CN105998729A - Preparation method of oral liquid for treating headache with syndrome of yin deficiency - Google Patents

Preparation method of oral liquid for treating headache with syndrome of yin deficiency Download PDF

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CN105998729A
CN105998729A CN201610372663.5A CN201610372663A CN105998729A CN 105998729 A CN105998729 A CN 105998729A CN 201610372663 A CN201610372663 A CN 201610372663A CN 105998729 A CN105998729 A CN 105998729A
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parts
radix
extraction
headache
oral liquid
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李冬琼
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract

The invention discloses a preparation method of oral liquid for treating headache with syndrome of yin deficiency. A traditional Chinese medicinal composition is dried and crushed, so that raw material powder is obtained; the traditional Chinese medicinal composition consists of the following raw materials in parts by weight: 5-8 parts of cassia twig, 5-8 parts of perilla leaf, 4-6 parts of radix saposhnikoviae, 5-8 parts of fistular onion stalks, 10-15 parts of cortex lycii radicis, 8-12 parts of radix stellariae, 8-12 parts of sweet wormwood herb, 8-12 parts of radix arnebiae seu lithospermi, 10-15 parts of radix scrophulariae, 6-9 parts of rhizoma anemarrhenae, 10-15 parts of radix rehmanniae praeparata, 8-12 parts of colla corii asini, 8-12 parts of mulberries, 8-12 parts of herba dendrobii, 8-12 parts of radix ophiopogonis and 8-12 parts of radix angelicae sinensis; and the oral liquid for treating the headache with syndrome of yin deficiency is prepared by the following steps: mixing the raw material powder and ethanol and conducting digestion, conducting heating after the digestion until the ethanol is evaporated, so that an extract is obtained, and diluting the extract, so that the oral liquid for treating the headache with syndrome of yin deficiency is obtained.

Description

The preparation method of the oral liquid for the treatment of deficiency of YIN headache
Technical field
The present invention relates to tcm field, particularly relate to the preparation of a kind of oral liquid treating deficiency of YIN headache Method.
Background technology
Headache (headache) is clinical common symptom, generally will be limited to the head first half, including Geisoma, helix upper limb and the outer knuckle line of pillow are referred to as headache with the pain of upper bit.Cause the cause of disease of headache Numerous, doctor trained in Western medicine is broadly divided into constitutional and Secondary cases two class.The former can not be owing to a certain definite disease Cause, it is possible to be referred to as idiopathic headache, common such as migraine, tension-type headache；The latter's cause of disease can relate to Various intracranial lesions such as cerebrovascular disease, intracranial infection, craniocerebral trauma, systemic disease as heating, interior Environment disturbance and abuse psychoactive drug etc..
Headache caused by cloudy blood and deficiency of YIN-essence." Jing Yue's complete work miscellaneous card plan ": " headache due to yin-deficiency, i.e. blood Belonging to also of void, all patients on long-term have it more." dynamic caused by deficiency of YIN fire.Card see headache and hold concurrently vexed interior-heat, face Red fire, insomnia, red tongue, stringy,thready and rapid pulse.
Summary of the invention
It is an object of the invention to solve at least the above and/or defect, and provide after at least and will say Bright advantage.
It is a further object to provide the preparation method of a kind of oral liquid treating deficiency of YIN headache, Can be effectively treated the deficiency of YIN headache oral liquid.
Other purposes with some for achieving the above object, the present invention adopts the following technical scheme that
The preparation method of a kind of oral liquid treating deficiency of YIN headache, comprises the following steps:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: Ramulus Cinnamomi 5-8, Folium Perillae 5-8, Radix Saposhnikoviae 4-6, Bulbus Allii Fistulosi 5-8, Cortex Lycii 10-15, Radix Stellariae 8-12, Herba Artemisiae Annuae 8-12, Radix Arnebiae (Radix Lithospermi) 8-12, Radix Scrophulariae 10-15, Rhizoma Anemarrhenae 6-9, Radix Rehmanniae Preparata Yellow 10-15, Colla Corii Asini 8-12, Fructus Mori 8-12, Herba Dendrobii 8-12, Radix Ophiopogonis 8-12 and Radix Angelicae Sinensis 8-12；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain the oral of described treatment deficiency of YIN headache Liquid.
Preferably, in the preparation method of the oral liquid of described treatment deficiency of YIN headache, in step 3 to What the treatment deficiency of YIN was had a headache oral liquid adds the maltose alcohol of 5-8%.
Preferably, in the preparation method of the oral liquid of described treatment deficiency of YIN headache, step 2 is soaked Extracting method is substep extraction, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
The present invention at least includes following beneficial effect: first, and the present invention utilizes the traditional Chinese medical science five elements and dialectical theory, Think the deficiency of YIN headache because of tremble with fear Shu Weiqi, therefore tense pulse and fur closes puckery obstructed, interior-heat does not goes out, heat consumption seminal fluid, Decocting with the passing of time, the deficiency of YIN can not go up foster brains, and produces headache due to yin-deficiency.The present invention is by Chinese medicine medicines Reasonable compatibility, dissipates its exogenous cold, is interlinked to the outside in making, clearind deficient heat, nourishing kidney-yin, foster brains, makes deficiency of YIN head Pain is cured.
Secondly, by the Chinese medicine composition that can effectively treat deficiency of YIN headache is carried out substep alcohol steep, Make the oral liquid not only taking convenience that the prepared treatment deficiency of YIN is had a headache, and beneficially medicine effectively becomes The absorption divided, the effectively headache of the treatment deficiency of YIN.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will By the research of the present invention and practice are understood by the person skilled in the art.
Detailed description of the invention
Below the present invention is elaborated, to make those of ordinary skill in the art refer to energy after this specification Enough implement according to this.
The preparation method of a kind of oral liquid treating deficiency of YIN headache, comprises the following steps:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: Ramulus Cinnamomi 5-8, Folium Perillae 5-8, Radix Saposhnikoviae 4-6, Bulbus Allii Fistulosi 5-8, Cortex Lycii 10-15, Radix Stellariae 8-12, Herba Artemisiae Annuae 8-12, Radix Arnebiae (Radix Lithospermi) 8-12, Radix Scrophulariae 10-15, Rhizoma Anemarrhenae 6-9, Radix Rehmanniae Preparata Yellow 10-15, Colla Corii Asini 8-12, Fructus Mori 8-12, Herba Dendrobii 8-12, Radix Ophiopogonis 8-12 and Radix Angelicae Sinensis 8-12；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain the headache of the described treatment deficiency of YIN mouth Take liquid.
The present invention utilizes the traditional Chinese medical science five elements and dialectical theory, it is believed that deficiency of YIN headache is because of cold Shu Weiqi, therefore tense pulse And fur closes puckery obstructed, interior-heat does not goes out, heat consumption seminal fluid, decocts with the passing of time, and the deficiency of YIN can not go up foster brains, and Produce headache due to yin-deficiency.
The concrete pharmacology of Chinese medicine composition of the present invention is:
Ramulus Cinnamomi, cold-dispelling, warming the meridian and promoting blood circulation；
Folium Perillae, dispersing wind-cold；
Radix Saposhnikoviae, expelling pathogenic wind from the body surface；
Bulbus Allii Fistulosi, dispelling cold and activating YANG, detoxicating and resolving stagnation of pathogens；
Cortex Lycii, clearind deficient heat；
Radix Stellariae, reducing the asthenic fever；
Herba Artemisiae Annuae, clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) dissipates thoroughly, is apt to make a cloudy point latent heat thoroughly reach outer dissipating；
Radix Arnebiae (Radix Lithospermi), heat-clearing and toxic substances removing；
Radix Scrophulariae, nourishing kidney-yin；
The Rhizoma Anemarrhenae, nourishing YIN to lower pathogenic fire；
Radix Rehmanniae Preparata, nourishing the blood and yin, vital essence replenishing and marrow benifiting；
Colla Corii Asini, nourishing YIN and benefiting blood；
Fructus Mori, nourishing YIN and supplementing blood, foster marrow；
Herba Dendrobii, nourishing kidney-yin, clearind deficient heat, tonifying five ZANG-organs；
Radix Ophiopogonis, nourishing lung-YIN, reinforcing stomach reg fluid；Radix Angelicae Sinensis, enriches blood and blood.
The present invention reasonable compatibility by Chinese medicine medicines, dissipates its exogenous cold, is interlinked to the outside in making, clearind deficient heat, Nourishing kidney-yin, foster brains, make deficiency of YIN headache be cured.
In the preparation method of the oral liquid of described treatment deficiency of YIN headache, to the treatment deficiency of YIN in step 3 Headache oral liquid in add the maltose alcohol of 5-8%.
In the preparation method of the oral liquid of described treatment deficiency of YIN headache, in step 2, leach extraction method is for dividing Step extraction, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
Substep extraction can make effective ingredient more fully discharge, and improves curative effect of medication.
Although embodiment of the present invention are disclosed as above, but it is not restricted to description and embodiment party Listed utilization in formula, it can be applied to various applicable the field of the invention completely, for being familiar with ability For the personnel in territory, be easily achieved other amendment, therefore without departing substantially from claim and etc. homotype Enclosing under limited general concept, the present invention is not limited to specific details.

Claims (3)

1. the preparation method of the oral liquid treating deficiency of YIN headache, it is characterised in that include following step Rapid:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: Ramulus Cinnamomi 5-8, Folium Perillae 5-8, Radix Saposhnikoviae 4-6, Bulbus Allii Fistulosi 5-8, Cortex Lycii 10-15, Radix Stellariae 8-12, Herba Artemisiae Annuae 8-12, Radix Arnebiae (Radix Lithospermi) 8-12, Radix Scrophulariae 10-15, Rhizoma Anemarrhenae 6-9, Radix Rehmanniae Preparata Yellow 10-15, Colla Corii Asini 8-12, Fructus Mori 8-12, Herba Dendrobii 8-12, Radix Ophiopogonis 8-12 and Radix Angelicae Sinensis 8-12；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain the oral of described treatment deficiency of YIN headache Liquid.
2. the preparation method of the oral liquid for the treatment of deficiency of YIN headache as claimed in claim 1, its feature exists In, in step 3 to treatment deficiency of YIN headache oral liquid in add the maltose alcohol of 5-8%.
3. the preparation method of the oral liquid for the treatment of deficiency of YIN headache as claimed in claim 1, its feature exists In, in step 2, leach extraction method is substep extraction, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
CN201610372663.5A 2016-05-31 2016-05-31 Preparation method of oral liquid for treating headache with syndrome of yin deficiency Pending CN105998729A (en)

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Application publication date: 20161012