CN106008276A - Synthesis method of phenylurea herbicide or deuteration-labeled phenylurea herbicide - Google Patents
Synthesis method of phenylurea herbicide or deuteration-labeled phenylurea herbicide Download PDFInfo
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- CN106008276A CN106008276A CN201610343357.9A CN201610343357A CN106008276A CN 106008276 A CN106008276 A CN 106008276A CN 201610343357 A CN201610343357 A CN 201610343357A CN 106008276 A CN106008276 A CN 106008276A
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- C—CHEMISTRY; METALLURGY
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- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
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Abstract
The invention relates to a synthesis method of a phenylurea herbicide or a deuteration-labeled phenylurea herbicide (a compound of a formula (I)). The compound of the formula (I) is obtained by reacting a compound of a formula (II) with a dimethylamine salt or D6-dimethylamine salt in the presence of an organic base. According to the synthesis method, the side reaction of substituted phenyl isocyanate and water or alcohol is avoided, the leakage of dimethylamine or dimethylamine-D6 is reduced, and the synthesis method has the advantages of simple operation, low requirements for equipment, low cost, high yield, and fewer by-products. The formula I is shown in the description.
Description
Technical field
The invention belongs to organic synthesis field, be specifically related to the synthesis of stable isotope labelled compound, particularly relate to
A kind of synthetic method of the phenylurea analog herbicide of phenylurea analog herbicide or deuterated labelling.
Background technology
Herbicide can be divided into substituted urea class, two pyridine classes, ethers, phenyl amines, heterocyclic, benzene sulfonylurea herbicidal by chemical constitution
Agent is the most widely used phenyl ureagroup herbicides of class, and its general character is: precursor structure comprises a phenylurea molecule (formula I), when
When R1, R2, R3, R4, R5 are replaced by different groups, form different phenylurea analog herbicides.
Phenylurea analog herbicide mainly by the photosynthesis of suppression grass cutting blade reach to prevent and kill off annual gramineous weed and
The purpose of some broad leaved weed.Phenylurea analog herbicide has the advantages such as high-efficiency broad spectrum, is widely used and develops, Zi Congliu
Since the compounds such as the ten's diuron, fenuron, fluometuron are applied as herbicide, the development of phenylurea compounds and application
Obtaining development rapidly, its kind is continuously increased, current commercial varieties reaches more than 20 kinds, and range of application constantly expands.
Phenylurea analog herbicide belongs to micro-virus kind pesticide, can be stable in the presence of water after using within a very long time
In environment, made people and animals' generation chronic hazard effect by food chain.As: destroy neural normal function, disturb human body
The balance of internal hormone, affects male fertility, immunodeficiency symptoms etc..Pesticide chronic hazard reduces body immunity, thus affects
Health, causes the prevalence of Other diseases and mortality rate to be gradually increasing.Report according to World Health Organization (WHO) and UNEP (United Nations Environment Program)
Accusing, the whole world has more than 100 ten thousand people to be poisoned because of herbicide every year, and wherein 100,000 people are dead.In developing country, situation is even more serious.
China's annual herbicide intoxication accident reaches nearly million person-times, death about people more than 20,000.International cancer research institution is according to zoopery
Confirmation, widely used herbicide has obvious carcinogenecity.According to estimates, cancer patient's number that the U.S. is relevant with chemical herbicide
Account for the 20% of Nattonal Cancer patient populations.
National governments all carry out strict control, to residual period length, harm to herbicide residue amount conventional in agricultural product
The herbicide that property is bigger also has clear and definite limit standard, such as: the states such as the U.S., Australia, Canada are to the meat of its import and meat
Residual quantity in goods defines strict limitation, and the highest residue limits is less than 0.0200mg/kg.Metoxuron, weed eradication
Grand, chloroxifenidium has been put into European Union's banned pesticides inventory, and Canada (Canadian method E3230) requires in drinking water single
Planting phenylurea analog herbicide and have to be lower than 150 μ g/L, Japan specifies that such herbicide residue limits in different food products the most very much not surpasses
Cross 2mg/kg.
Phenylurea analog herbicide in agricultural product is tested, it is possible to use the compound of corresponding deuterated labelling is as interior
Mark thing, uses isotope dilution mass spectrometry to carry out quantitative analysis accurately, it is to avoid due to the matrix effect of testing sample, pre-treatment
With factor impacts on measurement result such as mass detectors, significantly improve the response rate and the method stability of target compound.
The fenuron of deuterated labelling, metoxuron, 1,1-dimethyl-3-(p-chlorophenyl)urea, chlortoluron, fluometuron, isoproturon, diuron, difenoxuron etc.
Synthesize and report currently without pertinent literature.And the synthesis of the above-mentioned herbicide of non-deuterated labelling mainly has following methods: by replacing
Phenyl isocyanate obtain with excess dimethylamine generation aminating reaction.And be gas under dimethylamine normal temperature and pressure, soluble in water
And alcohol, take its aqueous solution, alcoholic solution more, or the form being passed directly into gas adds.Dimethylamine is high poison chemicals, and gas is easy
Combustion, has severe corrosive, and therefore it uses and transport and all there is certain danger, and its water, alcoholic solution is the most stable, but also deposits
At high temperature gaseous volatilization, the danger that container expands.Substituted phenyl isocyanate character is relatively active, and water or alcohol easily occur pair
Reaction, additionally, the synthesis of the above-mentioned phenylurea analog herbicide of deuterated labelling, need dimethylamine-D6 as raw material, and dimethylamine-D6
Expensive, if according to non-deuterium-labelled phenylurea analog herbicide synthetic method use excess dimethylamine raw material, certainly will
The significant wastage to material can be caused, considerably increase cost.
Summary of the invention
Based on this, it is an object of the invention to provide a kind of phenylurea analog herbicide or the phenylurea analog herbicide of deuterated labelling
The synthetic method of (Formulas I).
The concrete technical scheme realizing foregoing invention purpose is as follows:
The synthetic method of a kind of formula (I) compound, described formula (I) formula (II) compound is in the presence of organic base
With dimethylamine salt or dimethylamine-D6Reactant salt obtains:
Wherein, R1Selected from H, Cl, Br, methoxyl group, isopropyl, trifluoromethyl or 4-Difluoro-phenoxy；
R2Selected from H, Cl, Br, methoxyl group, isopropyl, trifluoromethyl or 4-Difluoro-phenoxy；
R3Selected from H or Cl；
R4And R5It is methyl or methyl D simultaneously3。
Wherein in some embodiments, described dimethylamine salt be selected from dimethylamine hydrochloride or dimethylamine sulfate, described two
Methylamine-D6Salt is selected from dimethylamine-D6Hydrochlorate or dimethylamine-D6Sulfate.
Wherein in some embodiments, described reaction is carried out in aprotic solvent.
Wherein in some embodiments, described aprotic solvent be selected from dichloromethane, carbon tetrachloride, chloroform, toluene,
Oxolane, ether, Isosorbide-5-Nitrae-dioxane or methyl tertiary butyl ether(MTBE).
Wherein in some embodiments, the synthetic method of described formula (I) compound comprises the following steps:
(1) by dimethylamine salt or dimethylamine-D6Salt suspension, in aprotic solvent, stirs, obtains suspending liquid A；
(2) formula (II) compound is dissolved in aprotic solvent, is slowly added to the suspending liquid A of step (1), stirring,
Obtain reactant liquor B；
(3) organic base is dissolved in aprotic solvent, is slowly added to the reactant liquor B of step (2), stirring reaction, i.e.
?.
Wherein in some embodiments, described formula (II) compound is selected from following compound:
3,4-dichlorophenyl isocyanates,
4-chlorophenyl isocyanate,
3-chloro-4-methylphenyl isocyanate,
3-trifluoromethylbenzene based isocyanate,
4-cumene based isocyanate,
Phenyl isocyanate,
3-chloro-4-methoxy phenyl isocyanate,
4-(4-chlorophenoxy) phenyl isocyanate,
4-(4-methoxyphenoxy) phenyl isocyanate,
2,3-dichlorophenyl isocyanate,
4-bromophenyl isocyanate；
Described formula (I) compound is selected from following compound:
3-(3,4-Dichlorobenzene base)-1,1-dimethyl urea,
3-(3,4-Dichlorobenzene base)-1,1-two (methyl D3) urea,
3-(4-chlorphenyl)-1,1-dimethyl urea,
3-(4-chlorphenyl)-1,1-two (methyl D3) urea,
3-(3-chloro-4-aminomethyl phenyl)-1,1-dimethyl urea,
3-(3-chloro-4-aminomethyl phenyl)-1,1-two (methyl D3) urea,
1,1-dimethyl-3-(3-(trifluoromethyl) phenyl) urea,
1,1-bis-(methyl D3)-3-(3-(trifluoromethyl) phenyl) urea,
3-(4-isopropyl phenyl)-1,1-dimethyl urea,
3-(4-isopropyl phenyl)-1,1-two (methyl D3) urea,
1,1-dimethyl-3-phenylurea,
1,1-bis-(methyl D3)-3-phenylurea,
3-(3-chloro-4-methoxy phenyl)-1,1-dimethyl urea,
3-(3-chloro-4-methoxy phenyl)-1,1-two (methyl D3) urea,
3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-dimethyl urea,
3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-two (methyl D3) urea,
3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-dimethyl urea,
3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-two (methyl D3) urea,
3-(2,3-Dichlorobenzene base)-1,1-dimethyl urea,
3-(2,3-Dichlorobenzene base)-1,1-two (methyl D3) urea,
3-(4-bromophenyl)-1,1-dimethyl urea,
3-(4-bromophenyl)-1,1-two (methyl D3) urea.
Wherein in some embodiments, dimethylamine salt or dimethylamine-D6Salt is 1.1-with the mol ratio of formula (II) compound
2.5:1。
Wherein in some embodiments, dimethylamine hydrochloride or dimethylamine-D6With the mol ratio of formula (II) compound it is
1.2-2.0:1。
Wherein in some embodiments, the temperature of described reaction is 0-50 DEG C, and the time of reaction is 2-24 hour.
Wherein in some embodiments, the temperature of described reaction is 20-40 DEG C, and the time of reaction is 2-16 hour.
Wherein in some embodiments, described organic base is selected from triethylamine, tri-n-butylamine, diisopropyl ethyl amine, N-methyl
Morpholine, tetramethylethylenediamine, pyridine or 1, the mixture of one or more in 8-diazabicylo 11 carbon-7-alkene (DBU).
Considering price and reaction effect, preferred organic base is triethylamine or diisopropyl ethyl amine.
Wherein in some embodiments, described organic base is 1-4:1 with the mol ratio of formula (II) compound.
Wherein in some embodiments, described reaction carries out under inert gas shielding or carries out in hermetic container.
Wherein in some embodiments, described noble gas is nitrogen or argon.
The synthetic method of the phenylurea analog herbicide of the present invention or the phenylurea analog herbicide of deuterated labelling have the following advantages with
And beneficial effect:
Inventor is by long-term experience accumulation and substantial amounts of experimental studies have found that: with dimethylamine salt or dimethylamine-D6
Salt (preferably hydrochlorate or sulfate) and substituted phenyl isocyanate are raw material, and at organic base, (preferably tertiary amines is organic
Alkali) catalytic action under, dimethylamine or dimethylamine-D6 from its salt gradually free out, be dissolved in solvent (the most non-matter immediately
Sub-solvent) neutralize substituted phenyl isocyanate and react, phenylurea analog herbicide or the benzene of deuterated labelling can be prepared
Carbamide herbicides.This synthetic method the most directly uses aqueous solution or the alcoholic solution of dimethylamine, thus avoids substituted benzene
The side reaction that based isocyanate occurs with water or alcohol；The most directly use dimethylamine gas, decrease use and transportation
In danger, decrease the unnecessary material waste caused because of the leakage problem of dimethylamine gas simultaneously, especially for
Expensive dimethylamine-D6, there is prominent practical significance；Further preferably aprotic solvent can be avoided taking as reaction medium
The phenyl isocyanate in generation and protonic solvent generation side reaction, reduce the generation of by-product, improves response speed and receives with reaction
Rate.
The phenylurea analog herbicide of the present invention or the synthetic method of the phenylurea analog herbicide of deuterated labelling, simple to operate, condition
Gentleness, low for equipment requirements, low cost, yield is high, and by-product is few.The phenylurea analog herbicide of the deuterated labelling prepared can be made
For the internal standard substance of pesticide residues, can effectively and accurately detect benzene sulfonylurea herbicidal in agricultural product in conjunction with isotope dilution mass spectrometry
The residual of agent, it is to avoid due to the matrix effect of testing sample, the impact on measurement result of the factor such as pre-treatment and mass detector,
Significantly improve the response rate and the method stability of target compound, provide reliable basis for the residual inspection of agriculture.
Accompanying drawing explanation
Fig. 1 is the hydrogen spectrogram of diuron；
Fig. 2 is diuron-D6Hydrogen spectrogram；
Fig. 3 is the hydrogen spectrogram of 1,1-dimethyl-3-(p-chlorophenyl)urea；
Fig. 4 is 1,1-dimethyl-3-(p-chlorophenyl)urea-D6Hydrogen spectrogram；
Fig. 5 is the hydrogen spectrogram of chlortoluron；
Fig. 6 is chlortoluron-D6Hydrogen spectrogram；
Fig. 7 is the hydrogen spectrogram of fluometuron；
Fig. 8 is fluometuron-D6Hydrogen spectrogram；
Fig. 9 is the hydrogen spectrogram of isoproturon；
Figure 10 is isoproturon D6Hydrogen spectrogram；
Figure 11 is the hydrogen spectrogram of fenuron；
Figure 12 is fenuron-D6Hydrogen spectrogram.
Detailed description of the invention
Below by way of specific embodiment, the synthetic method of the phenylurea analog herbicide of the deuterated labelling of the present invention is made further
Detailed description.
The synthesis of embodiment 1 3-(3,4-Dichlorobenzene base)-1,1-dimethyl urea (diuron)
Under nitrogen protection dimethylamine hydrochloride (414mg, 5.08mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, it is slowly added dropwise 3, and the dichloromethane solution of 4-dichlorophenyl isocyanate (2ml, containing 3,4-dichlorophenyl isocyanate
797mg, 4.24mmol), continue stirring 20 minutes, (2ml, containing triethylamine to be slowly added dropwise the dichloromethane solution of triethylamine
856mg, 8.474mmol), after dropping, 30 DEG C of reaction 2h, whole reaction is carried out under nitrogen protection, and reactant liquor is supervised through TLC
Control, shows 3, and 4-dichlorophenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 775mg, yield 82%.1HNMR(CDCl3, 400MHz), δ: 7.61 (d, 1H, J=2.0Hz)；7.31(d,
1H, J=8.0Hz)；7.23 (dd, 1H, J=8.0,2.0Hz)；6.46(brs,1H),3.02(s,6H)；See Fig. 1.
Embodiment 2 3-(3,4-Dichlorobenzene base)-1,1-two (methyl D3) urea (diuron-D6) synthesis
Under nitrogen protection dimethylamine-D6 hydrochlorate (445mg, 5.08mmol) is suspended in toluene (5ml), stirs 10
Minute, it is slowly added dropwise 3, the toluene solution of 4-dichlorophenyl isocyanate (2ml, containing 3,4-dichlorophenyl isocyanate 797mg,
4.24mmol), continuing stirring 20 minutes, (2ml, containing diisopropyl ethyl to be slowly added dropwise the toluene solution of diisopropyl ethyl amine
Amine 1.09g, 8.47mmol), after dropping, 40 DEG C of reaction 4h, whole reaction is carried out in closing container, and reactant liquor is through TLC
Monitoring, shows 3, and 4-dichlorophenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
Taking 3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is heavily tied with dichloromethane again
Crystalline substance, obtains clear crystal 861mg, yield 85%.1HNMR(CDCl3, 400MHz), δ: 7.61 (d, 1H, J=2.0Hz)；7.31
(d, 1H, J=8.0Hz)；7.23 (dd, 1H, J=8.0,2.0Hz)；6.40 (brs, 1H), see Fig. 2.
The synthesis of embodiment 3 3-(4-chlorphenyl)-1,1-dimethyl urea (1,1-dimethyl-3-(p-chlorophenyl)urea)
Under argon shield, dimethylamine hydrochloride (318mg, 3.90mmol) is suspended in oxolane (5ml), stirring
10 minutes, be slowly added dropwise 4-chlorophenyl isocyanate tetrahydrofuran solution (2ml, containing 4-chlorophenyl isocyanate 500mg,
3.25mmol), continuing stirring 20 minutes, (2ml, containing N-methylmorpholine to be slowly added dropwise the tetrahydrofuran solution of N-methylmorpholine
657mg, 6.51mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under argon shield, and reactant liquor is supervised through TLC
Control, display 4-chlorophenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts 3 times with 20ml dichloromethane,
Organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is used dichloromethane recrystallization again, obtained
Clear crystal 504mg, yield 78%.1HNMR(CDCl3, 400MHz), δ: 7.32 (m, 2H)；7.22(m,2H)；6.38(brs,
1H)；3.01 (s, 6H), see Fig. 3.
Embodiment 4 3-(4-chlorphenyl)-1,1-two (methyl D3) urea (1,1-dimethyl-3-(p-chlorophenyl)urea-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (342mg, 3.90mmol) is suspended in chloroform (5ml), stirs
Mix 10 minutes, be slowly added dropwise 4-chlorophenyl isocyanate chloroform soln (2ml, containing 4-chlorophenyl isocyanate 500mg,
3.25mmol), continue stirring 20 minutes, be slowly added dropwise pyridine chloroform soln (2ml, contains, pyridine 515mg,
6.51mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, aobvious
Showing that 4-chlorophenyl isocyanate converts the most completely, reactant liquor adds the stirring of 20ml water, with 20ml chloroform extraction 3 times, organic
Through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrating, concentrated solution is used chloroform recrystallization again, is obtained colourless
Crystal 533mg, yield 80%.1HNMR(CDCl3, 400MHz), δ: 7.33 (m, 2H)；7.24(m,2H)；6.33 (brs, 1H), ginseng
See Fig. 4.
The synthesis of embodiment 5 3-(3-chloro-4-aminomethyl phenyl)-1,1-dimethyl urea (chlortoluron)
Under nitrogen protection dimethylamine hydrochloride (292mg, 3.58mmol) is suspended in ether (5ml), stirs 10 points
Clock, (2ml, containing 3-chloro-4-methylphenyl isocyanate to be slowly added dropwise the diethyl ether solution of 3-chloro-4-methylphenyl isocyanate
500mg, 2.98mmol), continue stirring 20 minutes, (2ml, containing diisopropyl to be slowly added dropwise the diethyl ether solution of diisopropyl ethyl amine
Base ethylamine 770mg, 5.97mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, reaction
Liquid monitors through TLC, and display 3-chloro-4-methylphenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, uses 20ml
Dichloromethane extracts 3 times, and organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is again with two
Chloromethanes recrystallization, obtains clear crystal 527mg, yield 83%.1HNMR(CDCl3, 400MHz), δ: 7.45 (d, 1H, J=
2.0Hz)；7.16(m,1H)；7.10 (d, 1H, J=8.0Hz)；.36(brs,1H)；3.01(S,6H)；2.30 (s, 3H), see
Fig. 5.
Embodiment 6 3-(3-chloro-4-aminomethyl phenyl)-1,1-two (methyl D3) urea (chlortoluron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (313mg, 3.58mmol) is suspended in Isosorbide-5-Nitrae-dioxane (5ml)
In, stir 10 minutes, (2ml, containing the chloro-4-of 3-to be slowly added dropwise the Isosorbide-5-Nitrae-dioxane solution of 3-chloro-4-methylphenyl isocyanate
Methylphenyl isocyanate 500mg, 2.98mmol), continue stirring 20 minutes, the Isosorbide-5-Nitrae-dioxane being slowly added dropwise triethylamine is molten
Liquid (2ml, containing triethylamine 603mg, 5.97mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is entered under nitrogen protection
OK, reactant liquor monitors through TLC, and display 3-chloro-4-methylphenyl isocyanate converts the most completely, and reactant liquor adds 20ml water and stirs
Mixing, extract 3 times with 20ml dichloromethane, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, concentrates
Liquid uses dichloromethane recrystallization again, obtains clear crystal 561mg, yield 86%.1HNMR(CDCl3, 400MHz), δ: 7.45 (d,
1H, J=2.0Hz)；7.16(m,1H)；7.10 (d, 1H, J=8.0Hz)；6.28(brs,1H)；2.30 (s, 3H), see Fig. 6.
The synthesis of embodiment 7 1,1-dimethyl-3-(3-(trifluoromethyl) phenyl) urea (fluometuron)
Under nitrogen protection dimethylamine hydrochloride (262mg, 3.21mmol) is suspended in methyl tertiary butyl ether(MTBE) (5ml),
Stirring 10 minutes, (2ml, containing 3-trifluoromethyl to be slowly added dropwise the t-butyl methyl ether solution of 3-trifluoromethylbenzene based isocyanate
Phenyl isocyanate 500mg, 2.67mmol), continue stirring 20 minutes, be slowly added dropwise the methyl tertiary butyl ether(MTBE) of tetramethylethylenediamine
Solution (2ml, containing tetramethylethylenediamine 310mg, 2.67mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is at nitrogen
Carrying out under protection, reactant liquor monitors through TLC, and display 3-trifluoromethylbenzene based isocyanate converts the most completely, and reactant liquor adds
20ml water stirs, and extracts 3 times with 20ml dichloromethane, and organic facies is dried through washing, saturated common salt washing, anhydrous sodium sulfate,
Concentrating, concentrated solution is used dichloromethane recrystallization again, is obtained clear crystal 521mg, yield 84%.1HNMR(CDCl3, 400MHz),
δ:7.67(s,1H)；7.58 (d, 1H, J=8.0Hz)；7.37 (t, 1H, J=8.0Hz)；7.26 (d, 1H, J=8.0Hz)；
6.59(brs,1H)；3.03 (s, 6H), see Fig. 7.
Embodiment 8 1,1-bis-(methyl D3)-3-(3-(trifluoromethyl) phenyl) urea (fluometuron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (281mg, 3.21mmol) is suspended in dichloromethane (5ml), stirs
Mixing 10 minutes, (2ml, containing trifluoromethyl isocyanide to be slowly added dropwise the dichloromethane solution of 3-trifluoromethylbenzene based isocyanate
Acid esters 500mg, 2.67mmol), continue stirring 20 minutes, be slowly added dropwise DBU dichloromethane solution (2ml, containing DBU 812mg,
5.34mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, aobvious
Showing that 3-trifluoromethylbenzene based isocyanate converts the most completely, reactant liquor adds the stirring of 20ml water, extracts 3 with 20ml dichloromethane
Secondary, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 560mg, yield 88%.1HNMR(CDCl3, 400MHz), δ: 7.67 (s, 1H)；7.58 (d, 1H, J=
8.0Hz)；7.37 (t, 1H, J=8.0Hz)；7.26 (d, 1H, J=8.0Hz)；6.47 (brs, 1H), see Fig. 8.
The synthesis of embodiment 9 3-(4-isopropyl phenyl)-1,1-dimethyl urea (isoproturon)
Under nitrogen protection dimethylamine hydrochloride (303mg, 3.72mmol) is suspended in carbon tetrachloride (5ml), stirring
10 minutes, (2ml, containing 4-cumene based isocyanate to be slowly added dropwise the carbon tetrachloride solution of 4-cumene based isocyanate
500mg, 3.10mmol), continue stirring 20 minutes, (2ml, containing triethylamine to be slowly added dropwise the carbon tetrachloride solution of triethylamine
627mg, 6.20mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor is supervised through TLC
Control, display 4-cumene based isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 486mg, yield 76%.1HNMR(CDCl3, 400MHz), δ: 7.28 (d, 1H, J=8.0Hz)；7.14(d,
2H, J=8.0Hz)；6.27(brs,1H)；3.01(s,6H)；2.85(m,1H)；1.23(s,3H)；1.21 (s, 3H), see figure
9。
Embodiment 10 3-(4-isopropyl phenyl)-1,1-two (methyl D3) urea (isoproturon-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (406mg, 4.65mmol) is suspended in dichloromethane (5ml), stirs
Mixing 10 minutes, (2ml, containing 4-isopropyl phenyl Carbimide. to be slowly added dropwise the dichloromethane solution of 4-cumene based isocyanate
Ester 500mg, 3.10mmol), continue stirring 20 minutes, (3ml, containing triethylamine to be slowly added dropwise the dichloromethane solution of triethylamine
939mg, 9.3mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor is supervised through TLC
Control, display 4-cumene based isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 593mg, yield 90%.1HNMR(CDCl3, 400MHz), δ: 7.28 (d, 1H, J=8.0Hz)；7.14(d,
2H, J=8.0Hz)；6.27(brs,1H)；2.85(m,1H)；1.23(s,3H)；1.21 (s, 3H), see Figure 10.
The synthesis of embodiment 11 1,1-dimethyl-3-phenylurea (fenuron)
Under nitrogen protection dimethylamine hydrochloride (684.6mg, 8.4mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, it is slowly added dropwise the dichloromethane solution (2ml, containing phenyl isocyanate 500mg, 4.20mmol) of phenyl isocyanate,
Continue stirring 20 minutes, be slowly added dropwise the dichloromethane solution (5ml, containing triethylamine 1.7g, 16.78mmol) of triethylamine, dropping
After, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, shows phenyl isocyanate
Converting the most completely, reactant liquor adds the stirring of 20ml water, extracts 3 times with 20ml dichloromethane, and organic facies is through washing, saturated aqueous common salt
Wash, anhydrous sodium sulfate dried, concentrate, concentrated solution is used dichloromethane recrystallization again, is obtained clear crystal 614mg, yield 89%
。1HNMR(CDCl3, 400MHz), δ: 7.38 (dd, 1H, J=8.0,2.0Hz)；7.28(m,2H)；7.03(m,2H)；6.27
(brs,1H)；3.03 (s, 6H), see Figure 11.
Embodiment 12 1,1-bis-(methyl D3)-3-phenylurea (fenuron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (441mg, 5.04mmol) is suspended in dichloromethane (5ml), stirs
Mix 10 minutes, be slowly added dropwise phenyl isocyanate dichloromethane solution (2ml, containing phenyl isocyanate 500mg,
4.20mmol), continue stirring 20 minutes, be slowly added dropwise triethylamine dichloromethane solution (2ml, containing triethylamine 848mg,
8.39mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, aobvious
Showing that phenyl isocyanate converts the most completely, reactant liquor adds the stirring of 20ml water, extracts 3 times with 20ml dichloromethane, organic facies warp
Washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrate, and concentrated solution is used dichloromethane recrystallization again, obtained clear crystal
564mg, yield 79%.1HNMR(CDCl3, 400MHz), δ: 7.38 (dd, 1H, J=8.0,2.0Hz)；7.28(m,2H)；7.03
(m,2H)；6.27 (brs, 1H), see Figure 12.
The synthesis of embodiment 13 3-(3-chloro-4-methoxy phenyl)-1,1-dimethyl urea (metoxuron)
Under nitrogen protection dimethylamine hydrochloride (266mg, 3.27mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, (2ml, containing 3-chloro-4-methoxy benzene to be slowly added dropwise the dichloromethane solution of 3-chloro-4-methoxy phenyl isocyanate
Based isocyanate 500mg, 2.72mmol), continue stirring 20 minutes, (2ml contains to be slowly added dropwise the dichloromethane solution of triethylamine
Triethylamine 550mg, 5.44mmol), after dropping, 20 DEG C of reaction 24h, whole reaction is carried out under nitrogen protection, reactant liquor
Monitoring through TLC, display 3-chloro-4-methoxy phenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, uses 20ml
Dichloromethane extracts 3 times, and organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is again with two
Chloromethanes recrystallization, obtains clear crystal 492mg, yield 79%.1HNMR(CDCl3, 400MHz), δ: 7.34 (d, 1H, J=
8.0Hz)；7.17(m,2H)；6.95(brs,1H)；3.84(s,3H)；3.05(s,6H).
Embodiment 14 3-(3-chloro-4-methoxy phenyl)-1,1-two (methyl D3) urea (metoxuron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (286mg, 3.27mmol) is suspended in dichloromethane (5ml), stirs
Mixing 10 minutes, (2ml, containing 3-chloro-4-methoxy to be slowly added dropwise the dichloromethane solution of 3-chloro-4-methoxy phenyl isocyanate
Phenyl isocyanate 500mg, 2.72mmol), continue stirring 20 minutes, be slowly added dropwise triethylamine dichloromethane solution (2ml,
Containing triethylamine 550mg, 5.44mmol), after dropping, 20 DEG C of reaction 24h, whole reaction is carried out under nitrogen protection, reaction
Liquid monitors through TLC, and display 3-chloro-4-methoxy phenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, uses
20ml dichloromethane extracts 3 times, and organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is again
Use dichloromethane recrystallization, obtain clear crystal 504mg, yield 79%.1HNMR(CDCl3, 400MHz), δ: 7.34 (d, 1H, J
=8.0Hz)；7.17(m,2H)；6.97(brs,1H)；3.84(s,3H).
The synthesis of embodiment 15 3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-dimethyl urea (chloroxifenidium)
Under nitrogen protection dimethylamine hydrochloride (200mg, 2.44mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, (2ml, containing 4-(4-chlorophenoxy) to be slowly added dropwise the dichloromethane solution of 4-(4-chlorophenoxy) phenyl isocyanate
Phenyl isocyanate 500mg, 2.04mmol), continue stirring 20 minutes, be slowly added dropwise triethylamine dichloromethane solution (2ml,
Containing triethylamine 411mg, 4.07mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, reaction
Liquid monitors through TLC, and display 4-(4-chlorophenoxy) phenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, uses
20ml dichloromethane extracts 3 times, and organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution is again
Use dichloromethane recrystallization, obtain clear crystal 402mg, yield 68%.1HNMR(CDCl3, 400MHz), δ: 7.54 (d, 2H, J
=8.0Hz)；7.43 (d, 2H, J=8.0Hz)；7.38(m,2H)；6.86(m,2H)；3.06(s,6H).
Embodiment 16 3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-two (methyl D3) urea (chloroxifenidium-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (214mg, 2.44mmol) is suspended in dichloromethane (5ml), stirs
Mixing 10 minutes, (2ml, containing 4-(4-chlorobenzene oxygen to be slowly added dropwise the dichloromethane solution of 4-(4-chlorophenoxy) phenyl isocyanate
Base) phenyl isocyanate 500mg, 2.04mmol), continue stirring 20 minutes, be slowly added dropwise the dichloromethane solution of triethylamine
(2ml, containing triethylamine 411mg, 4.07mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection,
Reactant liquor monitors through TLC, and display 4-(4-chlorophenoxy) phenyl isocyanate converts the most completely, and reactant liquor adds 20ml water and stirs
Mixing, extract 3 times with 20ml dichloromethane, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, concentrates
Liquid uses dichloromethane recrystallization again, obtains clear crystal 380mg, yield 63%.1HNMR(CDCl3, 400MHz), δ: 7.54 (d,
2H, J=8.0Hz)；7.43 (d, 2H, J=8.0Hz)；7.38(m,2H)；6.86(m,2H).
The synthesis of embodiment 17 3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-dimethyl urea (difenoxuron)
Under nitrogen protection dimethylamine hydrochloride (203mg, 2.49mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, (2ml, containing 4-(4-methoxyl group to be slowly added dropwise the dichloromethane solution of 4-(4-methoxyphenoxy) phenyl isocyanate
Phenoxy group) phenyl isocyanate 500mg, 2.07mmol), continuing stirring 20 minutes, the dichloromethane being slowly added dropwise triethylamine is molten
Liquid (2ml, containing triethylamine 419mg, 4.15mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is entered under nitrogen protection
OK, reactant liquor monitors through TLC, and display 4-(4-methoxyphenoxy) phenyl isocyanate converts the most completely, and reactant liquor adds
20ml water stirs, and extracts 3 times with 20ml dichloromethane, and organic facies is dried through washing, saturated common salt washing, anhydrous sodium sulfate,
Concentrating, concentrated solution is used dichloromethane recrystallization again, is obtained clear crystal 386mg, yield 65%.1HNMR(CDCl3, 400MHz),
δ: 7.37 (d, 2H, J=8.0Hz)；7.18 (d, 2H, J=8.0Hz)；6.93(m,2H)；6.85(m,2H)；3.05(s,6H).
Embodiment 18 3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-two (methyl D3) urea (difenoxuron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (218mg, 2.49mmol) is suspended in dichloromethane (5ml), stirs
Mixing 10 minutes, (2ml, containing 4-(4-methoxy to be slowly added dropwise the dichloromethane solution of 4-(4-methoxyphenoxy) phenyl isocyanate
Phenoxyl) phenyl isocyanate 500mg, 2.07mmol), continue stirring 20 minutes, be slowly added dropwise the dichloromethane of triethylamine
Solution (2ml, containing triethylamine 419mg, 4.15mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is under nitrogen protection
Carrying out, reactant liquor monitors through TLC, and display 4-(4-methoxyphenoxy) phenyl isocyanate converts the most completely, and reactant liquor adds
20ml water stirs, and extracts 3 times with 20ml dichloromethane, and organic facies is dried through washing, saturated common salt washing, anhydrous sodium sulfate,
Concentrating, concentrated solution is used dichloromethane recrystallization again, is obtained clear crystal 364mg, yield 60%.1HNMR(CDCl3, 400MHz),
δ: 7.37 (d, 2H, J=8.0Hz)；7.18 (d, 2H, J=8.0Hz)；6.93(m,2H)；6.85(m,2H).
The synthesis of embodiment 19 3-(2,3-Dichlorobenzene base)-1,1-dimethyl urea (2,3-diuron)
Under nitrogen protection dimethylamine hydrochloride (260mg, 3.19mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, it is slowly added dropwise 2, and the dichloromethane solution of 3-dichlorophenyl isocyanate (2ml, containing 2,3-dichlorophenyl isocyanate
500mg, 2.66mmol), continue stirring 20 minutes, (2ml, containing triethylamine to be slowly added dropwise the dichloromethane solution of triethylamine
537mg, 5.31mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor is supervised through TLC
Control, shows 2, and 3-dichlorophenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 490mg, yield 79%.1HNMR(CDCl3, 400MHz), δ: 8.20 (d, 1H, J=8.0Hz)；7.12(m,
2H)；6.44(brs,1H)；3.08(s,6H).
Embodiment 20 3-(2,3-Dichlorobenzene base)-1,1-two (methyl D3) urea (2,3-diuron-D6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (280mg, 3.19mmol) is suspended in dichloromethane (5ml), stirs
Mix 10 minutes, be slowly added dropwise 2, and the dichloromethane solution of 3-dichlorophenyl isocyanate (2ml, containing 2,3-Dichlorobenzene base Carbimide.
Ester 500mg, 2.66mmol), continue stirring 20 minutes, (2ml, containing triethylamine to be slowly added dropwise the dichloromethane solution of triethylamine
537mg, 5.31mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor is supervised through TLC
Control, shows 2, and 3-dichlorophenyl isocyanate converts the most completely, and reactant liquor adds the stirring of 20ml water, extracts with 20ml dichloromethane
3 times, organic facies through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrates, and concentrated solution uses dichloromethane recrystallization again,
Obtain clear crystal 521mg, yield 82%.1HNMR(CDCl3, 400MHz), δ: 8.20 (d, 1H, J=8.0Hz)；7.12(m,
2H)；6.40(brs,1H).
The synthesis of embodiment 21 3-(4-bromophenyl)-1,1-dimethyl urea (elegant grass is grand)
Under nitrogen protection dimethylamine hydrochloride (247mg, 3.03mmol) is suspended in dichloromethane (5ml), stirring
10 minutes, be slowly added dropwise 4-bromophenyl isocyanate dichloromethane solution (2ml, containing 4-bromophenyl isocyanate 500mg,
2.52mmol), continue stirring 20 minutes, be slowly added dropwise triethylamine dichloromethane solution (2ml, containing triethylamine 510mg,
5.05mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, aobvious
Showing that 4-bromophenyl isocyanate converts the most completely, reactant liquor adds the stirring of 20ml water, extracts 3 times with 20ml dichloromethane, organic
Through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrating, concentrated solution is used dichloromethane recrystallization again, is obtained colourless
Crystal 528mg, yield 86%.1HNMR(CDCl3, 400MHz), δ: 7.32-7.25 (m, 2H)；7.23-7.15(m,2H)；6.26
(brs,1H)；2.93(s,6H).
Embodiment 22 3-(4-bromophenyl)-1,1-two (methyl D3) urea (grand-D of elegant grass6) synthesis
Under nitrogen protection by dimethylamine-D6Hydrochlorate (265mg, 3.03mmol) is suspended in dichloromethane (5ml), stirs
Mix 10 minutes, be slowly added dropwise 4-bromophenyl isocyanate dichloromethane solution (2ml, containing 4-bromophenyl isocyanate 500mg,
2.52mmol), continue stirring 20 minutes, be slowly added dropwise triethylamine dichloromethane solution (2ml, containing triethylamine 510mg,
5.05mmol), after dropping, 20 DEG C of reaction 16h, whole reaction is carried out under nitrogen protection, and reactant liquor monitors through TLC, aobvious
Showing that 4-bromophenyl isocyanate converts the most completely, reactant liquor adds the stirring of 20ml water, extracts 3 times with 20ml dichloromethane, organic
Through washing, saturated common salt washing, anhydrous sodium sulfate after drying, concentrating, concentrated solution is used dichloromethane recrystallization again, is obtained colourless
Crystal 540mg, yield 88%.1HNMR(CDCl3, 400MHz), δ: 7.32-7.25 (m, 2H)；7.23-7.15(m,2H)；6.26
(brs,1H)。
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, not to above-mentioned reality
The all possible combination of each technical characteristic executed in example is all described, but, as long as the combination of these technical characteristics is not deposited
In contradiction, all it is considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that, come for those of ordinary skill in the art
Saying, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. the synthetic method of formula (I) compound, it is characterised in that described formula (I) formula (II) compound is having
With dimethylamine salt or dimethylamine-D in the presence of machine alkali6Reactant salt obtains:
Wherein, R1Selected from H, Cl, Br, methoxyl group, isopropyl, trifluoromethyl or 4-Difluoro-phenoxy；
R2Selected from H, Cl, Br, methoxyl group, isopropyl, trifluoromethyl or 4-Difluoro-phenoxy；
R3Selected from H or Cl；
R4And R5It is methyl or methyl D simultaneously3。
The synthetic method of formula the most according to claim 1 (I) compound, it is characterised in that described dimethylamine salt is selected from two
Methylamine hydrochloride or dimethylamine sulfate, described dimethylamine-D6Salt is selected from dimethylamine-D6Hydrochlorate or dimethylamine-D6Sulfate.
The synthetic method of formula the most according to claim 1 (I) compound, it is characterised in that described reaction is non-proton molten
Agent is carried out.
The synthetic method of formula the most according to claim 3 (I) compound, it is characterised in that described aprotic solvent is selected from
Dichloromethane, carbon tetrachloride, chloroform, toluene, oxolane, ether, Isosorbide-5-Nitrae-dioxane or methyl tertiary butyl ether(MTBE).
5. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that described formula (II)
Compound is selected from following compound:
3,4-dichlorophenyl isocyanates,
4-chlorophenyl isocyanate,
3-chloro-4-methylphenyl isocyanate,
3-trifluoromethylbenzene based isocyanate,
4-cumene based isocyanate,
Phenyl isocyanate,
3-chloro-4-methoxy phenyl isocyanate,
4-(4-chlorophenoxy) phenyl isocyanate,
4-(4-methoxyphenoxy) phenyl isocyanate,
2,3-dichlorophenyl isocyanate,
4-bromophenyl isocyanate；
Described formula (I) compound is selected from following compound:
3-(3,4-Dichlorobenzene base)-1,1-dimethyl urea,
3-(3,4-Dichlorobenzene base)-1,1-two (methyl D3) urea,
3-(4-chlorphenyl)-1,1-dimethyl urea,
3-(4-chlorphenyl)-1,1-two (methyl D3) urea,
3-(3-chloro-4-aminomethyl phenyl)-1,1-dimethyl urea,
3-(3-chloro-4-aminomethyl phenyl)-1,1-two (methyl D3) urea,
1,1-dimethyl-3-(3-(trifluoromethyl) phenyl) urea,
1,1-bis-(methyl D3)-3-(3-(trifluoromethyl) phenyl) urea,
3-(4-isopropyl phenyl)-1,1-dimethyl urea,
3-(4-isopropyl phenyl)-1,1-two (methyl D3) urea,
1,1-dimethyl-3-phenylurea,
1,1-bis-(methyl D3)-3-phenylurea,
3-(3-chloro-4-methoxy phenyl)-1,1-dimethyl urea,
3-(3-chloro-4-methoxy phenyl)-1,1-two (methyl D3) urea,
3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-dimethyl urea,
3-(4-(4-chlorobenzene oxygen) phenyl)-1,1-two (methyl D3) urea,
3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-dimethyl urea,
3-(4-(4-methoxybenzene oxygen) phenyl)-1,1-two (methyl D3) urea,
3-(2,3-Dichlorobenzene base)-1,1-dimethyl urea,
3-(2,3-Dichlorobenzene base)-1,1-two (methyl D3) urea,
3-(4-bromophenyl)-1,1-dimethyl urea,
3-(4-bromophenyl)-1,1-two (methyl D3) urea.
6. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that dimethylamine salt or
Dimethylamine-D6Salt is 1.1-2.5:1 with the mol ratio of formula (II) compound.
7. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that described reaction
Temperature is 0-50 DEG C, and the time of reaction is 2-24 hour.
8. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that described organic base
Selected from triethylamine, tri-n-butylamine, diisopropyl ethyl amine, N-methylmorpholine, tetramethylethylenediamine, trimethylamine, pyridine or 1,8-bis-
The mixture of one or more in azabicyclic 11 carbon-7-alkene.
9. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that described organic base
It is 1-4:1 with the mol ratio of formula (II) compound.
10. according to the synthetic method of formula (I) compound described in any one of claim 1-4, it is characterised in that described reaction exists
Carry out under inert gas shielding or carry out in hermetic container.
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