CN105879115A - Dental implant and surface preparation method thereof - Google Patents
Dental implant and surface preparation method thereof Download PDFInfo
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- CN105879115A CN105879115A CN201610346189.9A CN201610346189A CN105879115A CN 105879115 A CN105879115 A CN 105879115A CN 201610346189 A CN201610346189 A CN 201610346189A CN 105879115 A CN105879115 A CN 105879115A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention relates to a dental implant and a surface preparation method thereof. The dental implant is characterized by taking medical titanium or a titanium alloy as a substrate and generating a bionic polydopamine coating with strong adhesion on the surface of the substrate through in situ autopolymerization, thus obtaining a dental implant surface with excellent bioactivity. The dental implant and the surface preparation method have the beneficial effects that by closely adhering a layer of thin protein analog (polydopamine) to the surface of the implant, the hydrophilicity and corrosion resistance of the surface can be improved, adhesion, spreading and alkaline phosphatase activities of osteoblasts on the surface of the implant can be effectively reinforced, early osseointegration of the implant can be accelerated and firm bonding between materials and organism interfaces can be achieved, thus increasing the stability and success rate of the implant.
Description
Technical field
The present invention relates to dentistry implant Material Field, particularly to a kind of dentistry implant and bioactivity surface processing method thereof.
Background technology
Tooth-planting material substitutes tooth, the osseous tissue of defect and the osseous tissue of disappearance in referring to be implanted to oromaxillo-facial region tissue
The rectification of deformity, to recover physiology profile and the biomaterial of function of patient.Implantation body implants in human body, the thing of material surface
Physicochemical character and surface texture can the sticking of significant impact cell, stretch, grow, breed and the activity of cell and guiding.
Titanium or titanium alloy has good mechanical performance and certain biocompatibility makes it extensive in clinical practice, but titanium is biological
Inert material, itself does not the most possess biological function, and long service rear surface is corroded in vivo, free gold out
Genus ion can enter in tissue and make it go bad.In order to improve corrosion resistance and the biological activity of implantation body, induction and osseous tissue form life
Physical property combines, and implantation body is carried out surface modification so that its surface obtains specific physical pattern, chemical composition and bioid
Learn to modify and be proved to be a kind of further mode improving implantation body's effect.
Marine mussel can secrete the gland liquid of a kind of superstrong adhesive, and this gland liquid can be solidified into byssus gland in the seawater, and it is main
Wanting composition is mussel adhesion protein (Mussel adhensive proteins, MAPS), and MAPs is rich in substantial amounts of mussel byssus
Albumen-5 (Mytilus foot protein 5, Mfp-5), wherein Mfp-5 is considered as the key factor realizing MAPs adhesion,
The aminoacid sequence of Mfp-5 has again L-3,4 dihydroxyphenylalanine amine and the lysine residue of 30%.Both is considered to play in adhesiveness
Important effect.Dopamine (dopamine, 3,4-dihydroxy benzenes propylamine) is the catechol derivatives of L-3,4 dihydroxyphenylalanine amine, at solution
In can occur to aoxidize self-polymeric reaction, and autohemagglutination product presents superpower adhesion property.Dopamine is special bionical due to it
Performance is considered as a kind of simple and the material surface modifying method of highly versatile, i.e. in the Tris solution that pH is 8.5, adds
Dopamine hydrochloride, under conditions of oxygen, is polymerized to poly-dopamine certainly.The deposition of poly-dopamine for the surface of material, size,
Profile does not limit, and mild condition, and therefore the scope of application is the widest.The thickness of poly-dopamine film layer is typically from several nanometers to tens
Nanometer, and thickness can be controlled by changing condition.Substantial amounts of amino, hydroxyl are contained in the poly-dopamine thickness surface produced
Deng functional group, provide a good platform for follow-up twice-modified and modification.
Summary of the invention
In order to improve the biological activity of existing dental implant surface, solve the deficiency of the universal relatively low grade of modified coating bond strength, this
The purpose of invention is to provide a kind of dentistry implant and bioactivity surface processing method thereof, it is thus achieved that a kind of surface has bionical spy
Property strong coherent bio coating dentistry implant, make dental implant surface obtain more preferable hydrophilic, the ability such as protein adsorption,
Thus improve long-time stability and the success rate of dentistry implant.
The present invention provides a kind of dentistry implant, the poly-DOPA urotropinum of strong adhesion generated including titanio material and surface in situ auto polymerization thereof
Raw coating, described titanio material is medical pure titanium or titanium alloy, and described poly-dopamine bionic surface even film layer adheres to sprawl, containing ammonia
Base, hydroxy functional group, wherein carbon-nitrogen ratio is 0.1～0.2, and thickness is 10～20nm.
A kind of method preparing above-mentioned dentistry implant, it is characterised in that including:
(1) medical titanium matrix cleans: implantation body sequentially passes through acetone, dehydrated alcohol, each ultrasonic cleaning of deionized water 15 minutes,
Natural drying；And
(2) dentistry implant after step (1) being processed is immersed in 1～2mg/ml dopamine solution, dopamine autohemagglutination in situ
Close thus prepare and strong adhere to poly-dopamine bionic surface, described 1～2mg/ml dopamine solution be dissolved in 10 by dopamine hydrochloride
Preparing in mmol/L tris solution, wherein tris solution is adjusted by the hydrochloric acid solution of 1mol/L
Joint pH to 8.5, reaction temperature is room temperature, and the response time is 12～24h.
Beneficial effects of the present invention:
1. the invention provides a kind of simple process for treating surface scheme, it is not necessary to implant surface pattern was done multiprocessing, in office
What shape face all can obtain the stabilate active coating that adhesion is the strongest；
2. generating one layer of thin albumen analog (poly-dopamine) in titanium substrate surface quick in situ auto polymerization, preparation technology is simple,
And surface hydrophilicity, and the decay resistance of tooth implant can be improved, accelerate the speed of implantation body's Integrated implant in early days, real
Now make material and organism interface strong bonded, thus improve stability and the success rate of implantation body.
Accompanying drawing explanation
Fig. 1 is that in the present invention, dentistry implant bioactivity surface builds route map.
Fig. 2 is medical titanio material (a) and poly-dopamine bioactivity surface (b) atomic force microscopy in the present invention；
Fig. 3 is medical titanium base material (a) and poly-dopamine bioactivity surface (b) hydrophilic angle photo used in the present invention；
Fig. 4 is medical titanium base material (a) and the X-ray photoelectricity of poly-dopamine bioactivity surface (b) used in the present invention
Sub-power spectrum and concrete component content thereof；
Fig. 5 is the dentistry implant (b) of medical titanium base material (a) and present invention corrosion current change song during potential polarization
Line, under human-body potential, corrosion electric current density is the lowest, and corrosion resisting property is the best；
Fig. 6 is that mouse bone-forming cell MC3T3-E1 is respectively medical titanium base material (a) and poly-dopamine bioactivity surface (b)
Cultivate the cellular morphology fluorescence staining picture of 2 days, wherein blue for nucleus, green for actin, red for knob
Albumen；
Fig. 7 is at medical titanium base material (Ti) and the mouse bone-forming cell MC3T3-E1 of poly-dopamine bioactivity surface (D-Ti)
Cultivate the alkaline phosphatase activities result of 2 days.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is expanded on further.Should be understood that these embodiments be merely to illustrate the present invention and not
For limiting the scope of the present invention.In addition, it is to be understood that after having read the content that the present invention lectures, those skilled in the art can
To make various changes or modifications the present invention, these equivalent form of values fall within the application appended claims limited range equally.
Embodiment 1
A kind of dentistry implant, its surface processes by the following method:
(1) select medical pure titanium as matrix, and carry out surface clean: sequentially pass through acetone, dehydrated alcohol, deionized water each
Ultrasonic cleaning 15 minutes, natural drying；
(2) configuration dopamine auto polymerization precursor aqueous solution: deionized water is solvent, is respectively configured 10mmol/L trihydroxy methyl amino
Dichloromethane and the hydrochloric acid solution of 1mol/L, be added dropwise over hydrochloric acid solution in the tris solution configured
Until regulation pH value is 8.5；Using the TRIS buffer that obtains as solvent, the hydrochloric acid of configuration 2mg/ml is many
Bar amine aqueous solution；
(3) dentistry implant after step (1) being processed vertically is completely soaked the dopamine hydrochloride solution configured in step (2)
In, magnetic agitation solution also soaks 12 hours under logical oxygen environment, rinses the most in deionized water, natural drying,
The dentistry implant with bioactivity surface in the present invention.
Fig. 2 is medical titanio material (a) and poly-dopamine bioactivity surface (b) atomic force microscopy in the present invention.
The titanio material smooth surface of the most non-depositional coating, roughness is only 0.397nm, and deposits poly-dopamine film layer
After, its surface irregularity, present obvious granule deposition morphology, roughness is 1.565nm, the surface roughness of implantation body
It is improved；
Fig. 3 is medical titanium base material (a) and poly-dopamine bioactivity surface (b) hydrophilic angle photo used in the present invention.
The deposition of poly-dopamine film layer reduces the contact angle of implant surface and water, illustrates that surface hydrophilicity is improved；
Fig. 4 is medical titanium base material (a) and the X-ray photoelectricity of poly-dopamine bioactivity surface (b) used in the present invention
Sub-power spectrum, its concrete component content percentage ratio is listed by following table.From full spectrum it is observed that on medical titanium base material (a) spectrogram
Mainly there are Ti, O to also have the peak of C, and poly-dopamine bioactivity surface (b) is it is observed that the peak of N (1s) occurs, and
The intensity at C (1s) peak is also greatly enhanced, and carbon-nitrogen ratio is 0.103, close to the carbon-nitrogen ratio (0.125) that dopamine is theoretical, poly-DOPA is described
Amine film is at implant surface successful deposition；
Fig. 5 is dentistry implant polarization curve in 0.9wt% sodium chloride solution in pure titanium matched group and the present invention.Can be clear
Ground sees there is the widest passivation region at anode part, but in the present invention, the passive current density of dentistry implant is at whole anode
District will be less than pure titanium matched group, illustrates that composite bio-active surface improves the corrosion resistance of dentistry implant, beneficially implantation body
Long-time stability；
Fig. 6 is that mouse bone-forming cell MC3T3-E1 is respectively medical titanium base material (a) and poly-dopamine bioactivity surface (b)
Cultivating the cellular morphology fluorescence staining picture of 2 days, wherein blue is nucleus, and green is actin, red for knob
Albumen.When cell is cultivated two days later, on medical titanium base material, the cell of growth compares and sprawls but present the shape of contraction in edge
State, by contrast, has the cells show of growth on the surface of poly-dopamine film layer to go out obvious extension state, and edge is permissible
See substantial amounts of filopodia, have the expression of a small amount of vinculin simultaneously.This illustrates that poly-dopamine film layer is conducive to the adhesion of cell
With growth；
Fig. 7 is at medical titanium base material (Ti) and the mouse bone-forming cell MC3T3-E1 of poly-dopamine bioactivity surface (D-Ti)
Cultivate the alkaline phosphatase activities result of 2 days.Alkali phosphatase is the product of cell osteogenic differentiation process, is usually used in cell is described
Osteogenic activity.Through the cultivation of 2 days seen from figure, the alkaline phosphatase activities on poly-dopamine bioactive implant surface is high
In matched group, show that in the present invention, implant surface is conducive to the Osteoblast Differentiation of cell.
Embodiment 2
A kind of dentistry implant, its surface processes by the following method:
(1) select medical pure titanium as matrix, and carry out surface clean: sequentially pass through acetone, dehydrated alcohol, deionized water each
Ultrasonic cleaning 15 minutes, natural drying；
(2) configuration dopamine auto polymerization precursor aqueous solution: deionized water is solvent, is respectively configured 10mmol/L trihydroxy methyl amino
Dichloromethane and the hydrochloric acid solution of 1mol/L, be added dropwise over hydrochloric acid solution in the tris solution configured
Until regulation pH value is 8.5；Using the TRIS buffer that obtains as solvent, the hydrochloric acid of configuration 1.5mg/ml
Dopamine solution；
(3) dentistry implant after step (1) being processed vertically is completely soaked the dopamine hydrochloride solution configured in step (2)
In, magnetic agitation solution also soaks 12 hours under logical oxygen environment, rinses the most in deionized water, natural drying,
The dentistry implant with bioactivity surface in the present invention.
Embodiment 3
A kind of dentistry implant, its surface processes by the following method:
(1) select medical pure titanium as matrix, and carry out surface clean: sequentially pass through acetone, dehydrated alcohol, deionized water each
Ultrasonic cleaning 15 minutes, natural drying；
(2) configuration dopamine auto polymerization precursor aqueous solution: deionized water is solvent, is respectively configured 10mmol/L trihydroxy methyl amino
Dichloromethane and the hydrochloric acid solution of 1mol/L, be added dropwise over hydrochloric acid solution in the tris solution configured
Until regulation pH value is 8.5；Using the TRIS buffer that obtains as solvent, the hydrochloric acid of configuration 1.5mg/ml
Dopamine solution；
(3) dentistry implant after step (1) being processed vertically is completely soaked the dopamine hydrochloride solution configured in step (2)
In, magnetic agitation solution also soaks 18 hours under logical oxygen environment, rinses the most in deionized water, natural drying,
The dentistry implant with bioactivity surface in the present invention.
Embodiment 4
A kind of dentistry implant, its surface processes by the following method:
(1) select medical pure titanium as matrix, and carry out surface clean: sequentially pass through acetone, dehydrated alcohol, deionized water each
Ultrasonic cleaning 15 minutes, natural drying；
(2) configuration dopamine auto polymerization precursor aqueous solution: deionized water is solvent, is respectively configured 10mmol/L trihydroxy methyl amino
Dichloromethane and the hydrochloric acid solution of 1mol/L, be added dropwise over hydrochloric acid solution in the tris solution configured
Until regulation pH value is 8.5；Using the TRIS buffer that obtains as solvent, the hydrochloric acid of configuration 2mg/ml is many
Bar amine aqueous solution；
(3) dentistry implant after step (1) being processed vertically is completely soaked the dopamine hydrochloride solution configured in step (2)
In, magnetic agitation solution also soaks 24 hours under logical oxygen environment, rinses the most in deionized water, natural drying,
The dentistry implant with bioactivity surface in the present invention.
Claims (2)
1. a dentistry implant, it is characterized in that: described dentistry implant includes the poly-dopamine bionic coating of strong adhesion that titanio material and surface in situ auto polymerization thereof generate, described titanio material is medical pure titanium or titanium alloy, described poly-dopamine bionic surface even film layer adheres to sprawl, containing amino, hydroxy functional group, wherein carbon-nitrogen ratio is 0.1 ~ 0.2, and thickness is 10 ~ 20 nm.
2. the surface preparation method of the dentistry implant prepared described in claim 1, it is characterised in that including:
(1) medical titanium matrix cleans: implantation body sequentially passes through acetone, dehydrated alcohol, each ultrasonic cleaning of deionized water 15 minutes, natural drying；And
(2) dentistry implant after step (1) being processed is immersed in 1 ~ 2 mg/ml dopamine solution, dopamine in situ auto polymerization thus prepare and strong adhere to poly-dopamine bionic surface, described 1 ~ 2 mg/ml dopamine solution is dissolved in 10 mmol/L tris solutions by dopamine hydrochloride and prepares, wherein tris solution is regulated pH to 8.5 by the hydrochloric acid solution of 1 mol/L, reaction temperature is room temperature, and the response time is 12 ~ 24 h.
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| CN201610346189.9A CN105879115A (en) | 2016-05-23 | 2016-05-23 | Dental implant and surface preparation method thereof |
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| CN201610346189.9A CN105879115A (en) | 2016-05-23 | 2016-05-23 | Dental implant and surface preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821522A (en) * | 2016-12-30 | 2017-06-13 | 江阴金泰克生物技术有限公司 | It is a kind of to rapidly promote the tooth implant processing method that tooth implant is combined with alveolar bone |
| CN108853604A (en) * | 2018-06-06 | 2018-11-23 | 湖北大学 | A method of quickly eliminating bone implant surface bacteria biomembrane using near-infrared |
| CN110117463A (en) * | 2019-05-07 | 2019-08-13 | 中南大学 | Medical composite material and preparation method thereof |
| CN111839768A (en) * | 2020-07-28 | 2020-10-30 | 中日友好医院(中日友好临床医学研究所) | Zinc-modified implant and preparation method thereof |
| CN113368301A (en) * | 2021-05-28 | 2021-09-10 | 吉林大学 | Pure titanium product with DOPA-IGF1 surface coating and preparation method and application thereof |
| CN114306757A (en) * | 2022-01-04 | 2022-04-12 | 中山大学附属口腔医院 | Wet bonding barrier film and preparation method and application thereof |
| CN114344562A (en) * | 2022-01-13 | 2022-04-15 | 吉林大学第一医院 | Method for improving bioactivity of bone-like trabecular-structure titanium alloy stent and application |
| CN114504685A (en) * | 2022-02-14 | 2022-05-17 | 无锡领缔生物科技有限公司 | Guide film and preparation method thereof |
| CN115212355A (en) * | 2022-07-25 | 2022-10-21 | 西南大学 | Photo-thermal photodynamic synergistic low-temperature antibacterial dental implant material with infrared-visible light |
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| CN104141124A (en) * | 2014-06-17 | 2014-11-12 | 天津大学 | Method for improving biological activity of pure titanium surface by using dopamine to be bonded with graphene oxide |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106821522A (en) * | 2016-12-30 | 2017-06-13 | 江阴金泰克生物技术有限公司 | It is a kind of to rapidly promote the tooth implant processing method that tooth implant is combined with alveolar bone |
| CN108853604A (en) * | 2018-06-06 | 2018-11-23 | 湖北大学 | A method of quickly eliminating bone implant surface bacteria biomembrane using near-infrared |
| CN108853604B (en) * | 2018-06-06 | 2020-11-27 | 湖北大学 | Method for rapidly eliminating bacterial biofilm on surface of bone implant by utilizing near infrared |
| CN110117463A (en) * | 2019-05-07 | 2019-08-13 | 中南大学 | Medical composite material and preparation method thereof |
| CN111839768A (en) * | 2020-07-28 | 2020-10-30 | 中日友好医院(中日友好临床医学研究所) | Zinc-modified implant and preparation method thereof |
| CN113368301A (en) * | 2021-05-28 | 2021-09-10 | 吉林大学 | Pure titanium product with DOPA-IGF1 surface coating and preparation method and application thereof |
| CN114306757A (en) * | 2022-01-04 | 2022-04-12 | 中山大学附属口腔医院 | Wet bonding barrier film and preparation method and application thereof |
| CN114344562A (en) * | 2022-01-13 | 2022-04-15 | 吉林大学第一医院 | Method for improving bioactivity of bone-like trabecular-structure titanium alloy stent and application |
| CN114504685A (en) * | 2022-02-14 | 2022-05-17 | 无锡领缔生物科技有限公司 | Guide film and preparation method thereof |
| CN115212355A (en) * | 2022-07-25 | 2022-10-21 | 西南大学 | Photo-thermal photodynamic synergistic low-temperature antibacterial dental implant material with infrared-visible light |
| CN115212355B (en) * | 2022-07-25 | 2023-06-09 | 西南大学 | Photo-thermal-photo-dynamic synergistic low-temperature antibacterial dental implant material with infrared-visible light |
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Application publication date: 20160824 |