CN105894445B - A kind of coronary artery image processing method and device - Google Patents
A kind of coronary artery image processing method and device Download PDFInfo
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- CN105894445B CN105894445B CN201610201387.6A CN201610201387A CN105894445B CN 105894445 B CN105894445 B CN 105894445B CN 201610201387 A CN201610201387 A CN 201610201387A CN 105894445 B CN105894445 B CN 105894445B
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- 210000004351 coronary vessel Anatomy 0.000 title claims abstract description 435
- 238000003672 processing method Methods 0.000 title claims abstract description 14
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- 238000002156 mixing Methods 0.000 claims abstract description 30
- 230000002708 enhancing effect Effects 0.000 claims description 47
- 238000012545 processing Methods 0.000 claims description 19
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- 238000002583 angiography Methods 0.000 claims description 12
- 210000004204 blood vessel Anatomy 0.000 claims description 12
- 238000005516 engineering process Methods 0.000 claims description 10
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- 238000002591 computed tomography Methods 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 210000001367 artery Anatomy 0.000 claims description 3
- 210000003462 vein Anatomy 0.000 claims description 2
- 230000003902 lesion Effects 0.000 abstract description 5
- 210000000709 aorta Anatomy 0.000 description 14
- 230000001225 therapeutic effect Effects 0.000 description 14
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- 208000031481 Pathologic Constriction Diseases 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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Abstract
The present invention provides a kind of coronary artery image processing method and devices, which comprises obtains the coronary artery CTA image and coronary artery DSA image sequence of patient；Three-dimensional reconstruction is carried out to obtained coronary artery CTA image, obtains three-dimensional coronary artery image, and from obtained three-dimensional coronary artery image, obtains the simulation contrastographic picture of coronary artery blood vessel CTA picture centre line and coronary artery blood vessel；From the coronary artery DSA image sequence got, the coronary artery DSA image and coronary artery blood vessel DSA picture centre line most like with simulation contrastographic picture are determined；By being registrated to coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line, the coronary artery blending image of simulation contrastographic picture and coronary artery DSA image is obtained.Doctor can be made to carry out diagnoses and treatment according to Coronary Artery Lesions of the clearly coronary artery image to patient through the invention.
Description
Technical field
The present invention relates to technical field of image processing, in particular to a kind of coronary artery image processing method and device.
Background technique
Currently, medical image refers in order to which medical treatment or medical research take human body or human body part with non-intruding mode
The inside of human body tissue image obtained.Existing medical image mainly includes computer tomography angiography (Computed
Tomographic Angiography, CTA) and Technology of Digital Subtraction Angiography (Digital Subtraction
Angiography, DSA) etc..When doctor is in the process of coronary artery (abbreviation coronary artery) the illness progress diagnoses and treatment to patient
In, the coronary angiography image of patient can be first obtained, and the coronary angiography image by obtaining carries out come the coronary condition to patient
Diagnoses and treatment.
The angiographic procedure of existing coronary angiography image is first to inject the iodine contrast medium as contrast agent using DSA and be preced with
Arteries and veins opening, the direction flowed through by iodine contrast medium and full coronary artery blood vessel, then by the coronary blood of x-ray assisted acquisition patient
The contrastographic picture of the coronary artery blood vessel filled in pipe by iodine contrast medium.
But doctor is during carrying out diagnoses and treatment to coronary condition by the coronary angiography image of patient, due to
To contrastographic picture in do not show the radiography of coronary artery blood vessel that iodine contrast medium is not flowed through and filled, so doctor cannot be right
The lesion that non-radiography vasculature part occurs in coronary artery blood vessel carries out diagnoses and treatment, so that doctor can not be in the whole for grasping patient
The therapeutic scheme to patient is obtained in the case where coronary artery information, the therapeutic scheme that may cause to the therapeutic effect of patient not
The defect of length of good and treatment time.
Summary of the invention
In view of this, the embodiment of the present invention is designed to provide a kind of coronary artery image processing method and device, so that doctor
Life can carry out diagnoses and treatment according to Coronary Artery Lesions of the clearly coronary artery image to patient, increase treatment of the therapeutic scheme to patient
Effect.
In a first aspect, the embodiment of the invention provides a kind of coronary artery image processing methods, comprising:
Obtain the coronary artery computer tomography angiography CTA image and coronary artery digital subtraction angiography skill of patient
Art DSA image sequence；
Three-dimensional reconstruction is carried out to the obtained coronary artery blood vessel CTA image, obtains three-dimensional coronary artery image, and from obtained institute
It states in three-dimensional coronary artery image, obtains the simulation contrastographic picture of coronary artery blood vessel CTA picture centre line and coronary artery blood vessel；
From the coronary artery blood vessel DSA image sequence got, determine most like with the simulation contrastographic picture
Coronary artery DSA image and coronary artery blood vessel DSA picture centre line；
By being registrated to the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line, obtain
To the coronary artery blending image of the simulation contrastographic picture and the coronary artery blood vessel DSA image.
With reference to first aspect, the embodiment of the invention provides the first possible embodiments of first aspect, wherein from
In the obtained three-dimensional coronary artery image, the simulation contrastographic picture of the coronary artery blood vessel is obtained, comprising:
By preset projection leading role degree and secondary angle is projected, the three-dimensional coronary artery image is projected, is obtained
Multiple coronary artery projected images, wherein projection leading role's degree is projection light source in the coronary artery blood vessel CTA picture centre line direction
The angle of upper rotation, the secondary angle of the projection is projection light source on perpendicular to the coronary artery blood vessel CTA picture centre line direction
The angle of rotation；
By obtained multiple coronary artery projected images shows to doctor；
The image that the doctor selects from multiple coronary artery projected images is made as the simulation of the coronary artery blood vessel
Shadow image.
With reference to first aspect, the embodiment of the invention provides second of possible embodiments of first aspect, wherein from
In the coronary artery blood vessel DSA image sequence got, the coronary artery blood vessel DSA most like with the simulation contrastographic picture is determined
Image and coronary artery blood vessel DSA picture centre line, comprising:
From the coronary artery blood vessel DSA image sequence got, determine most like with the simulation contrastographic picture
Coronary artery DSA image；
The determining coronary artery blood vessel DSA image is enhanced, coronary artery DSA enhancing image is obtained；
Coronary artery blood vessel DSA picture centre line is determined from obtained coronary artery DSA enhancing image.
With reference to first aspect, the embodiment of the invention provides the third possible embodiments of first aspect, wherein right
The determining coronary artery blood vessel DSA image is enhanced, and coronary artery DSA enhancing image is obtained, comprising:
Under preset multiple vessel radius, the coronary artery blood vessel DSA image is obtained the multiple by following formula
The corresponding image enhancement parameter of each vessel radius in vessel radius:
Wherein, λ is the maximum value of the characteristic value of HESSIAN matrix at image s, and RB and S are preset constant, controls image
Enhancing dynamics, β and c are weighted factor, and V (s) indicates image enhancement parameter；
From each of obtaining selecting maximum image enhancement parameter pair in the corresponding image enhancement parameter of the vessel radius
The coronary artery blood vessel DSA image is enhanced, and coronary artery DSA enhancing image is obtained.
With reference to first aspect, the embodiment of the invention provides the 4th kind of possible embodiments of first aspect, wherein logical
It crosses and the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line is registrated, obtain the simulation
The coronary artery blending image of contrastographic picture and the coronary artery blood vessel DSA image, comprising:
The coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line are shown Xiang doctor；
Doctor is obtained to identify on the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line
Registration point out；
According to the registration point that the doctor identification goes out, to the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel
CTA picture centre line is registrated, and the coronary artery fusion figure of the simulation contrastographic picture and coronary artery DSA enhancing image is obtained
Picture.
Second aspect, the embodiment of the invention provides a kind of coronary artery image processing apparatus, comprising:
Image collection module, for obtaining the coronary artery computer tomography angiography CTA image and coronary artery of patient
Technology of Digital Subtraction Angiography DSA image sequence；
First image processing module obtains three-dimensional for carrying out three-dimensional reconstruction to the obtained coronary artery blood vessel CTA image
Coronary artery image, and from the obtained three-dimensional coronary artery image, obtain the mould of coronary artery blood vessel CTA picture centre line and coronary artery blood vessel
Quasi- contrastographic picture；
Second image processing module, for from the coronary artery blood vessel DSA image sequence got, determine with it is described
Simulate contrastographic picture most like coronary artery blood vessel DSA image and coronary artery blood vessel DSA picture centre line；
Image co-registration module, for by the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA image
Center line is registrated, and the coronary artery blending image of the simulation contrastographic picture and the coronary artery blood vessel DSA image is obtained.
In conjunction with second aspect, the embodiment of the invention provides the first possible embodiments of second aspect, wherein institute
State the first image processing module, comprising:
Projecting cell is used for through preset projection leading role degree and projects secondary angle, to the three-dimensional coronary artery image
It is projected, obtains multiple coronary artery projected images, wherein projection leading role's degree is projection light source in the coronary artery blood vessel CTA
The angle rotated on picture centre line direction, the secondary angle of the projection are that projection light source is schemed perpendicular to the coronary artery blood vessel CTA
The angle rotated on inconocenter line direction；
Display unit, for by obtained multiple coronary artery projected images shows to doctor；
Determination unit, the image for selecting the doctor from multiple coronary artery projected images is as the coronary artery
The simulation contrastographic picture of blood vessel.
In conjunction with second aspect, the embodiment of the invention provides second of possible embodiments of second aspect, wherein institute
State the second image processing module, comprising:
Similar image determination unit, for from the coronary artery blood vessel DSA image sequence got, determine with it is described
Simulate the most like coronary artery blood vessel DSA image of contrastographic picture；
Image enhancing unit obtains coronary artery DSA enhancing for enhancing the determining coronary artery blood vessel DSA image
Image；
Extraction unit, for determining coronary artery blood vessel DSA picture centre from obtained coronary artery DSA enhancing image
Line.
In conjunction with second aspect, the embodiment of the invention provides the third possible embodiments of second aspect, wherein institute
State image enhancing unit, comprising:
Computation subunit, for obtaining the coronary artery blood vessel DSA by following formula under preset multiple vessel radius
The corresponding image enhancement parameter of each vessel radius of the image in the multiple vessel radius:
Wherein, λ is the maximum value of the characteristic value of HESSIAN matrix at image s, and RB and S are preset constant, controls image
Enhancing dynamics, β and c are weighted factor, and V (s) indicates image enhancement parameter；
Enhanson, for maximum from each of obtaining selecting in the corresponding image enhancement parameter of the vessel radius
Image enhancement parameter enhances the coronary artery blood vessel DSA image, obtains coronary artery DSA enhancing image.
In conjunction with second aspect, the embodiment of the invention provides the 4th kind of possible embodiments of second aspect, wherein institute
State image co-registration module, comprising:
Center line display unit shows the coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA figure Xiang doctor
Inconocenter line；
Registration point acquiring unit, for obtaining doctor in the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel
The registration point identified on CTA picture centre line；
Integrated unit, the registration point for being gone out according to the doctor identification, to the coronary artery blood vessel DSA picture centre line and
The coronary artery blood vessel CTA picture centre line is registrated, and obtaining the simulation contrastographic picture and the coronary artery DSA enhances image
Coronary artery blending image.
Coronary artery image processing method and device provided in an embodiment of the present invention, by will be from the coronary artery CTA after three-dimensional reconstruction
The coronary artery blood vessel CTA picture centre line and coronary blood got respectively in image and coronary artery blood vessel DSA image sequence
Pipe DSA picture centre line is registrated, to the simulation contrastographic picture as obtained in coronary artery blood vessel CTA image and by coronary artery blood vessel
Coronary artery blood vessel DSA image obtained in DSA image sequence carries out image co-registration, obtains simulation contrastographic picture and coronary artery blood vessel DSA
The coronary artery blending image of image carries out medical diagnosis phase to doctor with being had in the prior art to coronary angiography image be returned to
Than that the coronary artery blending image returned Xiang doctor can be made not influenced by contrast agent, by patient's clearly coronary artery blending image exhibition
Show to doctor, doctor is allowed to obtain the therapeutic scheme to patient in the case where grasping whole coronary artery information of patient；From
And the therapeutic scheme made has the characteristics that specific aim is stronger, therapeutic effect is more preferable and treatment time is short.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate
Appended attached drawing, is described in detail below.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 shows a kind of flow chart of coronary artery image processing method provided by the embodiment of the present invention 1；
Fig. 2 shows a kind of structural schematic diagrams of coronary artery image processing apparatus provided by the embodiment of the present invention 2.
Specific embodiment
Below in conjunction with attached drawing in the embodiment of the present invention, technical solution in the embodiment of the present invention carries out clear, complete
Ground description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Usually exist
The component of the embodiment of the present invention described and illustrated in attached drawing can be arranged and be designed with a variety of different configurations herein.Cause
This, is not intended to limit claimed invention to the detailed description of the embodiment of the present invention provided in the accompanying drawings below
Range, but it is merely representative of selected embodiment of the invention.Based on the embodiment of the present invention, those skilled in the art are not doing
Every other embodiment obtained under the premise of creative work out, shall fall within the protection scope of the present invention.
In view of in the related technology, doctor carries out diagnoses and treatment to coronary condition in the coronary angiography image by patient
In the process, due to not showing the radiography of coronary artery blood vessel that iodine contrast medium is not flowed through and filled, institute in obtained contrastographic picture
Diagnoses and treatment cannot be carried out to the lesion that radiography vasculature part non-in coronary artery blood vessel occurs with doctor, so that doctor can not be
The therapeutic scheme to patient is obtained in the case where the whole coronary artery information for grasping patient, the therapeutic scheme that may cause is to disease
The defect that the therapeutic effect of people is bad and treatment time is long.Based on this, the embodiment of the invention provides a kind of coronary artery image procossings
Method and apparatus are described below by embodiment.
Embodiment 1
Present embodiments provide a kind of coronary artery image processing method, the executing subject of the embodiment of the present invention be include service
The Medical Imaging System of device, CTA machine and DSA machine, wherein server carries out data interaction, doctor with CTA machine and DSA machine respectively
It first passes through server and issues instruction to CTA machine and DSA machine, respectively obtain the coronary artery blood vessel CTA image and coronary artery blood vessel DSA of patient
Image sequence, then server can obtain respectively the coronary artery blood vessel CTA image and coronary artery blood vessel of patient from CTA machine and DSA machine
DSA image sequence, and handled, obtain coronary artery blending image.
Wherein, the computing terminal of existing any model can be used in server, no longer repeats one by one here.
The coronary artery image processing method proposed referring to Fig. 1, the present embodiment, comprising the following steps:
Step 100, the coronary artery blood vessel CTA image and coronary artery blood vessel DSA image sequence for obtaining patient.
Wherein, coronary artery blood vessel CTA image and coronary artery blood vessel DSA image sequence are that patient obtains in CTA machine and DSA machine respectively
The medical image arrived.
Coronary artery blood vessel DSA image sequence, including multiple coronary artery blood vessel DSA images.
Step 102 carries out three-dimensional reconstruction to obtained coronary artery blood vessel CTA image, obtains three-dimensional coronary artery image, and from obtaining
Three-dimensional coronary artery image in, obtain coronary artery blood vessel CTA picture centre line and coronary artery blood vessel simulation contrastographic picture.
Wherein, server passes through existing any three-dimensional reconstruction algorithm to obtained coronary artery blood vessel CTA image, to CT coronary artery
Contrastographic picture carries out three-dimensional reconstruction, no longer repeats one by one here.
Doctor can be clearly seen that the tendency and state of every coronary artery blood vessel by three-dimensional reconstruction image, to help to cure
Life the state of an illness of patient's entirety is more clearly understood, doctor also can more clearly the stenosis to lesion coronary artery blood vessel and
Narrow location is judged.
Specifically, from obtained three-dimensional coronary artery image, extract coronary artery blood vessel CTA picture centre line, specifically include with
Lower step (1) is to step (3):
(1) Hough loop truss algorithm is utilized, the center of aorta ascendens image is determined from coronary artery blood vessel CTA image；
(2) according to the center of determining aorta ascendens image, coronary artery vessel graph is extracted from coronary artery blood vessel CTA image
Picture；
(3) from the coronary artery blood-vessel image extracted, coronary artery blood vessel CTA picture centre line is determined.
In step 1, initial from patient's sequence image using Hough loop truss algorithm using the cylindric characteristic of aorta ascendens
Layer successively carries out circle detection to whole image, when wherein some center of circle is in continuous several layers of upper position variation range very littles
It waits, server can determine that the center of circle is the center of aorta ascendens.
Step 2 specifically includes following steps (21) to step (23):
(21) according to the center of aorta ascendens image, aorta ascendens image is extracted using region growing algorithm；
(22) the coronary artery blood-vessel image in three-dimensional coronary artery image is enhanced using dilation erosion algorithm；
(23) aorta ascendens image is utilized, region growth is carried out to enhanced coronary artery blood-vessel image, extracts coronary blood
Pipe image.
In step (23), using all in the aorta ascendens outmost surface extracted in enhanced image
Point is used as seed point, does region growth in enhancing image, wherein increasing length longest and different two blood vessels are coronary artery
Blood vessel or so two.The extracting method of aorta ascendens outmost surface is to carry out corrosion behaviour to aorta ascendens using Morphology Algorithm
Make, then subtracting the aorta ascendens image after corrosion using former aorta ascendens image, you can get it.
It possibly can not be automatically extracted out for the serious blood vessel of vascular occlusion because occlusion part blood vessel development is unobvious,
It needs exist for doctor and carries out manual extraction for occlusion serious vascular.It is locally similar that manual extraction process can use blood vessel CT value
Property, blood vessel is extracted in a small range to guarantee the continuity of blood vessel with multiple seed points.
Step 3 specifically includes following steps (31) to step (33):
(31) binarization operation is carried out to coronary artery blood-vessel image, obtains the bianry image of coronary artery blood vessel；
(32) three-dimensional Refinement operation is carried out to the bianry image of coronary artery blood vessel, extracts the rough center line of blood vessel；
(33) connected domain detection is carried out to the rough center line of coronary artery blood vessel, determines the endpoint of coronary artery blood vessel；
(34) calculate aorta ascendens image center to coronary artery blood vessel endpoint shortest path, with obtained shortest path
As coronary artery blood vessel CTA picture centre line.
In step 33, connected domain testing result indicates the number of every bit consecutive points in the three dimensional neighborhood of 1 pixel.
When result is 1, which is the endpoint of coronary artery blood vessel.Statistics connected domain detects all results and is 1 and belongs to coronary blood
Point on pipe is the endpoint of every coronary artery vessel branch.
In step 34, it is converted according to Euclidean distance and range conversion is carried out to the bianry image of the coronary artery blood vessel extracted,
Calculated separately in distance field aorta ascendens geometry midpoint to coronary artery blood vessel distal point shortest path.Each distal point and liter are led
The shortest path that the geometric center of artery is constituted is denoted as center line corresponding to this blood vessel.
Step 104, from the coronary artery blood vessel DSA image sequence got, determine with simulation contrastographic picture it is most like
Coronary artery DSA image and coronary artery blood vessel DSA picture centre line.
Step 106, by being registrated to coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line, obtain
To the coronary artery blending image of simulation contrastographic picture and coronary artery blood vessel DSA image.
In conclusion coronary artery image processing method provided in this embodiment, by will scheme from the coronary artery CTA after three-dimensional reconstruction
In the coronary artery blood vessel CTA picture centre line and coronary artery blood vessel DSA image got respectively in picture and coronary artery blood vessel DSA image sequence
Heart line is registrated, to the simulation contrastographic picture as obtained in coronary artery blood vessel CTA image and by coronary artery blood vessel DSA image sequence
Obtained coronary artery blood vessel DSA image carries out image co-registration, obtains the coronary artery fusion of simulation contrastographic picture and coronary artery blood vessel DSA image
Image can make compared with being had in the prior art to coronary angiography image be returned to and carrying out medical diagnosis to doctor Xiang doctor
The coronary artery blending image of return is not influenced by contrast agent, and by patient, clearly coronary artery blending image shows doctor, so that doctor
Life can obtain the therapeutic scheme to patient in the case where grasping whole coronary artery information of patient；To the treatment made
Scheme has the characteristics that specific aim is stronger, therapeutic effect is more preferable and treatment time is short.
In the related technology, when carrying out image co-registration, two images to be fused can be selected to be merged, but if selection
The image similarity of two images to be fused is not high, then the clarity that will lead to fused image is not high；So in order to more
Good obtains simulated projections image, and in the above example, from obtained three-dimensional coronary artery image, the simulation for obtaining coronary artery blood vessel is made
Shadow image includes the following steps (1) to step (3):
(1) by preset projection leading role degree and the secondary angle of projection, three-dimensional coronary artery image is projected, is obtained more
A coronary artery projected image, wherein projection leading role's degree is the angle that projection light source rotates on coronary artery blood vessel CTA picture centre line direction
Degree, projecting secondary angle is the angle that projection light source rotates on perpendicular to coronary artery blood vessel CTA picture centre line direction；
(2) by obtained multiple coronary artery projected images shows to doctor；
(3) image for selecting doctor from multiple coronary artery projected images is as the simulation contrastographic picture of coronary artery blood vessel.
In step 1, projection leading role's degree spin matrix is as follows:
It is as follows to project secondary angle spin matrix:
Further, in order to guarantee the similarities of two images to be fused, in this example, from the coronary artery DSA got
In image sequence, the coronary artery blood vessel DSA image and coronary artery blood vessel DSA picture centre most like with simulation contrastographic picture are determined
Line includes the following steps (1) to step (3):
(1) from the coronary artery blood vessel DSA image sequence got, the coronary artery most like with simulation contrastographic picture is determined
DSA image；
(2) determining coronary artery blood vessel DSA image is enhanced, obtains coronary artery DSA enhancing image；
(3) coronary artery blood vessel DSA picture centre line is determined from obtained coronary artery DSA enhancing image.
Wherein, from the coronary artery blood vessel DSA image sequence got, the coronary artery most like with simulation contrastographic picture is determined
DSA image specifically comprises the following steps (11) to (12):
(11) each coronary artery blood vessel DSA image in coronary artery blood vessel DSA image sequence is calculated one by one and simulates contrastographic picture
Similarity；
(12) according to obtained similarity, determine the maximum coronary artery blood vessel DSA image of similarity as with simulation radiography figure
As most like coronary artery blood vessel DSA image.
In a step 11, by global detection algorithm, local detection algorithm or coronary artery blood vessel DSA image sequence can be calculated
The Hamming distance of each coronary artery blood vessel DSA image and simulation contrastographic picture in column, to determine in coronary artery blood vessel DSA image sequence
The similarity of each coronary artery DSA image and simulation contrastographic picture.
In step 2, in order to make fusion after image it is apparent, determining coronary artery blood vessel DSA image is enhanced,
Coronary artery DSA enhancing image is obtained, includes the following steps (21) to step (22):
(21) under preset multiple vessel radius, coronary artery blood vessel DSA image is obtained in multiple blood vessels by following formula
The corresponding image enhancement parameter of each vessel radius in radius:
Wherein, λ is the maximum value of the characteristic value of HESSIAN matrix at image s, and RB and S are preset constant, controls image
Enhancing dynamics, β and c are weighted factor, and V (s) indicates image enhancement parameter；
(22) maximum image enhancement parameter pair is selected from the obtained corresponding image enhancement parameter of each vessel radius
Coronary artery blood vessel DSA image is enhanced, and coronary artery DSA enhancing image is obtained.
In conclusion image enhancement parameter obtained by calculation enhances coronary artery blood vessel DSA image, coronary artery is obtained
DSA enhances image, obtained coronary artery DSA enhancing image and simulation contrastographic picture is then carried out image co-registration, to make to merge
Image afterwards is apparent.
Specifically, extracting coronary artery blood vessel DSA picture centre line from obtained coronary artery DSA enhancing image includes following step
Suddenly (31) to step (32):
(31) by gradient watershed algorithm, the coronary artery DSA extracted enhances the coronary artery blood vessel in image；
(32) by two-dimentional thinning algorithm, coronary artery blood vessel DSA picture centre line is determined from the coronary artery blood vessel extracted.
In conclusion by that will be projected to obtain multiple coronary artery projected images shows to three-dimensional coronary artery image to doctor,
And the image for selecting doctor from multiple coronary artery projected images is as the simulation contrastographic picture of coronary artery blood vessel, and from getting
In coronary artery blood vessel DSA image sequence, determine with the most like coronary artery blood vessel DSA image of simulation contrastographic picture, so as to
In subsequent image co-registration step, the high image to be fused of two similarities is subjected to image co-registration, ensure that fused figure
The clarity of picture.
In the related technology, server can only carry out image co-registration, the accuracy of image co-registration according to the rule of setting themselves
It is relatively low, it be easy to cause the blending image clarity obtained after fusion poor, so, in order to further increase fused fusion figure
The clarity of picture, in this example, by coronary artery blood vessel DSA picture centre line and the progress of coronary artery blood vessel CTA picture centre line
Registration obtains the coronary artery blending image of simulation contrastographic picture and coronary artery blood vessel DSA image, includes the following steps (1) to step
(3):
(1) coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line are shown Xiang doctor；
(2) what acquisition doctor identified on coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line matches
On schedule；
(3) registration point gone out according to doctor identification, in coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA image
Heart line is registrated, and the coronary artery blending image of simulation contrastographic picture and coronary artery DSA enhancing image is obtained.
In step 2, doctor can identify the first registration point on coronary artery blood vessel DSA picture centre line, in coronary artery blood vessel
The second registration point is identified on CTA picture centre line, then can establish the corresponding relationship of the first registration point and the second registration point, and
By identify registration point coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line and the first registration point and
The corresponding relationship of second registration point returns to server, so that server is according to the coronary artery blood vessel DSA image for identifying registration point
The corresponding relationship of center line and coronary artery blood vessel CTA picture centre line and the first registration point and the second registration point, to coronary artery blood vessel
DSA picture centre line and coronary artery blood vessel CTA picture centre line are registrated, and simulation contrastographic picture and coronary artery DSA enhancing figure are obtained
The coronary artery blending image of picture.
In conclusion being distinguished on coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line by doctor
The registration point identified is registrated coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line, obtains mould
The coronary artery blending image of quasi- contrastographic picture and coronary artery DSA enhancing image, available outstanding registration result, to guarantee to merge
The clarity of the coronary artery blending image obtained afterwards is higher, meets the needs of diagnosis treatment.
Embodiment 2
Referring to fig. 2, the present embodiment provides a kind of coronary artery image processing apparatus, for executing above-mentioned coronary artery image processing method
Method, the device specifically include:
Image collection module 200, for obtaining the coronary artery blood vessel CTA image and coronary artery blood vessel DSA image sequence of patient；
First image processing module 202 obtains three-dimensional for carrying out three-dimensional reconstruction to obtained coronary artery blood vessel CTA image
Coronary artery image, and from obtained three-dimensional coronary artery image, the simulation for obtaining coronary artery blood vessel CTA picture centre line and coronary artery blood vessel is made
Shadow image；
Second image processing module 204, for determining and simulating from the coronary artery blood vessel DSA image sequence got
The most like coronary artery blood vessel DSA image of contrastographic picture and coronary artery blood vessel DSA picture centre line；
Image co-registration module 206, for by coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre
Line is registrated, and the coronary artery blending image of simulation contrastographic picture and coronary artery blood vessel DSA image is obtained.
In the related technology, when carrying out image co-registration, two images to be fused can be selected to be merged, but if selection
The image similarity of two images to be fused is not high, then the clarity that will lead to fused image is not high；So in order to more
Good obtains simulated projections image, the first image processing module 202, comprising:
Projecting cell, for being carried out to three-dimensional coronary artery image by preset projection leading role degree and the secondary angle of projection
Projection, obtains multiple coronary artery projected images, wherein projection leading role's degree is projection light source in coronary artery blood vessel CTA picture centre line side
The angle rotated upwards, projecting secondary angle is that projection light source rotates on perpendicular to coronary artery blood vessel CTA picture centre line direction
Angle；
Display unit, for by obtained multiple coronary artery projected images shows to doctor；
Determination unit, the image for selecting doctor from multiple coronary artery projected images are made as the simulation of coronary artery blood vessel
Shadow image.
Further, in order to guarantee the similarities of two images to be fused, in this example, the second image processing module
204, comprising:
Similar image determination unit, for from the coronary artery blood vessel DSA image sequence got, determining and simulation radiography
The most like coronary artery blood vessel DSA image of image；
Image enhancing unit obtains coronary artery DSA enhancing image for enhancing determining coronary artery blood vessel DSA image；
Extraction unit, for determining coronary artery blood vessel DSA picture centre line from obtained coronary artery DSA enhancing image.
In conclusion by that will be projected to obtain multiple coronary artery projected images shows to three-dimensional coronary artery image to doctor,
And the image for selecting doctor from multiple coronary artery projected images is as the simulation contrastographic picture of coronary artery blood vessel, and from getting
In coronary artery blood vessel DSA image sequence, determine with the most like coronary artery blood vessel DSA image of simulation contrastographic picture, so as to
In subsequent image co-registration step, the high image to be fused of two similarities is subjected to image co-registration, ensure that fused figure
The clarity of picture.
In order to keep the image after fusion apparent, image enhancing unit, comprising:
Computation subunit, for obtaining coronary artery blood vessel DSA image by following formula under preset multiple vessel radius
The corresponding image enhancement parameter of each vessel radius in multiple vessel radius:
Wherein, λ is the maximum value of the characteristic value of HESSIAN matrix at image s, and RB and S are preset constant, controls image
Enhancing dynamics, β and c are weighted factor, and V (s) indicates image enhancement parameter；
Enhanson, for selecting maximum image from the obtained corresponding image enhancement parameter of each vessel radius
Enhancing parameter enhances coronary artery blood vessel DSA image, obtains coronary artery DSA enhancing image.
In conclusion image enhancement parameter obtained by calculation enhances coronary artery blood vessel DSA image, coronary artery is obtained
DSA enhances image, obtained coronary artery DSA enhancing image and simulation contrastographic picture is then carried out image co-registration, to make to merge
Image afterwards is apparent.
In the related technology, server can only carry out image co-registration, the accuracy of image co-registration according to the rule of setting themselves
It is relatively low, it be easy to cause the blending image clarity obtained after fusion poor, so, in order to further increase fused fusion figure
The clarity of picture, image co-registration module, comprising:
Center line display unit shows coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre Xiang doctor
Line；
Registration point acquiring unit, for obtaining doctor in coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA image
The registration point identified on heart line；
Integrated unit, the registration point for being gone out according to doctor identification, to coronary artery blood vessel DSA picture centre line and coronary artery blood vessel
CTA picture centre line is registrated, and the coronary artery blending image of simulation contrastographic picture and coronary artery DSA enhancing image is obtained.
In conclusion being distinguished on coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line by doctor
The registration point identified is registrated coronary artery blood vessel DSA picture centre line and coronary artery blood vessel CTA picture centre line, obtains mould
The coronary artery blending image of quasi- contrastographic picture and coronary artery DSA enhancing image, available outstanding registration result, to guarantee to merge
The clarity of the coronary artery blending image obtained afterwards is higher, meets the needs of diagnosis treatment.
In conclusion coronary artery image processing apparatus provided in this embodiment, by will scheme from the coronary artery CTA after three-dimensional reconstruction
In the coronary artery blood vessel CTA picture centre line and coronary artery blood vessel DSA image got respectively in picture and coronary artery blood vessel DSA image sequence
Heart line is registrated, to the simulation contrastographic picture as obtained in coronary artery blood vessel CTA image and by coronary artery blood vessel DSA image sequence
Obtained coronary artery blood vessel DSA image carries out image co-registration, obtains the coronary artery fusion of simulation contrastographic picture and coronary artery blood vessel DSA image
Image can make compared with being had in the prior art to coronary angiography image be returned to and carrying out medical diagnosis to doctor Xiang doctor
The coronary artery blending image of return is not influenced by contrast agent, and by patient, clearly coronary artery blending image shows doctor, so that doctor
Life can obtain the therapeutic scheme to patient in the case where grasping whole coronary artery information of patient；To the treatment made
Scheme has the characteristics that specific aim is stronger, therapeutic effect is more preferable and treatment time is short.
The computer program product of coronary artery image processing method is carried out provided by the embodiment of the present invention, including stores journey
The computer readable storage medium of sequence code, the instruction that said program code includes can be used for executing institute in previous methods embodiment
The method stated, specific implementation can be found in embodiment of the method, and details are not described herein.
It is apparent to those skilled in the art that for convenience and simplicity of description, the system of foregoing description,
The specific work process of device and unit, can refer to corresponding processes in the foregoing method embodiment, and details are not described herein.
In several embodiments provided herein, it should be understood that disclosed systems, devices and methods, it can be with
It realizes by another way.The apparatus embodiments described above are merely exemplary, for example, the division of the unit,
Only a kind of logical function partition, there may be another division manner in actual implementation, in another example, multiple units or components can
To combine or be desirably integrated into another system, or some features can be ignored or not executed.Another point, it is shown or beg for
The mutual coupling, direct-coupling or communication connection of opinion can be through some communication interfaces, device or unit it is indirect
Coupling or communication connection can be electrical property, mechanical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.It can select some or all of unit therein according to the actual needs to realize the mesh of this embodiment scheme
's.
It, can also be in addition, the functional units in various embodiments of the present invention may be integrated into one processing unit
It is that each unit physically exists alone, can also be integrated in one unit with two or more units.
It, can be with if the function is realized in the form of SFU software functional unit and when sold or used as an independent product
It is stored in a computer readable storage medium.Based on this understanding, technical solution of the present invention is substantially in other words
The part of the part that contributes to existing technology or the technical solution can be embodied in the form of software products, the meter
Calculation machine software product is stored in a storage medium, including some instructions are used so that a computer equipment (can be a
People's computer, server or network equipment etc.) it performs all or part of the steps of the method described in the various embodiments of the present invention.
And storage medium above-mentioned includes: that USB flash disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), arbitrary access are deposited
The various media that can store program code such as reservoir (RAM, Random Access Memory), magnetic or disk.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. a kind of coronary artery image processing method characterized by comprising
Obtain the coronary artery computer tomography angiography CTA image and coronary artery Technology of Digital Subtraction Angiography of patient
DSA image sequence；
Three-dimensional reconstruction is carried out to the obtained coronary artery blood vessel CTA image, obtains three-dimensional coronary artery image, and from described three obtained
It ties up in coronary artery image, obtains the simulation contrastographic picture of coronary artery blood vessel CTA picture centre line and coronary artery blood vessel；
From the coronary artery blood vessel DSA image sequence got, the coronary artery most like with the simulation contrastographic picture is determined
Blood vessel DSA image and coronary artery blood vessel DSA picture centre line；
By being registrated to the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line, institute is obtained
State the coronary artery blending image of simulation contrastographic picture and the coronary artery blood vessel DSA image；
From the obtained three-dimensional coronary artery image, the simulation contrastographic picture of the coronary artery blood vessel is obtained, comprising:
By preset projection leading role degree and secondary angle is projected, the three-dimensional coronary artery image is projected, is obtained multiple
Coronary artery projected image, wherein projection leading role's degree is that projection light source is revolved on the coronary artery blood vessel CTA picture centre line direction
The angle turned, the secondary angle of the projection is that projection light source rotates on perpendicular to the coronary artery blood vessel CTA picture centre line direction
Angle；
By obtained multiple coronary artery projected images shows to doctor；
The image that the doctor is selected from multiple coronary artery projected images is as the simulation radiography figure of the coronary artery blood vessel
Picture.
2. the method according to claim 1, wherein from the coronary artery blood vessel DSA image sequence got,
Determine the coronary artery blood vessel DSA image and coronary artery blood vessel DSA picture centre line most like with the simulation contrastographic picture, comprising:
From the coronary artery blood vessel DSA image sequence got, the coronary artery most like with the simulation contrastographic picture is determined
Blood vessel DSA image；
The determining coronary artery blood vessel DSA image is enhanced, coronary artery DSA enhancing image is obtained；
Coronary artery blood vessel DSA picture centre line is determined from obtained coronary artery DSA enhancing image.
3. according to the method described in claim 2, it is characterized in that, enhance the determining coronary artery blood vessel DSA image,
Obtain coronary artery DSA enhancing image, comprising:
Under preset multiple vessel radius, the coronary artery blood vessel DSA image is obtained in the multiple blood vessel by following formula
The corresponding image enhancement parameter of each vessel radius in radius:
Wherein, λ, RBIt is preset constant with S, β and c are weighted factor, and V (s) indicates image enhancement parameter；
From each of obtaining selecting maximum image enhancement parameter to described in the corresponding image enhancement parameter of the vessel radius
Coronary artery blood vessel DSA image is enhanced, and coronary artery DSA enhancing image is obtained.
4. according to the method described in claim 2, it is characterized in that, by the coronary artery blood vessel DSA picture centre line and institute
It states coronary artery blood vessel CTA picture centre line to be registrated, obtains the hat of the simulation contrastographic picture and the coronary artery blood vessel DSA image
Arteries and veins blending image, comprising:
The coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line are shown Xiang doctor；
Obtain what doctor identified on the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre line
Registration point；
According to the registration point that the doctor identification goes out, the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA are schemed
Inconocenter line is registrated, and the coronary artery blending image of the simulation contrastographic picture and coronary artery DSA enhancing image is obtained.
5. a kind of coronary artery image processing apparatus characterized by comprising
Image collection module, for obtaining the coronary artery computer tomography angiography CTA image and coronary artery number of patient
Subtractive angiography technology DSA image sequence；
First image processing module obtains three-dimensional coronary artery for carrying out three-dimensional reconstruction to the obtained coronary artery blood vessel CTA image
Image, and from the obtained three-dimensional coronary artery image, the simulation for obtaining coronary artery blood vessel CTA picture centre line and coronary artery blood vessel is made
Shadow image；
Second image processing module, for determining and the simulation from the coronary artery blood vessel DSA image sequence got
The most like coronary artery blood vessel DSA image of contrastographic picture and coronary artery blood vessel DSA picture centre line；
Image co-registration module, for by the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA picture centre
Line is registrated, and the coronary artery blending image of the simulation contrastographic picture and the coronary artery blood vessel DSA image is obtained；
The first image processing module, comprising:
Projecting cell, for being carried out to the three-dimensional coronary artery image by preset projection leading role degree and the secondary angle of projection
Projection, obtains multiple coronary artery projected images, wherein projection leading role's degree is projection light source in the coronary artery blood vessel CTA image
The angle rotated on centerline direction, the secondary angle of the projection is projection light source in perpendicular to the coronary artery blood vessel CTA image
The angle rotated on heart line direction；
Display unit, for by obtained multiple coronary artery projected images shows to doctor；
Determination unit, the image for selecting the doctor from multiple coronary artery projected images is as the coronary artery blood vessel
Simulation contrastographic picture.
6. device according to claim 5, which is characterized in that second image processing module, comprising:
Similar image determination unit, for determining and the simulation from the coronary artery blood vessel DSA image sequence got
The most like coronary artery blood vessel DSA image of contrastographic picture；
Image enhancing unit obtains coronary artery DSA enhancing image for enhancing the determining coronary artery blood vessel DSA image；
Extraction unit, for determining coronary artery blood vessel DSA picture centre line from obtained coronary artery DSA enhancing image.
7. device according to claim 6, which is characterized in that described image enhancement unit, comprising:
Computation subunit, for obtaining the coronary artery blood vessel DSA image by following formula under preset multiple vessel radius
The corresponding image enhancement parameter of each vessel radius in the multiple vessel radius:
Wherein, λ, RBIt is preset constant with S, β and c are weighted factor, and V (s) indicates image enhancement parameter；
Enhanson, for from each of obtaining selecting maximum image in the corresponding image enhancement parameter of the vessel radius
Enhancing parameter enhances the coronary artery blood vessel DSA image, obtains coronary artery DSA enhancing image.
8. device according to claim 6, which is characterized in that described image Fusion Module, comprising:
Center line display unit is shown in the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA image Xiang doctor
Heart line；
Registration point acquiring unit is schemed for obtaining doctor in the coronary artery blood vessel DSA picture centre line and the coronary artery blood vessel CTA
The registration point identified on inconocenter line；
Integrated unit, the registration point for being gone out according to the doctor identification, to the coronary artery blood vessel DSA picture centre line and described
Coronary artery blood vessel CTA picture centre line is registrated, and the coronary artery of the simulation contrastographic picture and coronary artery DSA enhancing image is obtained
Blending image.
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| WO2019019053A1 (en) * | 2017-07-26 | 2019-01-31 | 深圳先进技术研究院 | Method for extracting heart and blood vessels in cta image, device, equipment and storage medium |
| CN108242075A (en) * | 2018-01-05 | 2018-07-03 | 苏州润迈德医疗科技有限公司 | A kind of multi-angle reconstructing blood vessel method based on X ray coronary angiography image |
| CN110458848B (en) * | 2019-07-05 | 2021-11-26 | 心医国际数字医疗系统(大连)有限公司 | Method for judging coronary artery branch in image coronary artery segmentation |
| CN111882510A (en) * | 2020-06-30 | 2020-11-03 | 首都医科大学附属北京友谊医院 | Projection method, image processing method and device for CTA three-dimensional reconstruction mirror image data |
| CN112690814B (en) * | 2020-11-06 | 2022-10-14 | 杭州阿特瑞科技有限公司 | Low-error coronary artery blood flow reserve fraction measuring method |
| CN112648935A (en) * | 2020-12-14 | 2021-04-13 | 杭州思锐迪科技有限公司 | Image processing method and device and three-dimensional scanning system |
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