CN105913461A - Rat brain function magnetic resonance imaging standard space map template construction method - Google Patents
Rat brain function magnetic resonance imaging standard space map template construction method Download PDFInfo
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- CN105913461A CN105913461A CN201610207362.7A CN201610207362A CN105913461A CN 105913461 A CN105913461 A CN 105913461A CN 201610207362 A CN201610207362 A CN 201610207362A CN 105913461 A CN105913461 A CN 105913461A
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- magnetic resonance
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- rat brain
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- 230000003925 brain function Effects 0.000 title claims abstract description 19
- 238000010276 construction Methods 0.000 title claims abstract description 9
- 238000002595 magnetic resonance imaging Methods 0.000 title abstract description 4
- 210000004556 brain Anatomy 0.000 claims abstract description 13
- 241000700159 Rattus Species 0.000 claims description 25
- 238000005481 NMR spectroscopy Methods 0.000 claims description 7
- 238000012952 Resampling Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 3
- 210000004761 scalp Anatomy 0.000 claims description 3
- 238000002224 dissection Methods 0.000 abstract description 3
- 230000009466 transformation Effects 0.000 abstract 1
- 238000011835 investigation Methods 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T3/00—Geometric image transformations in the plane of the image
- G06T3/40—Scaling of whole images or parts thereof, e.g. expanding or contracting
- G06T3/4023—Scaling of whole images or parts thereof, e.g. expanding or contracting based on decimating pixels or lines of pixels; based on inserting pixels or lines of pixels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T3/00—Geometric image transformations in the plane of the image
- G06T3/06—Topological mapping of higher dimensional structures onto lower dimensional surfaces
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T5/00—Image enhancement or restoration
- G06T5/70—Denoising; Smoothing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10088—Magnetic resonance imaging [MRI]
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30016—Brain
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Molecular Biology (AREA)
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- High Energy & Nuclear Physics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
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Abstract
The invention discloses a rat brain function magnetic resonance imaging standard space map template construction method. On the basis of a rat brain standard dissection map and a rat 3D magnetic resonance high resolution T2 weighted image, through two-dimensional three-dimensional transformation, a rat brain standard space map template is accurately registered and generated, accurate and convenient research result dissection positioning can be provided for rat brain function magnetic resonance imaging researchers, and scientific research result accuracy and scientific research efficiency are improved.
Description
Technical field
The present invention relates to Brain Function of Rats magnetic resonance imaging arts, be specifically related to a kind of Brain Function of Rats magnetic resonance
The construction method of imaging standards space collection of illustrative plates template.
Background technology
Toy brain function MR investigation is the direction of scientific rersearch currently risen, especially Brain Function of Rats
MR investigation, it will convert, for the research of mankind's preclinical phase and scientific research, the information providing important.But,
The rat brain space collection of illustrative plates template of standard is lacked during the presenting of Brain Function of Rats nuclear magnetic resonance result,
It is unfavorable for the dissection comparison of scientific research result, has a strong impact on accuracy and the scientific research efficiency of scientific research result.
Summary of the invention
For solving the problems referred to above, the invention provides a kind of Brain Function of Rats nuclear magnetic resonance normed space collection of illustrative plates
The construction method of template, based on rat brain standard anatomical atlas and rat 3D magnetic resonance high-resolution T2
Weighted image, by the three-dimensional conversion of two dimension, accuracy registration and generate rat brain normed space collection of illustrative plates template,
Can be that Brain Function of Rats MRI investigation personnel provide accurate and convenient result of study Anatomical orientation, from
And improve accuracy and the scientific research efficiency of scientific research result.
For achieving the above object, the technical scheme that the present invention takes is:
The construction method of a kind of Brain Function of Rats nuclear magnetic resonance normed space collection of illustrative plates template, including walking as follows
Rapid:
S1, utilize AFNI software by rat brain high-resolution 3D T2 weighted magnetic resonance images resampling become differentiate
Rate is 0.2 × 0.2 × 0.2mm；
S2, AFNI software is utilized to remove the scalp in above-mentioned image, reservation size brain image information；
S3, the image after resampling is carried out locus fine setting, keep itself and 2D standard anatomical atlas
Direction in space is consistent；
S4, determine anatomic landmark (anterior commissure) in 2D standard anatomical atlas and 3D magnetic resonance image (MRI) respectively
Position；
S5, determine and the figure layer of the 2D standard anatomical atlas corresponding to 3D magnetic resonance image (MRI), and mark successively
Note, preserves into a series of image file；
The image file that S6, switch process S5 generate is AFNI software readable written document；
S7,2D standard step S6 generated are dissected atlas image file and are registrated to the 3D that step S3 generates
In magnetic resonance image (MRI)；
S8, ultimately generate the Brain Function of Rats magnetic resonance normed space template with anatomic information.
The method have the advantages that
Based on rat brain standard anatomical atlas and rat 3D magnetic resonance high-resolution t2 weighted image, pass through
The three-dimensional conversion of two dimension, accuracy registration and generate rat brain normed space collection of illustrative plates template, can be Brain Function of Rats
MRI investigation personnel provide accurate and convenient result of study Anatomical orientation, thus improve scientific research result
Accuracy and scientific research efficiency.
Accompanying drawing explanation
Fig. 1 is the structure of the embodiment of the present invention a kind of Brain Function of Rats nuclear magnetic resonance normed space collection of illustrative plates template
The flow chart of construction method.
Detailed description of the invention
In order to make objects and advantages of the present invention clearer, below in conjunction with embodiment, the present invention is carried out
Further describe.Should be appreciated that specific embodiment described herein only in order to explain the present invention,
It is not intended to limit the present invention.
As it is shown in figure 1, embodiments provide a kind of Brain Function of Rats nuclear magnetic resonance normed space figure
The construction method of spectrum template, comprises the steps:
S1, utilize AFNI software by rat brain high-resolution 3D T2 weighted magnetic resonance images resampling become differentiate
Rate is 0.2 × 0.2 × 0.2mm；
S2, AFNI software is utilized to remove the scalp in above-mentioned image, reservation size brain image information；
S3, the image after resampling is carried out locus fine setting, keep itself and 2D standard anatomical atlas
Direction in space is consistent；
S4, determine anatomic landmark (anterior commissure) in 2D standard anatomical atlas and 3D magnetic resonance image (MRI) respectively
Position；
S5, determine and the figure layer of the 2D standard anatomical atlas corresponding to 3D magnetic resonance image (MRI), and mark successively
Note, preserves into a series of image file；
The image file that S6, switch process S5 generate is AFNI software readable written document；
S7,2D standard step S6 generated are dissected atlas image file and are registrated to the 3D that step S3 generates
In magnetic resonance image (MRI)；
S8, ultimately generate the Brain Function of Rats magnetic resonance normed space template with anatomic information.
The above is only the preferred embodiment of the present invention, it is noted that common for the art
For technical staff, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications,
These improvements and modifications also should be regarded as protection scope of the present invention.
Claims (1)
1. a construction method for Brain Function of Rats nuclear magnetic resonance normed space collection of illustrative plates template, its feature exists
In, comprise the steps:
S1, utilize AFNI software by rat brain high-resolution 3D T2 weighted magnetic resonance images resampling become differentiate
Rate is 0.2 × 0.2 × 0.2mm；
S2, AFNI software is utilized to remove the scalp in above-mentioned image, reservation size brain image information；
S3, the image after resampling is carried out locus fine setting, keep itself and 2D standard anatomical atlas
Direction in space is consistent；
S4, determine anatomic landmark (anterior commissure) in 2D standard anatomical atlas and 3D magnetic resonance image (MRI) respectively
Position；
S5, determine and the figure layer of the 2D standard anatomical atlas corresponding to 3D magnetic resonance image (MRI), and mark successively
Note, preserves into a series of image file；
The image file that S6, switch process S5 generate is AFNI software readable written document；
S7,2D standard step S6 generated are dissected atlas image file and are registrated to the 3D that step S3 generates
In magnetic resonance image (MRI)；
S8, ultimately generate the Brain Function of Rats magnetic resonance normed space template with anatomic information.
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| CN201610207362.7A CN105913461A (en) | 2016-03-31 | 2016-03-31 | Rat brain function magnetic resonance imaging standard space map template construction method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113066113A (en) * | 2021-04-27 | 2021-07-02 | 河北医科大学第二医院 | Method and equipment for constructing spontaneous hypertensive rat brain template and map set |
Citations (5)
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| CN101903908A (en) * | 2007-12-18 | 2010-12-01 | 皇家飞利浦电子股份有限公司 | Features-based 2D/3D image registration |
| US20130129168A1 (en) * | 2011-11-23 | 2013-05-23 | The Regents Of The University Of Michigan | Voxel-Based Approach for Disease Detection and Evolution |
| CN103886328A (en) * | 2014-03-19 | 2014-06-25 | 太原理工大学 | Functional magnetic resonance image data classification method based on brain network modular structure characteristics |
| CN104103066A (en) * | 2013-04-03 | 2014-10-15 | 瑞士西门子有限公司 | Atlas-free brain tissue segmentation method |
| CN104224175A (en) * | 2013-09-27 | 2014-12-24 | 复旦大学附属华山医院 | Method of fusing two-dimensional magnetic resonance spectrum and three-dimensional magnetic resonance navigation image |
-
2016
- 2016-03-31 CN CN201610207362.7A patent/CN105913461A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903908A (en) * | 2007-12-18 | 2010-12-01 | 皇家飞利浦电子股份有限公司 | Features-based 2D/3D image registration |
| US20130129168A1 (en) * | 2011-11-23 | 2013-05-23 | The Regents Of The University Of Michigan | Voxel-Based Approach for Disease Detection and Evolution |
| CN104103066A (en) * | 2013-04-03 | 2014-10-15 | 瑞士西门子有限公司 | Atlas-free brain tissue segmentation method |
| CN104224175A (en) * | 2013-09-27 | 2014-12-24 | 复旦大学附属华山医院 | Method of fusing two-dimensional magnetic resonance spectrum and three-dimensional magnetic resonance navigation image |
| CN103886328A (en) * | 2014-03-19 | 2014-06-25 | 太原理工大学 | Functional magnetic resonance image data classification method based on brain network modular structure characteristics |
Non-Patent Citations (2)
| Title |
|---|
| 刘树伟，尹岭，唐一源: "《功能神经影像学》", 1 August 2011 * |
| 曹捷: "大鼠脑三维标准图谱的构建及磁共振图像分析系统的研究及实现", 《中国优秀硕士学位论文全文数据库 信息科技辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113066113A (en) * | 2021-04-27 | 2021-07-02 | 河北医科大学第二医院 | Method and equipment for constructing spontaneous hypertensive rat brain template and map set |
| CN113066113B (en) * | 2021-04-27 | 2022-01-11 | 河北医科大学第二医院 | Method and equipment for constructing spontaneous hypertensive rat brain template and map set |
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