CN106001602A - Nano-silver preparation method - Google Patents
Nano-silver preparation method Download PDFInfo
- Publication number
- CN106001602A CN106001602A CN201610401465.7A CN201610401465A CN106001602A CN 106001602 A CN106001602 A CN 106001602A CN 201610401465 A CN201610401465 A CN 201610401465A CN 106001602 A CN106001602 A CN 106001602A
- Authority
- CN
- China
- Prior art keywords
- silver
- nano
- preparation
- artemisinin
- nanometer silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F9/00—Making metallic powder or suspensions thereof
- B22F9/16—Making metallic powder or suspensions thereof using chemical processes
- B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
- B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
- B22F1/05—Metallic powder characterised by the size or surface area of the particles
- B22F1/054—Nanosized particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F2999/00—Aspects linked to processes or compositions used in powder metallurgy
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a nano-silver preparation method which comprises the following steps: preparing 1-100 g/L of a silver nitrate methanol or ethanol solution, and then slowly adding an artemisinin-based drug for uniformly stirring; then putting the obtained mixture under an ultraviolet lamp for 5-60 minutes' illumination, so as to obtain a nano-silver colloidal solution, wherein the wave length and the power of the ultraviolet lamp are 365 nm and 50 W respectively; and then rinsing with ethanol as well as performing centrifugation and drying treatment, so as to obtain nano-silver. According to the nano-silver preparation method provided by the invention, artemisinin-based drugs are adopted as reducing agents and protecting agents of nano-silver; the nano-silver preparation method has the characteristics of being simple in process, wide in raw material source, mild in reaction, environmentally friendly and the like; and the prepared nano-silver has double effects of bacteria resistance and malaria resistance.
Description
Technical field
The invention belongs to field of nanometer material technology, particularly to the preparation method of a kind of nanometer silver.
Background technology
Nanometer silver has excellent conductivity of heat, electric conductivity, surface activity and catalytic performance, has huge using value in optics, catalysis, microelectronics, bio-sensing, the field such as antibacterial.The preparation of traditional nanometer silver is divided into Physical and chemical method.Instrument and equipment is required higher by Physical, and producing cost is expensive.Chemical method many employings hydrazine hydrate, formaldehyde, polyhydric alcohol, organic amine etc. make reducing agent, although these reducing agents have high activity, but to bad environmental, and easily there is agglomeration in the nanometer silver prepared.
In recent years, green, environmental protection, efficient and cheap method is used to prepare nanometer silver and be increasingly becoming the focus of research.The green reducing agent used at present specifically includes that vitamin, sodium citrate, pyro acid, hydroquinone, tea polyphenols, glucose, fructose, sucrose, plant and peel extract, microorganism etc..
Arteannuin is the sesquiterpene lactones medicine having peroxy-radical extracted from plant Artemisia annua leaf.Conjoint therapy based on artemisinin-based drug has become as the malaria standard treatment of world health organisation recommendations.World Health Organization is thought, arteannuin conjoint therapy is the maximally effective means of malaria for the treatment of at present, also it is resistant to the medicine that malaria drug resistance effect is best, the Chinese discovery side as antimalarial agent arteannuin and largest production side, in malaria process is resisted in the whole world, plays important function.Especially in Africa, malaria severely afflicated area, arteannuin has saved life up to a million.According to the statistical data of World Health Organization, from 2000, area, Sub-Saharan Africa about 2.4 hundred million population benefits from arteannuin conjoint therapy, and about 1,500,000 people avoid, because of this therapy, the death that malaria causes.In October, 2015, Chinese Human-Female pharmacy man slaughter cry of a deer because formulating novel antimalarial artemisinin and the contribution of dihydroarteannuin, with other two scientists share 2015 year Nobel prize's soul.This is the world-class highest Grand Prix that Chinese biomedical circle obtains up to now.
The arteannuin one the sesquiterpene lactones compound containing peroxy-radical, molecular formula is C15H22O5, 15 carbon have 7 to be chiral carbon.Molecular weight 282.33, constituent content: C 63.81%, H 7.85%, O 28.33%, colourless acicular crystal, bitter in the mouth.In acetone, ethyl acetate, chloroform, benzene and glacial acetic acid readily soluble, solubilized in ethanol and methanol, ether and petroleum ether, the most insoluble in water.Fusing point: 156-157 DEG C.Have no that the reducing agent using artemisinin-based drug as nanometer silver and protective agent, preparation have the report of the antibacterial nanometer silver with antimalarial effect at present both at home and abroad.
Summary of the invention
The present invention is directed to the deficiency that prior art exists, it is desirable to provide the preparation method of a kind of nanometer silver.
The technical scheme is that:
The silver nitrate methanol of configuration 1-100g/L or ethanol solution, be then slowly added into artemisinin-based drug, stir, it is subsequently placed in wavelength 365nm, under the uviol lamp of power 50w, illumination 5-60min, obtains nano-class silver colloidal solution, obtains nanometer silver after ethanol purge, centrifugal, dried.
As a kind of preferred version, described artemisinin-based drug includes arteannuin and derivant thereof.
As a kind of preferred version, described artemisinin derivative includes dihydroartemisinine, Artemether, artesunate etc..
As a kind of preferred version, described artemisinin-based drug is 10:1-1:1 with the mass ratio of silver nitrate.
There is advantages that
The present invention use artemisinin-based drug as the reducing agent of nanometer silver and protective agent, have that technique is simple, raw material sources extensively, the feature such as reaction gentleness, environmental protection, and the nanometer silver prepared has antibacterial and malaria double effects simultaneously.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is expanded on further.
Embodiment 1:
1g silver nitrate is dissolved in the methanol of 10mL the silver nitrate solution configuring 100g/L, it is then slowly added into 2g arteannuin, stir, it is subsequently placed in wavelength 365nm, illumination 60min under the uviol lamp of power 50w, obtain nano-class silver colloidal solution, after ethanol purge, centrifugal, dried, obtain nanometer silver.
Embodiment 2:
1g silver nitrate is dissolved in the methanol of 10mL the silver nitrate solution configuring 100g/L, it is then slowly added into 5g dihydroartemisinine, stir, it is subsequently placed in wavelength 365nm, illumination 30min under the uviol lamp of power 50w, obtain nano-class silver colloidal solution, after ethanol purge, centrifugal, dried, obtain nanometer silver.
Embodiment 3:
1g silver nitrate is dissolved in the ethanol of 10mL the silver nitrate solution configuring 100g/L, it is then slowly added into 10g artesunate, stir, it is subsequently placed in wavelength 365nm, illumination 10min under the uviol lamp of power 50w, obtain nano-class silver colloidal solution, after ethanol purge, centrifugal, dried, obtain nanometer silver.
Obviously, the above embodiment of the present invention is only for clearly demonstrating example of the present invention, and is not the restriction to embodiments of the present invention.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot all of embodiment be given exhaustive.Every belong to obvious change that technical scheme amplified out or the variation row still in protection scope of the present invention.
Claims (5)
1. the preparation method of a nanometer silver, it is characterized in that: the silver nitrate methanol of configuration 1-100g/L or ethanol solution, it is then slowly added into artemisinin-based drug, stir, it is subsequently placed in illumination 5-60min under uviol lamp, obtain nano-class silver colloidal solution, after ethanol purge, centrifugal, dried, obtain nanometer silver.
The preparation method of a kind of nanometer silver the most according to claim 1, it is characterised in that described artemisinin-based drug includes arteannuin and derivant thereof.
The preparation method of a kind of nanometer silver the most according to claim 1, it is characterised in that described artemisinin derivative includes dihydroartemisinine, Artemether, artesunate etc..
The preparation method of a kind of nanometer silver the most according to claim 1, it is characterised in that described artemisinin-based drug is 10:1-1:1 with the mass ratio of silver nitrate.
The preparation method of a kind of nanometer silver the most according to claim 1, it is characterised in that described uviol lamp wavelength 365nm, power 50w.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610401465.7A CN106001602A (en) | 2016-06-10 | 2016-06-10 | Nano-silver preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610401465.7A CN106001602A (en) | 2016-06-10 | 2016-06-10 | Nano-silver preparation method |
Publications (1)
| Publication Number | Publication Date |
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| CN106001602A true CN106001602A (en) | 2016-10-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610401465.7A Pending CN106001602A (en) | 2016-06-10 | 2016-06-10 | Nano-silver preparation method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108213457A (en) * | 2017-12-30 | 2018-06-29 | 吉林农业大学 | A kind of small size even Argent grain and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791704A (en) * | 2010-03-25 | 2010-08-04 | 江苏大学 | Method for preparing nano silver |
| CN101999412A (en) * | 2010-11-19 | 2011-04-06 | 佘振定 | Nano-silver solution and preparation method thereof |
| CN103385875A (en) * | 2013-05-29 | 2013-11-13 | 四川绵阳四〇四医院 | Nanometer chitosan artemisinin compound and preparation method thereof |
-
2016
- 2016-06-10 CN CN201610401465.7A patent/CN106001602A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101791704A (en) * | 2010-03-25 | 2010-08-04 | 江苏大学 | Method for preparing nano silver |
| CN101999412A (en) * | 2010-11-19 | 2011-04-06 | 佘振定 | Nano-silver solution and preparation method thereof |
| CN103385875A (en) * | 2013-05-29 | 2013-11-13 | 四川绵阳四〇四医院 | Nanometer chitosan artemisinin compound and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| A. S. JOHNSON ET AL.: "Green synthesis of silver nanoparticles using Artemisia annua and Sida acuta leaves extract and their antimicrobial，antioxidant and corrosion inhibition potentials", 《J. MATER. ENVIRON. SCI.》 * |
| MOHAMMAD ALI ET AL: "Green synthesis and characterization of silver nanoparticles using Artemisia absinthium aqueous extract — A comprehensive study", 《MATERIALS SCIENCE AND ENGINEERING》 * |
| NAGARAJ BASAVEGOWDA等: "Preparation of Au and Ag nanoparticles using Artemisia annua and their in vitro antibacterial and tyrosinase inhibitory activities", 《MATERIALS SCIENCE AND ENGINEERING》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108213457A (en) * | 2017-12-30 | 2018-06-29 | 吉林农业大学 | A kind of small size even Argent grain and preparation method thereof |
| CN108213457B (en) * | 2017-12-30 | 2021-05-28 | 吉林农业大学 | Small-size uniform nano silver particles and preparation method thereof |
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Application publication date: 20161012 |