as face, vagina, and have ignored the pathological changes such as cervix uteri, uterine cavity and have the possibility cancerated.If there being long-term uterus
The damage of neck, broken skin, erosion, inflammation, all may be changed into uterine cancer cells in early days.Pathological tissues is diffused into downwards from uterus
Cervical canal, diffuses upward into ovary from fallopian tube；Periuterine tissue can also be infiltrated；Or by lymphsystem and blood
Loop jump is to the position away from uterus.
Summary of the invention
According to the deficiencies in the prior art, it is provided that a kind of endoscopic probe and novel primary fluorescence diagnostic meter for tumor, this diagnosis
Instrument abandon before diagnostic method, utilize and the perfect adaptation of hysteroscope, it is possible to earlier be diagnosed to be precancerous lesion, it is possible to accurately
Find out Precancerous Lesion and take out pathological tissues by biopsy channel.
The present invention is realized by techniques below scheme:
A kind of endoscopic probe, including Fiber Optic Probe, is provided with shooting passage, fluorescent exciting in described Fiber Optic Probe
Output channel, white light output channel and biopsy channel, be provided with video camera in shooting passage, be provided with in white light output channel
White light source；The rear end of described Fiber Optic Probe is provided with camera signal delivery outlet, fluorescent exciting output interface, power supply connect
Mouth and biopsy channel entrance.
Preferably, described video camera uses the video camera being not less than 795*596 pixel.
Preferably, the rear end of described Fiber Optic Probe is additionally provided with light-control knob, it is possible to according to detection environment or quilt
Inspection lesions position clinic needs to regulate the intensity of fluorescent exciting.
A kind of novel primary fluorescence diagnostic meter for tumor, including a kind of endoscopic probe described in claim 1, this diagnostic apparatus
Including support, described frame upper surface is provided with display, and the side of described support is provided with primary fluorescence generator and fluorescence
Exciting light outfan, described fluorescent exciting output interface is connected with fluorescence excitation light output end by optical fibers, described
Camera signal delivery outlet is connected with display by wire.
Preferably, described primary fluorescence generator includes that housing, described enclosure interior are spaced setting the most successively
There are filter lens, condenser lens, mercury lamp, reflector and axial blower fan, described filter lens, condenser lens, mercury lamp, reflector and axial blower fan
Centrage on the same line.
Preferably, the right side of described condenser lens is provided with prefocus cup, and prefocus cup is solid with condenser lens by condenser lens fastener
It is scheduled on together.
Preferably, fibre-optical probe adapter it is provided with on the left of filter lens.
Preferably, described filter lens is 66mm with the distance of condenser lens, and condenser lens is 48.38mm with the distance of mercury lamp,
Mercury lamp is 38.43mm with the distance of reflector.
Preferably, the focal length of described condenser lens is 66mm.
Preferably, described filter lens employing specification is: 18x2mm, model is L-365 filter lens, and optical filtering degree is
365nm。
The method have the benefit that
(1) fluorescent exciting is transmitted to lesions position by original primary fluorescence external Fiber Optic Probe of infantile tumour diagnostic apparatus,
Observe vagina by electronic colposcope camera system and whether the tested tissue of cervical surface has pathological changes, before early discovery tumor or cancer
Pathological changes, and have ignored the pathological changes such as cervix uteri, uterine cavity and have the possibility cancerated.
(2) novel primary fluorescence diagnostic meter for tumor by fluorescent exciting and Hysteroscopy as system perfect adaptation, not only
Vagina and cervical surface preferably can be diagnosed and early discovery tumor internal to the uterus such as cervix uteri, uterine cavity or precancerosis
Become.
(3) novel primary fluorescence diagnostic meter for tumor is by perfect adaptations one such as fluorescent exciting, biopsy channel, camera systems
Body.
(4) if having long-term Cervical damage, broken skin, erosion, inflammation, uterine cancer cells in early days may be all changed into.
Pathological tissues is diffused into downwards cervical canal from uterus, diffuses upward into ovary from fallopian tube；Periuterine can also be infiltrated
Tissue；Or transfer to the position away from uterus by lymphsystem and blood circulation, the primary fluorescence tumor novel by this is examined
Disconnected instrument can be diagnosed to be precancerous lesion earlier, utilizes this instrument to find out Precancerous Lesion accurately and is led to by this equipment biopsy
Road takes out pathological tissues.
(5) novel primary fluorescence infantile tumour diagnostic apparatus has dimming function, can be according to detection environment or tested focus
Position clinic needs to regulate the intensity of fluorescent exciting, and detection thus can be made more convenient more accurate.
Accompanying drawing explanation
Fig. 1 is the endoscopic probe structural profile schematic diagram in the present invention；
Fig. 2 is the novel primary fluorescence diagnostic meter for tumor structural representation in the present invention；
Fig. 3 is the primary fluorescence generator architecture generalized section in the present invention；
In figure: 1 Fiber Optic Probe, 2 shooting passages, 2-1 video camera, 3 fluorescent exciting output channels, 4 is white
Light output channel, 4-1 white light source, 5 biopsy channels, 6 camera signal delivery outlets, 7 fluorescent exciting output interfaces,
8 power interfaces, 9 biopsy channel entrances, 10 light-control knobs, 100 supports, 101 display, 200 primary fluorescences
Generator, 201 housings, 202 filter lenss, 203 condenser lenss, 204 mercury lamps, 205 reflectors, 206 prefocus cups,
207 condenser lens fasteners, 208 axial blower fans, 209 fibre-optical probe adapters, 300 fluorescence excitation light output ends.
Detailed description of the invention
It is described in further detail below in conjunction with the accompanying drawings and preferred embodiment to the present invention.Claim is constituted and wants
In part and embodiment, the corresponding relation between instantiation can be exemplified below.Here description is intended to confirm in embodiment
In describe for supporting the instantiation of theme stated in the claims, owing to describing example in an embodiment, no
Mean that this instantiation does not indicates that constitutive requirements.Even if on the contrary, containing instantiation at this as a corresponding composition
The element characteristic of important document, does not means that this instantiation does not indicates that other constitutive requirements any yet.
Additionally, description here does not means that corresponding to all themes of the instantiation of statement in embodiment all in right
Requirement refer to.In other words, this entity is not denied in description here, the instantiation that i.e. corresponding embodiment comprises, but
Be not included in its any one claim, i.e. can afterwards revise by division and apply for or increase may invent
Entity.
Embodiment one:
As it is shown in figure 1, a kind of endoscopic probe, including Fiber Optic Probe 1, be provided with in Fiber Optic Probe 1 shooting passage 2,
Fluorescent exciting output channel 3, white light output channel 4 and biopsy channel 5, be provided with video camera 2-1, in vain in shooting passage 2
White light source 4-1 is installed in light output channel 4；The rear end of Fiber Optic Probe 1 is provided with camera signal delivery outlet 6, fluorescence
Exciting light output interface 7, power interface 8 and biopsy channel entrance 9.
Video camera 2-1 uses the video camera being not less than 795*596 pixel.
The rear end of Fiber Optic Probe 1 is additionally provided with light-control knob 10, it is possible to according to detection environment or tested lesions position
The clinical intensity needing to regulate fluorescent exciting.
Embodiment two:
As shown in Figure 1, Figure 2, Figure 3 shows, a kind of novel primary fluorescence diagnostic meter for tumor, this diagnostic apparatus includes support 100, support
100 upper surfaces are provided with display 101, and the side of support 100 is provided with primary fluorescence generator 200 and fluorescent exciting output
End 300, primary fluorescence generator 200 includes housing 201, and housing 201 is internal is sequentially arranged at intervals with filter lens from left to right
202, condenser lens 203, mercury lamp 204, reflector 205 and axial blower fan 208, filter lens 202, condenser lens 203, mercury lamp 204, reflective
The centrage of cup 205 and axial blower fan 208 is on the same line.The right side of condenser lens 203 is provided with prefocus cup 206, prefocus cup 206
It is fixed together with condenser lens 203 by condenser lens fastener 207.Fibre-optical probe adapter 209 it is provided with on the left of filter lens 202.
Filter lens 202 is 66mm with the distance of condenser lens 203, and condenser lens 203 is 48.38mm with the distance of mercury lamp 204, mercury lamp 204 with
The distance of reflector 205 is 38.43mm.The focal length of condenser lens 203 is 66mm.Filter lens 202 uses specification: 18x2mm, model
For L-365 filter lens, optical filtering degree is 365nm.
A kind of endoscopic probe, including Fiber Optic Probe 1, is provided with shooting passage 2, fluorescence swashs in Fiber Optic Probe 1
Luminous output channel 3, white light output channel 4 and biopsy channel 5, be provided with video camera 2-1 in shooting passage 2, and white light exports
White light source 4-1 is installed in passage 4；The rear end of Fiber Optic Probe 1 is provided with camera signal delivery outlet 6, fluorescent exciting
Output interface 7, power interface 8 and biopsy channel entrance 9.
Fluorescent exciting output interface 7 is connected with fluorescence excitation light output end 300 by optical fibers, camera signal
Delivery outlet 6 is connected with display 101 by wire.
Work process:
During inspection, by Fiber Optic Probe 1 in the case of white light provides illumination, put into uterus by vagina, cervix uteri, now close
Close white light to switch to fluorescent state and utilize fluorescent exciting output channel 3 can penetrate 2mm under mucosa, the disease as deep as 2mm can be detected
Stove is observed in uterine cavity, and fluorescent exciting is transmitted to the lesions position range size according to diseased region by optical fibers
Can be regulated the power of fluorescence by light-control knob 10, the material particle comprised from abnormal structure because of human normal tissue is different,
Different material particle produces the fluorescence of different color and luster under fluorescence, i.e. can determine whether that tested tissue is the most ill by different color and lusters
Become, early discovery tumor or precancerous lesion (such as CIN I CIN II), find pathological changes when the non-ulceration of mucosa, can intuitively find:
Tumor or precancerous lesion, abnormal uterine bleeding, submucosal myoma of uterus, endometrial polyp etc. use digital camera technology to make
Lens shooting to image conducted by optical fibers, and show in real time in monitor screen.And by biopsy channel entrance 9 profit
Take or pathological tissues is taken out in puncture etc. from cutting the most more accurately, clamp with fluorescent exciting, carry out pathological examination, from
And improve biopsy accuracy rate.
Fluoroscopic image Differential Diagnosis standard
| The primary fluorescence color of tested tissue | Diagnosis |
| Blue and white | Negative normal structure |
| Orange colour, salmon pink | Negative benign lesion (inflammation) |
| Yellow, the bright spot of bulb sample | Negative benign lesion (Nabothian cyst) |
| Purple, atropurpureus or aubergine | Positive carcinoma tissue, precancerous lesion (CIN) |
Although illustrate and describing the present invention referring particularly to its preferred embodiment, but those skilled in the art can managing
Solve, can be to make the various changes in form and details without deviating from the scope of the present invention described in appended claims.
Specific embodiment above in association with the present invention is described in detail, but is not limitation of the present invention.Every according to the present invention
Technical spirit to any simple modification made for any of the above embodiments, all still fall within the scope of technical solution of the present invention.
Claims (10)
1. an endoscopic probe, including Fiber Optic Probe (1), it is characterised in that: described Fiber Optic Probe is provided with in (1)
Shooting passage (2), fluorescent exciting output channel (3), white light output channel (4) and biopsy channel (5), in shooting passage (2)
Video camera (2-1) is inside installed, white light source (4-1) is installed in white light output channel (4)；
The rear end of described Fiber Optic Probe (1) be provided with camera signal delivery outlet (6), fluorescent exciting output interface (7),
Power interface (8) and biopsy channel entrance (9).
A kind of endoscopic probe the most according to claim 1, it is characterised in that: described video camera (2-1) uses and is not less than
The video camera of 795*596 pixel.
A kind of endoscopic probe the most according to claim 1, it is characterised in that: the rear end of described Fiber Optic Probe (1) is also
It is provided with light-control knob (10), it is possible to need to regulate the strong of fluorescent exciting according to detection environment or tested lesions position clinic
Degree.
4. a novel primary fluorescence diagnostic meter for tumor, including a kind of endoscopic probe described in claim 1, its feature exists
In: this diagnostic apparatus includes that support (100), described support (100) upper surface are provided with display (101), described support (100)
Side is provided with primary fluorescence generator (200) and fluorescence excitation light output end (300), described fluorescent exciting output interface
(7) being connected with fluorescence excitation light output end (300) by optical fibers, described camera signal delivery outlet (6) passes through wire
It is connected with display (101).
Novel primary fluorescence diagnostic meter for tumor the most according to claim 4, it is characterised in that: described primary fluorescence occurs
Device (200) includes housing (201), and described housing (201) is internal is sequentially arranged at intervals with filter lens (202), optically focused from left to right
Mirror (203), mercury lamp (204), reflector (205) and axial blower fan (208), described filter lens (202), condenser lens (203), mercury lamp
(204), the centrage of reflector (205) and axial blower fan (208) is on the same line.
Novel primary fluorescence diagnostic meter for tumor the most according to claim 5, it is characterised in that: described condenser lens (203)
Right side be provided with prefocus cup (206), prefocus cup (206) is fixed on one by condenser lens fastener (207) and condenser lens (203)
Rise.
Novel primary fluorescence diagnostic meter for tumor the most according to claim 5, it is characterised in that: described filter lens (202)
Left side is provided with fibre-optical probe adapter (209).
Novel primary fluorescence diagnostic meter for tumor the most according to claim 5, it is characterised in that:
Described filter lens (202) is 66mm with the distance of condenser lens (203), and condenser lens (203) with the distance of mercury lamp (204) is
48.38mm, mercury lamp (204) is 38.43mm with the distance of reflector (205).
Novel primary fluorescence diagnostic meter for tumor the most according to claim 5, it is characterised in that: described condenser lens (203)
Focal length be 66mm.
Novel primary fluorescence diagnostic meter for tumor the most according to claim 5, it is characterised in that: described filter lens (202)
The specification used is: 18x2mm, model is L-365 filter lens, and optical filtering degree is 365nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610618392.7A CN106037617A (en) | 2016-08-01 | 2016-08-01 | Endoscope probe and novel inherent fluorescence tumor diagnostic apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610618392.7A CN106037617A (en) | 2016-08-01 | 2016-08-01 | Endoscope probe and novel inherent fluorescence tumor diagnostic apparatus |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107397533A (en) * | 2017-08-24 | 2017-11-28 | 生标（上海）医疗器械科技有限公司 | Height filtering strengthens fluorescence solution as diagnostic equipment |
| CN108714029A (en) * | 2018-06-12 | 2018-10-30 | 李长寿 | A kind of natural fluorscence diagnosis instrument used for diagnosising malignant tumour |
| CN108814539A (en) * | 2018-05-02 | 2018-11-16 | 河南科技大学第附属医院 | A kind of diagnostic equipment of upper gastrointestinal road tumour |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107397533A (en) * | 2017-08-24 | 2017-11-28 | 生标（上海）医疗器械科技有限公司 | Height filtering strengthens fluorescence solution as diagnostic equipment |
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| CN108714029A (en) * | 2018-06-12 | 2018-10-30 | 李长寿 | A kind of natural fluorscence diagnosis instrument used for diagnosising malignant tumour |
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Application publication date: 20161026 |