CN105911261A - Thrombus elastometer - Google Patents
Thrombus elastometer Download PDFInfo
- Publication number
- CN105911261A CN105911261A CN201610347496.9A CN201610347496A CN105911261A CN 105911261 A CN105911261 A CN 105911261A CN 201610347496 A CN201610347496 A CN 201610347496A CN 105911261 A CN105911261 A CN 105911261A
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- China
- Prior art keywords
- light
- hole
- optical pickup
- pickup apparatus
- container
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Abstract
The invention discloses a thrombus elastometer. The thrombus elastometer is composed of a plurality of thrombus elastometer components (2) in horizontal arraignment and is characterized in that each of the thrombus elastometer components (2) comprises a workbench (4), a frame (5), a test bar (6), a tester (8) and a processer. The thrombus elastometer is capable of overcoming the defect of inaccurate result of the thrombus elastometer in the prior art, the amount of the reflected rays is taken as the reference for the evaluation of the thrombus elastic force and the result is more accurate.
Description
Technical field
The present invention relates to a kind of thrombosis elastometer.
Background technology
Thrombosis instrument is the experimental apparatus of a kind of vitro detection blood blood clotting.
The thrombin in blood can be excited to produce condensation and fibrinolytic etc. after human blood through radiation extraction a series of
The change of state.By clinical monitoring, the blood of human body of normal and morbid state (cardiovascular and cerebrovascular disease) is whole
During the state of blood change and have significant difference, this significant difference to be mainly reflected in condensation with fine
Molten speed and the intensity of condensation, cardio-cerebrovascular diseases can be faced by the difference of this speed and intensity
Bed diagnosis provides objectively to be instructed.The Cleaning Principle of thrombosis elastometer is the physical characteristic for blood of human body
(speed, intensity) carries out what detection was analyzed, is different from other Hemostasis examination analytical equipment just for blood coagulation
The time slice of process detects, and thrombosis elastometer can reflect the blood coagulation overall picture of human body, the most whole condensation
With fibrinolytic process.
Thrombosis elastometer is that the physical characteristic for blood of human body carries out detection analysis, and the physics of blood is special
Property change be by blood condense with fibrinolytic during the stress that produces of blood cause.The stress of blood is solidifying
During blood, the absolute magnitude of change is less, uses the sensor of product type to measure, its certainty of measurement and survey
Amount result cannot react the dynamic change of blood really, thus have impact on thrombosis elastic force detector and cure in clinic
Application in.
Summary of the invention
It is an object of the invention to provide the thrombosis elastometer that a kind of certainty of measurement is high.
For solving the problems referred to above, the invention provides a kind of thrombosis elastometer, some horizontal alignment arrange
Thrombosis elastometer split forms, it is characterised in that described thrombosis elastometer split includes:
-workbench, including being disposed thereon surface, for accommodating the container of blood, and drives described container
The power set rotated, are provided with heater and can control described heater by described appearance in described container
Blood heat in device is to the controller of design temperature；
-frame, is fixed on described workbench；
-test bar, is positioned at the surface of described container, and can be at least partially inserted into the blood of described container
In, described test bar is rotatably connected in described frame, the side of described test bar is additionally provided with vertical anti-
Bright finish；
-tester, it is fixing with described frame is connected, described tester be provided with accommodate described test bar pass,
And the first through hole being vertically arranged, and it is horizontally disposed with and second through hole through with described first through hole, institute
Stating reflective surface to be positioned in described first through hole, described second through hole, at least provided with two, is respectively arranged with in it
Light emitting devices and optical pickup apparatus, described light emitting devices can put into line light on described reflective surface,
Described optical pickup apparatus is able to receive that the line light that described reflective surface reflects；
-processor, it is possible to the amount of the line light received by described optical pickup apparatus is converted into the ginseng of reflection blood clotting
Number information, described parameter information is directly proportional to the amount of the light that described optical pickup apparatus receives.
As a further improvement on the present invention, described frame includes fixing first be connected with described tester
Frame and fix the second support being connected with described test bar, described first support includes being fixed on described test
On instrument and two root posts that are vertically arranged, and connect two described columns and horizontally disposed first crossbeam,
Described second support includes accommodating the opening that described first crossbeam passes, and is positioned at described first crossbeam and just goes up
Square and horizontally disposed second cross beam, the centre position of described second cross beam lower surface is provided with downwardly projecting top
Cone, the upper surface of described first crossbeam is provided with jewel bearing, described jewel bearing be positioned at described addendum cone just under
Side, described addendum cone is point cantact with the shrinkage pool of described jewel bearing.
As a further improvement on the present invention, the upper surface of described first crossbeam and the following table of described second cross beam
Face is provided with Magnet the most relatively, and the magnetic pole in the face that described Magnet is relative is identical.
As a further improvement on the present invention, described reflective surface is provided with two, and is parallel to each other, and described second
Through hole is provided with four, is respectively used to accommodate described light launcher or described light receiver device, institute
State light launcher and described light receiver device is respectively arranged with two.
As a further improvement on the present invention, hollow light-guiding pillar, described light it are equipped with in described second through hole
Discharger or described optical pickup apparatus are positioned at described light-guiding pillar, and described light emitting devices is light-emitting diodes
Pipe.
As a further improvement on the present invention, described optical pickup apparatus connects has photoelectric source, described photoelectric source to depend on
Secondary magnification circuit plate and the a/d converter of being electrically connected with, described a/d converter is connected with described processor.
As a further improvement on the present invention, one end that described light-guiding pillar is close with described first through hole is provided with energy
Enough light barriers that light-guiding pillar is cut off with described reflective surface, described light barrier is provided with light hole, described in be in the light
Sheet can be limited light and be only capable of being passed by described light hole.
As a further improvement on the present invention, also include the outer circumference surface static connection of inner ring and described test bar,
Outer ring and the hairspring spring of column static connection.
The beneficial effects of the present invention is, in the present invention, power set drive container to rotate, because in container
Blood tool be a bit sticky, test bar therefore will be driven to rotate, on test bar setting reflective surface also
Rotating with, and the position of optical pickup apparatus and light reflecting device is constant, therefore light is penetrated at reflective surface
On amount light can change, the amount light that the light that reflective surface reflects can be received also can produce
Change.The elastic force of evaluating blood is carried out, relative to traditional sensor by the amount of the final light received change
For, degree of accuracy is high.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention；
Fig. 2 is the structural representation of thrombosis elastometer split in Fig. 1；
Fig. 3 is the phantom of Fig. 2；
Fig. 4 is the partial enlarged drawing of A in Fig. 2；
Wherein: 2-thrombosis elastometer split；3-container；4-workbench；5-frame；6-test bar；7-is reflective
Face；8-tester；10-the first through hole；12-the second through hole；14-light emitting devices；16-optical pickup apparatus；
18-the first support；20-the second support；22-column；24-first crossbeam；26-second cross beam；28-addendum cone；
30-jewel bearing；32-light-guiding pillar；34-light barrier；36-hairspring spring
Detailed description of the invention
Below the detailed description of the invention of the present invention is described in further detail.
As it is shown in figure 1, the thrombosis elastometer split 2 that the present invention is arranged by some horizontal alignment forms, it is special
Levying and be, described thrombosis elastometer split 2 includes:
-workbench 4, including being disposed thereon surface, for accommodating the container 3 of blood, and drives described
The power set that container 3 rotates, are provided with heater and can control described heater in described container 3
Controller by the blood heat in described container 3 to design temperature；
-frame 5, is fixed on described workbench 4；
-test bar 6, is positioned at the surface of described container 3, and can be at least partially inserted into described container 3
Blood in, described test bar 6 is rotatably connected in described frame 5, on the side of described test bar 6 also
It is provided with vertical reflective surface 7；
-tester 8, it is fixing with described frame 5 is connected, and described tester 8 is provided with and accommodates described test
The first through hole 10 that rod 6 passes and is vertically arranged, and be horizontally disposed with and through with described first through hole 10
The second through hole 12, described reflective surface 7 is positioned in described first through hole 10, and described second through hole 12 is at least
It is provided with two, in it, is respectively arranged with light emitting devices 14 and optical pickup apparatus 16, described light emitting devices
14 can put into line light on described reflective surface 7, and described optical pickup apparatus 16 is able to receive that described reflective
The line light that face 7 reflects；
-processor, it is possible to the amount of the line light received by described optical pickup apparatus 16 is converted into reflection blood clotting
Parameter information, described parameter information is directly proportional to the amount of the light that described optical pickup apparatus 16 receives.
Power set drive container 3 to rotate, because the blood tool in container 3 is a bit sticky, therefore will
Test bar 6 can be driven to rotate, and the reflective surface 7 that test bar 6 is arranged also rotates with, and optical pickup apparatus
16 and the position of light reflecting device be constant, therefore light is penetrated the amount light on reflective surface 7 and can be changed,
The amount light that the light that reflective surface 7 reflects can be received also can produce change.Received by final
The amount of light change carry out the elastic force of evaluating blood, for traditional sensor, degree of accuracy is high.
As a further improvement on the present invention, described frame 5 include fixing with described tester 8 be connected the
One support 18 and second support 20 that be connected fixing with described test bar 6, described first support 18 includes
Two root posts 22 being fixed on described tester 8 and being vertically arranged, and connect two described columns 22 and
Horizontally disposed first crossbeam 24, described second support 20 includes accommodating that described first crossbeam 24 passes opens
Mouthful, and it is positioned at directly over described first crossbeam 24 and horizontally disposed second cross beam 26, described second cross beam
The centre position of 26 lower surfaces is provided with downwardly projecting addendum cone 28, and the upper surface of described first crossbeam 24 is provided with
Jewel bearing 30, described jewel bearing 30 is positioned at the underface of described addendum cone 28, and described addendum cone 28 is with described
The shrinkage pool of jewel bearing 30 is point cantact.
Second cross beam 26 lower surface is provided with addendum cone 28, and first crossbeam 24 upper surface being fixedly installed is provided with gem
Bearing 30, addendum cone 28 is positioned in the shrinkage pool of jewel bearing 30, and between be point cantact, thus be substantially reduced
Frictional force between jewel bearing 30 and addendum cone 28, it is meant that the resistance rotating test bar 6 is the most significantly
Degree reduces.
As a further improvement on the present invention, the upper surface of described first crossbeam 24 and described second cross beam 26
Lower surface be the most relatively provided with Magnet, the magnetic pole in the face that described Magnet is relative is identical.
It is provided with the Magnet that magnetic is identical, many institutes with the lower surface of second cross beam 26 on first crossbeam 24
The known Magnet same sex is mutually exclusive, and first crossbeam 24 is fixedly installed, the Magnet on first crossbeam 24
To one repulsive force upwards of the Magnet on second cross beam 26, this power acts on second cross beam 26, it is possible to
Offset a part with the gravity of second cross beam 26 and test bar 6, and then reduce jewel bearing 30 and top
Point frictional force between cone 28, reduce further the resistance rotating test bar 6.
As a further improvement on the present invention, described reflective surface 7 is provided with two, and is parallel to each other, and described
Two through holes 12 are provided with four, are respectively used to accommodate described light launcher or described light receiver device,
Described light launcher and described light receiver device are respectively arranged with two.
Constitute two groups of light line loops, it is ensured that the amount light that optical pickup apparatus 16 receives.
As a further improvement on the present invention, it is equipped with hollow light-guiding pillar 32, institute in described second through hole 12
Stating light emitting devices 14 or described optical pickup apparatus 16 is positioned at described light-guiding pillar 32, described light emission fills
Put 14 for light emitting diode.
Light-guiding pillar 32 is set, improves the light intensity at center, have the effect of optically focused.
As a further improvement on the present invention, described optical pickup apparatus 16 connects photoelectric source, described photoelectric source
Being sequentially connected electrically magnification circuit plate and a/d converter, described a/d converter is connected with described processor.
Use photoelectric source as optical pickup apparatus 16, simple and efficiency is high.
As a further improvement on the present invention, one end that described light-guiding pillar 32 is close with described first through hole 10
Being provided with the light barrier 34 that can be cut off by light-guiding pillar 32 with described reflective surface 7, described light barrier 34 is provided with
Light hole, described light barrier 34 can be limited light and be only capable of being passed by described light hole.
Light barrier 34 and light hole are set, for optically focused.
As a further improvement on the present invention, also include the outer circumference surface static connection of inner ring and described test bar 6,
Outer ring and the hairspring spring 36 of column 22 static connection.
Hairspring spring 36 is set, test bar 6 is played the effect of deceleration buffer, it is ensured that measure stablizing of numerical value
Property, additionally after blood stops the rotation, the power on test bar 6 that acts on disappears, and hairspring spring 36 discharges
Deformation force restores to the original state and makes test bar 6 return to the initial position fixed
Above example is only the present invention a kind of embodiment therein, and it describes more concrete and detailed, but
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that, for this area
For those of ordinary skill, without departing from the inventive concept of the premise, it is also possible to make some deformation and change
Entering, these broadly fall into protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be with appended power
Profit requires to be as the criterion.
Claims (8)
1. thrombosis elastometer, some horizontal alignment thrombosis elastometer split (2) arranged forms, and it is special
Levying and be, described thrombosis elastometer split (2) including:
-workbench (4), including being disposed thereon surface, for accommodating the container (3) of blood, and drives
The power set that dynamic described container (3) rotates, are provided with heater and can control in described container (3)
Make the described heater controller by the blood heat in described container (3) to design temperature；
-frame (5), is fixed on described workbench (4)；
-test bar (6), is positioned at the surface of described container (3), and can be at least partially inserted into described
In the blood of container (3), described test bar (6) is rotatably connected in described frame (5), described test
It is additionally provided with vertical reflective surface (7) on the side of rod (6)；
-tester (8), it is fixing with described frame (5) is connected, and described tester (8) is provided with appearance
The first through hole (10) that described test bar (6) of receiving passes and is vertically arranged, and be horizontally disposed with and with institute
Stating the second through hole (12) that the first through hole (10) is through, described reflective surface (7) is positioned at described first through hole
(10), in, described second through hole (12), at least provided with two, is respectively arranged with light emitting devices (14) in it
And optical pickup apparatus (16), described light emitting devices (14) can be to the upper input of described reflective surface (7)
Line light, described optical pickup apparatus (16) is able to receive that the line light that described reflective surface (7) reflects；
-processor, it is possible to the amount of the line light received by described optical pickup apparatus (16) is converted into reflection blood
Solidifying parameter information, described parameter information is directly proportional to the amount of the light that described optical pickup apparatus (16) receives.
Thrombosis elastometer the most according to claim 1, it is characterised in that described frame (5) includes
Fix the first support (18) being connected with described tester (8) and fix even with described test bar (6)
The second support (20) connect, it is upper and perpendicular that described first support (18) includes being fixed on described tester (8)
Straight two root posts (22) arranged, and connect two described columns (22) and horizontally disposed first horizontal stroke
Beam (24), described second support (20) includes accommodating the opening that described first crossbeam (24) passes, with
And it is positioned at directly over described first crossbeam (24) and horizontally disposed second cross beam (26), described second is horizontal
The centre position of beam (26) lower surface is provided with downwardly projecting addendum cone (28), described first crossbeam (24)
Upper surface be provided with jewel bearing (30), described jewel bearing (30) is just being positioned at described addendum cone (28)
Lower section, described addendum cone (28) is point cantact with the shrinkage pool of described jewel bearing (30).
Thrombosis elastometer the most according to claim 2, it is characterised in that described first crossbeam (24)
Upper surface be provided with Magnet the most relative with the lower surface of described second cross beam (26), the face that described Magnet is relative
Magnetic pole identical.
Thrombosis elastometer the most according to claim 3, it is characterised in that described reflective surface (7) sets
Having two, and be parallel to each other, described second through hole (12) is provided with four, is respectively used to accommodate described light
Line discharger (14) or described light receiver device (16), described light launcher (14) and
Described light receiver device (16) is respectively arranged with two.
Thrombosis elastometer the most according to claim 4, it is characterised in that described second through hole (12)
Inside it is equipped with hollow light-guiding pillar (32), described light emitting devices (14) or described optical pickup apparatus (16)
Being positioned at described light-guiding pillar (32), described light emitting devices (14) is light emitting diode.
Thrombosis elastometer the most according to claim 5, it is characterised in that described optical pickup apparatus (16)
Connecting has photoelectric source, described photoelectric source to be sequentially connected electrically magnification circuit plate and a/d converter, and described AD turns
Parallel operation is connected with described processor.
Thrombosis elastometer the most according to claim 6, it is characterised in that described light-guiding pillar (32) with
The close one end of described first through hole (10) be provided with can by light-guiding pillar (20) and described reflective surface (7) every
Disconnected light barrier (34), described light barrier (34) is provided with light hole, and described light barrier (34) can
Limit light to be only capable of being passed by described light hole.
Thrombosis elastometer the most according to claim 7, it is characterised in that also include inner ring and described survey
The hairspring spring (36) of the outer circumference surface static connection of coupon (6), outer ring and column (22) static connection.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610347496.9A CN105911261A (en) | 2016-05-24 | 2016-05-24 | Thrombus elastometer |
| PCT/CN2017/082777 WO2017186187A1 (en) | 2016-04-29 | 2017-05-02 | Thrombelastography device, heating apparatus, blood coagulation analysis system, and rotational angle measurement method |
| US16/096,956 US11366094B2 (en) | 2016-04-29 | 2017-05-02 | Thrombelastography device, heating apparatus, blood coagulation analysis system and rotational angle measurement method |
| PCT/CN2017/082755 WO2017186184A1 (en) | 2016-04-29 | 2017-05-02 | Apparatus for measuring blood coagulation data |
| US17/748,679 US11927587B2 (en) | 2016-04-29 | 2022-05-19 | Thrombelastography device, heating apparatus, blood coagulation analysis system and rotational angle measurement method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610347496.9A CN105911261A (en) | 2016-05-24 | 2016-05-24 | Thrombus elastometer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105911261A true CN105911261A (en) | 2016-08-31 |
Family
ID=56741415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610347496.9A Pending CN105911261A (en) | 2016-04-29 | 2016-05-24 | Thrombus elastometer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105911261A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017186184A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data |
| WO2017186187A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Thrombelastography device, heating apparatus, blood coagulation analysis system, and rotational angle measurement method |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980830A (en) * | 1996-05-20 | 1999-11-09 | Sendx Medical, Inc. | Portable modular blood analyzer with simplified fluid handling sequence |
| CN103398922A (en) * | 2013-07-09 | 2013-11-20 | 广东石油化工学院 | Measurement device and method for thrombus elasticity |
| CN204065105U (en) * | 2014-08-22 | 2014-12-31 | 中国科学院苏州生物医学工程技术研究所 | A kind of thrombus elasticity testing device |
| CN205038216U (en) * | 2015-10-10 | 2016-02-17 | 嘉兴凯实生物科技有限公司 | Thrombelastogram instrument |
| CN205786644U (en) * | 2016-05-24 | 2016-12-07 | 苏州品诺维新医疗科技有限公司 | A kind of thrombosis elastometer |
-
2016
- 2016-05-24 CN CN201610347496.9A patent/CN105911261A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5980830A (en) * | 1996-05-20 | 1999-11-09 | Sendx Medical, Inc. | Portable modular blood analyzer with simplified fluid handling sequence |
| CN103398922A (en) * | 2013-07-09 | 2013-11-20 | 广东石油化工学院 | Measurement device and method for thrombus elasticity |
| CN204065105U (en) * | 2014-08-22 | 2014-12-31 | 中国科学院苏州生物医学工程技术研究所 | A kind of thrombus elasticity testing device |
| CN205038216U (en) * | 2015-10-10 | 2016-02-17 | 嘉兴凯实生物科技有限公司 | Thrombelastogram instrument |
| CN205786644U (en) * | 2016-05-24 | 2016-12-07 | 苏州品诺维新医疗科技有限公司 | A kind of thrombosis elastometer |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017186184A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Apparatus for measuring blood coagulation data |
| WO2017186187A1 (en) * | 2016-04-29 | 2017-11-02 | 诺泰科生物科技（苏州）有限公司 | Thrombelastography device, heating apparatus, blood coagulation analysis system, and rotational angle measurement method |
| US11366094B2 (en) | 2016-04-29 | 2022-06-21 | Haemonetics Corporation | Thrombelastography device, heating apparatus, blood coagulation analysis system and rotational angle measurement method |
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Effective date of registration: 20161219 Address after: Xinghu street Suzhou Industrial Park in Jiangsu province 215000 No. 218 BioBAY A2-423 unit Applicant after: Noteko biological technology (Suzhou) Co., Ltd. Address before: 215000 Suzhou high tech Zone, Jinfeng Road, No. 8, Jiangsu Applicant before: Suzhou Pinnuo New Medical Technology Co., Ltd. |
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