CN105968055B - A kind of preparation method of Arylpyrimidines and its derivative - Google Patents
A kind of preparation method of Arylpyrimidines and its derivative Download PDFInfo
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- CN105968055B CN105968055B CN201610595512.6A CN201610595512A CN105968055B CN 105968055 B CN105968055 B CN 105968055B CN 201610595512 A CN201610595512 A CN 201610595512A CN 105968055 B CN105968055 B CN 105968055B
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- CGDOULKQSSMJTD-UHFFFAOYSA-N Nc(cc1)ccc1-c(nc1)ncc1-c(cc1)ccc1[N+]([O-])=O Chemical compound Nc(cc1)ccc1-c(nc1)ncc1-c(cc1)ccc1[N+]([O-])=O CGDOULKQSSMJTD-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
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Abstract
The present invention provides the preparation methods of a kind of Arylpyrimidines and its derivative, include the following steps：S1 nitrile-based compound shown in 2 substitution malonaldehyde diimmonium salts, formula (III) shown in formula (II) is reacted in organic solvent with the first basic catalyst), obtains mixed liquor；S2 ammonium salt and the second basic catalyst) are added in the mixed liquor, is reacted, obtains Arylpyrimidines and its derivative shown in formula (I).Compared with prior art, under the conditions of the present invention is existing for basic catalyst, 2 substitution malonaldehyde diimmonium salts, nitrile-based compound and ammonium salt carry out [3+2+1] ternary annulation and build pyrimidine ring, to obtain Arylpyrimidines and its derivative, this method without using noble metal catalyst, route is succinct, at low cost, process control is high, easy industrialization, the discharge for reducing waste and yield it is higher.
Description
Technical field
The invention belongs to technical field of organic synthesis more particularly to the preparation methods of a kind of Arylpyrimidines and its derivative.
Background technology
Arylpyrimidines and its derivative can be applied due to its unique coordination as the ligand of metallic catalyst
In the indicator etc. of photosensitizer and detection metal ion, moreover, 2,5- diaryl pyrimidine derivatives are as polyimides, polyamides
The monomer of the heat-proof macromolecules such as amine, polyether-ether-ketone has also attracted extensive concern.
The synthesis of Arylpyrimidines at present mainly uses cross-coupling reaction, such as the Suzuki coupling reactions of aryl boric acid,
But this kind of coupling reaction needs noble metal catalyst.Especially for diaryl substituted pyrimidines, two substituent groups are carried out at the same time
When coupling reaction, tend not to obtain satisfied yield.
2003, Hughes etc. was reported using tetrakis triphenylphosphine palladium as catalyst, 2,5- bis- Bromopyrimidines and benzene boron
Suzuki coupling reactions occur for acid, synthesize 2,5- diphenylpyrimidins, yield is only 43%, in addition there is 32% single coupled product；
When using three tertiary butyl phosphines and tris(dibenzylideneacetone) dipalladium as catalyst, the yield of 2,5- diphenylpyrimidins can carry
Height to 62% (Organic and Biomolecular Chemistry, 2003,1：3069-3077).
2014, Hong etc. used two (triphenylphosphine) palladium bichlorides, and uses higher reaction temperature, this coupling is anti-
Answer yield be increased to 79% (Chemical Communications, 2014,50：4129-4132).
Expensive palladium catalyst is not used only in these cross-coupling reactions, and the synthesis of aryl boric acid generally requires gold
Belong to the harsh reaction condition such as organic reagent, low temperature, atmosphere of inert gases, be not easy largely to prepare, of high cost, process is complicated.
Invention content
In view of this, the technical problem to be solved in the present invention is to provide the preparation side of a kind of Arylpyrimidines and its derivative
Method, this method is simple and yield is higher.
The present invention provides the preparation methods of a kind of Arylpyrimidines and its derivative, include the following steps：
S1 2- shown in formula (II)) is replaced into nitrile-based compound and the first alkali shown in malonaldehyde diimmonium salt, formula (III)
Property catalyst reacts in organic solvent, obtains mixed liquor；
S2 ammonium salt and the second basic catalyst) are added in the mixed liquor, is reacted, obtains fragrant shown in formula (I)
Yl pyrimidines and its derivative；
Wherein, R1For aryl, heterocycle, substituted aryl, substituted heterocyclic radical, hydrogen, chlorine, bromine, nitro, cyano, C1~C6
The alkoxy of alkyl or C1~C6；
Ar is aryl, heterocycle, substituted aryl or substituted heterocyclic radical；
R2For the alkyl of aryl, heterocycle or C1~C8；
R3For the alkyl of aryl, heterocycle or C1~C8；
Or R2And R3Pyrroles, piperidines or morpholine are constituted with the nitrogen-atoms or oxygen atom being bonded；
A is halogen.
Preferably, the step S1) be specially：
2- shown in formula (II) is replaced into nitrile-based compound and organic solvent shown in malonaldehyde diimmonium salt, formula (III)
Mixing is added the first basic catalyst, after reaction, is mixed then under conditions of controlled at -10 DEG C~30 DEG C
Liquid.
Preferably, 2- shown in the formula (II) replace nitrile-based compound shown in malonaldehyde diimmonium salt, formula (III) with
The molar ratio of first basic catalyst is 1：(0.98~1.02)：(0.05~0.2).
Preferably, the step S1) in react temperature be 0 DEG C~30 DEG C；The time of reaction is 1~3h.
Preferably, ammonium in 2- substitution malonaldehyde diimmonium salt, the second basic catalyst and ammonium salt shown in the formula (II)
The molar ratio of ion is 1：(1.1~1.4)：(2~5).
Preferably, the step S2) be specially：
Ammonium salt is added in the mixed liquor, after 20 DEG C~50 DEG C are reacted 2~20h, the second basic catalyst is added, carries out
Reaction, obtains Arylpyrimidines and its derivative shown in formula (I).
Preferably, the step S2) in react temperature be 50 DEG C~150 DEG C；The time of reaction is 2~8h.
Preferably, first basic catalyst and the second basic catalyst are each independently alkali metal hydride, alkali
It is one or more in earth metal hydride, alkali metal alcoholates and alkaline-earth alkoxides.
Preferably, the anion in the ammonium salt is HCOO-, CH3COO-、Cl-、Br-、CO3 2-、NO3-、SO4 2-、HSO4-
With PO4In it is one or more.
Preferably, 2- shown in the formula (II) replaces malonaldehyde diimmonium salt to prepare in accordance with the following methods：
A formyl adduct shown in formula (IV) compound represented, formula (V) is reacted with halide reagent), obtains formula
(II) 2- shown in replaces malonaldehyde diimmonium salt；
The present invention provides the preparation methods of a kind of Arylpyrimidines and its derivative, include the following steps：S1) by formula (II)
Shown in 2- substitutions malonaldehyde diimmonium salt, nitrile-based compound and the first basic catalyst shown in formula (III) in organic solvent
Middle reaction, obtains mixed liquor；S2 ammonium salt and the second basic catalyst) are added in the mixed liquor, is reacted, obtains formula
(I) Arylpyrimidines and its derivative shown in；Wherein, R1For aryl, heterocycle, substituted aryl, substituted heterocyclic radical, hydrogen, chlorine,
The alkoxy of bromine, nitro, cyano, the alkyl of C1~C6 or C1~C6；Ar is aryl, heterocycle, substituted aryl or substituted heterocycle
Base；R2For the alkyl of aryl, heterocycle or C1~C8；R3For the alkyl of aryl, heterocycle or C1~C8；Or R2And R3With key
The nitrogen-atoms or oxygen atom of conjunction constitute pyrroles, piperidines or morpholine；A is halogen.Compared with prior art, the present invention is in alkalinity
Under the conditions of catalyst is existing, it is anti-that 2- replaces malonaldehyde diimmonium salt, nitrile-based compound and ammonium salt to carry out [3+2+1] ternary cyclization
Pyrimidine ring should be built, to obtain Arylpyrimidines and its derivative, this method is without using noble metal catalyst, route is succinct, cost
It is low, process control is high, it is easy industrialization, reduce waste discharge and yield it is higher.
It can be seen from the experiment that the yield of preparation method of the present invention is higher than 90%.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
The present invention provides the preparation method of a kind of Arylpyrimidines and its derivative, which is characterized in that includes the following steps：
S1 2- shown in formula (II)) is replaced into nitrile-based compound and the first alkali shown in malonaldehyde diimmonium salt, formula (III)
Property catalyst reacts in organic solvent, obtains mixed liquor；
S2 ammonium salt and the second basic catalyst) are added in the mixed liquor, is reacted, obtains fragrant shown in formula (I)
Yl pyrimidines and its derivative；
Wherein, R1For aryl, heterocycle, substituted aryl, substituted heterocyclic radical, hydrogen, chlorine, bromine, nitro, cyano, C1~C6
The alkoxy of alkyl or C1~C6, the preferably aryl of C6~C20, the heterocycle of C6~C20, the substituted aryl of C6~C20, C6
The substituted heterocyclic radical of~C20, the alkoxy of hydrogen, chlorine, bromine, nitro, cyano, the alkyl of C1~C6 or C1~C6, more preferably C6
The aryl of~C10, the heterocycle of C6~C10, the substituted aryl of C6~C10, the substituted heterocyclic radical of C6~C10, hydrogen, chlorine, bromine, nitre
The alkoxy of base, cyano, the alkyl of C1~C6 or C1~C6 is further preferably the aryl of C6~C10, the heterocycle of C6~C10, C6
The substituted aryl of~C10, the substituted heterocyclic radical of C6~C10, hydrogen, chlorine, bromine, nitro, cyano, the alkyl of C1~C3 or C1~C3
Alkoxy, most preferably phenyl, pyrimidine radicals, naphthalene, pyridyl group, furyl, thienyl, substituted-phenyl, substituted pyrimidyl, substitution
The alkoxy of naphthalene, substituted pyridinyl, substituted furan base, substituted thiophene base, the alkyl of C1~C3 or C1~C3；It is wherein described to take
It is preferably the alkyl or C1 of chlorine, bromine, nitro, cyano, C1~C6 each independently for the substituent group in aryl and substituted heterocyclic radical
The alkoxy of the alkoxy of~C6, more preferably chlorine, bromine, nitro, cyano, the alkyl of C1~C3 or C1~C3；It is carried in the present invention
In some embodiments supplied, the R1Preferably phenyl；In some embodiments provided by the invention, the R1Preferably bromine；
In some embodiments provided by the invention, the R1Preferably methyl；In other embodiments provided by the invention, the R1
Preferably p-nitrophenyl.
Ar be aryl, heterocycle, substituted aryl or substituted heterocyclic radical, preferably the aryl of C6~C20, C6~C20 it is miscellaneous
The substituted heterocyclic radical of ring group, the substituted aryl of C6~C20, C6~C20, the more preferably aryl of C6~C10, C6~C10 it is miscellaneous
The substituted heterocyclic radical of ring group, the substituted aryl of C6~C10, C6~C10 is further preferably phenyl, pyrimidine radicals, naphthalene, pyridyl group, furan
It mutters base, thienyl, substituted-phenyl, substituted pyrimidyl, substituted naphthyl, substituted pyridinyl, substituted furan base or substituted thiophene base；Its
Described in substituent group in substituted aryl and substituted heterocyclic radical be preferably chlorine, bromine, nitro, cyano, C1~C6 each independently
The alkoxy of the alkoxy of alkyl or C1~C6, more preferably chlorine, bromine, nitro, cyano, the alkyl of C1~C3 or C1~C3；
In some embodiments provided by the invention, the Ar is preferably phenyl；In other embodiments provided by the invention, the Ar
Preferably p-nitrophenyl.
R2For the alkyl of aryl, heterocycle or C1~C8, the preferably heterocycle or C1 of the aryl of C6~C20, C6~C20
The alkyl of the alkyl of~C6, the more preferably aryl of C6~C10, the heterocycle of C6~C10 or C1~C6, further preferably for C6~
The alkyl of the aryl of C10, the heterocycle of C6~C10 or C1~C3, most preferably phenyl, pyrimidine radicals, naphthalene, pyridyl group, furans
The alkyl of base, thienyl or C1~C3；In some embodiments provided by the invention, the R2Preferably methyl.
R3For the alkyl of aryl, heterocycle or C1~C8, the preferably heterocycle or C1 of the aryl of C6~C20, C6~C20
The alkyl of the alkyl of~C6, the more preferably aryl of C6~C10, the heterocycle of C6~C10 or C1~C6, further preferably for C6~
The alkyl of the aryl of C10, the heterocycle of C6~C10 or C1~C3, most preferably phenyl, pyrimidine radicals, naphthalene, pyridyl group, furans
The alkyl of base, thienyl or C1~C3；In some embodiments provided by the invention, the R3Preferably methyl.
Or R2And R3Pyrroles, piperidines or morpholine are constituted with the nitrogen-atoms or oxygen atom being bonded；
A is halogen, and in the present invention, A- is preferably Br- or Cl-.
Mentioned alkyl in the present invention can be straight chained alkyl or branched alkyl, have no special limitation.
Wherein, the present invention is not particularly limited the source of all raw materials, for commercially available or self-control.
In the present invention, 2- shown in the formula (II) replaces malonaldehyde diimmonium salt preferably to prepare in accordance with the following methods：
A formyl adduct shown in formula (IV) compound represented, formula (V) is reacted with halide reagent), is obtained shown in formula (II)
2- replaces malonaldehyde diimmonium salt；
Wherein, the R1、R2With R3Same as above, details are not described herein.
In the present invention, preferably first formula (IV) compound represented is mixed with formyl adduct shown in formula (V)；It is described
Formyl adduct shown in formula (V) is preferably n,N-Dimethylformamide, N- formyl piperidines, N- formyl piperidine pyrrolidines
Or N- formyl-morpholines.
After mixing, be preferably heated to 40 DEG C~80 DEG C, be more preferably heated to 50 DEG C~70 DEG C, be further preferably heated to 50 DEG C~
60 DEG C, halide reagent is then added；The halide reagent is halide reagent well known to those skilled in the art, and it is special to have no
Limitation, it is preferably one or more in phosphorus oxychloride, tribromo oxygen phosphorus, oxalyl chloride and thionyl chloride in the present invention；The formula
(IV) compound represented, the molar ratio of formyl adduct and halide reagent shown in formula (V) are preferably 1：(3~5)：(2~
4), more preferably 1：(4~5)：(2~4) are further preferably 1：(4~5)：(2~3)；In some embodiments provided by the invention
In, the molar ratio of formyl adduct and halide reagent shown in formula (IV) compound represented, formula (V) is preferably 1：4：
3；In some embodiments provided by the invention, formula (IV) compound represented, formyl adduct shown in formula (V) with
The molar ratio of halide reagent is preferably 1：5：2.5；In some embodiments provided by the invention, chemical combination shown in the formula (IV)
The molar ratio of formyl adduct and halide reagent shown in object, formula (V) is preferably 1：5：2.2；More provided by the invention
In embodiment, the molar ratio of formyl adduct and halide reagent shown in formula (IV) compound represented, formula (V) is preferred
It is 1：4：2.5.It is preferably slowly added to halide reagent in the present invention.
After halide reagent is added, reacted；The temperature of the reaction is preferably 40 DEG C~80 DEG C, more preferably 50 DEG C~
70 DEG C, be further preferably 50 DEG C~60 DEG C；The time of the reaction is preferably 1~5h, more preferably 2~4h, further preferably for 3~
4h, most preferably 3h.
After reaction, reaction system is preferably cooled to 10 DEG C~30 DEG C, reaction system is more preferably cooled to 10 DEG C
~25 DEG C, then be added dropwise in atent solvent, solid is precipitated, obtains 2- shown in formula (II) and replaces malonaldehyde diimmonium salt；
The atent solvent is atent solvent well known to those skilled in the art, has no special limitation, is preferably in the present invention
N-hexane, petroleum ether, ethyl acetate, tert-butyl acetate, glycol dimethyl ether, tetrahydrofuran, dioxane, methyl tertbutyl
It is one or more in ether, acetonitrile, acetone and butanone.
2- shown in formula (II) is replaced into nitrile-based compound shown in malonaldehyde diimmonium salt, formula (III) and the first alkalinity
Catalyst reacts in organic solvent, obtains mixed liquor；Wherein, the organic solvent is well known to those skilled in the art organic
Solvent has no special limitation, is preferably methanol, ethyl alcohol, tetrahydrofuran, dioxane, glycol dinitrate in the present invention
Ether, ethylene glycol diethyl ether, methyl tertiary butyl ether(MTBE), isopropanol, the tert-butyl alcohol, dimethylformamide, dimethylacetylamide, methylpyrrole
Alkanone and one or more in dimethyl sulfoxide (DMSO), more preferably methanol, ethyl alcohol, tetrahydrofuran, dioxane, glycol dinitrate
Ether, ethylene glycol diethyl ether, methyl tertiary butyl ether(MTBE), isopropanol, the tert-butyl alcohol, dimethylformamide, dimethylacetylamide, methylpyrrole
One or both of alkanone and dimethyl sulfoxide (DMSO)；The mass ratio of the organic solvent and nitrile-based compound shown in formula (III)
For (10~50)：1, more preferably (20~50)：1, it is further preferably (20~40)：1, most preferably (24~35)：1.
In the present invention, it is preferred to which 2- shown in formula (II) is first replaced itrile group shown in malonaldehyde diimmonium salt, formula (III)
Compound is mixed with organic solvent, then under conditions of controlled at -10 DEG C~30 DEG C, more preferably controlled at 0
DEG C~30 DEG C under conditions of, further preferably under conditions of controlled at 10 DEG C~20 DEG C, most preferably controlled at 20
Under conditions of DEG C, the first basic catalyst is added；2- shown in the formula (II) replaces malonaldehyde diimmonium salt, formula (III) institute
The molar ratio of the nitrile-based compound and the first basic catalyst that show is preferably 1：(0.98~1.02)：(0.05~0.2), more preferably
It is 1：(0.98~1.02)：(0.1~0.2)；The type of first basic catalyst is alkali well known to those skilled in the art
Property catalyst, have no special limitation, preferably alkali metal hydride, alkaline earth metal hydride, alkali metal in the present invention
Alkoxide with it is one or more in alkaline-earth alkoxides；The wherein described alkali metal is preferably sodium or potassium；The alkali metal alcoholates with
Alcohol in alkaline-earth alkoxides is preferably methanol, ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol or the tert-butyl alcohol；In the present invention, most
It is preferred that the first basic catalyst is sodium methoxide or potassium tert-butoxide.
It after the first basic catalyst is added, is reacted, obtains mixed liquor；The temperature of the reaction is preferably 0 DEG C~30
DEG C, more preferably 10 DEG C~30 DEG C, be further preferably 15 DEG C~25 DEG C, most preferably 20 DEG C；The time of the reaction is preferably 1~
3h, more preferably 2~3h are further preferably 2h.
Ammonium salt is added in mixed liquor；Anion in the ammonium salt is preferably that the anion in the ammonium salt is preferably
HCOO-、CH3COO-、Cl-、Br-、CO3 2-、NO3-、SO4 2-、HSO4With PO4In it is one or more；Shown in the formula (II)
2- substitution malonaldehyde diimmonium salt and ammonium salt in the molar ratio of ammonium ion be preferably 1：(2~5), more preferably 1：(3~4).
After ammonium salt is added, 2~20h is preferably reacted at 20 DEG C~50 DEG C, and 2~15h is more preferably reacted at 30 DEG C~50 DEG C, then
It is preferred that reacting 2~10h at 30 DEG C~50 DEG C, 2~8h is reacted further preferably at 30 DEG C~50 DEG C, is reacted further preferably at 30 DEG C~50 DEG C
4~6h most preferably first reacts 4~5h at 40 DEG C.
Then it is preferably added to the second basic catalyst；The type of second basic catalyst is that those skilled in the art are ripe
The basic catalyst known, has no special limitation, in the present invention preferably alkali metal hydride, alkaline earth metal hydride,
Alkali metal alcoholates with it is one or more in alkaline-earth alkoxides；The wherein described alkali metal is preferably sodium or potassium；The alkali metal
Alkoxide is preferably methanol, ethyl alcohol, normal propyl alcohol, isopropanol, n-butanol or the tert-butyl alcohol with the alcohol in alkaline-earth alkoxides；In the present invention
In, most preferably the first basic catalyst is sodium methoxide or potassium tert-butoxide.In the present invention, the first basic catalyst and the second alkalinity
Catalyst may be the same or different, and have no special limitation.
After the second basic catalyst is added, then heats up and reacted；The temperature of the heating is preferably 50 DEG C~150 DEG C,
80 DEG C~140 DEG C are more selected as, is further preferably 90 DEG C~120 DEG C, is further preferably 90 DEG C~110 DEG C, is further preferably 95 DEG C~100
DEG C, most preferably flow back；The time of the reaction is preferably 2~8h, more preferably 3~8h, is further preferably 4~8h, most preferably
For 5~8h.
After reaction, it is preferably dropped to room temperature, filters, after washing, obtains Arylpyrimidines and its derivative shown in formula (I)
Object.
Under the conditions of the present invention is existing for basic catalyst, 2- replaces malonaldehyde diimmonium salt, nitrile-based compound and ammonium salt
It carries out [3+2+1] ternary annulation and builds pyrimidine ring, to obtain Arylpyrimidines and its derivative, reaction process is：
This method without using noble metal catalyst, route is succinct, at low cost, process control is high, it is easy industrialization, reduce
The discharge of waste and yield is higher.
In order to further illustrate the present invention, with reference to embodiments to a kind of Arylpyrimidines provided by the invention and its derivative
The preparation method of object is described in detail.
Reagent used in following embodiment is commercially available.
Embodiment 1
511 grams of phenylacetic acids and 875 milliliters of n,N-Dimethylformamide are added into reaction vessel, are heated to 50 DEG C
Afterwards, 50 DEG C~60 DEG C of temperature in control, is slowly added dropwise 697 milliliters of phosphorus oxychloride.It finishes, continues to be heated to 80 DEG C, reaction 5 is small
When.20 DEG C are down to, 3 liters of mixed solvents (volume ratio, petroleum ethers are added drop-wise to：Acetone=2：1) in, solid is precipitated, filters, it is dry,
Obtain 699 grams of N, N, N ', N '-tetramethyls -2- phenyl-malonaldehyde diimmonium salt hydrochlorate.
101.06 grams of benzonitriles, 238.76 grams of above-mentioned homemade N, N, N ', N '-tetramethyls -2- are added into reaction vessel
Phenyl-malonaldehyde diimmonium salt hydrochlorate and methanol.20 DEG C of temperature is controlled, 5.40 grams of sodium methoxides are added into reaction system, is continued
Reaction 2 hours.160.47 grams of ammonium chlorides are added, at 40 DEG C, react 5 hours.Add 64.82 grams of sodium methoxides, and back flow reaction 6
Hour.It is down to room temperature, is filtered, is washed, it is dry, obtain 211.38 grams of 2,5- diphenylpyrimidins, yield 92.9%, HPLC purity
It is 99.1%.
2, the 5- diphenylpyrimidins obtained in embodiment 1 are analyzed using nuclear magnetic resonance, obtain its hydrogen nuclear magnetic resonance
Composing result is：1H NMR(CDCl3, 400MHz) and δ 7.45 (t, 2H), 7.52 (m, 4H), 7.64 (d, 2H), 8.50 (dd, 2H),
9.03 (s, 2H).
Embodiment 2
522 grams of bromoacetic acids and 875 milliliters of n,N-Dimethylformamide are added into reaction vessel, are heated to 40 DEG C
Afterwards, 40 DEG C~50 DEG C of temperature in control, is slowly added dropwise 697 milliliters of phosphorus oxychloride.It finishes, continues to be heated to 70 DEG C, reaction 5 is small
When.20 DEG C are down to, 3 liters of mixed solvents (volume ratio, petroleum ethers are added drop-wise to：Acetone=3：1) in, solid is precipitated, filters, it is dry,
Obtain 687 grams of N, N, N ', the bromo- malonaldehyde diimmonium salt hydrochlorates of N '-tetramethyls -2-.
101.06 grams of benzonitriles, 241.56 grams of above-mentioned homemade N, N, N ', N '-tetramethyls -2- are added into reaction vessel
Bromo- malonaldehyde diimmonium salt hydrochlorate and methanol.20 DEG C of temperature is controlled, 5.40 grams of sodium methoxides are added into reaction system, is continued anti-
It answers 2 hours.160.47 grams of ammonium chlorides are added, 40 DEG C are reacted 4 hours.Add 64.82 grams of sodium methoxides, and back flow reaction 5 hours.
It is down to room temperature, is filtered, is washed, it is dry, obtain 208.64 grams of 2- phenyl -5- Bromopyrimidines.Yield is that 90.6%, HPLC purity is
98.8%.
2- phenyl -5- the Bromopyrimidines obtained in embodiment 2 are analyzed using nuclear magnetic resonance, obtain its hydrogen nuclear magnetic resonance
Composing result is：1H NMR(CDCl3, 500MHz) and δ 8.84 (s, 2H), 8.41 (m, 2H), 7.50 (m, 3H).
Embodiment 3
278 grams of propionic acid and 875 milliliters of n,N-Dimethylformamide are added into reaction vessel, after being heated to 50 DEG C,
50 DEG C~60 DEG C of temperature, is slowly added dropwise 697 milliliters of phosphorus oxychloride in control.It finishes, continues to be heated to 75 DEG C, react 5 hours.
10 DEG C are down to, 3 liters of mixed solvents (volume ratio, petroleum ethers are added drop-wise to：Acetone=5：1) in, solid is precipitated, filters, it is dry, it obtains
483 grams of N, N, N ', N '-tetramethyls -2- methyl-malonaldehyde diimmonium salt hydrochlorate.
103.12 grams of benzonitriles, 176.69 grams of above-mentioned homemade N, N, N ', N '-tetramethyls -2- are added into reaction vessel
Methyl-malonaldehyde diimmonium salt hydrochlorate and methanol.20 DEG C of temperature is controlled, 5.40 grams of sodium methoxides are added into reaction system, is continued
Reaction 2 hours.160.47 grams of ammonium chlorides are added, 40 DEG C are reacted 5 hours.64.82 grams of sodium methoxides are added, and back flow reaction 8 is small
When.It is down to room temperature, is filtered, is washed, it is dry, obtain 153.85 grams of 2- phenyl -5- methylpyrimidines.Yield is 90.4%, HPLC pure
Degree is 98.9%.
2- phenyl -5- the methylpyrimidines obtained in embodiment 3 are analyzed using nuclear magnetic resonance, obtain its nuclear magnetic resonance
Hydrogen composes result：1H NMR(CDCl3, 500MHz) and δ 8.64 (d, 2H), 8.37-8.45 (m, 2H), 7.44-7.54 (m, 3H),
2.34 (s, 3H).
Embodiment 4
680 grams of paranitrophenylacetic acids and 875 milliliters of n,N-Dimethylformamide are added into reaction vessel, are heated to
After 50 DEG C, interior 50 DEG C~60 DEG C of temperature is controlled, 697 milliliters of phosphorus oxychloride are slowly added dropwise.It finishes, continues to be heated to 80 DEG C, instead
It answers 4 hours.20 DEG C are down to, 3 liters of mixed solvents (volume ratio, petroleum ethers are added drop-wise to：Acetone=2：1) in, solid is precipitated, filters,
It is dry, 907 grams of N, N, N ' are obtained, N '-tetramethyl -2- are to nitro-malonaldehyde diimmonium salt hydrochlorate.
148.12 grams of p-nitrobenzonitfiles, 283.75 grams of above-mentioned homemade N, N, N ', N '-tetramethyls are added into reaction vessel
Base -2- is to nitro-malonaldehyde diimmonium salt hydrochlorate and methanol.20 DEG C of temperature is controlled, 11.22 grams of tertiary fourths are added into reaction system
Potassium alcoholate, the reaction was continued 2 hours.231.24 grams of ammonium acetates are added, 40 DEG C are reacted 5 hours.134.65 grams of potassium tert-butoxides are added, and
Back flow reaction 6 hours.It is down to room temperature, is filtered, is washed, it is dry, obtain 304.96 grams of 2,5- bis- (4- nitrobenzophenones) pyrimidines.Yield
It is 99.3% for 94.6%, HPLC purity.
2,5- bis- (4- nitrobenzophenones) pyrimidine obtained in embodiment 4 is analyzed using nuclear magnetic resonance, obtains its core
Magnetic resonance hydrogen composes result：1H NMR (DMSO, 300MHz) δ 9.45 (s, 2H), 8.69 (d, 2H), 8.40 (dd, 4H), 8.21
(d, 2H).
Claims (10)
1. a kind of preparation method of Arylpyrimidines, which is characterized in that include the following steps：
S1) nitrile-based compound shown in malonaldehyde diimmonium salt, formula (III) is replaced to be urged with the first alkalinity 2- shown in formula (II)
Agent is reacted in organic solvent, obtains mixed liquor；
S2 ammonium salt and the second basic catalyst) are added in the mixed liquor, is reacted, it is phonetic to obtain aryl shown in formula (I)
Pyridine；
Wherein, R1For aryl, heterocycle, substituted aryl, substituted heterocyclic radical, hydrogen, chlorine, bromine, nitro, cyano, C1~C6 alkyl or
The alkoxy of C1~C6；
Ar is aryl, heterocycle, substituted aryl or substituted heterocyclic radical；
R2For the alkyl of aryl, heterocycle or C1~C8；
R3For the alkyl of aryl, heterocycle or C1~C8；
Or R2And R3Pyrroles, piperidines or morpholine are constituted with the nitrogen-atoms or oxygen atom being bonded；
A is halogen.
2. preparation method according to claim 1, which is characterized in that the step S1) be specially：
Nitrile-based compound shown in malonaldehyde diimmonium salt, formula (III) is replaced to be mixed with organic solvent 2- shown in formula (II),
Then under conditions of controlled at -10 DEG C~30 DEG C, the first basic catalyst is added, after reaction, obtains mixed liquor.
3. preparation method according to claim 1, which is characterized in that 2- shown in the formula (II) replaces malonaldehyde two sub-
The molar ratio of nitrile-based compound and the first basic catalyst shown in amine salt, formula (III) is 1：(0.98~1.02)：(0.05~
0.2)。
4. preparation method according to claim 1, which is characterized in that the step S1) in react temperature be 0 DEG C~30
℃；The time of reaction is 1~3h.
5. preparation method according to claim 1, which is characterized in that 2- shown in the formula (II) replaces malonaldehyde two sub-
The molar ratio of amine salt, the second basic catalyst and ammonium ion in ammonium salt is 1：(1.1~1.4)：(2~5).
6. preparation method according to claim 1, which is characterized in that the step S2) be specially：
Ammonium salt is added in the mixed liquor, after 20 DEG C~50 DEG C are reacted 2~20h, the second basic catalyst is added, carries out anti-
It answers, obtains Arylpyrimidines shown in formula (I).
7. preparation method according to claim 1, which is characterized in that the step S2) in react temperature be 50 DEG C~
150℃；The time of reaction is 2~8h.
8. preparation method according to claim 1, which is characterized in that first basic catalyst and the second base catalysis
Agent be each independently one kind in alkali metal hydride, alkaline earth metal hydride, alkali metal alcoholates and alkaline-earth alkoxides or
It is a variety of.
9. according to the preparation method described in claim 1~8 any one, which is characterized in that the anion in the ammonium salt is
HCOO-、CH3COO-、Cl-、Br-、CO3 2-、NO3 -、SO4 2-、HSO4 -With PO4 3-In it is one or more.
10. according to the preparation method described in claim 1~8 any one, which is characterized in that 2- takes shown in the formula (II)
It is prepared in accordance with the following methods for malonaldehyde diimmonium salt：
A formyl adduct shown in formula (IV) compound represented, formula (V) is reacted with halide reagent), obtains formula (II) institute
The 2- substitution malonaldehyde diimmonium salts shown；
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