CN105944144A - Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure - Google Patents
Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure Download PDFInfo
- Publication number
- CN105944144A CN105944144A CN201610280106.0A CN201610280106A CN105944144A CN 105944144 A CN105944144 A CN 105944144A CN 201610280106 A CN201610280106 A CN 201610280106A CN 105944144 A CN105944144 A CN 105944144A
- Authority
- CN
- China
- Prior art keywords
- bone tissue
- shape
- shape memory
- bone
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention provides a bone tissue repair structure based on a shape memory composite material as well as a preparation method and an application method of the bone tissue repair structure. The preparation method comprises the following steps: (1) diagnosing the size and the shape of a bone injury part, so that a three-dimensional figure is obtained; (2) in accordance with the three-dimensional figure, constructing a preset shape of the shape memory composite material during printing by virtue of a computer; (3) uniformly mixing the following components in parts by weight by virtue of an ultrasonic dispersion method: 90-99 parts of a shape memory polymer, 1-5 parts of a reinforcing material and 1-10 parts of magnetic nanoparticles, so as to obtain a thick liquid, curing and cutting the cured liquid so as to obtain a solid in the form of a block; and (4) sequentially conducting extrusion-molding, three-dimensional printing and ultraviolet irradiation cross-linking on the block-shaped solid, so that the bone tissue repair structure of the shape memory composite material in the preset shape is obtained. The bone tissue repair structure disclosed by the invention has the beneficial effects that bone tissue cells can be induced to grow along the recovery direction of the bone tissue repair structure when the bone tissue repair structure is driven by an external magnetic field, so that repair of bone defect is achieved and the bone cells can grow more tightly.
Description
Technical field
The present invention relates to bone tissue restoration structure, particularly relate to a kind of bone based on composite material of shape memory
Tissue restoration structure and methods for making and using same thereof.
Background technology
The cell scaffold material being presently used for bone tissue engineer has two big classes, and a class is autosynthetic calls
Timbering material, another kind of for n cell timbering material.Iyodo etc. are by thin for the rabbit ilium skeletonization of separation and Culture
Born of the same parents and hydroxyapatite combined transplantation are at the defect of autologous ulna 6mm, through X-ray and group after 13 weeks
Knitting and check that confirmation defect is repaired the most completely, though hydroxyapatite has preferable biocompatibility, but it is moulded
Shape is difficult, fragility is big, and application is greatly limited；Polyglycolic acid non-woven fibre is propped up by Breitbart etc.
The holostrome Cranial defect of diameter 15mm made by frame, and after 12 weeks, there is a large amount of osteogenesis defective region；Puelacher etc.
With the scapula periosteum of cattle as cell derived, with polylactic acid and polyglycolic acid copolymers as carrier, plant
Enter at the artificial bone defect of nude mice femur, just visible bulk bone formation after 12 weeks, and osseous tissue has bone marrow
Being formed, cartilage is the most a little remaining, and polymer is substantially absorbed；Petite etc. with Corallium Japonicum Kishinouye as timbering material,
It is seed cell with autologous bone marrow stromal cells, constructs engineered bone of wasting time, repaired sheep and wasted time bone
The Cranial defect of 25mm.
Deepening continuously and clinical extensive application however as study, it has been found that current Clinical practice
Biomaterial also exists or biological activity is not enough, or degradation property is undesirable, and material is deposited in " foreign body " state
It is internal, can not merge with surrounding tissue and participate in the shortcomings such as normal metabolic activity, these all shadows
Hard tissue repairing material using effect clinically and doctor and the satisfaction of patient are rung.
In view of drawbacks described above, creator of the present invention obtains this finally through research for a long time and practice
Bright.
Summary of the invention
For solving the problems referred to above, the technical solution used in the present invention is, on the one hand provides a kind of based on shape
The preparation method of the bone tissue restoration structure of shape memory composite material, comprises the following steps: (1) diagnosis bone
The size and shape of damage location, obtains three-dimensional graph；(2) according to described three-dimensional graph,
The reservation shape of composite material of shape memory when building 3 D-printing by computer；(3) by composition by weight
Shape-memory polymer, the reinforcing material of 1-5 part and the magnetic nanoparticle of 1-10 part for 90-99 part
Utilize ultrasonic dispersion mix homogeneously, obtain thick liquid, solidification, it is cut into blocks of solid；(4) by institute
State blocks of solid by pultrusion make thread, again by three-dimensional printing technology one-body molded after carry out purple
Outer light irradiates the bone tissue restoration structure that crosslinking obtains the composite material of shape memory of described reservation shape.
Further, described magnetic nanoparticle is Fe3O4Or γ-Fe2O3。
Further, described shape-memory polymer is shape memory polycaprolactone, shape memory polylactic acid
With the one in shape memory polyurethane.
Further, described reinforcing material be starch, cellulose, chitin, lignin, hyaluronic acid and
One or more mixture in alginic acid.
On the other hand, it is provided that the preparation side of a kind of bone tissue restoration structure based on composite material of shape memory
The bone tissue restoration structure that method is made, the vitrification point of described bone tissue restoration structure is 40-60 DEG C.
There is provided the application process of a kind of bone tissue restoration structure based on composite material of shape memory, bag simultaneously
Include following steps: described bone tissue restoration structure is heated to described vitrification point by (1), by described
Bone tissue restoration structure compresses is to minimum shape, and keeps described minimum shape, is cooled to room temperature；(2)
Described bone tissue restoration structure under room temperature is implanted described bone injury site by Minimally Invasive Surgery, the most right
Described bone tissue restoration structure applies alternating magnetic field, returns back to described predetermined in described bone tissue restoration structure
While shape, induction bone and its cells is grown to described reservation shape.
The beneficial effects of the present invention is compared with the prior art:
1. utilize composite material of shape memory 3 D-printing bone tissue restoration structure, print the osseous tissue obtained
Reparation structure is integrated, and stability is strong, mechanical property good, and the reparation for bone and its cells provides
Supporting construction, by external magnetic field drive described in bone tissue restoration structure, it is possible to induction osseous tissue is thin
Born of the same parents reply direction growth along described bone tissue restoration structure, it is achieved that the reparation of Cranial defect, make osteocyte raw
Long tighter；
2. bone tissue restoration structure described in, is once in implanting state, starts accelerated degradation from eight month,
To the 18th month, undegraded remnants were less than 20%；
3. utilize bone tissue restoration structure repair Cranial defect position based on composite material of shape memory, not only
Improve bone conductibility, shorten cycle of reparation, and it is strong to repair controlled shape, it is easy to excipient.
Accompanying drawing explanation
Fig. 1 is present invention bone tissue restoration based on composite material of shape memory structure repair Cranial defect position
Procedure chart.
Detailed description of the invention
Below in conjunction with accompanying drawing, to the present invention, above-mentioned and other technical characteristic and advantage are made in more detail
Bright.
Embodiment one
The preparation method of bone tissue restoration structure based on composite material of shape memory, comprises the following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polycaprolactone that composition by weight is 90 parts, the reinforcing material of 1 part and 1 part
Fe3O4Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into block solid
Body, wherein said reinforcing material is starch or cellulose；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Above-mentioned preparation method, utilizes composite material of shape memory 3 D-printing bone tissue restoration structure, prints
The bone tissue restoration structure obtained is integrated, and stability is strong, mechanical property good, thin for osseous tissue
The reparation of born of the same parents provides supporting construction, by external magnetic field drive described in bone tissue restoration structure, it is possible to
Induction bone and its cells replys direction growth along described bone tissue restoration structure, it is achieved that the reparation of Cranial defect,
Make bone cell growth tighter.
The vitrification point of bone tissue restoration structure described above is 40-60 DEG C.
The described bone tissue restoration structure prepared in the present embodiment, is once in implanting state, from the 8th
Individual month starts accelerated degradation, and to the 18th month, undegraded remnants were less than 20%.
Embodiment two
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polylactic acid that composition by weight is 92 parts, the reinforcing material of 3 parts and 3 parts
Fe3O4Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into block solid
Body, wherein said reinforcing material is chitin；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Embodiment three
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polyurethane that composition by weight is 94 parts, the reinforcing material of 2 parts and the γ of 5 parts
-Fe2O3Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into block solid
Body, wherein said reinforcing material is lignin or hyaluronic acid or alginic acid；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Embodiment four
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polycaprolactone that composition by weight is 95 parts, the reinforcing material of 3 parts and 5 parts
γ-Fe2O3Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into bulk
Solid, wherein said reinforcing material is the mixture of starch and cellulose；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Embodiment five
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polycaprolactone that composition by weight is 97 parts, the reinforcing material of 5 parts and 7 parts
Fe3O4Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into block solid
Body, wherein said reinforcing material is the mixture of cellulose, chitin and alginic acid；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Embodiment six
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polycaprolactone that composition by weight is 99 parts, the reinforcing material of 5 parts and 10 parts
γ-Fe2O3Nano-particle utilizes ultrasonic dispersion mix homogeneously, obtains thick liquid, solidification, is cut into block
Shape solid, wherein said reinforcing material is the mixture of starch, chitin, lignin and hyaluronic acid；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
Embodiment seven
The preparation method of bone tissue restoration structure based on composite material of shape memory as above, including
Following steps,
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, when building 3 D-printing by computer, shape memory is combined
The reservation shape of material；
(3) by the shape memory polycaprolactone that composition by weight is 99 parts, the reinforcing material of 5 parts, 10 parts
γ-Fe2O3The degradable catalyst of nano-particle and 5 parts utilizes ultrasonic dispersion mix homogeneously, is glued
Thick liquid, solidification, it is cut into blocks of solid, wherein said reinforcing material is starch, chitin, lignin
Mixture with hyaluronic acid；
(4) described blocks of solid is made thread, again by three-dimensional printing technology one by pultrusion
Carry out after molding ultraviolet lighting penetrate crosslinking obtain bone tissue restoration structure based on composite material of shape memory.
In the present embodiment, by adding described degradable catalyst in described bone tissue restoration structure, use
To regulate the degradation rate of described bone tissue restoration structure.
Embodiment eight
The preparation method of bone tissue restoration structure based on composite material of shape memory as above is made
Bone tissue restoration structure, as it is shown in figure 1, its osseous tissue based on composite material of shape memory that is the present invention
Repairing the procedure chart at structure repair Cranial defect position, 1 is Cranial defect defective region, and 2 is multiple based on shape memory
The bone tissue restoration structure of condensation material, wherein, A figure represents Cranial defect organization charts, and B figure represents described bone
Tissue restoration structure implants the osseous tissue figure of bone injury site, and C-D represents and executes described bone tissue restoration structure
Adding magnetic stimulation, described bone group is repaired structure and is returned to the procedure chart of described reservation shape, and E represents described bone
Osseous tissue figure after tissue restoration structure degraded, described bone tissue restoration structure application process includes following step
Rapid:
(1) described bone tissue restoration structure is heated to described vitrification point, described osseous tissue is repaiied
Complex structure is compressed to minimum shape, and keeps described minimum shape, is cooled to room temperature；
(2) the described bone tissue restoration structure under room temperature is implanted described bone injury portion by Minimally Invasive Surgery
Position, periodically applies alternating magnetic field to described bone tissue restoration structure, replys in described bone tissue restoration structure
While described reservation shape, induction bone and its cells is grown to described reservation shape.
The present invention utilizes bone tissue restoration structure repair Cranial defect position based on composite material of shape memory,
Not only increase bone conductibility, shorten cycle of reparation, and bone growth can be made uniform, bone
Cell growth is more tight, and in addition, bone tissue restoration structure based on composite material of shape memory is repaiied
Complex shape controllability is strong, and is prone to excipient.
The above is only the preferred embodiment of the present invention, it is noted that general for the art
Logical technical staff, on the premise of without departing from the inventive method, it is also possible to makes some improvement and supplements,
These improve and supplement and also should be regarded as protection scope of the present invention.
Claims (6)
1. the preparation method of bone tissue restoration structure based on composite material of shape memory, its feature
It is, comprises the following steps:
(1) diagnose the size and shape of bone injury site, obtain three-dimensional graph；
(2) according to described three-dimensional graph, shape when building 3 D-printing by computer
The reservation shape of memory composite material；
(3) it is the shape-memory polymer of 90-99 part, the enhancing of 1-5 part by composition by weight
The magnetic nanoparticle of material and 1-10 part utilizes ultrasonic dispersion mix homogeneously, obtains thickness
Liquid, solidification, it is cut into blocks of solid；
(4) by described blocks of solid by pultrusion make thread, pass through 3 D-printing again
Carry out ultraviolet lighting after technology is one-body molded to penetrate crosslinking and obtain the shape memory of described reservation shape
The bone tissue restoration structure of composite.
Bone tissue restoration based on composite material of shape memory the most according to claim 1
The preparation method of structure, it is characterised in that described magnetic nanoparticle is Fe3O4Or γ
-Fe2O3。
Bone tissue restoration based on composite material of shape memory the most according to claim 2
The preparation method of structure, it is characterised in that described shape-memory polymer is that shape memory gathers
One in caprolactone, shape memory polylactic acid and shape memory polyurethane.
Bone tissue restoration based on composite material of shape memory the most according to claim 3
The preparation method of structure, it is characterised in that described reinforcing material is starch, cellulose, carapace
One or more mixture in element, lignin, hyaluronic acid and alginic acid.
5. the bone based on composite material of shape memory as described in claim 1-4 is arbitrary
The bone tissue restoration structure that the preparation method of tissue restoration structure is made, it is characterised in that described
The vitrification point of bone tissue restoration structure is 40-60 DEG C.
6. an osseous tissue based on composite material of shape memory as claimed in claim 5 is repaiied
The application process of complex structure, it is characterised in that comprise the following steps:
(1) described bone tissue restoration structure is heated to described vitrification point, by described
Bone tissue restoration structure compresses is to minimum shape, and keeps described minimum shape, is cooled to room temperature；
(2) the described bone tissue restoration structure under room temperature is implanted described bone by Minimally Invasive Surgery
Damage location, periodically applies alternating magnetic field to described bone tissue restoration structure, at described osseous tissue
While reparation structure returns back to described reservation shape, induction bone and its cells is grown to described pre-
Shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610280106.0A CN105944144A (en) | 2016-04-29 | 2016-04-29 | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610280106.0A CN105944144A (en) | 2016-04-29 | 2016-04-29 | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105944144A true CN105944144A (en) | 2016-09-21 |
Family
ID=56916336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610280106.0A Pending CN105944144A (en) | 2016-04-29 | 2016-04-29 | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105944144A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913914A (en) * | 2017-04-04 | 2017-07-04 | 西南交通大学 | A kind of preparation method for visualizing shape memory high molecule intravascular stent |
| CN107837132A (en) * | 2017-10-31 | 2018-03-27 | 陕西聚高增材智造科技发展有限公司 | A kind of interconnection 3D printing method towards personalized orthopaedics implant |
| CN108324336A (en) * | 2018-01-16 | 2018-07-27 | 冠昊生物科技股份有限公司 | A kind of New cranial bottom repair materials and its preparation method and application |
| CN108542486A (en) * | 2018-04-25 | 2018-09-18 | 哈尔滨工业大学 | A kind of biodegradable shape memory polymers encircle bone fracture device and its 4D printing preparation methods and driving method |
| CN109771700A (en) * | 2019-02-22 | 2019-05-21 | 华南农业大学 | A kind of nano combined biological support of magnetic thermal response-type shape memory multi-stage porous and its preparation and application based on the building of 3D printing lotion |
| CN110327489A (en) * | 2019-06-18 | 2019-10-15 | 中南大学湘雅二医院 | A kind of cmposite artificial bone and preparation method thereof carrying magnetic nanoparticle |
| CN111138833A (en) * | 2019-12-20 | 2020-05-12 | 东莞深圳清华大学研究院创新中心 | 3D printing magnetic thermoplastic polyurethane elastomer material and preparation method and application thereof |
| CN112980165A (en) * | 2021-02-25 | 2021-06-18 | 四川大学 | Self-repairing shape memory composite material with photo-magnetic response and preparation and application thereof |
| WO2022120902A1 (en) * | 2020-12-11 | 2022-06-16 | 深圳先进技术研究院 | Bone repair scaffold and preparation method therefor |
| CN114921087A (en) * | 2022-06-07 | 2022-08-19 | 西南交通大学 | Ultraviolet stimulus response lignin nanotube shape memory composite material and preparation method and application thereof |
| CN116139343A (en) * | 2022-09-07 | 2023-05-23 | 东华大学 | Preparation method and application of mechanically active bone tissue engineering scaffold |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654090A (en) * | 2005-02-07 | 2005-08-17 | 武汉理工大学 | Magnetic combine powder type vessel embolizing material |
| CN101240116A (en) * | 2008-02-18 | 2008-08-13 | 西南交通大学 | Biodegradable macromolecule composite material with shape memory function and its preparation method and use |
| CN102764168A (en) * | 2011-05-03 | 2012-11-07 | 上海理工大学 | Elastic shape memory recyclable bracket and manufacturing method and using method thereof |
| WO2013050775A1 (en) * | 2011-10-05 | 2013-04-11 | Smith & Nephew Plc | Medical devices containing shape memory polymer compositions |
| CN105013006A (en) * | 2015-06-24 | 2015-11-04 | 东莞天天向上医疗科技有限公司 | Bioabsorbable bone repair material and its use and manufacturing method |
| CN105504715A (en) * | 2016-01-15 | 2016-04-20 | 暨南大学 | Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof |
-
2016
- 2016-04-29 CN CN201610280106.0A patent/CN105944144A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654090A (en) * | 2005-02-07 | 2005-08-17 | 武汉理工大学 | Magnetic combine powder type vessel embolizing material |
| CN101240116A (en) * | 2008-02-18 | 2008-08-13 | 西南交通大学 | Biodegradable macromolecule composite material with shape memory function and its preparation method and use |
| CN102764168A (en) * | 2011-05-03 | 2012-11-07 | 上海理工大学 | Elastic shape memory recyclable bracket and manufacturing method and using method thereof |
| WO2013050775A1 (en) * | 2011-10-05 | 2013-04-11 | Smith & Nephew Plc | Medical devices containing shape memory polymer compositions |
| CN105013006A (en) * | 2015-06-24 | 2015-11-04 | 东莞天天向上医疗科技有限公司 | Bioabsorbable bone repair material and its use and manufacturing method |
| CN105504715A (en) * | 2016-01-15 | 2016-04-20 | 暨南大学 | Chitin whisker/magnesium oxide whisker/biodegradable polyester composite material as well as preparation method and application thereof |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913914A (en) * | 2017-04-04 | 2017-07-04 | 西南交通大学 | A kind of preparation method for visualizing shape memory high molecule intravascular stent |
| CN107837132A (en) * | 2017-10-31 | 2018-03-27 | 陕西聚高增材智造科技发展有限公司 | A kind of interconnection 3D printing method towards personalized orthopaedics implant |
| CN108324336A (en) * | 2018-01-16 | 2018-07-27 | 冠昊生物科技股份有限公司 | A kind of New cranial bottom repair materials and its preparation method and application |
| CN108542486A (en) * | 2018-04-25 | 2018-09-18 | 哈尔滨工业大学 | A kind of biodegradable shape memory polymers encircle bone fracture device and its 4D printing preparation methods and driving method |
| CN109771700A (en) * | 2019-02-22 | 2019-05-21 | 华南农业大学 | A kind of nano combined biological support of magnetic thermal response-type shape memory multi-stage porous and its preparation and application based on the building of 3D printing lotion |
| CN110327489B (en) * | 2019-06-18 | 2021-10-19 | 中南大学湘雅二医院 | Composite artificial bone loaded with magnetic nanoparticles and preparation method thereof |
| CN110327489A (en) * | 2019-06-18 | 2019-10-15 | 中南大学湘雅二医院 | A kind of cmposite artificial bone and preparation method thereof carrying magnetic nanoparticle |
| CN111138833A (en) * | 2019-12-20 | 2020-05-12 | 东莞深圳清华大学研究院创新中心 | 3D printing magnetic thermoplastic polyurethane elastomer material and preparation method and application thereof |
| WO2022120902A1 (en) * | 2020-12-11 | 2022-06-16 | 深圳先进技术研究院 | Bone repair scaffold and preparation method therefor |
| CN112980165A (en) * | 2021-02-25 | 2021-06-18 | 四川大学 | Self-repairing shape memory composite material with photo-magnetic response and preparation and application thereof |
| CN112980165B (en) * | 2021-02-25 | 2022-04-22 | 四川大学 | Self-repairing shape memory composite material with photo-magnetic response and preparation and application thereof |
| CN114921087A (en) * | 2022-06-07 | 2022-08-19 | 西南交通大学 | Ultraviolet stimulus response lignin nanotube shape memory composite material and preparation method and application thereof |
| CN114921087B (en) * | 2022-06-07 | 2023-08-18 | 西南交通大学 | Lignin nanotube shape memory composite material with ultraviolet stimulus response and preparation method and application thereof |
| CN116139343A (en) * | 2022-09-07 | 2023-05-23 | 东华大学 | Preparation method and application of mechanically active bone tissue engineering scaffold |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105944144A (en) | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure | |
| JP3916516B2 (en) | Scaffolding material for hard tissue-soft tissue interface regeneration | |
| Beier et al. | Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model | |
| DE69821774T2 (en) | Biodegradable composites | |
| Bao et al. | Effects of electrospun submicron fibers in calcium phosphate cement scaffold on mechanical properties and osteogenic differentiation of umbilical cord stem cells | |
| Latimer et al. | Regenerative medicine technologies to treat dental, oral, and craniofacial defects | |
| CN102526809B (en) | Stent for osteochondral defect repair and preparation method thereof | |
| US8968401B2 (en) | Synthetic scaffolds and organ and tissue transplantation | |
| CN106421929B (en) | A kind of injectable calcium phosphate/natural high molecular composite material and its preparation method and application | |
| Zhang et al. | Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model | |
| WO2015185219A1 (en) | Production of a component for cultivating a joint surface implant | |
| CN104474589A (en) | Guided tissue regeneration membrane as well as preparation method and application thereof | |
| CN104667345A (en) | Cranioplasty prosthesis with biological activity and preparation method of cranioplasty prosthesis | |
| CN101934092A (en) | Injection-type cartilage bionic matrix for regenerative repair of cartilage and method for using same | |
| Zhang et al. | 3D-printed pre-tapped-hole scaffolds facilitate one-step surgery of predictable alveolar bone augmentation and simultaneous dental implantation | |
| KR102316879B1 (en) | Scaffold for regenerating periodontal tissue containing horse bone-derived nanoceramics and PCL and its manufacturing method | |
| CN102008748B (en) | Application of injectable degradable calcium sulfate and calcium phosphate material in repairing femoral head necrosis | |
| CN102643514B (en) | Polyetheretherketone composite material and bone repairing body as well as preparation method and application thereof | |
| CN108273131A (en) | A kind of composite bone cement, preparation method and applications and a kind of bone renovating material | |
| Zhou et al. | In vivo efficacy of bone marrow stromal cells coated with beta-tricalcium phosphate for the reconstruction of orbital defects in canines | |
| Suruagy et al. | Physico-chemical and histomorphometric evaluation of zinc-containing hydroxyapatite in rabbits calvaria | |
| CN106730011A (en) | A kind of xenogenesis acellular nerve graft thing with prevention tissue adhesion function and preparation method thereof | |
| CN105536047A (en) | Skull repair material and preparation method for same | |
| CN105327394A (en) | Mineralized collagen-based biological tooth root scaffold material and preparation method thereof | |
| CN102240233B (en) | Degradable stent for sternum defect repair and manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160921 |
|
| RJ01 | Rejection of invention patent application after publication |