CN105983135A - Developing-able neural restoration conduit and preparation method thereof - Google Patents
Developing-able neural restoration conduit and preparation method thereof Download PDFInfo
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- CN105983135A CN105983135A CN201510043341.1A CN201510043341A CN105983135A CN 105983135 A CN105983135 A CN 105983135A CN 201510043341 A CN201510043341 A CN 201510043341A CN 105983135 A CN105983135 A CN 105983135A
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Abstract
The invention discloses a developing-able neural restoration conduit and a preparation method thereof. The developing-able neural restoration conduit includes a main conduit and a developing layer including a developing material. The developing layer covers an inner wall or an outer wall of the main conduit. The main conduit is prepared from one or more of collagen, chitosan, silk fibroin and derivatives thereof. The neural restoration conduit can achieve neural restoration in body and meanwhile achieves in-vivo material developing, thereby determining changes on the shape and position of an implant material. The neural restoration conduit has a wide application prospect in the field of neural restoration.
Description
Technical field
The present invention relates to implanted medical device and internal developing technique field, the nerve being specifically related to develop is repaiied
Multiple conduit and preparation method thereof.
Background technology
Due to the quickening of rhythm of life, people's chance of injury increases, and nerve injury is the most common, especially
It it is peripheral nerve injury.Current clinical commonly used nerve autograft or epineurium, perineurium seam
Conjunction is repaired, but donor nerve source is limited, and is required to carry out sewing up easily occur that sensory nerve is fine
Dimension and the problem such as the misconnection of Motor nerve fibre and broken ends of fractured bone scar tissue intrusion.According to the most
The neural renewal theory that selects that many scholars confirm, employing artificial neuron sheath pipe carries out Peripheral nerve repair becomes one
Individual preferable alternative method, it provides selectivity regenerative space induced damage god mainly by broken ends of fractured bone slot milling
Through regeneration.The most conventional nerve repair material is broadly divided into two classes: Biodegradable material and biology can not drop
Solve material.Employing Biodegradable material such as collagen, chitosan, fibroin albumen and derivant thereof all can be with bodies
Interior degraded and biocompatibility are good, thus overcome the drawback needing to use second operation to remove sheath pipe.
But clinically, nerve sheath tube material is because it uses X-ray or X-CT not to enter after implanting
Row development, it is impossible to represent postoperative change of shape and misalignment, this repairs the straight of situation to postoperative nerve
See judgement and cause difficulty, bring very big inconvenience also to corresponding medical research.
Summary of the invention
Nerve rehabilitating tube that present invention offer can be developed and preparation method thereof, to solve the nerve of prior art
Repair materials can not carry out the technical problem developed.
The present invention provides a kind of nerve rehabilitating tube developed, including: main body tube with comprise developing material
Developing layer；Described developing layer is covered in inwall or the outer wall of described main body tube；Described main body tube by collagen,
One or more in chitosan, fibroin albumen and derivant thereof prepare.
The present invention also provides for a kind of nerve rehabilitating tube developed, the described nerve rehabilitating tube developed
Main body tube is prepared by one or more in collagen, chitosan, fibroin albumen and derivant thereof, described master
Body pipe also comprises developing material.
Further, a diameter of required of the described nerve rehabilitating tube developed repairs neural 1.1-1.3
Times, the pipe thickness of the described nerve rehabilitating tube developed is 0.2-1.0mm.
Further, described developing material comprises: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate,
The general glucose of iohexol, iopamidol, cardiografin, Iodoaniline, amidotrizoic acid, bis-conray, first, iodine are bent
Logical sequence, Iopromide, the acid of iodine sea, ioversol, iodixanol, iodized oil, iofendylate one or more.
Further, described main body tube contains the medicative seed cell of tool, and described seed cell is selected from:
One in neural stem cell, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell or
Multiple.
Further, described main body tube contains the medicative cytokine of tool, and described cytokine is selected from:
One or more in nerve growth factor, neurotrophic factor, basic fibroblast growth factor.
The present invention also provides for the preparation method of a kind of nerve rehabilitating tube developed, including:
Utilize macromolecule material solution, use the method for electrostatic spinning to be collected by cylinder collection device and obtain god
The main body tube of repaired conduit, or, after using artificial neuron sheath pipe mold to carry out lyophilization, form removal has
Main body tube to nerve rehabilitating tube；
The developing material that particle diameter is 20nm-500um is uniformly compounded in inwall or the outer wall of described main body tube,
And thermoplastic compound after form developing layer.
The present invention also provides for the preparation method of a kind of nerve rehabilitating tube developed, including:
The developing material that macromolecular material aqueous solution and particle diameter are 20nm-500um is utilized to be sufficiently mixed；
After using artificial neuron sheath pipe mold to carry out lyophilization, form removal tool obtains comprising the nerve of developing material and repaiies
Multiple conduit, and thermoplastic is compound.
Further, described developing material comprises: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate,
The general glucose of iohexol, iopamidol, cardiografin, Iodoaniline, amidotrizoic acid, bis-conray, first, iodine are bent
Logical sequence, Iopromide, the acid of iodine sea, ioversol, iodixanol, iodized oil, iofendylate one or more.
Further, after the nerve rehabilitating tube that can develop described in preparation completes, also include:
Being injected into the described nerve rehabilitating tube that can develop by having medicative seed cell, formation comprises
The nerve rehabilitating tube developed of compound seed cell；Wherein, described seed cell is selected from: nerve trunk is thin
One or more in born of the same parents, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell；
Or, it is injected into the described nerve rehabilitating tube that can develop, shape by having medicative cytokine
Become to comprise the nerve rehabilitating tube developed of multiple cytokine；Wherein, described cytokine is selected from: god
One or more in somatomedin, neurotrophic factor, basic fibroblast growth factor.
Nerve rehabilitating tube developed that the present invention provides and preparation method thereof, it is possible to repair nerve well
Damage, and when available conventional X-ray or X-CT inspection method check, nerve rehabilitating tube can develop；Meanwhile,
This nerve rehabilitating tube is nontoxic, has good biocompatibility.Owing to the nerve rehabilitating tube of the present invention can
To realize realizing internal material Develop while carrying out CO2 laser weld in vivo, thus to embedded material shape and
Change in location judges, has broad application prospects in CO2 laser weld field.
Accompanying drawing explanation
For the technical scheme being illustrated more clearly that in the embodiment of the present invention, institute in embodiment being described below
The accompanying drawing used is needed to be briefly described, it should be apparent that, the accompanying drawing in describing below is the one of the present invention
A little embodiments, for those of ordinary skill in the art, on the premise of not paying creative work,
Other accompanying drawing can also be obtained according to these accompanying drawings:
Fig. 1 is the perspective view of the nerve rehabilitating tube developed of the embodiment of the present invention one；
Fig. 2 is the side cross sectional views of the nerve rehabilitating tube developed of the embodiment of the present invention one.
Detailed description of the invention:
For making the purpose of the embodiment of the present invention, technical scheme and advantage clearer, below in conjunction with the present invention
Accompanying drawing in embodiment, is clearly and completely described the technical scheme in the embodiment of the present invention, it is clear that
Described embodiment is a part of embodiment of the present invention rather than whole embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art obtained under not making creative work premise all its
His embodiment, broadly falls into the scope of protection of the invention.
Embodiment one
Fig. 1 is the perspective view of the nerve rehabilitating tube developed of the embodiment of the present invention one, and Fig. 2 is
The side cross sectional views of the nerve rehabilitating tube developed of the embodiment of the present invention one, as depicted in figs. 1 and 2,
The nerve rehabilitating tube 100 developed of the embodiment of the present invention one, including: main body tube 110 with comprise development material
The developing layer 120 of material；Described developing layer 120 is covered in the outer wall of described main body tube 110；Described main body tube 110
Prepared by one or more in collagen, chitosan, fibroin albumen and derivant thereof.Additionally, developing layer
The inwall of main body tube can also be covered in, the most do not limit.
Further, the described nerve rehabilitating tube 100 developed a diameter of required is repaired neural
1.1-1.3 again, the pipe thickness of the described nerve rehabilitating tube 100 developed is 0.2-1.0mm.Described development
Material comprises: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate, iohexol, iopamidol, general
Shadow Portugal amine, Iodoaniline, amidotrizoic acid, bis-conray, the general glucose of first, iotrolan, Iopromide, iodine sea
Acid, ioversol, iodixanol, iodized oil, iofendylate one or more.Wherein, hydroxyapatite,
β tricalcium phosphate, calcium carbonate or calcium sulfate are inorganic developing material, and these inorganic developing materials remove development effect
Outward, also there is reinforcement material intensity effect.
Further, described main body tube 110 is containing having medicative seed cell, and described seed cell is selected from:
One in neural stem cell, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell or
Multiple.Or, described main body tube 110 is containing having medicative cytokine, and described cytokine is selected from:
One or more in nerve growth factor, neurotrophic factor, basic fibroblast growth factor.
Embodiment two
The nerve rehabilitating tube developed of the embodiment of the present invention two, the described nerve rehabilitating tube developed
Main body tube is prepared by one or more in collagen, chitosan, fibroin albumen and derivant thereof, described master
Body pipe also comprises developing material.The nerve rehabilitating tube developed of embodiment two and developing of embodiment one
Nerve rehabilitating tube essentially identical, its principle repeats no more.Its difference is, embodiment two can
Development nerve rehabilitating tube and be provided without double-decker, but use single layer structure, prepared by developing material
In nerve rehabilitating tube.
Embodiment three
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention three, including:
Step S301, the macromolecule material solution utilizing mass fraction to be 30 parts-85 parts, use electrostatic spinning
Method collects the main body tube obtaining nerve rehabilitating tube by cylinder collection device, or, use artificial neuron
After sheath pipe mold carries out lyophilization, form removal has the main body tube obtaining nerve rehabilitating tube；Macromolecule material solution
Water or organic solvent is used to dissolve；Solvent used in method of electrostatic spinning is that hexafluoroisopropanol etc. is organic
Solvent, uses specific rotation catching device；Freeze-drying refers to special artificial of the materials such as tetrafluoroethene
Nerve sheath pipe mold loads serosity, fixing mould, is frozen into solid-state, the demoulding, then lyophilizing, takes off at-80 DEG C
Anhydrate a point formation nerve rehabilitating tube；
Step S302, is 70-15 part by mass fraction and developing material that particle diameter is 20nm-500um is uniformly combined
At inwall or the outer wall of described main body tube, and thermoplastic compound after form developing layer；Wherein, developing material bag
Contain: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate, iohexol, iopamidol, cardiografin,
The general glucose of Iodoaniline, amidotrizoic acid, bis-conray, first, iotrolan, Iopromide, the acid of iodine sea, iodine Buddhist
Alcohol, iodixanol, iodized oil, iofendylate one or more；
Step S303, is injected into the described nerve rehabilitating tube that can develop by having medicative seed cell,
Form the nerve rehabilitating tube developed comprising compound seed cell；Wherein, described seed cell is selected from:
One in neural stem cell, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell or
Multiple；Or, it is injected into the described nerve rehabilitating tube that can develop by having medicative cytokine,
Form the nerve rehabilitating tube developed comprising multiple cytokine；Wherein, described cytokine is selected from:
One or more in nerve growth factor, neurotrophic factor, basic fibroblast growth factor.
Embodiment four
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention four, including:
Step S401, utilizing the macromolecular material aqueous solution that mass fraction is 30-85 part is 0-15 with mass fraction
Part and the developing material that particle diameter is 20nm-500um are sufficiently mixed；Wherein, described developing material comprises: hydroxyl
Apatite, β tricalcium phosphate, calcium carbonate or calcium sulfate, iohexol, iopamidol, cardiografin, Iodoaniline,
The general glucose of amidotrizoic acid, bis-conray, first, iotrolan, Iopromide, the acid of iodine sea, ioversol, iodine gram
Husky alcohol, iodized oil, iofendylate one or more；
Step S402, after using artificial neuron sheath pipe mold to carry out lyophilization, form removal tool obtains comprising development material
The nerve rehabilitating tube of material, and thermoplastic is compound；
Step S403, is injected into the described nerve rehabilitating tube that can develop by having medicative seed cell,
Form the nerve rehabilitating tube developed comprising compound seed cell；Wherein, described seed cell is selected from:
One in neural stem cell, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell or
Multiple；Or, it is injected into the described nerve rehabilitating tube that can develop by having medicative cytokine,
Form the nerve rehabilitating tube developed comprising multiple cytokine；Wherein, described cytokine is selected from:
One or more in nerve growth factor, neurotrophic factor, basic fibroblast growth factor.
Embodiment five
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention five, including:
Step S501, boils 20-30min by natural silk mass fraction 0.05% sodium carbonate liquor, repeats three
The pure fibroin fiber of secondary acquisition, is dissolved in 80 degrees Celsius of stirring and dissolving in lithium bromide ethanol solution, dialysis
Become regenerated silk fibroin film after drying；
Step S502, is dissolved in formic acid by obtained for step S501 fibroin protein film, is obtained by method of electrostatic spinning
Obtain fibroin albumen artificial neuron and repair conduit；
Step S503, by 1/3rd and the granularity that quality is nerve rehabilitating tube prepared by step S502 be
The hydroxyapatite uniform fold nerve rehabilitating tube outer surface of 100nm, and it is in 140 DEG C, 10MPa
The compound 10min of heat, i.e. available can the nerve rehabilitating tube of internal development.
Embodiment six
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention six, including:
Step S601, configures 2% chitosan aqueous solution, and by chitosan mass (dry weight) 1/3rd and
Granularity is that the hydroxyapatite of 100nm adds in chitosan solution and is sufficiently stirred for, and is prepared as suspension；
Step S602, injects specific sheath pipe removable sleeve mould, the most manually by step S601 gained suspension
Nerve sheath pipe mold, puts into-80 DEG C of pre-freeze 48h, postlyophilization can obtain can body development nerve repair
Multiple conduit.
Embodiment seven
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention seven, including:
Step S701, configures 2% chitosan aqueous solution, and by chitosan mass (dry weight) 1/3rd and
Granularity is that the β tricalcium phosphate powder of 100nm adds in chitosan solution and is sufficiently stirred for, and prepares suspension；
Step S702, injects specific sheath pipe removable sleeve mould, the most manually by step S701 gained suspension
Nerve sheath pipe mold, puts into-80 DEG C of pre-freeze 48h, postlyophilization can obtain can body development nerve repair
Multiple conduit.
Embodiment eight
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention eight, including:
Step S801, configures 2% chitosan aqueous solution, adds iohexol about 1-5% (volume ratio) and is sufficiently stirred for,
Obtain mixed liquor；
Step S802, injects specific sheath pipe removable sleeve mould, the most manually by step S801 gained suspension
Nerve sheath pipe mold, puts into-80 DEG C of pre-freeze 48h, postlyophilization can obtain can body development nerve repair
Multiple conduit.
Embodiment nine
The preparation method of the nerve rehabilitating tube developed of the embodiment of the present invention nine, including:
Step S901, boils 20-30min by natural silk mass fraction 0.05% sodium carbonate liquor, repeats three
The pure fibroin fiber of secondary acquisition, is dissolved in 80 degrees Celsius of stirring and dissolving in lithium bromide ethanol solution, dialysis
Become regenerated silk fibroin film after drying；
Step S902, is dissolved in formic acid by obtained for step S901 fibroin protein film, is obtained by method of electrostatic spinning
Obtain fibroin albumen artificial neuron and repair conduit；
Step S903, by 1/3rd and the granularity that quality is nerve rehabilitating tube prepared by step S902 be
The hydroxyapatite uniform fold nerve rehabilitating tube outer surface of 100nm, and it is in 140 DEG C, 10MPa
The compound 10min of heat, i.e. available can the nerve rehabilitating tube of internal development；
Step S904, is injected into Schwann cell in step S903 in prepared nerve rehabilitating tube, is formed
The nerve rehabilitating tube of compound seed cell.
Last it is noted that various embodiments above is only in order to illustrate technical scheme, it is not intended to limit；
Although being described in detail the present invention with reference to foregoing embodiments, those of ordinary skill in the art should
Work as understanding: the technical scheme described in foregoing embodiments still can be modified by it, or to wherein
Some or all of technical characteristic carries out equivalent；And these amendments or replacement, do not make relevant art
The essence of scheme departs from the scope of various embodiments of the present invention technical scheme.
Claims (10)
1. the nerve rehabilitating tube that can develop, it is characterised in that including: main body tube and comprise development material
The developing layer of material；Described developing layer is covered in inwall or the outer wall of described main body tube；Described main body tube is by glue
One or more in former, chitosan, fibroin albumen and derivant thereof prepare.
2. the nerve rehabilitating tube that can develop, it is characterised in that the described nerve rehabilitating tube developed
Main body tube prepared by one or more in collagen, chitosan, fibroin albumen and derivant thereof, described
Main body tube also comprises developing material.
The nerve rehabilitating tube developed the most according to claim 1 and 2, it is characterised in that described can
The a diameter of required of the nerve rehabilitating tube of development repairs neural 1.1 times-1.3 times, the described god developed
The pipe thickness of repaired conduit is 0.2mm-1.0mm.
The nerve rehabilitating tube developed the most according to claim 1 and 2, it is characterised in that described aobvious
Shadow material comprises: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate, iohexol, iopamidol,
The general glucose of cardiografin, Iodoaniline, amidotrizoic acid, bis-conray, first, iotrolan, Iopromide, iodine
Sea acid, ioversol, iodixanol, iodized oil, iofendylate one or more.
The nerve rehabilitating tube developed the most according to claim 1 and 2, it is characterised in that described master
Body pipe contains the medicative seed cell of tool, and described seed cell is selected from: between neural stem cell, bone marrow
One or more in mesenchymal cells, embryonic stem cell, Schwann cell, Olfactory essheathing cell.
The nerve rehabilitating tube developed the most according to claim 1 and 2, it is characterised in that described master
Body pipe contains the medicative cytokine of tool, and described cytokine is selected from: nerve growth factor, nerve
One or more in trophic factors, basic fibroblast growth factor.
7. the preparation method of the nerve rehabilitating tube that can develop, it is characterised in that including:
Utilize macromolecule material solution, use the method for electrostatic spinning to be collected by cylinder collection device and obtain god
The main body tube of repaired conduit, or, after using artificial neuron sheath pipe mold to carry out lyophilization, form removal has
Main body tube to nerve rehabilitating tube；
The developing material that particle diameter is 20nm-500um is uniformly compounded in inwall or the outer wall of described main body tube,
And thermoplastic compound after form developing layer.
8. the preparation method of the nerve rehabilitating tube that can develop, it is characterised in that including:
The developing material that macromolecular material aqueous solution and particle diameter are 20nm-500um is utilized to be sufficiently mixed；
After using artificial neuron sheath pipe mold to carry out lyophilization, form removal tool obtains comprising the nerve of developing material and repaiies
Multiple conduit, and thermoplastic is compound.
9., according to the preparation method of the nerve rehabilitating tube developed described in claim 7 or 8, its feature exists
In, described developing material comprises: hydroxyapatite, β tricalcium phosphate, calcium carbonate or calcium sulfate, iohexol,
The general glucose of iopamidol, cardiografin, Iodoaniline, amidotrizoic acid, bis-conray, first, iotrolan, iodine are general
Sieve amine, the acid of iodine sea, ioversol, iodixanol, iodized oil, iofendylate one or more.
10. according to the preparation method of the nerve rehabilitating tube developed described in claim 7 or 8, its feature
It is, after the nerve rehabilitating tube that can develop completes, also includes described in preparation:
Being injected into the described nerve rehabilitating tube that can develop by having medicative seed cell, formation comprises
The nerve rehabilitating tube developed of compound seed cell；Wherein, described seed cell is selected from: nerve trunk is thin
One or more in born of the same parents, medulla mesenchyma cell, embryonic stem cell, Schwann cell, Olfactory essheathing cell；
Or, it is injected into the described nerve rehabilitating tube that can develop by having medicative cytokine, forms bag
The nerve rehabilitating tube developed containing multiple cytokine；Wherein, described cytokine is selected from: neural raw
One or more in the long factor, neurotrophic factor, basic fibroblast growth factor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510043341.1A CN105983135A (en) | 2015-01-28 | 2015-01-28 | Developing-able neural restoration conduit and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510043341.1A CN105983135A (en) | 2015-01-28 | 2015-01-28 | Developing-able neural restoration conduit and preparation method thereof |
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| CN201510043341.1A Pending CN105983135A (en) | 2015-01-28 | 2015-01-28 | Developing-able neural restoration conduit and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114832165A (en) * | 2022-05-18 | 2022-08-02 | 中国人民解放军空军军医大学 | Orthopedic screw and preparation method thereof |
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| CN103006286A (en) * | 2012-12-18 | 2013-04-03 | 邹旭华 | Developable sealed type woven body implantation material and conveying device |
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| EP1084686A1 (en) * | 1998-06-10 | 2001-03-21 | Tapic International Co., Ltd. | Artificial neural tube |
| TW201008601A (en) * | 2008-08-21 | 2010-03-01 | Univ Taipei Medical | Bio-acceptable conduits and method providing the same |
| CN101579246A (en) * | 2009-05-31 | 2009-11-18 | 苏州大学 | Artificial silk fibroin nano-fiber nerve repair conduit and preparation method thereof |
| CN101700418A (en) * | 2009-10-30 | 2010-05-05 | 上海锦葵医疗器械有限公司 | Developed degradable polymer composites and preparation method thereof |
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| CN114832165A (en) * | 2022-05-18 | 2022-08-02 | 中国人民解放军空军军医大学 | Orthopedic screw and preparation method thereof |
| CN114832165B (en) * | 2022-05-18 | 2023-09-01 | 中国人民解放军空军军医大学 | Screw for orthopaedics and preparation method thereof |
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Application publication date: 20161005 |
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| RJ01 | Rejection of invention patent application after publication |