CN1059470A - A kind of method of making the Chinese herbal medicine phinamide - Google Patents
A kind of method of making the Chinese herbal medicine phinamide Download PDFInfo
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- CN1059470A CN1059470A CN 90107240 CN90107240A CN1059470A CN 1059470 A CN1059470 A CN 1059470A CN 90107240 CN90107240 CN 90107240 CN 90107240 A CN90107240 A CN 90107240A CN 1059470 A CN1059470 A CN 1059470A
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Abstract
The present invention belongs to a kind of Chinese medicine manufacture method of preventing and treating rhinitis.Existing Drug therapy and operative treatment all have in various degree curative effect to rhinitis, but can not effect a radical cure mostly.The manufacture method of phinamide provided by the invention, adopting Flos Magnoliae, Rhizoma Coptidis, bright Chinese herbal medicine such as very light blue is raw material, through the apolegamy material, manufacturing process such as three immersions and decoction, composite, sterilization form.The drop safety of the inventive method made, nontoxic, have no side effect, short treating period, effective, effective percentage be more than 98%, and be better to simple property, chronic hypertrophic rhinitis therapeutic effect especially.
Description
The present invention belongs to a kind of Chinese medicine manufacture method of preventing and treating rhinitis.
Rhinitis is a kind of commonly encountered diseases of China, and frequently-occurring disease is particularly high and cold, the humid region sickness rate is higher.At present, the method and the employed medicament of treatment rhinitis all exist certain disadvantage.Doctor trained in Western medicine adopts the husband to block numb drop, though short term effect is fast, and i.e. recurrence after the drug withdrawal; The recurrence after operation rate is also very high with fixed attention to adopt electricity to iron electricity.Be prone to drowsiness side effect after, rhinitis comfortable with the synthetic Chinese patent medicine nose of Chinese and Western agent is peaceful, BIYANKANG etc. taken, take for a long time and also can cause forgetfully, especially teenager more should not take.
The purpose of this invention is to provide a kind of manufacture method with the Chinese herbal medicine extracting phinamide, the Chinese herbal medicine phinamide of making of this method has anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, the effect of strengthening body resistance and dispelling evil.And special efficacy is all arranged to treating various rhinitis, and nontoxic, have no side effect.This method has makes simply, and cost is low, advantages such as raw material abundance.
The method of making Chinese herbal medicine phinamide of the present invention comprises the apolegamy material, three immersions and decoction, composite, sterilization process:
(1) apolegamy material.Select clean, free from insect pests, the Flos Magnoliae that does not go mouldy, Rhizoma Coptidis for use, be Flos Magnoliae and Rhizoma Coptidis 9～9.5 by weight proportion: the prescription of 0.5-1 mixes, and pulverizes, and puts into vessel.
(2) immersion for the first time and decoction.In above-mentioned vessel, add the heavy 4-4.5 of crude drug amount water purification doubly, as tap water or spring water (clear water), water temperature is advisable with 4 ℃-8 ℃, in water purification, soaked 1.5-3 hour, water temperature is controlled at below 15 ℃ in the immersion, after very hot oven is fried in shallow oil 15-20 minute soon then, collect and be equivalent to 2/5ths heavy decoction medicine juice of crude drug amount, and filter the back storage with four layers of gauzes folder one deck absorbent cotton and go into standby in bottle 1.
(3) immersion for the second time and decoction.Collect the medicinal residues that decocted for the first time, put into vessel, and add 3～3.5 times heavy 40%(weight percent concentration of primary dose) ethanol, seal sealing, and soaked 10-14 hour, put fire then and go up decoction 20-25 minute, volatilization ethanol squeezes and presses medicine juice, and storage is gone in the bottle 2 standby.
In with the ethanol decoction process, generally also to consider alcoholic acid recovery problem.In the limited production process, can put into beaker to medicinal residues and ethanol and decoct, on beaker, cover the beaker lid that is equipped with recovery tube.Recovery tube is spiral helicine swan-neck, and the clips jacket layer is housed on the outer wall of swan-neck, and the chuck layer has two open tubes up and down, and recirculated cooling water goes out from the under shed pipe flow by the chuck layer from the upper shed pipe, and cooling circulates.The other end of swan-neck leads in the airtight recovery beaker.The ethanol volatilization gas is recycled water quench and becomes liquid through swan-neck, flows in the airtight recovery beaker, thereby makes ethanol obtain reclaiming, and can use repeatedly.In high volume production process, all alcohol recovering device to be installed.For example adopt spray column, in spray column, the water smoke of spray and ethanol volatilization gas form convection current, make to obtain in the dissolve with ethanol water reclaiming.
(4) soak for the third time and decoct.Collect the medicinal residues that decocted for the second time, put into vessel, and add the heavy 2.5-3 of primary dose 50%(weight percent concentration doubly) ethanol, and seal sealing, and soaked 7-9 hour, put fire then and go up decoction 20-25 minute, volatilization ethanol squeezes and presses medicine juice, and storage is gone in the bottle 3 standby.
Equally, in batch process, also alcohol recovering device to be set,, ethanol be used repeatedly in order to reclaim ethanol.
(5) composite.Soaking for the second time after medicine juice that decocts out and the medicine juice that decocts out for the third time mix, filter with four layers of gauzes folder one deck absorbent cotton, and put into triangular flask be concentrated into the crude drug amount heavy 3/5ths, the medicine juice that decocts out with immersion for the first time mixes then.
(6) sterilization.In above-mentioned mixed medicine juice, add antiseptic, put into pressure vessel then, 1.5 kilograms of pressure/(centimetre)
2Under the condition, pressurization sterilization 30 minutes is injected the drop bottle at last and is sealed sealing, promptly makes the Chinese herbal medicine phinamide.
The Chinese herbal medicine phinamide made from said method can directly use for the patient.In order further to increase the purity of medicine juice, reduce side effect, before sterilization, promptly after the medicine juice that three immersions decoct out mixes, above-mentioned mixed medicine juice is carried out a vacuum take out press filtration.Promptly communicate with the pipeline of vacuum pumping pump in the container of receiving filtration medicine juice, when starting vacuum pump, form negative pressure in the container of receiving filtration medicine juice, medicine juice enters in the container of receiving filtration medicine juice by filter course rapidly under the effect of negative pressure.Filter course can adopt four layers of gauze folder one deck absorbent cotton or other filtering material, and the control of vacuum size can be grasped according to the rate of filtration, and vacuum degree control big filter speed more is fast more, otherwise the rate of filtration is just slow more.Take out press filtration by current vacuum, can further filter out the fine hair of Flos Magnoliae,, produce sense of discomfort in case fine hair stimulates nasal membrane.
The Chinese herbal medicine phinamide of making in order to the top method contains Flos Magnoliae and Rhizoma Coptidis.Flos Magnoliae is warm in nature, and dispersing wind and cold, stuffy nose relieving effect are arranged, Rhizoma Coptidis act as heat clearing away, removing heat from blood and detoxifcation.The phinamide that contains Flos Magnoliae and Rhizoma Coptidis is called I type phinamide, has better curative effect to preventing and treating rhinitis.
In said method after the pressurization sterilization, promptly inject the sealing of drop bottle closure before, with recirculated cooling water medicine juice is cooled to 10 ℃-15 ℃, promptly be passed on the container outer wall that medicine juice is housed with recirculated cooling water, the mode by heat exchange makes the medicine juice cooling.4-8 hour bright very light blue natural juice of reuse disinfection by ultraviolet light is poured in the cooling medicine juice, and bright very light blue natural juice concentration in the medicine juice after mixing is the 2%-3%(percetage by weight).The bright very light blue clearing the nasal passage that mainly act as.Contain Flos Magnoliae, Rhizoma Coptidis and bright very light blue phinamide and be called II type phinamide.II type phinamide is suitable for Qiu Weihe to be used winter.Can use I type phinamide if any the people to very light blue allergy.No matter I type phinamide still is an II type phinamide, all has better curative effect to preventing and treating rhinitis.
This drop (comprising I type and II type phinamide) is a suspension, with before shaking up.Each 2-3 drips, and splashes into nasal cavity, lies on the back 5 minutes after dripping, and every day 4-6 time, one month is a course of treatment, and total dosage is 40-50ml, generally can cure.The optium concentration of this drop (comprising I type and II type phinamide) is the 90%-100%(percetage by weight) because of the liquor strength height, its matter thickness drips the back medicinal liquid and adheres to nasal cavity, and drug effect keeps playing a role for a long time.Pediatric pharmaceuticals concentration is generally in the 60%-75%(percetage by weight) between be advisable.When preparing the I type of 100% following concentration and II type phinamide, generally be to adopt distilled water diluting.
Method of the present invention adopts soak with ethanol to decoct, and this is because ethanol can increase the dissolubility of medicine, current meridians, on reach women's head-ornaments, can also strengthen the mechanism effect of medicine.
The sufficient raw that method of the present invention is used is made simply, and cost is low.The I type of made and II type phinamide, short treating period, instant effect, safety has no side effect, and effective percentage is more than 98%.Majority is taken BIYANKANG, the comfortable ineffective patient of nose, and the drop that uses the inventive method to make all takes effect very soon.Got final product relief of symptoms in general 1-2 days, with one month be a course of treatment, can effect a radical cure rhinitis, and be difficult for recurrence.Distinguished to sinusitis, allergic rhinitis curative effect, particularly to simple property, chronic hypertrophic rhinitis best results.Make the patient exempt the hardship of electric coagulation and operative treatment.Invent me and nineteen sixty-five once suffered from rhinitis, invalid through multi-treatment, very painful.The inventor has consulted a large amount of data with more than 20 years time for this reason, by comparing repeatedly, filters out this drop Fang Jian and manufacture method at last from the Chinese medicine medicine, through with the treatment of we's mirror drop, invents my rhinitis and obtains radical cure.
The I type of the inventive method made and II type phinamide, nontoxic through the chemical examination detection, the patient is relieved.PH value is all between 5.5-6.All be the sepia suspension, abnormal smells from the patient fragrant, splashing into nasal cavity has burning sensation slightly, if nasal membrane has the patient of serious ulcer, splash into after this agent pain more very the person should not use, treat can use after mucosal ulcer's healing.
Claims (4)
1, a kind of method of making the Chinese herbal medicine phinamide is characterized in that comprising apolegamy material, three immersions and decoction, composite, sterilization process:
(1) apolegamy material is selected clean, free from insect pests, the Flos Magnoliae that does not go mouldy, Rhizoma Coptidis for use, be Flos Magnoliae and Rhizoma Coptidis the prescription mixing of 9-9.5: 0.5-1 by weight proportion, and pulverizes, puts into vessel;
(2) immersion for the first time and decoction, in above-mentioned vessel, add the heavy 4-4.5 of crude drug amount water purification doubly, water temperature is 4 ℃-8 ℃, in water purification, soaked 1.5-3 hour, soaking water temperature is controlled at below 15 ℃, after very hot oven is fried in shallow oil 15-20 minute soon then, collect and be equivalent to 2/5ths heavy decoction medicine juice of crude drug amount, and filter the back storage with four layers of gauzes folder one deck absorbent cotton and go into standby in bottle 1;
(3) immersion for the second time and decoction, collect the medicinal residues that decocted for the first time, put into vessel, and add the heavy 3-3.5 of primary dose 40% (weight percent concentration) ethanol doubly, seal sealing and immersion 10-14 hour, put fire then and upward decocted 20-25 minute, volatilization ethanol, the crowded medicine juice that presses are store in the bottle 2 standby;
(4) soak for the third time and decoct, collect the medicinal residues that decocted for the second time, put into vessel, and add the heavy 2.5-3 of primary dose 50% (weight percent concentration) ethanol doubly, and seal sealing, soaked 7-9 hour, put fire then and go up decoction 20-25 minute, volatilization ethanol squeezes and presses medicine juice, and storage is gone in the bottle 3 standby;
(5) composite, soaking for the second time after medicine juice that decocts out and the medicine juice that decocts out for the third time mix, filter with four layers of gauzes folder one deck absorbent cotton, and put into triangular flask be concentrated into the crude drug amount heavy 3/5ths, the medicine juice that decocts out with immersion for the first time mixes then;
(6) sterilization, in above-mentioned mixed medicine juice, add antiseptic, put into pressure vessel then, 1.5 kilograms of pressure/(centimetre)
2Under the condition, pressurization sterilization 30 minutes is injected the drop bottle at last and is sealed sealing, promptly makes the Chinese herbal medicine phinamide.
2, the method for making Chinese herbal medicine phinamide according to claim 1 is characterized in that before sterilization, promptly after the medicine juice that three immersions decoct out mixes, above-mentioned mixed medicine juice is carried out a vacuum take out press filtration.
3, the method for making Chinese herbal medicine phinamide according to claim 1 and 2, it is characterized in that after the pressurization sterilization, with recirculated cooling water medicine juice is cooled to 4-8 hour bright very light blue natural juice of 10 ℃-15 ℃ reuse disinfection by ultraviolet lights and pours in the cooling medicine juice, and bright very light blue natural juice concentration in the medicine juice after mixing is the 2%-3%(percetage by weight).
4, the method for making Chinese herbal medicine phinamide according to claim 3 is characterized in that alcohol recovering device being set, in order to reclaim ethanol for the second time and soak in the decoction process for the third time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90107240 CN1027733C (en) | 1990-09-03 | 1990-09-03 | Prodn of rhinitis drops from Chinese heabal medicines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 90107240 CN1027733C (en) | 1990-09-03 | 1990-09-03 | Prodn of rhinitis drops from Chinese heabal medicines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1059470A true CN1059470A (en) | 1992-03-18 |
| CN1027733C CN1027733C (en) | 1995-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 90107240 Expired - Lifetime CN1027733C (en) | 1990-09-03 | 1990-09-03 | Prodn of rhinitis drops from Chinese heabal medicines |
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| Country | Link |
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| CN (1) | CN1027733C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317399C (en) * | 2000-11-16 | 2007-05-23 | 杰富意钢铁株式会社 | Converter oxygen blowing method and upward blowing lance for converter oxygen |
| CN100506203C (en) * | 2002-07-23 | 2009-07-01 | 钟根元 | Method for decocting Chinese medicines mixed liquid by using microwave and its application |
| CN103356763A (en) * | 2013-07-25 | 2013-10-23 | 北京首儿药厂 | Method for preparing orifice-opening rhinitis spray |
| CN106177117A (en) * | 2016-10-02 | 2016-12-07 | 王玲 | Chinese medicine drop for the treatment of chronic rhinitis and preparation method thereof |
-
1990
- 1990-09-03 CN CN 90107240 patent/CN1027733C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1317399C (en) * | 2000-11-16 | 2007-05-23 | 杰富意钢铁株式会社 | Converter oxygen blowing method and upward blowing lance for converter oxygen |
| CN100506203C (en) * | 2002-07-23 | 2009-07-01 | 钟根元 | Method for decocting Chinese medicines mixed liquid by using microwave and its application |
| CN103356763A (en) * | 2013-07-25 | 2013-10-23 | 北京首儿药厂 | Method for preparing orifice-opening rhinitis spray |
| CN106177117A (en) * | 2016-10-02 | 2016-12-07 | 王玲 | Chinese medicine drop for the treatment of chronic rhinitis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1027733C (en) | 1995-03-01 |
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