CN105879219A - Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation - Google Patents
Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation Download PDFInfo
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- CN105879219A CN105879219A CN201510069014.3A CN201510069014A CN105879219A CN 105879219 A CN105879219 A CN 105879219A CN 201510069014 A CN201510069014 A CN 201510069014A CN 105879219 A CN105879219 A CN 105879219A
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- 238000011491 transcranial magnetic stimulation Methods 0.000 title claims abstract description 22
- 239000003990 capacitor Substances 0.000 claims abstract description 18
- 238000004146 energy storage Methods 0.000 claims abstract description 15
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 11
- 229910052710 silicon Inorganic materials 0.000 claims description 11
- 239000010703 silicon Substances 0.000 claims description 11
- 238000002955 isolation Methods 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 4
- 238000010168 coupling process Methods 0.000 claims description 4
- 238000005859 coupling reaction Methods 0.000 claims description 4
- 230000000638 stimulation Effects 0.000 abstract description 12
- 238000013480 data collection Methods 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001143 conditioned effect Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000013548 repetitive transcranial magnetic stimulation Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 239000012528 membrane Substances 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
- 230000000008 neuroelectric effect Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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Abstract
The invention provides a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation. The multi-channel high-voltage pulse power generator is formed by an AC-DC module, n groups of DC-DC step-up modules (n is larger than or equal to 2), n groups of energy-storage-discharge switch modules (n is larger than or equal to 2), and a master control module. The AC-DC module converts input alternating current voltage into direct current voltage and is connected to the input end of the n groups of DC-DC step-up modules. The n groups of DC-DC step-up modules convert the direct current voltage outputted by the AC-DC module into n paths of direct current high voltage to supply power to the n energy storage capacitors in the n groups of energy-storage-discharge switch modules. Under the control of the master control module, the n groups of energy-storage-discharge switch modules discharge n externally connected stimulation coils. The master control module is connected to a computer through a data collection card interface. Under the control of the computer, the master control module controls the connection and charging voltage of the n groups of DC-DC modules, controls the n group of energy-storage-discharge switch modules to discharge the stimulation coil, and collects the temperature/voltage state of a power supply. The multi-channel high-voltage pulse power generator comprises multiple paths of charging power modules, multiple energy storage capacitors and multiple discharge switches and can be equivalent to multiple transcranial magnetic stimulation high voltage pulse power supply generators, the stimulation of multiple coils at the same time can be realized, and each coil can be stimulated separately.
Description
Technical Field
The invention belongs to the field of transcranial magnetic stimulation, and particularly relates to a high-voltage pulse power generator for transcranial magnetic stimulation.
Background
Transcranial Magnetic Stimulation (TMS) was first established by Barker et al in 1985, and an induced electric field generated by a time-varying pulsed electromagnetic field acts on the central nervous system of the brain to change the membrane potential of cerebral cortical nerve cells and influence the intracerebral metabolism and neuroelectric activity, thereby causing a series of physiological and biochemical reactions. With the development of computer technology, the repetitive transcranial magnetic stimulation (rTMS) technology has gained increasing acceptance in the fields of cognitive neuroscience, clinical neuropsychiatric diseases, and rehabilitation. Israel approved for clinical use in 2002, and the U.S. Food and Drug Administration (FDA) approved for use in anti-drug refractory depression in 2008. The approved magnetic stimulator of China's national medicine supervision instruments No. 2002 is a II type medical electronic instrument.
The transcranial magnetic stimulation equipment mainly comprises a high-voltage pulse power supply generator, a stimulation coil and a control computer. The working principle is as follows: controlling the computer to send out a charging/discharging instruction to the high-voltage pulse power generator; when in charging, the high-voltage pulse power generator charges the internal energy storage capacitor; when discharging, the energy storage capacitor discharges to the stimulating coil to generate a pulse magnetic field, which acts on the brain to generate an induction electric field.
The high-voltage pulse power generator is the core of transcranial magnetic stimulation equipment, mainly comprises a high-voltage pulse power supply, an energy storage capacitor, a silicon controlled switch and a backward diode, and has the functions of receiving a control instruction of a computer, charging the energy storage capacitor and controlling the energy storage capacitor to discharge.
The transcranial magnetic stimulation device on the market at present consists of a high-voltage pulse power generator and a stimulation coil, such as Chinese patent CN101984548A, and the device has the defect that a single device cannot stimulate multiple parts simultaneously. Chinese patent CN101234231A proposes a magnetic stimulator with multiple stimulation coils, one of the characteristics is that one device shares one high voltage power supply, one energy storage capacitor, connects multiple coils; the second characteristic is that a plurality of power supplies are connected with a plurality of capacitors, a plurality of discharge switches and a plurality of coils. This structural system is complicated and the efficiency is reduced.
Disclosure of Invention
The invention provides a multi-path high-voltage pulse power supply generator for transcranial magnetic stimulation, which integrates all circuit modules into one power supply generator from the perspective of power supply design, reduces the complexity of a TMS system, reduces the cost of the TMS system, and improves the power supply efficiency of the system.
The invention adopts the following technical scheme to realize the technical purpose:
a multi-path high-voltage pulse power generator for transcranial magnetic stimulation is composed of an AC-DC module, n groups of DC-DC boosting modules (n is more than or equal to 2), n groups of energy storage-discharge switch modules (n is more than or equal to 2) and a main control module. Wherein,
the AC-DC module converts input alternating current voltage into direct current voltage, and is characterized in that one path of alternating current input and n paths of direct current output are connected to the input ends of n groups of DC-DC boosting modules;
the DC-DC boosting module is characterized in that the DC-DC boosting module is accessed and controlled by the control module, the output voltage range is adjustable from 0V to 2000V, and the output voltage value is controlled by a DC voltage signal of 0V to 10V of the control panel;
the n groups of energy storage-discharge switch modules are characterized in that each group comprises an energy storage capacitor, a silicon controlled discharge switch and a protection diode, and the main control module controls to turn on each silicon controlled discharge switch and discharge electricity to an external stimulation coil;
the main control module comprises a data acquisition card interface, an optical coupling isolation circuit and an acquisition and control circuit. The main control module collects the temperature/voltage state of the power supply and inputs the temperature/voltage state into the computer for processing through the collection card interface.
As mentioned above, the three control signals sent by the main control module are characterized in that: the first n high/low level signals control the access of n groups of DC-DC modules; the second n paths of voltage signals with the voltage of 0-10V control the charging voltage range of n groups of DC-DC modules to be 0-2000V; and the third type outputs n paths of clock pulse signals to control silicon controlled switches in the n groups of energy storage-discharge switch modules to be switched on, and the discharge frequency can be set to be 0-100 Hz.
In the invention, the input ends of the n groups of DC-DC boosting modules are the same AC-DC module, so that the overall efficiency of the power supply is improved compared with a mode (CN101984548A) of adopting a plurality of high-voltage power supplies. According to the peak power consumption of each path of 1.5KVA, the power generator of the invention has the power consumption of more than 3KVA (n is more than or equal to 2).
The multi-channel high-voltage pulse power generator for transcranial magnetic stimulation is completely independent in the aspects of charging power, energy storage capacitor, discharge switch and stimulating coil, and can meet the requirements of magnetic stimulation treatment in various aspects. One application is that n coils correspond to n patients, and one device is used for simultaneously treating a plurality of patients. The second application is that the same patient adopts n coils to stimulate n parts simultaneously, thus expanding the application field of treatment. And the third application is that n energy storage capacitors act on the same coil, and the stimulation frequencies are superposed by changing the discharge clocks of all paths, so that the stimulation frequency of a single coil is increased.
The invention adopts a multi-path high-voltage pulse power supply generator to replace a plurality of power supplies, increases the stimulation quantity, reduces the complexity of the TMS system, reduces the cost of the TMS system and expands the types and the range of treatment.
Drawings
FIG. 1 is a block diagram of a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation;
FIG. 2a an AC-DC circuit embodiment 1 as described in FIG. 1;
FIG. 2b AC-DC circuit embodiment 2 depicted in FIG. 1;
FIG. 3 is a schematic diagram of an implementation of a DC-DC boost module circuit as described in FIG. 1;
FIG. 4 is a schematic diagram of an embodiment of an energy storage-discharge switch module shown in FIG. 1;
fig. 5 is a schematic block diagram of an implementation of the main control module shown in fig. 1.
Detailed Description
The invention is further described with reference to the following drawings and detailed description.
Fig. 1 is a block diagram of a multi-channel high-voltage pulse power generator for transcranial magnetic stimulation. The working process of the invention is as follows: the input alternating current is converted into direct current through an AC-DC module, the direct current is divided into n paths, and the n paths of direct current charge capacitors in the n groups of energy storage-discharge switch modules after passing through n groups of DC-DC boosting modules; the main control module controls whether n groups of DC-DC boosting modules are connected or not, and controls output voltage through a charging control signal of the main control module to charge the capacitor; under the control of a discharge clock sent by the computer, the controllable silicon in the n groups of energy storage-discharge switch modules is switched on, and the n energy storage capacitors are controlled to discharge to the n stimulation coils.
Fig. 2a shows an AC-DC circuit embodiment 1, in which an AC rated input of 220V is converted into a DC power of 300V by using an EMI circuit and a rectifier bridge, and the DC power is divided into n paths, and the DC-DC boost module input stage is supplied with power through switches K1, K2. The switches K1, K2. The circuit is characterized in that the output direct-current voltage has larger fluctuation along with the change of the load, and the fluctuation is between 200V and 310V, thereby increasing the difficulty for the voltage adjustment of the post-stage DC-DC boost module circuit.
Fig. 2b shows an AC-DC circuit embodiment 2, in which an AC input of 90-260V is converted into a DC power with a nominal value of 400V by using an EMI circuit, a rectifier bridge and a PFC circuit, and the DC power is divided into n paths, and the n paths are supplied to an input stage of a DC-DC boost module through switches K1, K2. AC-DC circuit embodiment 2 has a wide AC voltage input range, accommodating the mains AC voltage of major countries worldwide. The fluctuation range of the direct current output by 400V is small, and the difficulty of voltage adjustment of a post-stage DC-DC boost module circuit is reduced.
Fig. 3 is a schematic diagram of an embodiment of a DC-DC boost module circuit shown in fig. 1. The invention realizes the output of n high voltages by n groups of circuits. For one path, the input direct current voltage is converted into direct current high voltage through a full-bridge inverter circuit, a high-frequency transformer and a high-frequency rectifying circuit to charge an energy storage capacitor. Through the direct current signal of 0 ~ 10V, through the duty cycle of adjusting full-bridge inverter circuit PWM signal, realize the voltage regulation of 0 ~ 2000V corresponding to it. The implementation of the DC-DC boost module is not limited to full-bridge inversion, but can also be half-bridge or other DC-DC topologies.
Fig. 4 is a schematic diagram of an embodiment of the energy storage-discharge switch module shown in fig. 1. The invention realizes n-path energy storage-discharge switch modules by n groups of circuits. One path of the energy storage capacitor Cs, the silicon controlled discharge switch SCR and the protection diode Dp are included, each silicon controlled discharge switch is controlled to be opened by a clock pulse signal sent by the main control module, and the clock pulse signal is adjustable in 0-100 Hz.
Fig. 5 is a schematic block diagram of an implementation of the main control module shown in fig. 1. The main control module comprises a data acquisition card interface, an optical coupling isolation circuit and an acquisition and control circuit. The main control module receives computer control signals through an acquisition card interface and uploads acquisition signals of voltage and temperature; the optical coupling isolation circuit realizes the signal isolation of the computer signal and the power supply; the acquisition and control circuit conditions three control signals sent by the computer and then sends the conditioned control signals to different functional modules. The three control signals include: n high/low level signals control the access of n groups of DC-DC modules; controlling the charging voltage range of n groups of DC-DC modules to be 0-2000V by n paths of 0-10V voltage signals; and the n paths of clock pulse signals control the silicon controlled switches in the n groups of energy storage-discharge switch modules to be switched on. The acquisition and control circuit also conditions the voltage and temperature signals and transmits the conditioned voltage and temperature signals to a computer interface through an optical coupler.
Claims (3)
1. A multi-path high-voltage pulse power generator for transcranial magnetic stimulation is composed of an AC-DC module, n groups of DC-DC boosting modules (n is more than or equal to 2), n groups of energy storage-discharge switch modules (n is more than or equal to 2) and a main control module.
2. The multi-channel high voltage pulse power generator for transcranial magnetic stimulation according to claim 1, wherein the AC-DC modules are characterized by one path of alternating current input and n paths of direct current output, and are connected to input ends of n groups of DC-DC boosting modules in parallel; the N groups of DC-DC boosting modules are characterized in that the access of the DC-DC boosting modules is controlled by a control module, the output voltage range is adjustable from 0V to 2000V, and the output voltage value is controlled by a direct current voltage signal of 0V to 10V of a control panel; the n groups of energy storage-discharge switch modules are characterized in that each group of energy storage-discharge switch modules comprises an energy storage capacitor, a silicon controlled discharge switch and a protection diode, and each silicon controlled discharge switch is controlled to be opened by a clock pulse signal sent by the main control module; the main control module comprises a data acquisition card interface, an optical coupling isolation circuit and an acquisition and control circuit, and is characterized by sending three control signals and acquiring the temperature/voltage state of a power supply.
3. The main control module of claim 2, wherein the three control signals are: the first n high/low level signals control the access of n groups of DC-DC modules; the second n paths of voltage signals with the voltage of 0-10V control the charging voltage range of n groups of DC-DC modules to be 0-2000V; and the third type outputs n paths of clock pulse signals to control the silicon controlled switches in the n groups of energy storage-discharge switch modules to be switched on.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510069014.3A CN105879219A (en) | 2015-02-10 | 2015-02-10 | Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation |
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| CN201510069014.3A CN105879219A (en) | 2015-02-10 | 2015-02-10 | Multi-channel high-voltage pulse power generator for transcranial magnetic stimulation |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108055023A (en) * | 2017-12-19 | 2018-05-18 | 乐普医学电子仪器股份有限公司 | A kind of boost pulse for Implantable Pulse Generator generates and control circuit |
| CN108134517A (en) * | 2018-01-31 | 2018-06-08 | 南京溯远基因科技有限公司 | High voltage power supply and DNA sequencer |
| CN108187231A (en) * | 2018-02-02 | 2018-06-22 | 河南正痛医疗服务有限公司 | A kind of pulsed magnetic field analgesia instrument |
| CN109276814A (en) * | 2018-10-31 | 2019-01-29 | 北京大学（天津滨海）新代信息技术研究院 | Multi-channel stimulation system and method for transcranial magnetic stimulation |
| CN109471393A (en) * | 2018-11-22 | 2019-03-15 | 广州龙之杰科技有限公司 | A kind of device and method in security control magnetic field |
| CN111744116A (en) * | 2020-06-15 | 2020-10-09 | 王继珍 | Multi-dimensional variable-frequency resonance infrared physiotherapy system and control method thereof |
| WO2021082156A1 (en) * | 2018-12-26 | 2021-05-06 | 苏州景昱医疗器械有限公司 | Voltage regulator module and implantable nerve stimulation system |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
| CN112996558A (en) * | 2018-09-27 | 2021-06-18 | 约纳·佩莱德 | Method and apparatus for multi-channel simultaneous high power magnetic coil driver |
| CN113101519A (en) * | 2021-03-31 | 2021-07-13 | 深圳市倍轻松科技股份有限公司 | Massager control circuit and massager |
| CN115282488A (en) * | 2022-06-21 | 2022-11-04 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
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2015
- 2015-02-10 CN CN201510069014.3A patent/CN105879219A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108055023A (en) * | 2017-12-19 | 2018-05-18 | 乐普医学电子仪器股份有限公司 | A kind of boost pulse for Implantable Pulse Generator generates and control circuit |
| CN108134517A (en) * | 2018-01-31 | 2018-06-08 | 南京溯远基因科技有限公司 | High voltage power supply and DNA sequencer |
| CN108134517B (en) * | 2018-01-31 | 2024-10-01 | 南京溯远基因科技有限公司 | High-voltage power supply and DNA sequencer |
| CN108187231A (en) * | 2018-02-02 | 2018-06-22 | 河南正痛医疗服务有限公司 | A kind of pulsed magnetic field analgesia instrument |
| CN112996558A (en) * | 2018-09-27 | 2021-06-18 | 约纳·佩莱德 | Method and apparatus for multi-channel simultaneous high power magnetic coil driver |
| CN109276814A (en) * | 2018-10-31 | 2019-01-29 | 北京大学（天津滨海）新代信息技术研究院 | Multi-channel stimulation system and method for transcranial magnetic stimulation |
| CN109471393A (en) * | 2018-11-22 | 2019-03-15 | 广州龙之杰科技有限公司 | A kind of device and method in security control magnetic field |
| WO2021082156A1 (en) * | 2018-12-26 | 2021-05-06 | 苏州景昱医疗器械有限公司 | Voltage regulator module and implantable nerve stimulation system |
| CN111744116A (en) * | 2020-06-15 | 2020-10-09 | 王继珍 | Multi-dimensional variable-frequency resonance infrared physiotherapy system and control method thereof |
| CN112891748A (en) * | 2021-01-21 | 2021-06-04 | 武汉依瑞德医疗设备新技术有限公司 | Magnetic shock therapeutic instrument |
| CN112755395A (en) * | 2021-01-21 | 2021-05-07 | 武汉依瑞德医疗设备新技术有限公司 | True and false pulse magnetic stimulation therapeutic instrument |
| CN113101519A (en) * | 2021-03-31 | 2021-07-13 | 深圳市倍轻松科技股份有限公司 | Massager control circuit and massager |
| CN113101519B (en) * | 2021-03-31 | 2024-10-18 | 深圳市倍轻松科技股份有限公司 | Massage device control circuit and massage device |
| CN115282488A (en) * | 2022-06-21 | 2022-11-04 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
| CN115282488B (en) * | 2022-06-21 | 2023-09-12 | 中国科学院自动化研究所 | Magnetic stimulation instrument |
| WO2023245928A1 (en) * | 2022-06-21 | 2023-12-28 | 中国科学院自动化研究所 | Magnetic stimulator |
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Application publication date: 20160824 |