CN105999771B - One kind can preengage online and synchronous automatic degerming removal of impurities degasser - Google Patents
One kind can preengage online and synchronous automatic degerming removal of impurities degasser Download PDFInfo
- Publication number
- CN105999771B CN105999771B CN201610527725.5A CN201610527725A CN105999771B CN 105999771 B CN105999771 B CN 105999771B CN 201610527725 A CN201610527725 A CN 201610527725A CN 105999771 B CN105999771 B CN 105999771B
- Authority
- CN
- China
- Prior art keywords
- filter film
- bidirectional helical
- helical pipe
- film type
- teflon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012535 impurity Substances 0.000 title claims abstract description 18
- 230000001360 synchronised effect Effects 0.000 title claims description 3
- 239000004809 Teflon Substances 0.000 claims abstract description 31
- 229920006362 Teflon® Polymers 0.000 claims abstract description 31
- 230000002457 bidirectional effect Effects 0.000 claims abstract description 30
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
- 238000001802 infusion Methods 0.000 claims abstract description 14
- 239000011324 bead Substances 0.000 claims abstract description 8
- 239000011521 glass Substances 0.000 claims abstract description 4
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- -1 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000012528 membrane Substances 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 abstract description 4
- 238000010276 construction Methods 0.000 abstract description 2
- 239000012071 phase Substances 0.000 description 25
- 238000007872 degassing Methods 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000007789 gas Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical compound FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 1
- 238000009849 vacuum degassing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
- B01D19/0031—Degasification of liquids by filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Degasification And Air Bubble Elimination (AREA)
Abstract
The invention belongs to experimental analysis equipment technical field, automatic degerming removal of impurities degasser can be preengage online more particularly to one kind, it is characterized in that, Y type teflon hoses upper end is connected with two reagent bottles with embedded mode respectively, flow speed controller is built in two branch roads of Y type teflon hoses respectively, bead is placed in two branch roads of Y type teflon hoses and the infall on total road, the total road in Y type teflon hoses lower end is connected with the first embedded Filter film type bidirectional helical pipe upper end, mixing reservoir both ends connect the first embedded Filter film type bidirectional helical pipe and the second embedded Filter film type bidirectional helical pipe by teflon hose respectively, second embedded Filter film type bidirectional helical pipe lower end is connected with infusion pump by teflon hose, mixing reservoir lower end exit is provided with check valve.The present invention is simple in construction, easy to operate, and filter membrane can slough bubble in mobile phase, impurity, bacterium etc., and flow speed controller automatically controls the proportioning of mobile phase, and glass ball can be such that mobile phase uniformly mixes and be not likely to produce bubble.
Description
Technical field
The invention belongs to experimental analysis equipment technical field, and in particular to one kind can preengage automatic degerming removal of impurities degassing online
Device.
Background technology
When carrying out efficient liquid phase experiment, the pre-treatment of mobile phase is can not be ignored the problem of.Mobile phase is because dissolving
There is oxygen or be mixed into air and influenceed experimental result.Bubble in mobile phase enters pipeline, can increase the noise of baseline, cause
Experimental result distortion；The oxygen dissolved in mobile phase is also possible to cause some components in sample to be oxidized, and bubble enters chromatographic column,
Cause the reduction of chromatographic column separating property.In addition, impurity, bacterium in mobile phase etc. enters pipeline and chromatographic column, chromatographic column is polluted,
Cause serious loss.So the removal of impurity, degerming, degassing process must be carried out before mobile phase use.
Online vacuum degassing technology is mainly the gas sloughed and be dissolved in mobile phase at present, can not remove visible gas
Bubble.And traditional bacteriological filtration mode is typically first to filter mobile phase, then the mobile phase filtered is transferred in reagent bottle, this
During be easy to produce bubble again.
The content of the invention
The purpose of the present invention is exactly to overcome above-mentioned deficiency, there is provided it is a kind of it is simple in construction, easy to operate it is online preengage from
Move degerming removal of impurities degasser.
The technical solution adopted for the present invention to solve the technical problems is：One kind can preengage automatic degerming removal of impurities degassing online
Device, including the first reagent bottle 1, the second reagent bottle 2, flow speed controller 3, bead 4, Y types teflon hose 5, first
Embedded Filter film type bidirectional helical pipe 6-1, the second embedded Filter film type bidirectional helical pipe 6-2, mixes reservoir 7, soft PTFE
Pipe 8, infusion pump 9 and check valve 10, it is characterised in that the upper end of Y types teflon hose 5 respectively with the first reagent bottle 1, second
Reagent bottle 2 is connected with embedded mode, and flow speed controller 3 is built in two branch roads of Y types teflon hose 5, glass respectively
Pearl 4 is placed in two branch roads of Y types teflon hose 5 and the infall on total road, plays a part of mixing mobile phase, Y types gather
The total road in the lower end of tetrafluoroethene flexible pipe 5 is connected with the first embedded Filter film type bidirectional helical pipe 6-1 upper ends, and mixing reservoir 7 both ends lead to
Cross teflon hose 8 and connect the first embedded embedded Filter film type bidirectional helicals of Filter film type bidirectional helical pipe 6-1 and second respectively
Pipe 6-2, the second embedded Filter film type bidirectional helical pipe 6-2 lower ends are connected with infusion pump 9 by teflon hose 8, mixing storage
The lower end exit of liquid bath 7 is provided with check valve 10.Mobile phase is passed through by distributing flow proportional by flow speed controller 3 in reagent bottle 1,2
The bead 4 crossed in Y types teflon hose 5 uniformly mixes, and flows through the first embedded Filter film type bidirectional helical pipe 6-1, passes through
After filter membrane carries out the first removal of impurity, degerming and degassing process, it is stand-by to flow into mixing reservoir 7.When infusion pump 9 needs to flow
Xiang Shi, opens check valve 10, and it is two-way by the stand-by mobile phase that handles for the first time to flow through the second embedded Filter film type in mixing reservoir 7
Screwed pipe 6-2 carries out the secondary removal of impurity, degerming and degassing process, then flows into infusion pump 9.
The invention has the advantages that filter membrane can not only slough the bubble in mobile phase, while flowing can be filtered out
Impurity, bacterium in phase etc., current velocity controller can automatically control the proportioning of mobile phase, and glass ball can make mobile phase
Uniformly mix and be not likely to produce bubble, using embedded Filter film type bidirectional helical pipe, be easy to the cleaning replacement of filter membrane.
Brief description of the drawings
Fig. 1 is a kind of structural representation that can preengage automatic degerming removal of impurities degasser online of the present invention.
In figure：1. the first reagent bottle, 2. second reagent bottles, 3. flow speed controllers, 4. beades, 5.Y type polytetrafluoroethylene (PTFE)
Flexible pipe, 6-1. first embed Filter film type bidirectional helical pipe, and 6-2. second embeds Filter film type bidirectional helical pipe, and 7. mix reservoirs,
8. teflon hose, 9. infusion pumps, 10. check valves.
Embodiment
The invention will be further described with reference to the accompanying drawings and examples.
Referring to Fig. 1, one kind proposed by the present invention can preengage automatic degerming removal of impurities degasser, including the first reagent bottle online
1, the second reagent bottle 2, flow speed controller 3, bead 4, Y types teflon hose 5, the first embedded Filter film type bidirectional helical pipe
6-1, the second embedded Filter film type bidirectional helical pipe 6-2, mixes reservoir 7, teflon hose 8, infusion pump 9 and check valve
The upper end of 10, Y type teflon hose 5 is connected with the first reagent bottle 1, the second reagent bottle 2 with embedded mode respectively, flow control
Device 3 is built in two branch roads of Y types teflon hose 5 respectively, and bead 4 is placed in two of Y types teflon hose 5
Branch road and the infall on total road, play a part of mixing mobile phase, the total road in lower end of Y types teflon hose 5 is embedded with first
Filter film type bidirectional helical pipe 6-1 upper ends are connected, and the mixing both ends of reservoir 7 are connected in first respectively by teflon hose 8
Embedding Filter film type bidirectional helical pipe 6-1 and second embeds Filter film type bidirectional helical pipe 6-2, the second embedded Filter film type bidirectional helical pipe 6-
2 lower ends are connected with infusion pump 9 by teflon hose 8, and mixing reservoir 7 lower end exit is provided with check valve 10.Flowing
Mutually by distributing flow proportional by flow speed controller 3 in reagent bottle 1,2, by the bead 4 in Y types teflon hose 5
Uniformly mixing, the first embedded Filter film type bidirectional helical pipe 6-1 is flowed through, the first removal of impurity, degerming and de- is carried out by filter membrane
After gas disposal, it is stand-by to flow into mixing reservoir 7.When infusion pump 9 needs mobile phase, check valve 10 is opened, is mixed in reservoir 7
By the stand-by mobile phase handled for the first time flow through the second embedded Filter film type bidirectional helical pipe 6-2 carry out the secondary removal of impurity, it is degerming and
Degassing process, then flow into infusion pump 9.
Using 60% methanol-water as mobile phase, it is necessary to which 2L mobile phases, at 8 points in the morning start exemplified by experiment.In first reagent bottle 1
It is water in the second reagent bottle 2 for efficient liquid phase methanol.Flow speed controller on 5 two branch roads of adjustable Y-shaped teflon hose
3, make to be installed on 6 points of start-up operations of the morning, adjust the flow velocity of mobile phase in the first reagent bottle 1 and the second reagent bottle 2, make methanol stream
Speed is 12ml/min, and the flow velocity of water is 8ml/min, and first alcohol and water is sufficiently mixed after bead 4, by the first embedded filter membrane
Formula bidirectional helical pipe 6-1, impurity in mobile phase, bacterium etc. are filtered to remove, while after sloughing the bubble in mobile phase, into mixed
Close reservoir 7.Device is automatically stopped after 100min, and flowing mixes.During work, check valve 10 is opened, adjusts the pressure of infusion pump 9
Power, the mobile phase in mixing reservoir 7 is set to enter infusion pump after the second embedded Filter film type bidirectional helical pipe 6-2 filtering degassings
9。
Claims (1)
1. one kind can preengage online and synchronous automatic degerming removal of impurities degasser, including the first reagent bottle（1）, the second reagent bottle
（2）, flow speed controller（3）, bead（4）, Y type teflon hoses（5）, the first embedded Filter film type bidirectional helical pipe（6-
1）, the second embedded Filter film type bidirectional helical pipe（6-2）, mix reservoir（7）, teflon hose（8）, infusion pump（9）With
Check valve（10）, it is characterised in that Y type teflon hoses（5）Upper end respectively with the first reagent bottle（1）, the second reagent bottle
（2）It is connected with embedded mode, flow speed controller（3）Y type teflon hoses are built in respectively（5）Two branch roads, glass
Pearl（4）It is placed in Y type teflon hoses（5）Two branch roads and total road infall, Y type teflon hoses（5）Under
Duan Zong roads and the first embedded Filter film type bidirectional helical pipe（6-1）Upper end is connected, and mixes reservoir（7）Both ends pass through polytetrafluoroethylene (PTFE)
Flexible pipe（8）The embedded Filter film type bidirectional helical pipe of connection first respectively（6-1）With the second embedded Filter film type bidirectional helical pipe（6-2）,
Second embedded Filter film type bidirectional helical pipe（6-2）Lower end and infusion pump（9）Pass through teflon hose（8）It is connected, mixing storage
Liquid bath（7）Lower end exit is provided with check valve（10）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610527725.5A CN105999771B (en) | 2016-07-06 | 2016-07-06 | One kind can preengage online and synchronous automatic degerming removal of impurities degasser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610527725.5A CN105999771B (en) | 2016-07-06 | 2016-07-06 | One kind can preengage online and synchronous automatic degerming removal of impurities degasser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105999771A CN105999771A (en) | 2016-10-12 |
| CN105999771B true CN105999771B (en) | 2018-01-16 |
Family
ID=57107353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610527725.5A Expired - Fee Related CN105999771B (en) | 2016-07-06 | 2016-07-06 | One kind can preengage online and synchronous automatic degerming removal of impurities degasser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999771B (en) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595496A (en) * | 1984-06-29 | 1986-06-17 | Millipore Corporation | Liquid composition control |
| CN2132987Y (en) * | 1992-08-11 | 1993-05-12 | 上海市环境保护科学研究所 | Flow continous-ion electrode analysis meter |
| CA2673789A1 (en) * | 2006-12-28 | 2008-07-10 | Carrier Corporation | Beverage proportioning |
| CN201060121Y (en) * | 2007-05-08 | 2008-05-14 | 华中科技大学同济医学院职业医学研究所 | High efficiency total dust sampling head |
| US9128071B2 (en) * | 2010-06-16 | 2015-09-08 | Hitachi High-Technologies Corporation | Liquid mixing device and liquid chromatograph |
| US9884266B2 (en) * | 2013-07-08 | 2018-02-06 | Orlab Chromatography, Llc | Fluoropolymer pneumatically/hydraulically actuated liquid chromatographic system for use with harsh reagents |
| CN204364947U (en) * | 2014-12-26 | 2015-06-03 | 中国水产科学研究院长江水产研究所 | SPE auxiliary piping system |
| CN204745739U (en) * | 2015-06-03 | 2015-11-11 | 中美华世通生物医药科技（武汉）有限公司 | Pressurization chromatographic system |
-
2016
- 2016-07-06 CN CN201610527725.5A patent/CN105999771B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN105999771A (en) | 2016-10-12 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180116 |
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| CF01 | Termination of patent right due to non-payment of annual fee |