CN105998474A - Traditional Chinese medicine composition for treating uterine fibroid - Google Patents
Traditional Chinese medicine composition for treating uterine fibroid Download PDFInfo
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a traditional Chinese medicine composition for treating uterine fibroid. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 30-35 parts of wild buckwheat, 20-25 parts of common bombax flower, 6-9 parts of grass-leaved sweetflag rhizome, 6-9 parts of alectoria asiatica du rietz, 10-15 parts of red vinespinach, 10-15 parts of madder, 3-5 parts of Uniflower Swisscentaury Root, 2-4 parts of Ampelopsis japonica, 8-12 parts of puffball fruiting body, 15-20 parts of Pteris multifida, 10-13 parts of seed of cowherb, 8-10 parts of rehmannia root, and 3-5 parts of anthriscus sylvestris leaf. The traditional Chinese medicine raw materials have the advantages of reasonable compatibility, have complementary relations and synergism, and have remarkable curative effect for treating uterine fibroid, the cure rate can reach as high as 90.8-95.8%, and total effective rate can reach as high as 97.5-98.3%; the traditional Chinese medicine composition has the advantages of no toxic and side effect, safety and reliability, and no rebound; in addition, the raw materials are abundant and easily available, have low cost, and are suitable for popularization.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for treating hysteromyoma.
Background technology
Hysteromyoma, also known as leiomyoma of uterus, is one of common gynecological diseases of women, and for women frequently-occurring disease, its sickness rate is high, although not crisis life, but can cause menorrhagia, causes hemorrhagic anemia, the most also can cause miscarriage, infertility.Hysteromyoma many employings hormonal medicaments treatment at present or operative treatment, wherein uterectomy is that one is thorough, uses and compare treatment means widely, but uterectomy often brings physiology and psychology to damage to patient；And in western medicine, although the size of tumor body can be improved, but life-time service can bring side effect, cause excretory system to damage, and the most easily recur after drug withdrawal.The formation of hysteromyoma, has endogenous cause of ill and exopathogenic factor.Outer because six evils attacks uterus in an opponent's defence, or exhaustion due to sexual indulgence fecund；In because damaged by excess of seven emotions, visceral dysfunction, the impairment of chong and ren channels, qi depression to blood stasis, caused by blood agglomeration uterus.It is rule for the treatment of with " dispersing tumor is not forgotten in hemostasis, and dispersing tumor takes into account hemostasis ", controls when with strengthening vital QI to eliminate pathogenic factors, dissipation lump in the abdomen.Therefore, a kind of Chinese medicine formula of invention can fundamentally treat hysteromyoma, and will not bring misery and side effect to patient.
Summary of the invention
Present invention aims to prior art not enough, it is provided that a kind of Chinese medicine composition for treating hysteromyoma.The raw material of Chinese medicine reasonable compatibility of the present invention, complements each other, synergism, and treatment hysteromyoma is evident in efficacy, and cure rate is up to 90.8 ~ 95.8%, and total effective rate is up to 97.5 ~ 98.3%, and has no side effect, safe and reliable, does not rebounds.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of Chinese medicine composition for treating hysteromyoma, counting by weight, its raw material includes: Rhizoma Fagopyri Dibotryis 30 ~ 35 parts, Flos Bombacis Malabarici 20 ~ 25 parts, Rhizoma Acori Graminei 6 ~ 9 parts, Alectoria asiatica Du Rietz 6 ~ 9 parts, Herba basellae rubrae 10 ~ 15 parts, 10 ~ 15 parts of Radix Rubiae, Radix Rhapontici 3 ~ 5 parts, Radix Ampelopsis 2 ~ 4 parts, Lasiosphaera Seu Calvatia 8 ~ 12 parts, Pteris multifida 15 ~ 20 parts, Semen Vaccariae 10 ~ 13 parts, Radix Rehmanniae 8 ~ 10 parts and Anthriscus syluestris (L.) Hoffm. 3 ~ 5 parts.
Preferably, a kind of Chinese medicine composition for treating hysteromyoma, counting by weight, its raw material includes: Rhizoma Fagopyri Dibotryis 33 parts, Flos Bombacis Malabarici 22 parts, Rhizoma Acori Graminei 8 parts, Alectoria asiatica Du Rietz 8 parts, Herba basellae rubrae 12 parts, 13 parts of Radix Rubiae, Radix Rhapontici 4 parts, Radix Ampelopsis 3 parts, Lasiosphaera Seu Calvatia 10 parts, Pteris multifida 18 parts, Semen Vaccariae 11 parts, Radix Rehmanniae 9 parts and Anthriscus syluestris (L.) Hoffm. 4 parts.
The preparation method of the Chinese medicine composition for treating hysteromyoma as above, specifically includes following steps:
(1) after Rhizoma Fagopyri Dibotryis, Flos Bombacis Malabarici, Rhizoma Acori Graminei, Alectoria asiatica Du Rietz, Herba basellae rubrae, Radix Rubiae, Radix Rhapontici, Radix Ampelopsis, Lasiosphaera Seu Calvatia, Pteris multifida, Semen Vaccariae, Radix Rehmanniae and Anthriscus syluestris (L.) Hoffm. being mixed by proportioning, by the ethanol solution reflux, extract, twice of the 95wt% of 8 times of weight, each 1 hour, merge twice extracting solution, reclaim ethanol；
(2) by the boiling water extraction 2 hours of 10 times of weight of gained filtering residue after step (1) alcohol extraction, filter and collect extracting solution；(3) step (1) alcohol extraction gained extracting solution is carried with step (2) water carry out being concentrated to give extractum after gained extracting solution merges, gained extractum is spray-dried to obtain mixed-powder, prepare described Chinese medicine composition.
The beneficial effects of the present invention is:The raw material of Chinese medicine reasonable compatibility of the present invention, complements each other, synergism, and treatment hysteromyoma is evident in efficacy, and cure rate is up to 90.8 ~ 95.8%, and total effective rate is up to 97.5 ~ 98.3%；And have no side effect, safe and reliable, do not rebound；Additionally, abundant raw materials is easy to get, low cost, it is suitable for promoting.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described, but the present invention is not limited only to these embodiments.
Embodiment 1
A kind of Chinese medicine composition for treating hysteromyoma, counting by weight, its raw material includes: Rhizoma Fagopyri Dibotryis 30 parts, Flos Bombacis Malabarici 20 parts, Rhizoma Acori Graminei 6 parts, Alectoria asiatica Du Rietz 6 parts, Herba basellae rubrae 10 parts, 10 parts of Radix Rubiae, Radix Rhapontici 3 parts, Radix Ampelopsis 2 parts, Lasiosphaera Seu Calvatia 8 parts, Pteris multifida 15 parts, Semen Vaccariae 10 parts, Radix Rehmanniae 8 parts and Anthriscus syluestris (L.) Hoffm. 3 parts.
Embodiment 2
A kind of Chinese medicine composition for treating hysteromyoma, counting by weight, its raw material includes: Rhizoma Fagopyri Dibotryis 35 parts, Flos Bombacis Malabarici 25 parts, Rhizoma Acori Graminei 9 parts, Alectoria asiatica Du Rietz 9 parts, Herba basellae rubrae 15 parts, 15 parts of Radix Rubiae, Radix Rhapontici 5 parts, Radix Ampelopsis 4 parts, Lasiosphaera Seu Calvatia 12 parts, Pteris multifida 20 parts, Semen Vaccariae 13 parts, Radix Rehmanniae 10 parts and Anthriscus syluestris (L.) Hoffm. 5 parts.
Embodiment 3
A kind of Chinese medicine composition for treating hysteromyoma, counting by weight, its raw material includes: Rhizoma Fagopyri Dibotryis 33 parts, Flos Bombacis Malabarici 22 parts, Rhizoma Acori Graminei 8 parts, Alectoria asiatica Du Rietz 8 parts, Herba basellae rubrae 12 parts, 13 parts of Radix Rubiae, Radix Rhapontici 4 parts, Radix Ampelopsis 3 parts, Lasiosphaera Seu Calvatia 10 parts, Pteris multifida 18 parts, Semen Vaccariae 11 parts, Radix Rehmanniae 9 parts and Anthriscus syluestris (L.) Hoffm. 4 parts.
The preparation method of Chinese medicine composition for treating hysteromyoma described in embodiment 1-3, specifically includes following steps:
(1) after Rhizoma Fagopyri Dibotryis, Flos Bombacis Malabarici, Rhizoma Acori Graminei, Alectoria asiatica Du Rietz, Herba basellae rubrae, Radix Rubiae, Radix Rhapontici, Radix Ampelopsis, Lasiosphaera Seu Calvatia, Pteris multifida, Semen Vaccariae, Radix Rehmanniae and Anthriscus syluestris (L.) Hoffm. being mixed by proportioning, by the ethanol solution reflux, extract, twice of the 95wt% of 8 times of weight, each 1 hour, merge twice extracting solution, reclaim ethanol；
(2) by the boiling water extraction 2 hours of 10 times of weight of gained filtering residue after step (1) alcohol extraction, filter and collect extracting solution；(3) step (1) alcohol extraction gained extracting solution is carried with step (2) water carry out being concentrated to give extractum after gained extracting solution merges, gained extractum is spray-dried to obtain mixed-powder, prepare described Chinese medicine composition.
One, Drug toxicity trails
Acute oral toxicity test: these product are by Ministry of Public Health " cosmetics health specification " (version in 2002) " test method(s) of once limiting the quantity in acute oral toxicity test ", one time per os gives white mice (body weight 18g～22g), 20, the Chinese medicine composition distilled water of the present invention is dissolved, obtain gavage amount 20ml/kg, per os gives 20 white mice, observe 15 days, experimental animal does not finds poisoning manifestations, without dead, place's post mortem is not apparent from exception, it is judged that the nontoxic level in these product border true to chmice acute Oral toxicity.
Two, clinical trial
1. clinical data: 360 example climacteric womens, 48 ~ 55 years old age, the course of disease more than 1 year；It is randomly divided into three groups, often organizes and take embodiment 1, embodiment 2 and the Chinese medicine composition of embodiment 3 respectively, often organize 120 people.
2. diagnostic criteria: " the Chinese medical disease Standardization of diagnosis and curative effect " formulated using State Administration of Traditional Chinese Medicine, as clinical diagnosis foundation, and has B ultrasonic to confirm.
3. treatment and observational technique: use invention formulation, consumption is decided according to patient condition and body constitution, adds and subtracts with disease, controls, at each 6-9 gram, three times a day, directly to take with warm water.Within 1 month, it is a course for the treatment of, treats 3 courses for the treatment of.Monthly do 1 ultrasound diagnosis (clean period 4～do in 7 days), observe muscular tumor and change situation.
4. criterion of therapeutical effect: have uterine fibroid disease efficacy assessment standard according in " traditional Chinese medical science Clinical Researches of New Drugs guideline " that Ministry of Public Health is formulated, recovery from illness: menstrual blood volume reduces to normally, and hysteromyoma disappears, and uterus is obviously reduced；Effective: menstrual blood volume reduces, and hysteromyoma reduces, and uterus reduces；Invalid: menstrual blood volume does not subtracts, hysteromyoma size is without changing, and uterus size is unchanged.
5. therapeutic outcome: after the course for the treatment of in March, the therapeutic effect of clinical trial patient is as shown in table 1.
The therapeutic effect of table 1 hysteromyoma
The foregoing is only presently preferred embodiments of the present invention, all impartial changes done according to scope of the present invention patent and modification, all should belong to the covering scope of the present invention.
Claims (3)
1. the Chinese medicine composition being used for treating hysteromyoma, it is characterized in that: count by weight, the raw material of described Chinese medicine composition includes: Rhizoma Fagopyri Dibotryis 30 ~ 35 parts, Flos Bombacis Malabarici 20 ~ 25 parts, Rhizoma Acori Graminei 6 ~ 9 parts, Alectoria asiatica Du Rietz 6 ~ 9 parts, Herba basellae rubrae 10 ~ 15 parts, 10 ~ 15 parts of Radix Rubiae, Radix Rhapontici 3 ~ 5 parts, Radix Ampelopsis 2 ~ 4 parts, Lasiosphaera Seu Calvatia 8 ~ 12 parts, Pteris multifida 15 ~ 20 parts, Semen Vaccariae 10 ~ 13 parts, Radix Rehmanniae 8 ~ 10 parts and Anthriscus syluestris (L.) Hoffm. 3 ~ 5 parts.
Chinese medicine composition for treating hysteromyoma the most according to claim 1, it is characterized in that: count by weight, the raw material of described Chinese medicine composition includes: Rhizoma Fagopyri Dibotryis 33 parts, Flos Bombacis Malabarici 22 parts, Rhizoma Acori Graminei 8 parts, Alectoria asiatica Du Rietz 8 parts, Herba basellae rubrae 12 parts, 13 parts of Radix Rubiae, Radix Rhapontici 4 parts, Radix Ampelopsis 3 parts, Lasiosphaera Seu Calvatia 10 parts, Pteris multifida 18 parts, Semen Vaccariae 11 parts, Radix Rehmanniae 9 parts and Anthriscus syluestris (L.) Hoffm. 4 parts.
3. prepare as claimed in claim 1 or 2 for the method treating the Chinese medicine composition of hysteromyoma for one kind, it is characterised in that: specifically include following steps:
(1) after Rhizoma Fagopyri Dibotryis, Flos Bombacis Malabarici, Rhizoma Acori Graminei, Alectoria asiatica Du Rietz, Herba basellae rubrae, Radix Rubiae, Radix Rhapontici, Radix Ampelopsis, Lasiosphaera Seu Calvatia, Pteris multifida, Semen Vaccariae, Radix Rehmanniae and Anthriscus syluestris (L.) Hoffm. being mixed by proportioning, by the ethanol solution reflux, extract, twice of the 95wt% of 8 times of weight, each 1 hour, merge twice extracting solution, reclaim ethanol；
(2) by the boiling water extraction 2 hours of 10 times of weight of gained filtering residue after step (1) alcohol extraction, filter and collect extracting solution；(3) step (1) alcohol extraction gained extracting solution is carried with step (2) water carry out being concentrated to give extractum after gained extracting solution merges, gained extractum is spray-dried to obtain mixed-powder, prepare described Chinese medicine composition.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073643A (en) * | 2006-05-19 | 2007-11-21 | 高尚先 | Chinese-medicinal preparation for preventing and treating alactasia and gynecopathy, its production and use |
| CN102225145A (en) * | 2011-06-27 | 2011-10-26 | 王丽 | Traditional Chinese medicine oral liquid for treating hysteromyoma and preparation method thereof |
| CN102670766A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Traditional Chinese medicine composition for treating uterine fibroid |
| CN105106494A (en) * | 2015-09-21 | 2015-12-02 | 潘剑崎 | Traditional Chinese medicine for treating uterine fibroid |
| CN105797005A (en) * | 2016-05-04 | 2016-07-27 | 宋毅 | Traditional Chinese medicine composition for treating hysteromyoma |
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- 2016-08-12 CN CN201610658216.6A patent/CN105998474A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073643A (en) * | 2006-05-19 | 2007-11-21 | 高尚先 | Chinese-medicinal preparation for preventing and treating alactasia and gynecopathy, its production and use |
| CN102670766A (en) * | 2011-03-09 | 2012-09-19 | 广州加原医药科技有限公司 | Traditional Chinese medicine composition for treating uterine fibroid |
| CN102225145A (en) * | 2011-06-27 | 2011-10-26 | 王丽 | Traditional Chinese medicine oral liquid for treating hysteromyoma and preparation method thereof |
| CN105106494A (en) * | 2015-09-21 | 2015-12-02 | 潘剑崎 | Traditional Chinese medicine for treating uterine fibroid |
| CN105797005A (en) * | 2016-05-04 | 2016-07-27 | 宋毅 | Traditional Chinese medicine composition for treating hysteromyoma |
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