CN105891346A - Ion chromatography system for controlling double-conductance-cell series technology through virtual instrument - Google Patents
Ion chromatography system for controlling double-conductance-cell series technology through virtual instrument Download PDFInfo
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- CN105891346A CN105891346A CN201610120746.5A CN201610120746A CN105891346A CN 105891346 A CN105891346 A CN 105891346A CN 201610120746 A CN201610120746 A CN 201610120746A CN 105891346 A CN105891346 A CN 105891346A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
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Abstract
The invention discloses an ion chromatography system for controlling a double-conductance-cell series technology through a virtual instrument. The system comprises an ion chromatography separation module fixed to an ion chromatography instrument, a suppressor flow path module, a conductance cell series module, an ion chromatography interface equipment card inserted into a microcomputer PCI slot, and a software measurement and control module located in a microcomputer. A specific analog or digital circuit in a traditional ion chromatography instrument is obtained through a software program to complete measuring and testing functions, noise can be greatly lowered, the signal to noise ratio is increased, and the measuring result is more precise. Samples with large concentration differences are tested at a time through the double-conductance-cell series technology, the temperature is unified, and measuring precision is improved. It is not needed to carry out high-concentration ion pretreatment on the samples with the large concentration differences, analysis time is shortened, measuring efficiency is improved, and the detection and operation cost is reduced.
Description
Technical field
The present invention relates to ion chromatography system, be specifically related to a kind of utilize virtual instrument to control double conductance cell serial connection technology
Ion chromatography system.
Background technology
Chromatography of ions is the novel liquid chromatograph grown up after 20 century 70s.This technology quickly grows,
Become the powerful tool separating with detecting different anions and canons.At present, known ion chromatograph is by high-pressure pump, enters
Sample valve, detached dowel, suppression unit, Conductivity detection unit and data processing units etc. six are most of to be constituted.At conventional ion color
In analysis of spectrum, tested component is separated, flow out mutually with flowing after suppression, enters conductance detecting pool and is measured.Conductance detecting pool
Continuously by the concentration of elution fraction in chromatographic column with flowing phase change detection out, and be changed into the signal of telecommunication continuously, defeated
Enter in data processing equipment, obtain a chromatogram changing over separation component.One preferable detector is to different
Sample, under the conditions of different sample concentrations and various leacheate, all energy is accurate, reflect the change of chromatographic peak in time continuously, and
And under difficult environmental conditions same sample is had identical response signal, so, conductance detecting pool should possess higher spirit
Sensitivity, the wider detection by quantitative range of linearity, selectivity and repeatability.
According to kohilraush law, electrical conductivity K=1/1000 A/L ∑ Ci λ i:A is that electrode sections is amassed, and L is the two poles of the earth
Between distance, when an actual conductance pond is fabricated to, then A/L is a fixed value, and referred to as cell constant of conductometric vessel K, Ci is that ion is dense
Degree, λ i is the authority molar conductance of ion.In the chromatography of ions, the ion concentration of system is less than 1mmol/L, at one enough
In dilute solution, the molar conductance of ion reaches maximum, and electric conductivity value is proportional with ion concentration.Ion is utilized at us
When chromatographic system carries out sample ions analysis and detection, sample contains the ion of a large amount of variable concentrations.When we utilize one
Conductance detecting pool by the concentration of elution fraction in chromatographic column with flowing phase change detection out, and be transformed into the signal of telecommunication, finally
The chromatogram changing over separation component obtained.Owing in sample, the concentration difference of different ions is relatively big, will go out
The chromatography of ions peak of existing low concentration is covered by the chromatographic peak of high concentration ion completely or low concentration chromatography of ions peak shows,
And high concentration ion is because of excessive concentration, the chromatographic peak generation peak shape shown or area distortion, and can not qualitative to it and
Determine quantitative analysis.
At present, in order to avoid the interference of this situation, often pre-treatment pillar is used to remove the height in sample in sample
Concentration ion or take first to determine sample low concentration ion, is then determined in sample further by dilute sample
High concentration ion.But use its use cost of pretreatment process high, and be disposable consumptive material, life-time service, detects into
Ben Taigao；And use two-step method to measure sample ions, along with the use ambient temperature of instrument is the most variant, inspection can be caused
Survey the change of signal, such as, baseline drift can occur, once drift beyond certain numerical value, ion chromatograph detection knot will be affected
Really.A kind of can eliminate the high concentration ion method to low concentration ion interference accordingly, it would be desirable to develop, both can ensure that sample from
The accuracy that son measures, can reduce again testing cost simultaneously, and improve analysis efficiency.
Summary of the invention
It is an object of the invention to provide a kind of ion chromatography system utilizing virtual instrument to control double conductance cell serial connection technology,
With the defect overcoming prior art to exist.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of ion chromatography system utilizing virtual instrument to control double conductance cell serial connection technology, including being fixed on ion chromatograph
Ion chromatographic separation module, suppressor stream module, conductance cell serial module structure, insert the ion color in micro computer PCI slot
Spectrum interface equipment card, be positioned at the measure and control software module within micro computer, it is characterised in that: described conductance cell serial module structure be by
Two conductance cells are connected, when sample flows through generation two detection analogue signal；Described chromatography of ions interface equipment card rank
Connect the communication of computer and ion chromatograph, by being inserted in pci card groove, the analogue signal that conductance cell produces can be acquired,
It is transmitted to measure and control software module；Described measure and control software module includes that A/D conversion, Digital Signal Analysis process, D/A changes；
Described A/D conversion: two analogue signals are converted into digital signal；
Described Digital Signal Analysis processes: is analyzed digital signal, regards signal and noise thereof as stochastic signal, pass through
Utilize its statistical nature, reduce noise and obtain signal itself and signal integration is obtained optimal digital signal,
Described D/A conversion: the optimal digital signal processed by analysis is changed into corresponding analog signal.
Furthermore, described conductance cell serial module structure is a Pyatyi conductance cell and two grades of conductance cells to be carried out
Series connection；
Furthermore, it is to utilize digital filtering, fft analysis, single product extraction, single-frequency inspection that described Digital Signal Analysis processes
Survey, Wavelet Denoising Method, autocorrelation analysis, weighted average value filtering, anti-impulse disturbances average value filtering, program judge filtering, adaptive
Should filter, linear neural network de-noising, curve matching method to realize correlation function.
Owing to sample intermediate ion concentration difference is relatively big, Pyatyi conductance cell and two grades of conductance cells are connected by the present invention,
Owing to Pyatyi conductance cell electric conductivity value is big, highly sensitive, for measuring the ion that concentration in sample is low, and two grades of conductance cell electric conductivity values
Relatively small, sensitivity decrease, may be used for measuring the ion of sample middle and high concentration, conductance cell serial module structure exports two simulation letters
Number, utilize measure and control software module to be analyzed processing, in conjunction with the mensuration advantage of two kinds of conductance cells, retain Pyatyi conductance cell and measure low
Concentration signal and two grades of conductance cells measure high concentration signal, thus realize the optimum integration of signal.
Traditional ion chromatograph is the measurement test merit realizing instrument by designing concrete analog or digital circuit
Can, the present invention utilizes software program this virtual instrument form to complete these functions.The mould that conductance cell serial module structure is exported
Intend signal to be extracted by the chromatography of ions interface equipment card being inserted on computer PCI draw-in groove, be input to software control module, come
Complete the measurement test of sample further.
The analogue signal that measure and control software module processes inputting by starting Digital Signal Analysis carries out A/D conversion, often adopts
Collection to one data are fed to Digital Signal Analysis process and are filtered computing, and operation result send D/A to be converted to analog quantity.
Being repeated continuously said process, the outfan in D/A conversion just obtains filtered analogue signal.In calculating process, not only
Signal is carried out denoising, and by two analogue signals of conductance cell serial module structure output, has been converted into by A/D
Two digital signals, and analyse and compare further, two digital signals are optimized combination, ultimately form an optimal digital
Signal, delivers to D/A and is converted to analog quantity, and then further form preferable chromatographic peak collection of illustrative plates.
Beneficial effects of the present invention:
(1) a kind of ion chromatography system utilizing virtual instrument to control double conductance cell serial connection technology of the present invention, utilizes software
Program realizes the measurement test function that analog or digital circuit concrete in conventional ion chromatograph completes, and can be substantially reduced
Noise, improves signal to noise ratio, makes measurement result more accurate；
(2) a kind of ion chromatography system utilizing virtual instrument to control double conductance cell serial connection technology of the present invention, by double electricity
Leading pond serial connection technology and the sample that concentration difference is big is disposably completed test, temperature is unified, improves measuring accuracy；
(3) a kind of ion chromatography system utilizing virtual instrument to control double conductance cell serial connection technology of the present invention, to concentration difference
Different big sample, without carrying out high concentration ion pretreatment, decreases analysis time, improves determination efficiency, reduces detection fortune
Row cost.
Accompanying drawing explanation
Accompanying drawing is used for providing a further understanding of the present invention, constitutes the part of the application, and the present invention's is schematic real
Execute example and illustrate for explaining the present invention, being not intended that inappropriate limitation of the present invention.In the accompanying drawings:
Fig. 1 is the flow process connection figure of the ion chromatography system utilizing the double conductance cell serial connection technology of virtual instrument control
Fig. 2 is through the color of conventional ion chromatographic system by the dilute sample containing high-concentration chlorine ion and low concentration nitrite anions
Spectrogram
Fig. 3 is that through virtual instrument, the sample containing high-concentration chlorine ion and low concentration nitrite anions is controlled double conductance cell series connection
The chromatograph of the ion chromatography system of technology
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the invention are described in detail, but the present invention can be defined by the claims and cover
The various different modes of lid are implemented.
Embodiment
1, system balancing
Will be equipped with the present invention utilize virtual instrument control double conductance cell serial connection technology ion chromatography system chromatography of ions
Instrument and ion chromatograph in the market carry out system balancing respectively.After leacheate enters ion isolation module, then access presses down
Device stream module processed, inhibited device enters conductance cell serial module structure, and the analogue signal of generation passes through chromatography of ions interface equipment card
Enter measure and control software module, to manifest the poised state of whole system.The system connection figure of the present invention is shown in Fig. 1.On market from
Sub-chromatograph system balancing the most here repeats.After system balancing, by the same sample in the range of identical sex-limited test one
Adding in ion chromatograph in the market after dilution, another is directly added into and utilizes virtual instrument control equipped with the present invention
The ion chromatography system of double conductance cell serial connection technologies ion chromatograph in carry out sample introduction analysis.
2, dilute sample analysis in conventional ion chromatograph
Ion chromatograph commercially after the solution of nitrite anions containing low concentration in high-concentration chlorine ion is diluted
In carry out sample introduction analysis, now sample is through detached dowel, after suppressor, finally enter conductance cell, on chromatographic software
To the chromatogram (see figure 2) of sample detection, the chromatographic peak of nitrite anions is complete from chromatogram it can be seen that in this case
Entirely covered by the chromatographic peak of high-concentration chlorine ion, need dilution further to measure chloride ion, and low concentration can not be obtained
The data of nitrite anions, need to utilize pretreatment column to remove high-concentration chlorine ion and measure further, so say and cause data
Inaccurate, thus it can not be carried out qualitative and quantitative analysis.
3, sample is in the ion chromatograph of the ion chromatography system of the double conductance cell serial connection technology of virtual instrument control
Analyze
The solution containing low concentration nitrite anions in high-concentration chlorine ion is being controlled double conductance cell series connection skill through virtual instrument
The ion chromatograph of the ion chromatography system of art carries out sample introduction analysis, and now sample is through ion isolation module, passes through suppressor
After stream module, finally entering conductance cell serial module structure, the analogue signal of generation enters soft by chromatography of ions interface equipment card
Part control module, obtains the chromatogram (see figure 3) of sample detection on chromatographic software, it can be seen that the present invention from chromatogram
By Pyatyi conductance cell and two grades of conductance cells are connected, owing to Pyatyi conductance cell electric conductivity value is big, highly sensitive, it is used for surveying
The ion that in random sample product, concentration is low, and two grades of conductance cell electric conductivity values are relatively small, sensitivity decrease, may be used for measuring in sample high
The ion of concentration, conductance cell serial module structure two analogue signals of output, utilize measure and control software module to be analyzed processing, in conjunction with two
Plant the mensuration advantage of conductance cell, retain Pyatyi conductance cell and measure low concentration signal and two grades of conductance cells mensuration high concentration signals, from
And realize the optimum integration of signal, thus obtain the separating effect figure of nitrite anions and chloride ion, can to its carry out qualitative and
Quantitative analysis.
Claims (3)
1. utilize virtual instrument to control an ion chromatography system for double conductance cell serial connection technology, including being fixed on ion chromatograph
On ion chromatographic separation module, suppressor stream module, conductance cell serial module structure, insert the ion in micro computer PCI slot
Chromatograph interface equipment card, is positioned at the measure and control software module within micro computer, it is characterised in that: described conductance cell serial module structure is
Two conductance cells are connected, when sample flows through generation two detection analogue signal；Described chromatography of ions interface equipment card
Linking computer and the communication of ion chromatograph, by being inserted in pci card groove, can adopt the analogue signal that conductance cell produces
Collection, is transmitted to measure and control software module；Described measure and control software module includes that A/D conversion, Digital Signal Analysis process, D/A changes；
Described A/D conversion: two analogue signals are converted into digital signal；
Described Digital Signal Analysis processes: is analyzed digital signal, regards signal and noise thereof as stochastic signal, pass through
Utilize its statistical nature, reduce noise and obtain signal itself and signal integration is obtained optimal digital signal,
Described D/A conversion: the optimal digital signal processed by analysis is changed into corresponding analog signal.
Conductance cell serial module structure the most according to claim 1 is a Pyatyi conductance cell and two grades of conductance cells to be carried out
Series connection.
It is to utilize digital filtering, fft analysis, Dan Pinti that described Digital Signal Analysis the most according to claim 1 processes
Take, single-frequency detection, Wavelet Denoising Method, autocorrelation analysis, weighted average value filtering, anti-impulse disturbances average value filtering, program judge
Filtering, adaptive-filtering, linear neural network de-noising, the method for curve matching realize correlation function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610120746.5A CN105891346A (en) | 2016-03-03 | 2016-03-03 | Ion chromatography system for controlling double-conductance-cell series technology through virtual instrument |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610120746.5A CN105891346A (en) | 2016-03-03 | 2016-03-03 | Ion chromatography system for controlling double-conductance-cell series technology through virtual instrument |
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| CN105891346A true CN105891346A (en) | 2016-08-24 |
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| CN201610120746.5A Pending CN105891346A (en) | 2016-03-03 | 2016-03-03 | Ion chromatography system for controlling double-conductance-cell series technology through virtual instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109100441A (en) * | 2018-08-23 | 2018-12-28 | 西南科技大学 | A kind of method of liquid chromatogram curve removal impulse disturbances |
Citations (3)
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| CN1063569A (en) * | 1991-01-25 | 1992-08-12 | 中国科学院大连化学物理研究所 | Chromatographic data processor with chinese charactor microcomputer |
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| CN1063569A (en) * | 1991-01-25 | 1992-08-12 | 中国科学院大连化学物理研究所 | Chromatographic data processor with chinese charactor microcomputer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109100441A (en) * | 2018-08-23 | 2018-12-28 | 西南科技大学 | A kind of method of liquid chromatogram curve removal impulse disturbances |
| CN109100441B (en) * | 2018-08-23 | 2021-05-07 | 西南科技大学 | Method for removing pulse interference of liquid chromatography curve |
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Application publication date: 20160824 |