CN105884626B - A kind of synthetic method of 2 aminoidan derivatives and products thereof - Google Patents

A kind of synthetic method of 2 aminoidan derivatives and products thereof Download PDF

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CN105884626B
CN105884626B CN201610290813.8A CN201610290813A CN105884626B CN 105884626 B CN105884626 B CN 105884626B CN 201610290813 A CN201610290813 A CN 201610290813A CN 105884626 B CN105884626 B CN 105884626B
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reaction
synthetic method
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room temperature
aminoidan
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CN105884626A (en
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朱宁
李春成
朱献明
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Long Xining (shanghai) Medical Technology Co Ltd
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Long Xining (shanghai) Medical Technology Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

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  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

The invention provides a kind of synthetic method of 2 aminoidan derivatives, i.e. with 5,6 two 1 indones of substitution are initiation material, first carry out bromination reaction, drop cloth riel reaction is carried out again, hydrazine hydrate is subsequently added into, and reaction is hydrolyzed while generating hydrazone, highly basic is finally added in high boiling solvent and carries out heating hydrolysis, the aminoidan derivatives of target product 2 are made.Present invention also offers 2 aminoidan derivatives as made from above-mentioned synthetic method.Compared with 2 aminoidan derivatives synthetic method of the prior art, synthetic method reaction raw materials provided by the present invention are cheap, reaction condition is gentle, reactions steps are simple, it is easily operated, and the yield of products obtained therefrom is higher, suitable for industrialized production, therefore, with good application prospect and market potential.

Description

A kind of synthetic method of 2- aminoidan derivatives and products thereof
Technical field
The invention belongs to organic synthesis field, it is related to a kind of synthetic method of medicine intermediate, more particularly to a kind of 2- ammonia The synthetic method of base indan derivative, and the 2- aminoidan derivatives product as made from the synthetic method.
Background technology
2- aminoidans and its derivative are a kind of common and widely used medicine intermediates, for example, 5,6- diethyls Base -2,3- dihydro -1H- indenes -2- amine hydrochlorates can be used for the adrenal gland of β 2 of the synthesis indication such as asthma and chronic obstructive pulmonary disease Plain receptor stimulating agent；And for example, antihypertensive drugs Delapril and arrhythmia medicine Aprindine etc. are in its respective preparation work In skill, 2- aminoidans have all been used；In addition, EP1018514A1 discloses a kind of indan derivative as NF-KB inhibitor Deng.
The synthetic method of some 2- aminoidan derivatives is also provided in the prior art, and such as EP1018514A1 is provided A kind of method that use isoamyl nitrite prepares target product, after this method is reacted raw material and isoamyl nitrite, Target product is obtained through the reduction of palladium carbon high-pressure hydrogenation again, the route reaction condition is harsh, cost is higher, therefore be unfavorable for industrialization Production.And for example, Chinese patent CN1268605C discloses a kind of method of synthesis 2- aminoidan derivatives, including following step Suddenly：The amino of 2- aminoidans is protected, ethyl is reduced to shape by the ring acetylation in protected compound, then by acetyl group Into single ethyl derivative, then by single ethyl derivative acetylation, then by acetyl group reduction to generate diethyl radical derivative, most Deprotected afterwards by hydrolyzing, product is made；It can be seen that, the synthetic method step is very cumbersome, and yield is relatively low, is also unsuitable for big Technical scale metaplasia is produced.Other synthetic methods of 2- aminoidan derivatives also have：Such as using indenes as raw material, by itself and chloro amino T-butyl formate addition reaction, then product is made through reduction dechlorination.However, often there is reaction bar in these art methods Part is harsh, and reactions steps are cumbersome, is not easy to the defects such as operation.Therefore, a kind of new synthesis of 2- aminoidan derivatives is developed Method, is one of current research emphasis of this area research staff.
The content of the invention
In order to overcome shortcomings and deficiencies present in above-mentioned prior art, the present invention is intended to provide a kind of reactions steps it is few, Simple to operate, high income, cost are low, 2- aminoidan derivatives suitable for industrialized production synthetic methods.
Therefore, in order to realize foregoing invention purpose, the first aspect of the present invention provides a kind of 2- aminoidan derivatives Synthetic method, its synthetic route is as follows：
Also, the synthetic method comprises the following steps：
(1) using compound A1 as initiation material, i.e., with 5,6 two substitution 1- indones are initiation material, carry out bromination reaction, system Obtain intermediate A 2；
(2) intermediate A 2 is reacted through drop cloth riel is made intermediate A 3；
(3) hydrazine hydrate is added into the intermediate A 3, reaction is hydrolyzed while generating hydrazone, intermediate A 4 is made；
(4) reaction is hydrolyzed in intermediate A 4, that is, target product 2- aminoidan derivatives A is made；
Wherein, R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3-C30 cycloalkyl, C2-C30 alkene Base, C3-C30 cycloalkenyl group, C2-C30 alkynyl group, C1-C30 alkoxy, C7-C30 aryl alkoxies, C6-C30 virtue Alkyl, C4-C30 heterocyclic arene base.
Preferably, the synthetic method comprises the following steps：
(1) compound A1 is dissolved in solvent S, adds bromating agent and carry out bromination reaction, intermediate is made in post processing A2；
(2) intermediate A 2 and potassium phthalimide are added in DMF in the lump, at room temperature stirring reaction, after Processing, is made intermediate A 3；
(3) intermediate A 3 is added in methanol or ethanol, then adds hydrazine hydrate, return stirring reaction, rear place Reason, is made intermediate A 4；
(4) intermediate A 4 and highly basic are added into high boiling solvent in the lump, reaction is hydrolyzed in heating stirring, rear place Reason, is made target product 2- aminoidan derivatives A.
It is further preferred that in above-mentioned synthetic method, step (1) is：
Compound A1 is dissolved in solvent S, and bromine is slowly added dropwise below 10 DEG C, drips and finishes, stirred at 20 DEG C, carried out Intermediate A 2 is made in bromination reaction, post processing；Wherein, the solvent S is selected from following any one or more combination：Acetic acid second Ester, ether, dichloromethane.
It is further preferred that in above-mentioned synthetic method, step (2) is：
The intermediate A 2 and potassium phthalimide are added in DMF in the lump, 2~24 are stirred at room temperature small When, intermediate A 3 is made in post processing.
It is further preferred that in above-mentioned synthetic method, step (3) is：
The intermediate A 3 is added in methanol, hydrazine hydrate is then added at room temperature, then, return stirring reaction 2 ~9 hours, intermediate A 4 was made in post processing.
It is further preferred that in above-mentioned synthetic method, step (4) is：
At room temperature, intermediate A 4 and highly basic are added into high boiling solvent in the lump, heating stirring 0.5~4 hour, after Processing, is made target product 2- aminoidan derivatives A.
It is further preferred that in above-mentioned synthetic method, the highly basic is selected from following any one or more combination：Hydrogen Potassium oxide, sodium hydroxide, lithium hydroxide, calcium hydroxide.
It is further preferred that in above-mentioned synthetic method, the high boiling solvent is selected from following any one or more Combination：Ethylene glycol, glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, methyl phenyl ethers anisole, butyl ether, toluene, dimethylbenzene.
It is further preferred that in above-mentioned synthetic method, R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3-C30 cycloalkyl, C1-C30 alkoxy, C7-C30 aryl alkoxies.In addition, what deserves to be explained is, due to R1And R2 Can be H simultaneously, therefore, " 2- aminoidan derivatives " of the present invention actually including 2- aminoidans, this is specific Compound.
In addition, in above-mentioned synthetic method, " post processing " described in each reactions steps (1)~(4) is this area skill The suitable post processing that art personnel can make according to this step reaction mechanism and reaction condition etc., these post processings are intended to remove impurity elimination Matter is with solvent and ensures to obtain pure product to a certain extent.
Alternatively, the post processing in step (1) is referred to：After completion of the reaction, water is added into reaction solution, layering is quenched, Organic phase saturated common salt water washing, then with anhydrous sodium sulfate drying, is concentrated to dryness, obtains yellow oily liquid, in being Mesosome A2.
Alternatively, the post processing in step (2) is referred to：After completion of the reaction, reaction solution is poured into water, separated out a large amount of Solid, suction filtration, filter cake massive laundering obtains yellow solid, as intermediate A 3 after drying.
Alternatively, the post processing in step (3) is referred to：After completion of the reaction, reaction solution is cooled to room temperature, added certain Water is measured, a large amount of solids, suction filtration is separated out, then filter cake is washed with massive laundering, yellow solid, as intermediate A 4 are obtained after drying.
Alternatively, the post processing in step (4) is referred to：After completion of the reaction, reaction solution is cooled to room temperature, added certain Water is measured, is then extracted with dichloromethane, merges organic phase, and priority water and saturated common salt water washing, then use anhydrous sodium sulfate Dry, concentration obtains yellow oily liquid；Add thereto after ethyl acetate dissolved clarification, be passed through hydrogen chloride gas to pH=1~2, analysis Go out a large amount of white solids, suction filtration elutes filter cake with a small amount of ethyl acetate, obtains white solid after drying, that is, obtain target product A Hydrochloride.Target product A can be directly preserved in the form of hydrochloride；Also can be as known to the research staff of this area, by each Plant conventional method and free target product A is isolated from target product A hydrochloride, for example, in the aqueous solution of the hydrochloride It is middle to add excessive highly basic, then extracted with organic solvent, organic phase is isolated, organic phase is finally evaporated off.
The second aspect of the present invention is there is provided a kind of 2- aminoidan derivatives, and the 2- aminoidan derivatives are bases Target product A made from synthetic method described in first aspect present invention.
Compared with 2- aminoidan derivatives synthetic method of the prior art, synthetic method reaction provided by the present invention Raw material is cheap, and reaction condition is gentle, and reactions steps are simple, it is easy to operate, and the yield of products obtained therefrom is higher, suitable for industrialization Production, therefore, with good application prospect and market potential.
Embodiment
With reference to embodiment, the present invention is further elaborated, but the present invention is not limited to following embodiment party Formula.
The first aspect of the present invention is there is provided a kind of synthetic method of 2- aminoidan derivatives, and its synthetic route is as follows：
Also, the synthetic method comprises the following steps：
(1) using compound A1 as initiation material, bromination reaction is carried out, intermediate A 2 is made；
(2) intermediate A 2 is reacted through drop cloth riel is made intermediate A 3；
(3) hydrazine hydrate is added into the intermediate A 3, reaction is hydrolyzed while generating hydrazone, intermediate A 4 is made；
(4) reaction is hydrolyzed in intermediate A 4, that is, target product 2- aminoidan derivatives A is made；
Wherein, R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3-C30 cycloalkyl, C2-C30 alkene Base, C3-C30 cycloalkenyl group, C2-C30 alkynyl group, C1-C30 alkoxy, C7-C30 aryl alkoxies, C6-C30 virtue Alkyl, C4-C30 heterocyclic arene base.
In a preferred embodiment, the synthetic method comprises the following steps：
(1) compound A1 is dissolved in solvent S, adds bromating agent and carry out bromination reaction, intermediate is made in post processing A2；
(2) intermediate A 2 and potassium phthalimide are added in DMF in the lump, at room temperature stirring reaction, after Processing, is made intermediate A 3；
(3) intermediate A 3 is added in methanol or ethanol, then adds hydrazine hydrate, return stirring reaction, rear place Reason, is made intermediate A 4；
(4) intermediate A 4 and highly basic are added into high boiling solvent in the lump, reaction is hydrolyzed in heating stirring, rear place Reason, is made target product 2- aminoidan derivatives A.
In a further preferred embodiment, step (1) is：
Compound A1 is dissolved in solvent S, and bromine is slowly added dropwise below 10 DEG C, drips and finishes, stirred at 20 DEG C, carried out Intermediate A 2 is made in bromination reaction, post processing；Wherein, the solvent S is selected from following any one or more combination：Acetic acid second Ester, ether, dichloromethane.
In a further preferred embodiment, step (2) is：
The intermediate A 2 and potassium phthalimide are added in DMF in the lump, 2~24 are stirred at room temperature small When, intermediate A 3 is made in post processing.
In a further preferred embodiment, step (3) is：
The intermediate A 3 is added in methanol, hydrazine hydrate is then added at room temperature, then, return stirring reaction 2 ~9 hours, intermediate A 4 was made in post processing.
In a further preferred embodiment, step (4) is：
At room temperature, intermediate A 4 and highly basic are added into high boiling solvent in the lump, heating stirring 0.5~4 hour, after Processing, is made target product 2- aminoidan derivatives A.
In an embodiment still more preferably, the highly basic is selected from following any one or more combination：Hydrogen-oxygen Change potassium, sodium hydroxide, lithium hydroxide, calcium hydroxide.
In an embodiment still more preferably, the high boiling solvent is selected from following any one or more group Close：Ethylene glycol, glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, methyl phenyl ethers anisole, butyl ether, toluene, dimethylbenzene.
In an embodiment still more preferably, R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3- C30 cycloalkyl, C1-C30 alkoxy, C7-C30 aryl alkoxies.
The second aspect of the present invention is there is provided a kind of 2- aminoidan derivatives, and the 2- aminoidan derivatives are bases Target product A made from synthetic method described in first aspect present invention.
Step in the synthetic method of following 2- aminoidan derivatives is conventional method, the original unless otherwise instructed Material can be obtained from open commercial sources unless otherwise instructed.
The synthesis of the compound 1 of embodiment 1
(1) synthetic intermediate 12
96.1g compounds 11 (0.5mol) are dissolved in 500ml ethyl acetate at room temperature, and are slowly added dropwise below 10 DEG C Bromine 80g (0.5mol), drop finishes, and is maintained at 20 DEG C and continues to stir 30 minutes, and TLC monitoring reaction is until completely, be added dropwise 1000ml water, is quenched layering, and organic phase washed once with 1000ml saturated aqueous common salts, is concentrated to dryness after anhydrous sodium sulfate drying, Obtain yellow oily liquid 135.5g (yield 98%), as intermediate 12.
(2) synthetic intermediate 13
At room temperature, by 135.5g intermediates 12 (0.5mol) and 101.87g potassium phthalimides (0.55mol) one And be added in 1355mlDMF, and be stirred at room temperature overnight (about 20 hours), reaction solution is in dark-brown, and TLC monitoring reactions are straight To complete, after reaction completely, reaction solution is poured into 6775ml water, a large amount of solids of precipitation, suction filtration, filter cake massive laundering, Yellow solid 160.23g (yield 95%), as intermediate 13 are obtained after drying.
(3) synthetic intermediate 14
168.66g intermediates 13 (0.5mol) are added in 3.2L methanol, 147g85% water is then added in room temperature Hydrazine (2.5mol) is closed, back flow reaction is warming up to after adding 6 hours, TLC monitoring reaction is until completely, reaction is finished, by reaction solution Room temperature is down to, 3.2L water is added, a large amount of solids, suction filtration is separated out, then filter cake is washed with massive laundering, yellow solid is obtained after drying 99.56g (yield 90%), as intermediate 14.
(4) target product is synthesized
At room temperature, 110.63g intermediates 14 (0.5mol), 56.11g potassium hydroxide (1mol) are added to 1100ml in the lump In diethylene glycol dimethyl ether, be heated under stirring 120 DEG C react 1 hour, TLC monitoring reaction until completely, reaction completely after, will Reaction solution is down to room temperature, and add water 1100ml, is extracted 500ml*3 times with dichloromethane, merges organic phase, washes 500ml*3 times, satisfies Washed 500ml*1 times with salt, concentrated after anhydrous sodium sulfate drying, obtain yellow oily liquid 86.4g；Add thereto After 172.8ml ethyl acetate dissolved clarifications, lead to hydrogen chloride gas to pH=1~2, separate out a large amount of white solids, suction filtration uses a small amount of acetic acid Ethyl ester elutes filter cake, obtains white solid 97.62g (yield 85%) after drying, produces compound 1：
1H NMR δ 6.78 (s, 2H), 3.91-3.78 (dd, J=34.3,17.3Hz, 1H), 3.76-3.73 (d, J= 8.0Hz, 6H), 3.20-3.08 (dd, J=24.8,17.1Hz, 2H), 2.94-2.82 (dd, J=24.8,17.2Hz, 2H), 1.20-1.18(s,2H)。
The synthesis of the compound 2 of embodiment 2
(1) synthetic intermediate 22
81.1g compounds 21 (0.5mol) are dissolved in 500ml ethyl acetate at room temperature, less than 10 DEG C, slow drop are kept Plus bromine 80g (0.5mol), drip and finish, be maintained at 20 DEG C and continue to stir 30 minutes, TLC monitoring is reacted until completely, being added dropwise 1000ml water, is quenched layering, and organic phase washed once with 1000ml saturated aqueous common salts, is concentrated to dryness after anhydrous sodium sulfate drying, Obtain yellow oily liquid 120.54g (yield 99%), as intermediate 22.
(2) synthetic intermediate 23
At room temperature, by 120.54g intermediates 22 (0.5mol) and 101.87g potassium phthalimides (0.55mol) Be added in the lump in 1355ml DMF, and be stirred at room temperature reaction 2 hours, reaction solution be in dark-brown, TLC monitoring reaction until Completely, after reacting completely, reaction solution is poured into 6775ml water, a large amount of solids are separated out, suction filtration, filter cake massive laundering is done Yellow solid 150.56g (yield 98%), as intermediate 23 are obtained after dry.
(3) synthetic intermediate 24
153.65g intermediates 23 (0.5mol) are added in 3.07L methanol, 147g85% water is then added in room temperature Hydrazine (2.5mol) is closed, back flow reaction is warming up to after adding 8 hours, TLC monitoring reaction is until completely, reaction is finished, by reaction solution Room temperature is down to, 3.2L water is added, a large amount of solids, suction filtration is separated out, then filter cake is washed with massive laundering, yellow solid is obtained after drying 90.89g (yield 93%), as intermediate 24.
(4) target product is synthesized
At room temperature, 95.61g intermediates 24 (0.5mol), 56.11g potassium hydroxide (1mol) are added to 1100ml in the lump In diethylene glycol dimethyl ether, be heated under stirring 120 DEG C react 2 hours, TLC monitoring reaction until completely, reaction completely after, will Reaction solution is down to room temperature, and add water 1100ml, is extracted 500ml*3 times with dichloromethane, merges organic phase, washes 500ml*3 times, satisfies Washed 500ml*1 times with salt, concentrated after anhydrous sodium sulfate drying, obtain yellow oily liquid 73.44g；Add thereto After 146.89ml ethyl acetate dissolved clarifications, lead to hydrogen chloride gas to pH=1~2, separate out a large amount of white solids, suction filtration uses a small amount of second Acetoacetic ester elutes filter cake, obtains white solid 87.86g (yield 88%) after drying, produces compound 2：
1H NMR δ 7.24-7.18 (d, J=15.0Hz, 1H), 6.82-6.78 (d, J=2.9Hz, 1H), 6.63-6.56 (dd, J=15.0,3.1Hz, 1H), 3.92-3.74 (p, J=17.2Hz, 1H), 3.72-3.67 (s, 3H), 3.20-3.05 (dd, J=24.8,17.1Hz, 2H), 2.93-2.81 (dd, J=24.8,17.2Hz, 2H), 1.22-1.15 (s, 2H).
The synthesis of the compound 3 of embodiment 3
(1) synthetic intermediate 32
88.1g compounds 31 (0.5mol) are dissolved in 500ml ether at room temperature, 0~5 DEG C is maintained at, bromine is slowly added dropwise Plain 80g (0.5mol), drop finishes, and is maintained at 20 DEG C and continues to stir 30 minutes, and TLC monitoring reaction is until completely, be added dropwise 1000ml Water, is quenched layering, and organic phase washed once with 1000ml saturated aqueous common salts, is concentrated to dryness after anhydrous sodium sulfate drying, obtain yellow Oily liquids 127.55g (yield 99%), as intermediate 32.
(2) synthetic intermediate 33
At room temperature, by 127.55g intermediates 32 (0.5mol) and 101.87g potassium phthalimides (0.55mol) It is added in 1355ml DMF, and is stirred at room temperature 2 hours in the lump, reaction solution is in dark-brown, and TLC monitoring reactions are until complete Entirely, after reacting completely, reaction solution is poured into 6775ml water, a large amount of solids are separated out, suction filtration, filter cake massive laundering is dried Yellow solid 155.56g (yield 96.8%), as intermediate 33 are obtained afterwards.
(3) synthetic intermediate 34
160.66g intermediates 33 (0.5mol) are added in 3.2L methanol, 147g85% water is then added in room temperature Hydrazine (2.5mol) is closed, back flow reaction is warming up to after adding 4 hours, TLC monitoring reaction is until completely, reaction is finished, by reaction solution Room temperature is down to, 3.2L water is added, a large amount of solids, suction filtration is separated out, then filter cake is washed with massive laundering, yellow solid is obtained after drying 94.42g (yield 94%), as intermediate 34.
(4) target product is synthesized
At room temperature, 102.63g intermediates 34 (0.5mol), 56.11g potassium hydroxide (1mol) are added to 1100ml in the lump In dimethylbenzene, 120 DEG C are heated under stirring and is reacted 0.5 hour, reaction solution is down to room temperature by TLC monitoring reactions up to complete, plus Water 1100ml, is extracted 500ml*3 times with dichloromethane, merges organic phase, is washed 500ml*3 times, saturated common salt washing 500ml*1 It is secondary, concentrated after anhydrous sodium sulfate drying, obtain yellow oily liquid 80g；Add thereto after 400ml ethyl acetate dissolved clarifications, lead to chlorine Change hydrogen to pH=1~2, separate out a large amount of white solids, suction filtration elutes filter cake with a small amount of ethyl acetate, obtains white after drying Solid 91.89g (yield 86%), produces compound 3：
1H NMR (500MHz, chloroform) δ 7.12-7.05 (s, 1H), 6.70-6.65 (s, 1H), 3.94-3.75 (s, 1H), 3.72-3.65(s,3H),3.20-3.06(s,2H),2.94-2.82(s,2H),2.17-2.11(s,3H),1.22-1.15(d, 2H)。
The synthesis of the compound 4 of embodiment 4
(1) synthetic intermediate 42
188.27g compounds 41 (1mol) are dissolved in 940ml ether at room temperature, 0~5 DEG C is maintained at, bromine is slowly added dropwise Plain 160g (1mol), drop finishes, and is maintained at 20 DEG C and continues to stir 30 minutes, and TLC monitoring reaction is until completely, be added dropwise 2000ml Water, is quenched layering, and organic phase washed once with 1000ml saturated aqueous common salts, is concentrated to dryness after anhydrous sodium sulfate drying, obtain yellow Oily liquids 267.16g (yield 99%), as intermediate 42.
(2) synthetic intermediate 43
At room temperature, by 267.16g intermediates 42 (1mol) and 203.74g potassium phthalimides (1.1mol) in the lump Be added in 2600ml DMF, and be stirred at room temperature 5 hours, reaction solution be in dark-brown, TLC monitoring reaction until completely, instead After answering completely, reaction solution is poured into 5200ml water, a large amount of solids are separated out, suction filtration, filter cake massive laundering obtains yellow after drying Color solid 318.04g (yield 95.4%), as intermediate 43.
(3) synthetic intermediate 44
333.38g intermediates 43 (1mol) are added in 3.2L methanol, 294g85% hydration is then added in room temperature Hydrazine (5mol), is warming up to back flow reaction 2 hours after adding, TLC monitoring reaction is until completely, reaction is finished, and reaction solution is down to Room temperature, adds 3.2L water, separates out a large amount of solids, suction filtration, then washs filter cake with massive laundering, and yellow solid 204.92g is obtained after drying (yield 94.3%), as intermediate 44.
(4) target product is synthesized
At room temperature, 217.31g intermediates 44 (1mol), 80g sodium hydroxides (2mol) are added to 1100ml second two in the lump In alcohol, 120 DEG C are heated under stirring and is reacted 4 hours, TLC monitoring reaction is until completely, being down to room temperature by reaction solution, adding water 1100ml, is extracted 500ml*3 times with dichloromethane, merges organic phase, is washed 500ml*3 times, saturated common salt washing 500ml*1 It is secondary, concentrated after anhydrous sodium sulfate drying, obtain yellow oily liquid 185g；Add thereto after 370ml ethyl acetate dissolved clarifications, lead to chlorine Change hydrogen to pH=1~2, separate out a large amount of white solids, suction filtration elutes filter cake with a small amount of ethyl acetate, obtains white after drying Solid 194.83g (yield 86.3%), produces compound 4：
1H NMR (500MHz, chloroform) δ 7.22-7.18 (s, 1H), 7.11-7.07 (s, 1H), 3.88-3.76 (s, 1H), 3.17-3.09 (s, 2H), 2.92-2.82 (d, J=5.0Hz, 3H), 2.32-2.26 (s, 3H), 1.18 (d, J=0.5Hz, 2H), 1.17(s,3H),1.16(s,3H)。
The synthesis of the compound 5 of embodiment 5
(1) synthetic intermediate 52
26.83g compounds 51 (0.1mol) are dissolved in 268ml dichloromethane at room temperature, 0~5 DEG C is maintained at, slow drop Plus bromine 16g (0.1mol), drip and finish, be maintained at 20 DEG C and continue to stir 30 minutes, TLC monitoring is reacted until completely, being added dropwise 268ml water, is quenched layering, and organic phase washed once with 100ml saturated aqueous common salts, be concentrated to dryness after anhydrous sodium sulfate drying, obtained Yellow oily liquid 34.72g (yield 99%), as intermediate 52.
(2) synthetic intermediate 53
At room temperature, by 34.72g intermediates 52 (0.1mol) and 20.37g potassium phthalimides (0.11mol) one And be added in 347ml DMF, and it is stirred at room temperature 16 hours, reaction solution is in dark-brown, TLC monitoring reaction until completely, After reaction completely, reaction solution is poured into 500ml water, a large amount of solids are separated out, suction filtration, filter cake massive laundering is obtained after drying Yellow solid 38.24g (yield 92.4%), as intermediate 53.
(3) synthetic intermediate 54
41.34g intermediates 53 (0.11mol) are added in 413ml ethanol, then add 29.4g's 85% in room temperature Hydrazine hydrate (0.5mol), is warming up to back flow reaction 2 hours after adding, TLC monitoring reaction is until completely, reaction is finished, and will be reacted Liquid is down to room temperature, adds 413ml water, separates out a large amount of solids, suction filtration, then washs filter cake with massive laundering, and yellow solid is obtained after drying 27.23g (yield 91.6%), as intermediate 54.
(4) target product is synthesized
At room temperature, 29.73g intermediates 54 (0.1mol), 5.61g sodium hydroxides (0.1mol) are added to 290ml in the lump In glycol dimethyl ether, 120 DEG C are heated under stirring and is reacted 2 hours, TLC monitoring reaction is until completely, room is down to by reaction solution Temperature, add water 580ml, is extracted 200ml*3 times with dichloromethane, merges organic phase, washes 200ml*3 times, saturated common salt washing 200ml*1 times, concentrate after anhydrous sodium sulfate drying, obtain yellow oily liquid 25g；50ml ethyl acetate dissolved clarifications are added thereto Afterwards, lead to hydrogen chloride gas to pH=1~2, separate out a large amount of white solids, suction filtration elutes filter cake with a small amount of ethyl acetate, after drying White solid 26.11g (yield 85.4%) is obtained, compound 5 is produced：
1H NMR (500MHz, chloroform) δ 7.52-7.26 (s, 5H), 7.00-6.95 (s, 1H), 6.90-6.85 (s, 1H), 5.16(s,4H),3.96-3.79(s,1H),3.78-3.71(s,3H),3.20-3.06(s,2H),2.94-2.82(s,2H), (1.24-1.16 d, J=3.8Hz, 2H).
The specific embodiment of the present invention is described in detail above, but it is intended only as example, and the present invention is not limited It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and Substitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and Modification, all should be contained within the scope of the invention.

Claims (8)

1. a kind of synthetic method of 2- aminoidan derivatives, it is characterised in that its synthetic route is as follows：
Also, the synthetic method comprises the following steps：
(1) using compound A1 as initiation material, bromination reaction is carried out, intermediate A 2 is made；
(2) intermediate A 2 is reacted through drop cloth riel is made intermediate A 3；
(3) hydrazine hydrate is added into the intermediate A 3, reaction is hydrolyzed while generating hydrazone, intermediate A 4 is made；
(4) reaction is hydrolyzed in intermediate A 4, that is, target product 2- aminoidan derivatives A is made；
Wherein, R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3-C30 cycloalkyl, C2-C30 alkenyl, C3-C30 cycloalkenyl group, C2-C30 alkynyl group, C1-C30 alkoxy, C7-C30 aryl alkoxies, C6-C30 aromatic hydrocarbons Base, C4-C30 heterocyclic arene base.
2. synthetic method according to claim 1, it is characterised in that the synthetic method comprises the following steps：
(1) compound A1 is dissolved in solvent S, adds bromating agent and carry out bromination reaction, intermediate A 2 is made in post processing；
(2) intermediate A 2 and potassium phthalimide are added in DMF in the lump, at room temperature stirring reaction, post processing, Intermediate A 3 is made；
(3) intermediate A 3 is added in methanol or ethanol, then adds hydrazine hydrate, return stirring reaction is post-processed, system Obtain intermediate A 4；
(4) intermediate A 4 and highly basic are added into high boiling solvent in the lump, reaction is hydrolyzed in heating stirring, post-processed, system Obtain target product 2- aminoidan derivatives A；
Wherein, the high boiling solvent is selected from following any one or more combination：Ethylene glycol, glycol dimethyl ether, ethylene glycol Diethyl ether, diethylene glycol dimethyl ether, methyl phenyl ethers anisole, butyl ether, toluene, dimethylbenzene.
3. synthetic method according to claim 2, it is characterised in that step (1) is：
Compound A1 is dissolved in solvent S, and bromine is slowly added dropwise below 10 DEG C, drips and finishes, stirred at 20 DEG C, carry out bromination Intermediate A 2 is made in reaction, post processing；Wherein, the solvent S is selected from following any one or more combination：Ethyl acetate, two Chloromethanes, ether.
4. synthetic method according to claim 2, it is characterised in that step (2) is：
The intermediate A 2 and potassium phthalimide are added in DMF in the lump, are stirred at room temperature 2~24 hours, after Processing, is made intermediate A 3.
5. synthetic method according to claim 2, it is characterised in that step (3) is：
The intermediate A 3 is added in methanol, hydrazine hydrate is then added at room temperature, then, return stirring reaction 2~9 is small When, intermediate A 4 is made in post processing.
6. synthetic method according to claim 2, it is characterised in that step (4) is：
At room temperature, intermediate A 4 and highly basic are added into the high boiling solvent in the lump, heating stirring 0.5~4 hour, after Processing, is made target product 2- aminoidan derivatives A.
7. synthetic method according to claim 6, it is characterised in that the highly basic is selected from following any one or more group Close：Potassium hydroxide, sodium hydroxide, lithium hydroxide, calcium hydroxide.
8. the synthetic method according to any one of claim 1-7, it is characterised in that R1And R2It is each independently selected from：H, C1-C30 alkyl group, C3-C30 cycloalkyl, C1-C30 alkoxy, C7-C30 aryl alkoxies.
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