CN105943842A - Preparation method of oral liquid for treating rheumatic heart disease - Google Patents

Preparation method of oral liquid for treating rheumatic heart disease Download PDF

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Publication number
CN105943842A
CN105943842A CN201610368648.3A CN201610368648A CN105943842A CN 105943842 A CN105943842 A CN 105943842A CN 201610368648 A CN201610368648 A CN 201610368648A CN 105943842 A CN105943842 A CN 105943842A
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parts
extraction
radix
heart disease
rheumatic heart
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黄莉娟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a preparation method of oral liquid for treating rheumatic heart disease. A traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 8 to 12 parts of Chinese pyrola herb, 8 to 12 parts of herba lycopodii, 8 to 12 parts of garden balsam stem, 8 to 12 parts of rhizoma drynariae, 8 to 12 parts of radix dipsaci, 18 to 22 parts of Zhejiang roasted rhizoma atractylodis, 8 to 12 parts of swordlike atractylodes rhizome, 18 to 22 parts of endothelium corneum gigeriae galli, 8 to 12 parts of radix angelicae sinensis, 8 to 12 parts of fructus lycii, 8 to 12 parts of rhizoma polygonati, 8 to 12 parts of rhizoma polygonati odorati, 8 to 12 parts of radix gentianae macrophyllae, 4 to 6 parts of radix stephaniae tetrandrae, 4 to 6 parts of rhizoma seu radix notopterygii, 4 to 6 parts of radix angelicae pubescentis, 8 to 12 parts of white peony root, 4 to 6 parts of cortex phellodendri, 4 to 6 parts of fructus gardenia and 13 to 18 parts of radix astragali. The preparation method of the oral liquid for treating the rheumatic heart disease comprises the following steps of drying and crushing the traditional Chinese medicinal composition to obtain raw material powder; mixing the raw material powder with ethanol and leaching; after leaching is ended, heating to evaporate the ethanol to obtain an extract; diluting the extract to obtain the oral liquid for treating the rheumatic heart disease.

Description

The preparation method of the oral liquid for the treatment of rheumatic heart disease
Technical field
The present invention relates to tcm field, particularly relate to the system of a kind of oral liquid treating rheumatic heart disease Preparation Method.
Background technology
Rheumatic heart disease is called for short rheumatic heart disease, and doctor trained in Western medicine thinks that rheumatic heart disease is due to rheumatic fever activity, The valve disorder involving cardiac valve and cause, shows as in Bicuspid valve, Tricuspid valve, aortic valve There are one or several valvular stenosis and (or) incompetence.Due to valvular pathological changes so that heart Go wrong during hemophoric, such as valvular stenosis so that resistance of blood flow strengthens, in order to penetrate Enough blood, heart diastole the most arduously and contraction, so make heart working intensity strengthen, effect Rate reduces, and heart fatiguability causes cardiac hypertrophy in the course of time.As mitral stenosis to a certain extent time Due to increasing of left atrial pressure, cause pulmonary vein and pulmonary capillary pressure to increase, form pulmonary venous pleonaemia, lung Following symptom is easily caused: 1. dyspnea after congestion；2. cough；3. hemoptysis, have there is also sound Sound is hoarse and dysphagia.
The existing Therapeutic Principle for rheumatic heart disease mainly keeps and strengthens the compensatory merit of heart Can, on the one hand should avoid heart over load, such as heavy physical labour, strenuous exercise etc., another aspect is the most also Need to be association of activity and inertia, suitably do some activity in power and exercises, health invigorating, improve the storage of heart Standby ability.Suitable physical exertion and rest, limit the intake of sodium salt and the prevention of respiratory tract infection and Treatment.Note preventing rheumatic fever and infective endocarditis.When merging heart failure, use digitalis preparation, Diuretic and vasodilation.Serious rheumatic heart disease takes operative treatment.
Summary of the invention
It is an object of the invention to solve at least the above and/or defect, and provide after at least and will say Bright advantage.
It is a further object to provide the preparation side of a kind of oral liquid treating rheumatic heart disease Method, it is possible to be effectively treated rheumatic heart disease oral liquid.
Other purposes with some for achieving the above object, the present invention adopts the following technical scheme that
The preparation method of a kind of oral liquid treating rheumatic heart disease, comprises the following steps:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: deer break grass 8-12, Herba Lycopodii 8-12, Herba speranskiae tuberculatae 8-12, Rhizoma Drynariae 8-12, Radix Dipsaci 8-12, the Zhejiang Rhizoma Atractylodis Macrocephalae fry 18-22, Atractylodes lancea (Thunb.) DC. 8-12, Endothelium Corneum Gigeriae Galli 18-22, Radix Angelicae Sinensis 8-12, Fructus Lycii Sub-8-12, Rhizoma Polygonati 8-12, Rhizoma Polygonati Odorati 8-12, Radix Gentianae Macrophyllae 8-12, Radix Stephaniae Tetrandrae 4-6, Rhizoma Et Radix Notopterygii 4-6, Radix Angelicae Pubescentis 4-6, Radix Paeoniae Alba 8-12, Cortex Phellodendri 4-6, Fructus Gardeniae 4-6 and Radix Astragali 13-18；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain the mouth of described treatment rheumatic heart disease Take liquid.
Preferably, in the preparation method of the oral liquid of described treatment rheumatic heart disease, in step 3 To treatment rheumatic heart disease oral liquid in add the maltose alcohol of 5-8%.
Preferably, in the preparation method of the oral liquid of described treatment rheumatic heart disease, in step 2 Leach extraction method is substep extraction, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
The present invention at least includes following beneficial effect: first, and the present invention utilizes the traditional Chinese medical science five elements and dialectical theory, Wind-damp dispelling, spleen invigorating fortune is wet, and dampness removing then dampness goes out, and the kidney invigorating strong the kidney warming sun then cold goes out, scattered wind then pathogenic wind Going out, wind and cold is wet all to be gone out, healthy energy extreme deficiency syndrome, prevents that it is weak with the medicine filled blood, and prolonged illness seven emotions fire-transformation produces Interior-heat, removes interior-heat, and wind and cold is wet all to be gone, and interior-heat must remove, and is just being so incensed that multiple, is making rheumatic heart disease obtain To cure.
Secondly, by by can effectively treat rheumatic heart disease Chinese medicine composition carry out substep ethanol and soak Carry, make the oral liquid not only taking convenience of prepared treatment rheumatic heart disease, and beneficially medicine The absorption of effective ingredient, effectively treats rheumatic heart disease.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will By the research of the present invention and practice are understood by the person skilled in the art.
Detailed description of the invention
Below the present invention is elaborated, to make those of ordinary skill in the art refer to energy after this specification Enough implement according to this.
The preparation method of a kind of oral liquid treating rheumatic heart disease, comprises the following steps:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: deer break grass 8-12, Herba Lycopodii 8-12, Herba speranskiae tuberculatae 8-12, Rhizoma Drynariae 8-12, Radix Dipsaci 8-12, the Zhejiang Rhizoma Atractylodis Macrocephalae fry 18-22, Atractylodes lancea (Thunb.) DC. 8-12, Endothelium Corneum Gigeriae Galli 18-22, Radix Angelicae Sinensis 8-12, Fructus Lycii Sub-8-12, Rhizoma Polygonati 8-12, Rhizoma Polygonati Odorati 8-12, Radix Gentianae Macrophyllae 8-12, Radix Stephaniae Tetrandrae 4-6, Rhizoma Et Radix Notopterygii 4-6, Radix Angelicae Pubescentis 4-6, Radix Paeoniae Alba 8-12, Cortex Phellodendri 4-6, Fructus Gardeniae 4-6 and Radix Astragali 13-18；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain described treatment rheumatic heart disease Oral liquid.
Deer break grass dispelling the wind and dampness pathogens arthralgia, expelling wind and removing dampness, qi-restoratives kidney tonifying；
Herba Lycopodii expelling wind and cold, dehumidifying detumescence, to anemofrigid-damp arthralgia, there is good action；
Herba speranskiae tuberculatae sweet in the mouth is pungent and warm, expelling wind and removing dampness, promoting blood circulation and stopping pain, relaxing muscles and tendons and activating QI and blood in the collateral；
Radix Dipsaci invigorating the liver and kidney, reuniting the fractured tendons and bones, blood circulation regulating；
Radix Stephaniae Tetrandrae treatment rheumatic arthritis；
The spleen being in charge of dampness, the most unnecessary dampness of spleen can not stop in vivo, insufficiency of the spleen, dampness in vivo and be Disease, spleen invigorating then dampness transporting.Zhejiang Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, stomach strengthening helps digestion, and coordinates Atractylodes lancea (Thunb.) DC. the spleen strengthening and damp drying, And have more the effect that scattered wind-dryness is wet, better；Endothelium Corneum Gigeriae Galli stomach strengthening is taken food, and stomach the most then spleen is strong, human body Being shaped with void, serious disease is near, how to begin from stomach, so-called " patient with full stomach-QI being easy to treat and having a favorable prognosis extreme hypofunction of the stomach is then the most also ".
The kidney being the origin of congenital constitution, and wind and cold invades kidney, then kidney yang is the weakest, kidney governing bones, and bone the most then kidney is also strong, Rhizoma Drynariae bone strengthening the kidney invigorating, Fructus Psoraleae warming and recuperating the kidney-YANG, kidney yang is strong, then cold is from removing；Fructus Lycii, the kidney invigorating benefit Marrow, nourishing YIN and benefiting blood.
Radix Gentianae Macrophyllae dissipates rheumatic pain killing, bitter in the mouth and dampness；
Notopterygium wind dispelling wet profit arthralgia relief, coordinates Radix Angelicae Pubescentis wind-damp dispelling analgesic effect to double；
Radix Angelicae Sinensis nourishes blood replenishing and activating blood；
Rhizoma Polygonati mends lean spleen kidney；
Rhizoma Polygonati Odorati YIN nourishing yin nourishing and property is gentle, have the merit that medicine is top grade；
Radix Astragali QI invigorating enhancing immunity；
The Radix Paeoniae Alba is nourished blood heat clearing away, and scattered wind then blood is dry, therefore nourishes blood receipts the moon with the Radix Paeoniae Alba；
Prolonged illness is vexed, and interior-heat perplexs, and uses Fructus Gardeniae clearing heat and relieving fidgetness, Cortex Phellodendri heat clearing and damp drying, and deficiency-heat does not rises.
Above Chinese medicine composition wind-damp dispelling, spleen invigorating fortune is wet, and dampness removing then dampness goes out, and the kidney invigorating strong the kidney warming sun is then Cold goes out, and scattered wind then pathogenic wind goes out, and wind and cold is wet all to be gone out, healthy energy extreme deficiency syndrome, prevents that it is weak with the medicine filled blood, Prolonged illness seven emotions fire-transformation, produces interior-heat, interior-heat is removed, and wind and cold is wet all to be gone, and interior-heat must remove, and is just being so incensed that multiple, Rheumatic heart disease is made to be cured.
By by can effectively treat rheumatic heart disease Chinese medicine composition carry out substep alcohol steep, make The oral liquid not only taking convenience of prepared treatment rheumatic heart disease, and beneficially medicine effectively becomes The absorption divided, effectively treats rheumatic heart disease.
In the preparation method of the oral liquid of described treatment rheumatic heart disease, to treatment rheumatism in step 3 The oral liquid that property is cardiopathic adds the maltose alcohol of 5-8%.
In the preparation method of the oral liquid of described treatment rheumatic heart disease, in step 2, leach extraction method is Extraction step by step, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
Substep extraction can make effective ingredient more fully discharge, and improves curative effect of medication.
Although embodiment of the present invention are disclosed as above, but it is not restricted to description and embodiment party Listed utilization in formula, it can be applied to various applicable the field of the invention completely, for being familiar with ability For the personnel in territory, be easily achieved other amendment, therefore without departing substantially from claim and etc. homotype Enclosing under limited general concept, the present invention is not limited to specific details.

Claims (3)

1. the preparation method of the oral liquid treating rheumatic heart disease, it is characterised in that include following Step:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition Raw material including following weight portion: deer break grass 8-12, Herba Lycopodii 8-12, Herba speranskiae tuberculatae 8-12, Rhizoma Drynariae 8-12, Radix Dipsaci 8-12, the Zhejiang Rhizoma Atractylodis Macrocephalae fry 18-22, Atractylodes lancea (Thunb.) DC. 8-12, Endothelium Corneum Gigeriae Galli 18-22, Radix Angelicae Sinensis 8-12, Fructus Lycii Sub-8-12, Rhizoma Polygonati 8-12, Rhizoma Polygonati Odorati 8-12, Radix Gentianae Macrophyllae 8-12, Radix Stephaniae Tetrandrae 4-6, Rhizoma Et Radix Notopterygii 4-6, Radix Angelicae Pubescentis 4-6, Radix Paeoniae Alba 8-12, Cortex Phellodendri 4-6, Fructus Gardeniae 4-6 and Radix Astragali 13-18；
Step 2, raw material powder is mixed with the 60-70% ethanol solution of 10-30 times of volume extraction, extraction knot Bundle post-heating makes ethanol evaporation, obtains extract；
Step 3, extract is added distilled water diluting 5-8 times, obtain the mouth of described treatment rheumatic heart disease Take liquid.
2. the preparation method of the oral liquid for the treatment of rheumatic heart disease as claimed in claim 1, its feature Be, in step 3 to treatment rheumatic heart disease oral liquid in add the maltose alcohol of 5-8%.
3. the preparation method of the oral liquid for the treatment of rheumatic heart disease as claimed in claim 1, its feature Being, in step 2, leach extraction method is substep extraction, method particularly includes:
Step 2.1, for the first time extraction, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, mistake Filter obtains the first lixiviating solution；
Step 2.2, second time extraction, mix the trapped substance of extraction filtration for the first time with ethanol and carry out second Secondary extraction, extraction temperature is 60-80 DEG C, and extraction time 20-30 minute is filtrated to get the second lixiviating solution；
Step 2.3, the first lixiviating solution and the second lixiviating solution are mixed, are heated to 80-85 DEG C and make ethanol evaporation, Obtain described extract.
CN201610368648.3A 2016-05-27 2016-05-27 Preparation method of oral liquid for treating rheumatic heart disease Pending CN105943842A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250676A (en) * 2015-11-25 2016-01-20 韦调才 Traditional Chinese medicine composition for treating rheumatism
CN105497683A (en) * 2015-12-25 2016-04-20 梁燕妮 Method for preparing oral liquid for treating jaundice

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105250676A (en) * 2015-11-25 2016-01-20 韦调才 Traditional Chinese medicine composition for treating rheumatism
CN105497683A (en) * 2015-12-25 2016-04-20 梁燕妮 Method for preparing oral liquid for treating jaundice

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Application publication date: 20160921