CN105877871A - Pituitary adenoma operation patch and producing method thereof - Google Patents
Pituitary adenoma operation patch and producing method thereof Download PDFInfo
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- CN105877871A CN105877871A CN201610421991.XA CN201610421991A CN105877871A CN 105877871 A CN105877871 A CN 105877871A CN 201610421991 A CN201610421991 A CN 201610421991A CN 105877871 A CN105877871 A CN 105877871A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
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- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
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- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
Abstract
The invention relates to a pituitary adenoma operation patch and a producing method thereof. The patch is filled at a skull base bone defect opening of pituitary adenoma operation, and the edge shape of the patch is matched with the edge shape of the bone defect opening; the patch is a piece made of a PCL-TCP material. The producing method of the patch comprises the following steps: performing data processing by virtue of computer image processing and three-dimensional substantive design software, and performing 3D printing to produce the patch. The pituitary adenoma operation patch has the beneficial effects that the advantages of a computer image processing technique is utilized, the pituitary adenoma operation patch is produced by combining the novel material PCL-TCP with the 3D printing technique, and then the bone defect is repaired. The pituitary adenoma operation patch is high in producing speed, high in structural property, excellent in biological property, high in precision and high in repair tightness, the surgery cost can be reduced, the operation time is shortened, the postoperative complications are reduced, the operative wound is alleviated, postoperative recovery is promoted, and the benefits of patients are maintained.
Description
Technical field
The invention belongs to neurosurgery equipment, particularly relate to a kind of Pituitaryadenoma operation sticking patch and manufacture method.
Background technology
Pituitary tumor is intracranial kinds of tumor, and intracranial sickness rate occupies the 3rd, accounts for the 10% of intracranial tumor, be one group from antepituitary and posterior lobe and the cytogenetic tumor of craniopharyhgeal canal epithelial rest.Pituitary tumor brings huge health hazard, stress, material consumption to patient and family.Some pituitary tumors are as without system diagnosis and treatment simultaneously, and the life span of patient can be greatly lowered, and what present clinical practice was most is scope per nasal-transsphenoidal pituitary tumor excision.The approach of operation is to enter sphenoid sinus through nostril, opens at the bottom of saddle, tumor resection；During opening at the bottom of saddle, Cranial defect can be caused to destroy.The opening produced due to Cranial defect destroys original hone lamella, it is likely to result in the seepage of cerebrospinal fluid, the phenomenon of cerebrospinal leak once occurs, be equivalent to the definitely clean region of intracranial and extraneous UNICOM, being easy to infection intracranial occur, the infection of intracranial is difficult to control to, and case fatality rate is high, consequence is serious, it is necessary to repair Cranial defect opening.Present operative repair method is typically to select bone cement shaped by hand to prune, and makes sticking patch, fills up at Cranial defect opening part；The flakelet of the most useful titanium alloy, makes sticking patch by manual pruning.Above traditional mode shortcoming is moulding not accurate, and model pattern is coarse, and generally requires pruning repeatedly and attempt, and extends operating time, adds the risk of operation.And the sticking patch profile of hammer-shears well cannot be agreed with Cranial defect opening, repair efficiency can not be guaranteed, sometimes also need to patient from stringing membrane tissue for repairing, add unnecessary operation wound.And the bone cement material that to be price high, the price of a bottle bone cement reaches about 30,000 yuan, and titanium alloy is also valuable metal material, cuts out the waste [t1] unavoidably occurring material in manufacturing process.Occur in that a kind of new material PCL-TCP at present, Chinese is polycaprolactone-tricalcium phosphate, PCL-TCP is the material in a kind of human implantable body, biological congruence is high, tissue intensity is high, and can promote that scar tissue generates, can degrade voluntarily the times of about 2 years, human body will not be remained and poison.PCL-TCP is by FDA(food and drug administration) approval use.PCL-TCP has good cost performance, and price is about every hectogram about 2000 yuan.Meanwhile, PCL-TCP can use 3D printing technique to shape.
Summary of the invention
The purpose of the present invention is to propose to a kind of Pituitaryadenoma operation sticking patch and the technical scheme of manufacture method, improve the repair efficiency of Cranial defect, shorten operating time, reduce and repair cost.
To achieve these goals, the technical scheme is that a kind of Pituitaryadenoma operation sticking patch, fill up the Cranial defect opening part in Pituitaryadenoma operation, the edge shape of described sticking patch coincide with the edge shape of described Cranial defect opening；Described sticking patch is the lamellar body of PCL-TCP material, and described sticking patch is to print, by 3D, the sticking patch made；It is provided with lever in the front of sticking patch.
Further, the sheet body thickness of described sticking patch is 0.8mm～2.0mm.
Further, in order to obtain good edge repair effect, described sticking patch is the wedge shape sticking patch that edge is provided with gradient.
Further, in order to obtain good edge repair effect, it is provided with the outer hiding described Cranial defect opening at the edge at the described sticking patch back side.
Further, for Appropriate application material, the front of described sticking patch is provided with groove and reinforcement, and the thickness of described patch structure thinnest part is not less than 0.3mm.
Further, the front of described sticking patch is provided with groove, is provided with cellular enhancement Layer in described groove, and the thickness of described patch structure thinnest part is not less than 0.2mm.
A kind of Pituitaryadenoma operation sticking patch manufacture method, for making the sticking patch filling up the Cranial defect opening part in Pituitaryadenoma operation, the edge shape of described sticking patch coincide with the edge shape of described Cranial defect opening；It is characterized in that, described method comprises the steps:
A. obtained the image of the described Cranial defect opening part with scale by surgical endoscope equipment, and be stored as by the operative image of computer disposal；
B. the described operative image that computer graphical processing software processes is obtained is used by step a, generate the opening contours figure of described Cranial defect opening shape, described opening contours figure is the planar graph only comprising background color and foreground color, and described opening contours figure includes the opening contours region representing described Cranial defect opening contours and the scale region representing described length of the scale；
C. the described opening contours figure using software processing to be obtained by step b, generates and records described Cranial defect opening contours and the vector graphics of length of the scale；
D. the described vector graphics generated step c zooms in and out process, and the length of the scale making described vector graphics is equal with the physical length of described scale；
E. using Computerized three-dimensional entity design software, the described vector graphics processed with the step d edge as sticking patch, generate the entity object of sticking patch, described sticking patch entity object is the entity object that sticking patch front is provided with lever；
F. the material object of sticking patch described in 3D printer printout is used.
Further:
The operative image obtained by step a is coloured image, and described scale is the rule that length is not more than described opening contours, and the length that scale shows is not less than 10mm；
The described opening contours figure generated by step b is black white image, described foreground color is black, described background color is white, and the image in described opening contours region and described scale region is foreground color, and the color of image beyond opening contours region and scale region is background color；
The vector graphics generated by step c includes the SPL representing described opening contours and straight line or the SPL representing described scale pattern edge；
Computerized three-dimensional entity design software is used to carry out described scaling process in step d；
The described sticking patch entity object generated in step e is the wedge shape sticking patch that edge is provided with gradient, and the edge of described sticking patch entity object is shunk to the inner side in front by the back side；
The edge at the described sticking patch entity object back side generated in step e also/or be provided with the outer hiding described Cranial defect opening,
Using the material object of sticking patch described in the 3D printer printout of melting fused deposition rapid moulding technology in step f, the printing material of described 3D printer is PCL-TCP.
Further, the front of the described sticking patch entity object generated in step e is provided with the entity object of groove and reinforcement.
Further, the front of the described sticking patch entity object generated in step e is provided with groove, is provided with the enhancement Layer of alveolate texture in described groove.
The invention has the beneficial effects as follows: utilize the advantage of computer image processing technology, use new material PCL-TCP to combine 3D printing technique and manufacture Pituitaryadenoma operation sticking patch, repair Cranial defect.It is fast that speed manufactured by sticking patch, and structural good, biological property is excellent, and precision is high, and repairing tightness is good, also can reduce surgery cost, shortens operating time, reduces post-operative complication, alleviates operation wound, promotes post-operative recovery, safeguards patients ' interest.
With embodiment, the present invention is described in detail below in conjunction with the accompanying drawings.
Accompanying drawing explanation
Fig. 1 is the structure chart of sticking patch of the present invention, is provided with groove and reinforcement in front；
Fig. 2 is the A-A sectional view of Fig. 1；
Fig. 3 is the structure chart of sticking patch of the present invention, is provided with the enhancement Layer of groove and alveolate texture in front；
Fig. 4 is the B-B sectional view of Fig. 3；
Fig. 5 is hypophysis cerebri schematic illustration of tissue；
Fig. 6 is the striograph of the Cranial defect opening part with scale；
Fig. 7 is the opening contours figure that the present invention obtains after computer processes, including the figure in the scale region in the opening contours region and expression length of the scale representing Cranial defect opening contours；
Fig. 8 is that the present invention uses Photoshop software, uses " Magnetic Lasso Tool " to delineate the computer operation screenshot capture of opening contours；
Fig. 9 is the computer operation screenshot capture that the present invention uses Photoshop Software Create opening contours figure；
Figure 10 is that the present invention uses Photoshop software, uses rectangular marquee to select the computer operation screenshot capture in scale region；
Figure 11 is that the present invention uses Photoshop software, generates the computer operation screenshot capture of " profile diagram "；
Figure 12 is that the present invention opens Solidworks software, selects the computer operation screenshot capture of " plug-in unit "；
Figure 13 is Solidworks software, chooses the computer operation screenshot capture of " Autotrace " option in " plug-in unit "；
Figure 14 is that the present invention uses Solidworks software, carries out " Element Design ", sets up the computer operation screenshot capture of sketch；
Figure 15 is that the present invention uses Solidworks software, opens the computer operation screenshot capture of " sketch picture "；
Figure 16 is that the present invention uses Solidworks software, uses " sketch picture " instrument, generates the computer operation screenshot capture of the SPL of opening contours；
Figure 17 is that the present invention uses Solidworks software, uses " sketch picture " instrument, generates the computer operation screenshot capture of the SPL in scale region；
Figure 18 is that the present invention uses Solidworks software, uses " smart dimensions " instrument, the computer operation screenshot capture of surveyors' staff zone length；
Figure 19 is that the present invention uses Solidworks software, uses " scaling " instrument, adjusts the computer operation screenshot capture of the batten trisquare cun of opening contours；
Figure 20 is that the present invention uses Solidworks software, uses " scaling " instrument, makes the computer operation screenshot capture that the SPL of opening contours is equal with actual size；
Figure 21 is that the present invention uses Solidworks software, and opening contours sketch (i.e. " sketch 1 ") carries out the computer operation screenshot capture that " flange stretch " generates the lamellar body of sticking patch；
Figure 22 is that the present invention uses Solidworks software, generates the computer operation screenshot capture of the sketch at sticking patch edge；
Figure 23 is that the present invention uses Solidworks software, uses " flange stretch " instrument to generate the computer operation screenshot capture at sticking patch edge.
Detailed description of the invention
As shown in Figure 1, Figure 2, Fig. 3, Fig. 4, a kind of Pituitaryadenoma operation sticking patch, fill up at the Cranial defect opening 1 of Pituitaryadenoma operation, edge 2 shape of described sticking patch is coincide with edge 3 shape of described Cranial defect opening；Described sticking patch is the lamellar body of PCL-TCP material, and described sticking patch is to print, by 3D, the sticking patch made；It is provided with lever 4 in the front of sticking patch.The front of sticking patch is the one side towards sphenoid sinus chamber (with reference in Fig. 5 11), and the back side of sticking patch is the one side towards hypophysial fossa (with reference in Fig. 5 12).The front of sticking patch is towards the side of operation technique.
The sheet body thickness of described sticking patch is 0.8mm～2.0mm.
Described sticking patch is the wedge shape sticking patch that edge is provided with gradient K.Described sticking patch edge is shunk to the inner side in front by the back side；
The outer 5 hiding described Cranial defect opening it is provided with at the edge at the described sticking patch back side.
As shown in Figure 1 and Figure 2, the front of described sticking patch is provided with groove 7 and reinforcement 8, and the thickness S of described patch structure thinnest part is not less than 0.3mm.
The front of sticking patch can also use structure as shown in Figure 3, Figure 4, the front of described sticking patch to be provided with groove 7, is provided with cellular enhancement Layer 6 in described groove, and the thickness S of described patch structure thinnest part is not less than 0.2mm.
A kind of Pituitaryadenoma operation sticking patch manufacture method, for making the sticking patch filling up the Cranial defect opening part in Pituitaryadenoma operation, the edge shape of described sticking patch coincide with the edge shape of described Cranial defect opening；It is characterized in that, described method comprises the steps:
The image of described Cranial defect opening part a. by the acquisition of surgical endoscope equipment with scale 9(as shown in Figure 6), and be stored as by the operative image of computer disposal；Described being referred to by the operative image of computer disposal can be by the computer documents of computer graphical processing software processes, such as JPGE formatted file；
B. the described operative image that computer graphical processing software processes is obtained is used by step a, generate the opening contours figure of described Cranial defect opening shape, described opening contours figure is the planar graph only comprising background color and foreground color, described opening contours figure includes the opening contours region representing described Cranial defect opening contours and the scale region representing described length of the scale, as shown in Figure 7；
C. the described opening contours figure using software processing to be obtained by step b, generates and records described Cranial defect opening contours and the vector graphics of length of the scale；
D. the described vector graphics generated step c zooms in and out process, and the size making described vector graphics is equal with described scale；
E. using Computerized three-dimensional entity design software, the described vector graphics processed with the step d edge as sticking patch, generate the entity object of sticking patch, described sticking patch entity object is the entity object that sticking patch front is provided with lever；
F. the material object of sticking patch described in 3D printer printout is used.
The operative image obtained by step a is coloured image, and described scale is the rule that length is not more than described opening contours, and the length that scale shows is not less than 10mm；
The described opening contours figure generated by step b is black white image, described foreground color is black, described background color is white, and the image in described opening contours region and described scale region is foreground color, and the color of image beyond opening contours region and scale region is background color；
The vector graphics generated by step c includes the SPL representing described opening contours and straight line or the SPL representing described scale pattern edge；
Computerized three-dimensional entity design software is used to carry out described scaling process in step d；
The described sticking patch entity object generated in step e is the wedge shape sticking patch that edge is provided with gradient, and the edge of described sticking patch entity object is shunk to the inner side in front by the back side；
The edge at the described sticking patch entity object back side generated in step e also/or be provided with the outer hiding described Cranial defect opening,
Using the material object of sticking patch described in the 3D printer printout of melting fused deposition rapid moulding technology in step f, the printing material of described 3D printer is PCL-TCP.
The Chinese of PCL-TCP is polycaprolactone-tricalcium phosphate, and PCL-TCP is the material in a kind of human implantable body.
The front of the described sticking patch entity object generated in step e is provided with the entity object of groove and reinforcement.
Can also use another kind of structure, the front of the described sticking patch entity object generated in step e is provided with groove, is provided with the enhancement Layer of alveolate texture in described groove.
Embodiment one:
As shown in Figure 1, Figure 2, Fig. 5, Fig. 6, a kind of Pituitaryadenoma operation sticking patch, fill up at the Cranial defect opening 1 of Pituitaryadenoma operation.As shown in Figure 6, Cranial defect opening is that a length is about 15mm, width is about the irregularly shaped of 8mm.
Edge 2 shape of sticking patch is to be formed according to after the image procossing of picked-up in operation, coincide with the shape height at the edge 3 of described Cranial defect opening.
The front of sticking patch is the one side towards sphenoid sinus chamber, and the back side of sticking patch is the one side towards hypophysial fossa.The front of sticking patch, towards the side of operation technique, is provided with lever 4 in the front of sticking patch.
Sticking patch is the wedge shape sticking patch that edge is provided with gradient K, and the gradient at edge is inwardly rolled by the back side tiltedly.Generally use the gradient that K is not more than 10 °, gradient K=5 ° at the edge of the present embodiment.
Be additionally provided with at the edge at the sticking patch back side hide Cranial defect opening outer 5, the thickness B1=0.3mm of outer, outer stretch out width C=1.0mm.Sticking patch is made to have good repairing tightness.
The sheet body thickness of sticking patch is B=1.3mm.
In order to keep the structural strength of sticking patch and save patching material, the front of sticking patch is provided with groove 7 and reinforcement 8, the height B2=0.5mm of reinforcement；The thinnest part of patch structure is the thickness of reinforcement, its thickness S=0.3mm.
Lever is arranged on reinforcement, is connected with reinforcement, can save the material needed for lever, and can reduce stretching out highly of lever.
Sticking patch is the lamellar body of PCL-TCP material, and sticking patch is to be printed by 3D to make.
The structure cumulative volume of the sticking patch of the present embodiment is 64.3 cubic millimeters.
The Pituitaryadenoma operation sticking patch of the present embodiment uses new material PCL-TCP to combine 3D printing technique and manufactures Pituitaryadenoma operation sticking patch, repairs Cranial defect opening.It is fast that speed manufactured by sticking patch, structural good, and precision is high, and repairing tightness is good, also can reduce surgery cost, safeguard patients ' interest.
Sticking patch sheet body thickness B according to operation in Cranial defect open state determine.The minimal structure wall thickness of sticking patch is the material according to sticking patch and 3D print characteristic and Degradation determines, according to surgical experience and gross data, minimal structure wall thickness preferably selects at 0.2mm～0.3mm.Generally should try one's best the minimal structure wall thickness of selection of small.
Embodiment two:
Such as Fig. 3, Fig. 4, a kind of Pituitaryadenoma operation sticking patch, the present embodiment is that a kind of structure of the Pituitaryadenoma operation sticking patch of embodiment one is improved.
Be provided with at the edge at the sticking patch back side hide Cranial defect opening outer 5, the thickness B1=0.2mm of outer, outer stretch out width C=1.0mm.
The sheet body thickness of sticking patch is B=1.2mm.
The front of sticking patch is provided with groove 7, is provided with cellular enhancement Layer 6 in groove, the wall thickness S=0.2mm of cellular enhancement Layer.The height B3=0.2mm of cellular enhancement Layer.
Patch structure thinnest part is the thickness B1 and the wall thickness S of cellular enhancement Layer of outer, and thickness is 0.2mm.
Lever is arranged on cellular enhancement Layer, is connected with cellular enhancement Layer.
The structure cumulative volume of the sticking patch of the present embodiment is 52.2 cubic millimeters.Patching material is saved further while meeting Structural strength calls.
Embodiment three:
A kind of Pituitaryadenoma operation sticking patch manufacture method, for making the sticking patch filling up the Cranial defect opening part in Pituitaryadenoma operation.As shown in Figure 6, Cranial defect opening is that a length is about 15mm, width is about the irregularly shaped of 8mm.
The manufacture method of opening sticking patch comprises the steps:
A. obtained the image of the described Cranial defect opening part with scale 9 by surgical endoscope equipment, as shown in Figure 6, and be stored as by the operative image of computer disposal；Pituitaryadenoma operation is carried out by surgical endoscope equipment, and surgical endoscope equipment is provided with the photographic head observing surgery situation, and operative image is to be obtained by the photographic head shooting of surgical endoscope equipment when operation is carried out；The rule that scale uses a segment length to be L=10mm, in order to not affect the clear of Cranial defect opening part image, rule is placed on outside opening contours；Operative image is coloured image, in order to accurately demonstrate the shape of Cranial defect opening, and operative image saves as the computer graphics metafile of JPGE form, file entitled " operative image ".
B. the described operative image that computer graphical processing software processes is obtained is used by step a, generate the opening contours figure of Cranial defect opening shape, as shown in Figure 7, described opening contours figure is the planar graph only comprising background color and foreground color, and described opening contours figure clearly represents described Cranial defect opening contours and described length of the scale.Method particularly includes:
Such as Fig. 8, use Adobe
Photoshop CS software.
Open " operative image " file.
" Magnetic Lasso Tool " is used to delineate opening contours；Delineate the human users that opening contours needs to have medical speciality technological know-how, to ensure that the profile delineated matches with actual aperture profile；
Upset foreground and background colour arrange, make foreground be white, background colour be black；
" deleting " image in opening contours, making the figure color in opening contours is background colour (black)；
" copy " opening contours；
Such as Fig. 9, new files, paste the opening contours of copy；Save as the JPGE formatted file of file entitled " profile diagram "；
Such as Figure 10, return to " operative image " file, use rectangular marquee to select scale region, be that the length in scale region is equal with the 10mm length that scale identifies；
Deleting the image in scale region, making the figure color in holding region is background colour (black)；
As Figure 11 " copies " scale region；" stick " in " profile diagram " file；
Upset foreground and background colour are normally to arrange, i.e. foreground is that black, background colour are for white；
Preserve " profile diagram " file.
C. the described opening contours figure using software processing to be obtained by step b, generates and records described Cranial defect opening contours and the vector graphics of length of the scale.Method particularly includes:
Such as Figure 12, Figure 13, open entity design software Solid works(2014), determine that " Autotrace " item in [instrument] [plug-in unit] is checked.
Such as Figure 14, select [newly-built] [part] operation, create a new file.
Selection reference face (above regards datum level), and " sketch 1 " object occurs in [skeletonizing].
Such as Figure 15, select [instrument] [sketch instrument] [sketch picture], open Cranial defect opening shape image file " profile diagram " with scale, under " sketch 1 " object, " sketch picture 1 " occurs.
Such as Figure 16, select [follow the tracks of and set] [select tool] [being used for getting colors], choose the color (black) in opening contours region.
Select [starting to follow the tracks of], generate the SPL of opening contours.
Select [follow the tracks of and set] [select tool] [being used for getting colors], choose the color (black) in scale region.
Select [starting to follow the tracks of], generate the SPL in scale region, such as Figure 17.
Delete " sketch picture 1 ".
D. the vector graphics generated step c zooms in and out process, and the size making vector graphics is equal with scale, even if the actual size of vectogram is equal with the Cranial defect opening size in operation.Method particularly includes:
Such as Figure 18, in the Sketching interface in Solidworks software, use the SPL length in [smart dimensions] surveyors' staff region；The a length of 290mm of measurement of the present embodiment.
Such as Figure 19, Figure 20, measure the ratio of length according to SPL length and reality；Selecting [sketch instrument] [scaling], input ratio " 10/290 ", the SPL making opening contours is equal with actual size.
Delete the SPL in scale region.
E. the described vector graphics using Computerized three-dimensional entity design software processes to be processed by step d, generates the entity object of sticking patch.Method particularly includes:
Such as Figure 21, in Solidworks software, using opening contours sketch, i.e. " sketch 1 ", select [flange stretch], sets stretching depth as 1mm, drafting angle is 5 °, the lamellar body of generation sticking patch.
Such as Figure 22, select the back side of sticking patch lamellar body, i.e. face on the basis of the plane at " sketch 1 " place, generate " sketch 2 ", in " sketch 2 ", the outer dead centre along " sketch 1 " opening contours SPL draws the SPL of a circulation closed, with this SPL outwards " equidistant entity ", generate the closing SPL of an outward expansion 1mm, then delete the SPL of inside.
Such as Figure 23, exiting the editor of " sketch 2 ", to " sketch 2 " [flange stretch] 0.3mm, direction is the opposite direction of " sketch 1 " draw direction, generates the outer of sticking patch；Now the thickness of the lamellar body of sticking patch is 1.3mm, and the stretching end face (being i.e. provided with the side of outer) of corresponding " sketch 2 " is the back side of sticking patch, and the stretching end face (side of i.e. corresponding opening contours) of corresponding " sketch 1 " is the front of sticking patch.
In order to save the material consumption of sticking patch, optimize the structure of sticking patch, make groove 7 and reinforcement 8, as shown in Figure 1, Figure 2, the height B2=0.5mm of reinforcement, thickness S=0.3mm in the front of sticking patch.The position being positioned at sticking patch central authorities on reinforcement makes a lever, is connected with reinforcement.Produce a Pituitaryadenoma operation sticking patch as described in embodiment one.
The entity design function using Solidworks software can be readily achieved aforesaid operations, the most no longer illustrates.
If desired for saving material further, " sketch 2 " [flange stretch] 0.2mm can be made groove 7 and cellular enhancement Layer 6, such as Fig. 3, Fig. 4, the wall thickness S=0.2mm of cellular enhancement Layer in the front of sticking patch；The height B3=0.2mm of cellular enhancement Layer.The position being positioned at sticking patch central authorities on cellular enhancement Layer makes a lever, and lever is connected with cellular enhancement Layer.Complete a Pituitaryadenoma operation sticking patch as described in embodiment two.
F. the material object of sticking patch described in 3D printer printout is used.The material object of sticking patch described in the 3D printer printout of the present embodiment employing melting fused deposition rapid moulding technology, the printing material of 3D printer is PCL-TCP.
The method of the present embodiment makes full use of the advantage of computer image processing technology, uses new material PCL-TCP to combine 3D printing technique and manufactures Pituitaryadenoma operation sticking patch, repairs Cranial defect.It is fast that speed manufactured by sticking patch, and structural good, biological property is excellent, and precision is high, and repairing tightness is good, also can reduce surgery cost, shortens operating time, reduces post-operative complication, alleviates operation wound, promotes post-operative recovery, safeguards patients ' interest.
Claims (10)
1. a Pituitaryadenoma operation sticking patch, fills up the Cranial defect opening part in Pituitaryadenoma operation, and the edge shape of described sticking patch coincide with the edge shape of described Cranial defect opening；It is characterized in that, described sticking patch is the lamellar body of PCL-TCP material, and described sticking patch is to print, by 3D, the sticking patch made；It is provided with lever in the front of sticking patch.
A kind of Pituitaryadenoma operation sticking patch the most according to claim 1, it is characterised in that the sheet body thickness of described sticking patch is 0.8mm～2.0mm.
A kind of Pituitaryadenoma operation sticking patch the most according to claim 1, it is characterised in that described sticking patch is the wedge shape sticking patch that edge is provided with gradient.
A kind of Pituitaryadenoma operation sticking patch the most according to claim 1, it is characterised in that be provided with the outer hiding described Cranial defect opening at the edge at the described sticking patch back side.
A kind of Pituitaryadenoma operation sticking patch the most according to claim 1, it is characterised in that the front of described sticking patch is provided with groove and reinforcement, and the thickness of described patch structure thinnest part is not less than 0.3mm.
A kind of Pituitaryadenoma operation sticking patch the most according to claim 1, it is characterised in that the front of described sticking patch is provided with groove, is provided with cellular enhancement Layer in described groove, and the thickness of described patch structure thinnest part is not less than 0.2mm.
7. a Pituitaryadenoma operation sticking patch manufacture method, for making the sticking patch filling up the Cranial defect opening part in Pituitaryadenoma operation, the edge shape of described sticking patch coincide with the edge shape of described Cranial defect opening；It is characterized in that, described method comprises the steps:
A. obtained the image of the described Cranial defect opening part with scale by surgical endoscope equipment, and be stored as by the operative image of computer disposal；
B. the described operative image that computer graphical processing software processes is obtained is used by step a, generate the opening contours figure of described Cranial defect opening shape, described opening contours figure is the planar graph only comprising background color and foreground color, and described opening contours figure includes the opening contours region representing described Cranial defect opening contours and the scale region representing described length of the scale；
C. the described opening contours figure using software processing to be obtained by step b, generates and records described Cranial defect opening contours and the vector graphics of length of the scale；
D. the described vector graphics generated step c zooms in and out process, and the length of the scale making described vector graphics is equal with the physical length of described scale；
E. using Computerized three-dimensional entity design software, the described vector graphics processed with the step d edge as sticking patch, generate the entity object of sticking patch, described sticking patch entity object is the entity object that sticking patch front is provided with lever；
F. the material object of sticking patch described in 3D printer printout is used.
A kind of Pituitaryadenoma operation sticking patch manufacture method the most according to claim 7, it is characterised in that:
The operative image obtained by step a is coloured image, and described scale is the rule that length is not more than described opening contours, and the length that scale shows is not less than 10mm；
The described opening contours figure generated by step b is black white image, described foreground color is black, described background color is white, and the image in described opening contours region and described scale region is foreground color, and the color of image beyond opening contours region and scale region is background color；
The vector graphics generated by step c includes the SPL representing described opening contours and straight line or the SPL representing described scale pattern edge；
Computerized three-dimensional entity design software is used to carry out described scaling process in step d；
The described sticking patch entity object generated in step e is the wedge shape sticking patch that edge is provided with gradient, and the edge of described sticking patch entity object is shunk to the inner side in front by the back side；
The edge at the described sticking patch entity object back side generated in step e also/or be provided with the outer hiding described Cranial defect opening,
Using the material object of sticking patch described in the 3D printer printout of melting fused deposition rapid moulding technology in step f, the printing material of described 3D printer is PCL-TCP.
A kind of Pituitaryadenoma operation sticking patch manufacture method the most according to claim 7, it is characterised in that the front of the described sticking patch entity object generated in step e is provided with the entity object of groove and reinforcement.
A kind of Pituitaryadenoma operation sticking patch manufacture method the most according to claim 7, it is characterised in that the front of the described sticking patch entity object generated in step e is provided with groove, is provided with the enhancement Layer of alveolate texture in described groove.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114480639A (en) * | 2021-12-24 | 2022-05-13 | 中国医学科学院北京协和医院 | Novel targets for diagnosis and treatment of pituitary adenomas |
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