CN105992591A - 用于降低抗原特异性免疫原性的组合物和方法 - Google Patents
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- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/106—Adducts, complexes, salts of phosphatides
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/577—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881857P | 2013-09-24 | 2013-09-24 | |
| US61/881,857 | 2013-09-24 | ||
| PCT/US2014/057234 WO2015048145A1 (en) | 2013-09-24 | 2014-09-24 | Compositions and methods for reducing antigen-specific immunogenicity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105992591A true CN105992591A (zh) | 2016-10-05 |
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| CN201480062068.0A Pending CN105992591A (zh) | 2013-09-24 | 2014-09-24 | 用于降低抗原特异性免疫原性的组合物和方法 |
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| Country | Link |
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| US (1) | US20160243220A1 (enExample) |
| EP (1) | EP3049103B1 (enExample) |
| JP (1) | JP6783652B2 (enExample) |
| CN (1) | CN105992591A (enExample) |
| ES (1) | ES2807550T3 (enExample) |
| WO (1) | WO2015048145A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022192899A1 (en) * | 2021-03-11 | 2022-09-15 | Lapix Therapeutics, Inc. | Compositions and methods for reducing immune intolerance |
| JP2024532810A (ja) * | 2021-08-13 | 2024-09-10 | ラピックス セラピューティクス， インコーポレイテッド | 免疫不寛容を軽減し、自己免疫障害を治療するための組成物及び方法 |
| CN117940407A (zh) | 2021-08-13 | 2024-04-26 | Lapix生物治疗股份有限公司 | 降低免疫不耐受和治疗自身免疫病症的组合物和方法 |
| EP4608969A1 (en) | 2022-10-25 | 2025-09-03 | Lapix Therapeutics, Inc. | Immune cell-engrafted non-human animals and non-human animal models |
| WO2024118602A1 (en) | 2022-11-29 | 2024-06-06 | Lapix Therapeutics, Inc. | Compositions and methods for reducing immune intolerance and treating autoimmune disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7625584B2 (en) | 2000-11-30 | 2009-12-01 | The Research Foundation Of State University Of New York | Method of complexing a protein by the use of a dispersed system and proteins thereof |
| US8110218B2 (en) | 2000-11-30 | 2012-02-07 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein-lipid complexes |
| US7351688B2 (en) * | 2003-02-05 | 2008-04-01 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein formulations |
| US7875288B2 (en) | 2006-03-30 | 2011-01-25 | The Research Foundation Of State University Of New York | Method for treating blood coagulation disorders |
| WO2007117469A2 (en) | 2006-03-30 | 2007-10-18 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
| US20120164189A1 (en) * | 2009-07-07 | 2012-06-28 | Balu-Iyer Sathy V | Lipidic Compositions for Induction of Immune Tolerance |
-
2014
- 2014-09-24 WO PCT/US2014/057234 patent/WO2015048145A1/en not_active Ceased
- 2014-09-24 CN CN201480062068.0A patent/CN105992591A/zh active Pending
- 2014-09-24 JP JP2016516601A patent/JP6783652B2/ja active Active
- 2014-09-24 US US15/024,071 patent/US20160243220A1/en not_active Abandoned
- 2014-09-24 EP EP14848904.0A patent/EP3049103B1/en active Active
- 2014-09-24 ES ES14848904T patent/ES2807550T3/es active Active
Non-Patent Citations (1)
| Title |
|---|
| VIVEK S.PUROHIT ET AL.: "Lower Inhibitor Development in Hemophilia A Mice following Administration of Recombinant Factor VIII-O-Phospho-L-serine Complex*", 《THE JOURNALOF BIOLOGICAL CHEMISTRY》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016531853A (ja) | 2016-10-13 |
| JP6783652B2 (ja) | 2020-11-11 |
| WO2015048145A1 (en) | 2015-04-02 |
| EP3049103A1 (en) | 2016-08-03 |
| EP3049103A4 (en) | 2017-09-27 |
| EP3049103B1 (en) | 2020-06-24 |
| WO2015048145A9 (en) | 2015-06-25 |
| ES2807550T3 (es) | 2021-02-23 |
| US20160243220A1 (en) | 2016-08-25 |
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Application publication date: 20161005 |