CN105998125B - The big Lian composition of radix aucklandiae and its application - Google Patents
The big Lian composition of radix aucklandiae and its application Download PDFInfo
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- CN105998125B CN105998125B CN201610521692.3A CN201610521692A CN105998125B CN 105998125 B CN105998125 B CN 105998125B CN 201610521692 A CN201610521692 A CN 201610521692A CN 105998125 B CN105998125 B CN 105998125B
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- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 239000000284 extract Substances 0.000 claims abstract description 72
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 53
- 235000019441 ethanol Nutrition 0.000 claims abstract description 28
- 239000000706 filtrate Substances 0.000 claims abstract description 12
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- 238000010992 reflux Methods 0.000 claims abstract description 9
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 208000007107 Stomach Ulcer Diseases 0.000 claims abstract description 7
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 7
- 201000005917 gastric ulcer Diseases 0.000 claims abstract description 7
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- 229940079593 drug Drugs 0.000 claims abstract description 6
- 238000004064 recycling Methods 0.000 claims abstract description 6
- 238000005238 degreasing Methods 0.000 claims abstract description 4
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 15
- 208000011906 peptic ulcer disease Diseases 0.000 claims description 15
- 239000002023 wood Substances 0.000 claims 1
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- 230000002496 gastric effect Effects 0.000 abstract description 13
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- 230000002401 inhibitory effect Effects 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
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- 241001674044 Blattodea Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- 230000001154 acute effect Effects 0.000 description 2
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- 238000002651 drug therapy Methods 0.000 description 2
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- HRYLQFBHBWLLLL-UHFFFAOYSA-N (+)-costunolide Natural products C1CC(C)=CCCC(C)=CC2OC(=O)C(=C)C21 HRYLQFBHBWLLLL-UHFFFAOYSA-N 0.000 description 1
- NETSQGRTUNRXEO-UHFFFAOYSA-N 3,6,9-Trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one Chemical compound C12OC(=O)C(=C)C2CCC(=C)C2C1C(=C)CC2 NETSQGRTUNRXEO-UHFFFAOYSA-N 0.000 description 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000238660 Blattidae Species 0.000 description 1
- CUGKULNFZMNVQI-UHFFFAOYSA-N Costunolid I Natural products CC1=CCC=C(/C)CCC2C(C1)OC(=O)C2=C CUGKULNFZMNVQI-UHFFFAOYSA-N 0.000 description 1
- WKSUCCVMYJRMFR-UHFFFAOYSA-N Dehydrocostus lactone Natural products C12OC(=O)C(=C)C2CCC(=C)C2(C)C1(C)C(=C)CC2 WKSUCCVMYJRMFR-UHFFFAOYSA-N 0.000 description 1
- 206010019375 Helicobacter infections Diseases 0.000 description 1
- 241000500891 Insecta Species 0.000 description 1
- 206010030201 Oesophageal ulcer Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
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- 244000272264 Saussurea lappa Species 0.000 description 1
- 235000006784 Saussurea lappa Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229940010048 aluminum sulfate Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 1
- 229960002626 clarithromycin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- HRYLQFBHBWLLLL-AHNJNIBGSA-N costunolide Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]21 HRYLQFBHBWLLLL-AHNJNIBGSA-N 0.000 description 1
- MMTZAJNKISZWFG-UHFFFAOYSA-N costunolide Natural products CC1CCC2C(CC(=C/C=C1)C)OC(=O)C2=C MMTZAJNKISZWFG-UHFFFAOYSA-N 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- YAZBKDRDYPAXAO-UHFFFAOYSA-N dehydro-alpha-curcumene Natural products CC(C)=CCCC(=C)C1=CC=C(C)C=C1 YAZBKDRDYPAXAO-UHFFFAOYSA-N 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 208000028299 esophageal disease Diseases 0.000 description 1
- 208000019064 esophageal ulcer Diseases 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000009246 food effect Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229960000381 omeprazole Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of big Lian composition of radix aucklandiae and its application, the composition is made of Radix Aucklandiae extract and big Lian extract；The Radix Aucklandiae extract the preparation method is as follows: refluxing extraction 1-3h obtains radix aucklandiae extracting solution in alcohol solvent by radix aucklandiae, radix aucklandiae extracting solution is filtered into obtain radix aucklandiae filtrate, radix aucklandiae decompression filtrate recycling ethanol is obtained into thick Radix Aucklandiae extract；The big Lian extract the preparation method is as follows: by after big Lian degreasing, refluxing extraction 1-3h obtains big Lian extracting solution in alcohol solvent, and big Lian extracting solution is filtered to obtain big Lian filtrate, big Lian decompression filtrate recycling ethanol is obtained big Lian extract.This composition is used to treat the drug action that peptic gastric ulcer has highly significant, especially for gastric injury caused by ethyl alcohol or aspirin, their drug action uses Radix Aucklandiae extract or big Lian extract more preferable than single.
Description
Technical field
The invention belongs to field of pharmaceutical formulations, in particular to the big Lian composition of radix aucklandiae and its in treatment peptic ulcer
Using.
Background technique
Gastric ulcer and duodenal ulcer simultaneously claim peptic ulcer, are the most common chronic gastrointestinal functions in global range
One of disorder disease, disease incidence are up to 10%.Helicobacter pylori infections, gastric acid and the pepsin equivalent damage factor and mucous membrane are certainly
The reduction of body protective capability is main pathogenesis generally acknowledged at present.Peptic ulcer clinical manifestation be upper abdomen pain, bleeding,
The complication such as perforation, still based on drug therapy, but it is big to treat difficulty.At present to the treatment of peptic ulcer still with drug therapy
Based on, including chemicals and Chinese medicine.Chemicals mainly have aluminum sulfate, Cimetidine, Omeprazole, clarithromycin, A Mo
XiLin, metronidazole etc., Chinese medicine are generally compound preparation.For chemical drugs, Chinese medicine treatment peptic ulcer has higher
Safety.
Radix aucklandiae is the dry root of compositae plant radix aucklandiae Aucklandia lappa Decne, has promoting qi circulation and relieving pain, and invigorating the spleen disappears
The effect of food.Chinese medicine is mainly used for treating chest gastral cavity distending pain, weight after rush down dysentery, dyspepsia, the diseases such as do not feel like eating.Clinical discovery is being controlled
It treats addition radix aucklandiae tool in qi-stagnating abdominalgia or the prescription of gastric ulcer to have a better effect, also it has been reported that radix aucklandiae supercritical extract pair
Experimental Gastric Ucler has good inhibiting effect.American cockroach (Periplaneta Americana) be Insecta, Blattaria,
Blattidae is commonly called as " cockroach ", first recorded in Shennong's Herbal.The medical fluid that American cockroach is extracted is used for canker sore, esophageal ulcer
And esophageal mucosa damage, promote the healing of gastric ulcer and duodenal ulcer, furthermore may also speed up the healing of wound.Thus may be used
See, in terms for the treatment of enterogastric diseases, radix aucklandiae and American cockroach have certain positive effect, but Papillary bursts to digestibility
The influence of ulcer there is no research to report.
Summary of the invention
In view of this, one of the objects of the present invention is to provide a kind of radix aucklandiae American cockroach compositions；The purpose of the present invention
Two be to provide application of the radix aucklandiae American cockroach composition in treatment peptic ulcer.
For achieving the above object, the invention provides the following technical scheme:
1, the big Lian composition of radix aucklandiae, the composition are made of Radix Aucklandiae extract and big Lian extract；
The Radix Aucklandiae extract the preparation method is as follows: by radix aucklandiae in alcohol solvent refluxing extraction 1-3h obtain radix aucklandiae extraction
Radix aucklandiae extracting solution is filtered to obtain radix aucklandiae filtrate, radix aucklandiae decompression filtrate recycling ethanol is obtained thick Radix Aucklandiae extract by liquid；
The big Lian extract the preparation method is as follows: by after big Lian degreasing, refluxing extraction 1-3h is obtained in alcohol solvent
Big Lian extracting solution is filtered to obtain big Lian filtrate, big Lian decompression filtrate recycling ethanol is obtained big Lian extract by big Lian extracting solution.
Preferably, the mass ratio of the Radix Aucklandiae extract in the composition and American-cockroach-extract is 1:0.5~1.5.
Preferably, the mass ratio of the Radix Aucklandiae extract in the composition and American-cockroach-extract is 1:1.
Preferably, when preparing Radix Aucklandiae extract and big Lian extract, the mass fraction of alcohol solvent used is 75-95%.
Preferably, when preparing Radix Aucklandiae extract and big Lian extract, the mass body of the radix aucklandiae or big Lian and alcohol solvent
Product is 1:10 than (g/ml).
Preferably, the big Lian is American cockroach.
Further, when preparing Radix Aucklandiae extract and big Lian extract, using supercritical CO2Extraction method prepares Radix Aucklandiae extract
With big Lian extract.
2, application of the big Lian composition of the radix aucklandiae in treatment peptic ulcer.
Further, the peptic ulcer is gastric injury caused by ethyl alcohol or aspirin.
The beneficial effects of the present invention are: the present invention extracts Radix Aucklandiae extract by simple method and big Lian is extracted
Then two kinds of extracts are combined to obtain their composition, are used for this composition to treat peptic gastric ulcer by object
There is the drug action of highly significant, especially for gastric injury caused by ethyl alcohol or aspirin, their drug action is than single
One use Radix Aucklandiae extract or big Lian extract are more preferable.
Specific embodiment
Below by a preferred embodiment of the present invention will be described in detail.The experiment of actual conditions is not specified in embodiment
Method, usually according to condition proposed by routine techniques or knowledge.
The preparation method of 1 extract of embodiment
Radix Aucklandiae extract: radix aucklandiae is ground into coarse powder, weighs 100g and is put into Soxhlet extractor, and 95% ethyl alcohol 1L, reflux is added
2h is extracted, extracting solution is collected, filtering is recovered under reduced pressure ethyl alcohol, obtains thick radix aucklandiae ethanol extract 7.23g, analyzes and leads through HPLC
Contain costunolide and dehydro-α-curcumene.
American-cockroach-extract: American cockroach is ground into coarse powder, weighs 100g and is put into Soxhlet extractor, is added 60~90 DEG C
Petroleum ether 1L, refluxing extraction 1h, carry out ungrease treatment, after collecting petroleum ether extract, remaining solid component, that is, degreasing beauty
The big Lian powder in continent continues to collect ethanol extract with 95% ethyl alcohol 1.5L refluxing extraction 1.5h, and filtering is recovered under reduced pressure ethyl alcohol, obtains beautiful
The big Lian extract in continent.It is measured by automatic amino acid analyzer, American-cockroach-extract contains 18 kinds of amino of constitutive protein matter
Acid, total amount reach 26.17%.
2 radix aucklandiae American cockroach composition of embodiment
Radix aucklandiae American cockroach composition, specific formula are as follows:
Formula: Radix Aucklandiae extract 1g, American-cockroach-extract 1g.
According to embodiment 1 carry out Radix Aucklandiae extract and American-cockroach-extract preparation, by the extract prepared according to
Above-mentioned recipe ratio carries out uniformly mixed, obtained radix aucklandiae American cockroach composition.
The application of 3 radix aucklandiae American cockroach composition of embodiment treatment ethyl alcohol gastric injury
Take rat 24, male and female each 12, be randomly divided into 4 groups, every group 6, respectively model group, Radix Aucklandiae extract group,
American-cockroach-extract group and radix aucklandiae American cockroach mixing group.Model group gives isometric 0.5%CMC-Na, and radix aucklandiae group is given
Radix Aucklandiae extract 1g/kg of the invention, American cockroach group give big Lian extract 1g/kg of the invention, and radix aucklandiae American cockroach is mixed
The mixture that object group gives radix aucklandiae and American-cockroach-extract 1:1 of the invention is closed, it is molten that extract is suspended in 0.5%CMC-Na
In liquid, daily gastric infusion is primary, and continuous 7 days.After last dose 1h, each group rat oral gavage gives dehydrated alcohol 1mL.Ethyl alcohol damage
After hurting 1h, rat is put to death, the inspection of gastric injury is carried out.
After rat dissection, full stomach is taken out, normal saline flushing immerses in 2% formalin solution and fixes 10min, then
Gastric ulcer area is measured under the microscope, and damaged area summation is area damage index (mm2).Damage inhibits percentage by following
Formula calculates:
Obtain inhibitory effect as shown in Table 1:
Inhibitory effect of the 1 radix aucklandiae American cockroach mixture (1:1) of table to ethyl alcohol induced Acute gastric injury
Note: inhibiting rate is in table with the mean value calculation of each group damage index；It is molten that model group gives isometric 0.5%CMC-Na
Liquid；The control of radix aucklandiae group, American cockroach group as radix aucklandiae American cockroach mixture group；When gastric injury, each group rat give 1mL without
Water-ethanol is primary.
As seen from Table 1, by the way that Radix Aucklandiae extract and American-cockroach-extract to be combined, it is subsequently used for treatment ethyl alcohol
Induced Acute gastric injury, inhibiting rate have reached 80.09%, than the significant effect of radix aucklandiae or American cockroach is used alone very
It is more.
The application of 4 radix aucklandiae American cockroach composition of embodiment treatment aspirin gastric injury
Rat 24, it is randomly divided into 4 groups, respectively model group, Radix Aucklandiae extract group, American-cockroach-extract group, radix aucklandiae
American-cockroach-extract mixture group (1:1).Model group gives isometric 0.5%CMC-Na, and radix aucklandiae group is given of the invention
Radix Aucklandiae extract 1g/kg, American cockroach group give American-cockroach-extract 1g/kg of the invention, radix aucklandiae American cockroach mixture
Group gives the mixture 1g/kg of radix aucklandiae and American-cockroach-extract 1:1 of the invention, and extract is suspended in 0.5%CMC-Na
In solution, daily gastric infusion is primary, and continuous 7 days.After last dose 1h, each group rat oral gavage gives aspirin 250mg/
kg.After giving aspirin 4h, rat is put to death, the inspection of gastric injury is carried out, obtains inhibitory effect as shown in Table 2:
Inhibitory effect of the big Lian mixture (1:1) of 2 radix aucklandiae of table to rat stomach injury caused by aspirin
Note: inhibiting rate is in table with the mean value calculation of each group damage index；Model group gives isometric 0.5%CMC-Na
Solution；The control of radix aucklandiae group, American cockroach group as radix aucklandiae American cockroach mixture group；Each group rat gives aspirin
250mg/kg is primary.
As seen from Table 2, by the way that Radix Aucklandiae extract and American-cockroach-extract to be combined, it is subsequently used for treatment Ah Si
Rat stomach injury caused by woods, inhibiting rate have reached 61.03%, than the significant effect that radix aucklandiae or American cockroach is used alone
Very much.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention and not to limit it, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (7)
1. the composition for treating peptic ulcer, which is characterized in that the composition is extracted by Radix Aucklandiae extract and big Lian
Object composition；
The Radix Aucklandiae extract the preparation method is as follows: refluxing extraction 1-3h obtains radix aucklandiae extracting solution in alcohol solvent by radix aucklandiae,
Radix aucklandiae extracting solution is filtered into obtain radix aucklandiae filtrate, radix aucklandiae decompression filtrate recycling ethanol is obtained into thick Radix Aucklandiae extract；
The big Lian extract the preparation method is as follows: by after big Lian degreasing, refluxing extraction 1-3h obtains big Lian in alcohol solvent
Big Lian extracting solution is filtered to obtain big Lian filtrate, big Lian decompression filtrate recycling ethanol is obtained big Lian extract by extracting solution；
The mass ratio of Radix Aucklandiae extract and American-cockroach-extract in the composition is 1:0.5 ~ 1.5.
2. according to claim 1 for treating the composition of peptic ulcer, which is characterized in that the wood in the composition
The mass ratio of fragrant extract and American-cockroach-extract is 1:1.
3. according to claim 1 for treating the composition of peptic ulcer, which is characterized in that prepare Radix Aucklandiae extract with
When big Lian extract, the mass fraction of alcohol solvent used is 75% ~ 95%.
4. according to claim 1 for treating the composition of peptic ulcer, which is characterized in that prepare Radix Aucklandiae extract with
When big Lian extract, the mass volume ratio (g/ml) of the radix aucklandiae or big Lian and alcohol solvent is 1:10.
5. according to claim 1 for treating the composition of peptic ulcer, which is characterized in that the big Lian is that America is big
Lian.
6. application of any one of claim 1 ~ 5 composition in the drug of preparation treatment peptic ulcer.
7. application according to claim 6, which is characterized in that the peptic ulcer is caused by ethyl alcohol or aspirin
Gastric ulcer.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN103919833A (en) * | 2014-04-30 | 2014-07-16 | 万世凤 | Preparation method of large-leafed capsella bursa-pastoris oral liquid |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101292997A (en) * | 2007-04-26 | 2008-10-29 | 四川科伦药业股份有限公司 | Pharmaceutical composition for treating empyrosis or gastric ulcer, and preparation method thereof |
| CN103919833A (en) * | 2014-04-30 | 2014-07-16 | 万世凤 | Preparation method of large-leafed capsella bursa-pastoris oral liquid |
Non-Patent Citations (1)
| Title |
|---|
| "木香超临界提取物抗实验性胃溃疡的研究";韩坚等;《"木香超临界提取物抗实验性胃溃疡的研究"》;20051130;第28卷(第11期);摘要，第1017页左栏第一段 * |
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