CN105861668A - Forensic physical evidence paternity testing and individual identification parameter calculating method - Google Patents
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Abstract
The invention discloses a forensic physical evidence paternity testing and individual identification parameter calculating method. The calculation of a paternity index, a biological full-sib state consistency score and an individual identification matching probability of paternity testing in forensic practice is carried out by adopting an Excel table; when parameters are calculated, a corresponding kit and a corresponding calculation formula are found; an allele is input into a corresponding locus of the Excel table to generate the parameters. The method disclosed by invention is combined with forensic physical evidence practice, and simple and easy, efficient and accurate calculation software is designed and programmed by taking genetic data of Yunnan population and kits which are commonly used in each laboratory and have stable properties as the foundation, so that the calculation of important forensic parameters including the paternity index, the biological full-sib state consistency score and the individual identification matching probability of the paternity testing in the forensic practice and the like can be solved very well, and powerful helps and technical supports are provided for more objectively and more conveniently obtaining testing opinions.
Description
Technical field
The invention belongs to paternity test field, particularly relate to a kind of forensic medicine in appraisal of material evidence paternity test and calculate individual
Identification parameter method.
Background technology
Forensic medicine in appraisal of material evidence is with forensic as object of study, for the purpose of scientific evidence to be provided, and research application
Life Sci-Tech solves the subject that biological material relevant with human body in case is identified.Subject is by right
The inspection of human-body biological sample and analysis, be finally reached individual and identify and the purpose of paternity test, thus for detecing
Look into and give a clue and provide scientific evidence for trial.In the forming process of this scientific evidence, there is a pole
Its important link is exactly the formation of expert opinion, and it depends on DNA typing result to whether there is parental right pass
It is or whether judges from same individuality, the phase that correct judgement to be issued according to the Ministry of Justice will be drawn
The technical appraisement specification closed calculates, especially " paternity identification technical specification " (SF/Z JD0105001-
2010), " biology, full sib relation identified implementation specification " (SF/Z JD0105002 2014), " method
Doctor's material evidence " (artificial satellite's third edition), genotyping result and population genetics data according to DNA draw parent
Power index, matching probability, state consistency scoring, thus from which further follow that according to these result of calculations objective
Ground expert opinion.But at present in medicolegal practice forensic medicine in appraisal of material evidence parameter paternity index, matching probability,
Calculating of state consistency scoring lacks unified practical software for calculation, and it is numerous and diverse that traditional way calculates process,
Ratio is relatively time-consuming, makes workload increase, and the software for calculation that market is developed makes due to laboratory expensive, each
With the multiformity of test kit, the areal variation of population genetics data so that software does not obtain universal answering
With, make for difficulty in various degree to juridical practice band.
In the case of forensic paternity test, assert the something lost of paternity parents to be seen and child
Biography marks whether to meet genetic development, also further to affirm paternity by calculating paternity index.Meter
The genetic marker number used during calculation is the most, and identification capacity is the strongest, and qualification result is the most reliable.?
When calculating sibship, the allele number owing to being used is more, computing formula is complicated so that manually count
Calculation process is numerous and diverse, time-consuming.
Summary of the invention
It is an object of the invention to provide a kind of forensic medicine in appraisal of material evidence paternity test and calculate individual identification parameter side
Method, it is intended to when solving to calculate at present sibship the allele number owing to being used is more, computing formula
Complicated so that the problem that artificial calculating process is numerous and diverse, time-consuming.
The present invention is achieved in that a kind of forensic medicine in appraisal of material evidence paternity test and calculates individual's identification parameter method,
Described forensic medicine in appraisal of material evidence paternity test and calculating individual's identification parameter method use Excell form to carry out legal medical expert
Learn practice in the paternity index of paternity test, biology full sib state consistency scoring, individual identify
Join the calculating of probability, when calculating parameter, find corresponding test kit and computing formula, allele is defeated
Enter on the locus that Excel form is corresponding, generate parameter；Use the establishment of Excel table, standard triplet, bigeminy
Body and DNA establishing identity have three tables, are divided into table one, table two and data；
Biology, full sib had two tables, was divided into table one and table two；
Table one is the worksheet of input associated alleles；Table two is the worksheet carrying out relevant speciality computing,
Data are the worksheets of the related gene frequency of added up crowd.
Further, described forensic medicine in appraisal of material evidence paternity test and calculating individual's identification parameter method specifically include:
Dyad is by design function operational formula, by standard triplet, dyad, DNA establishing identity
It is programmed in function with the relevant computing formula of full sib biology and carries out computing, generate and meet bar accordingly
The result of part；
When inputting allele in triplet, qualified computing formula will in dyad automatically
Being formed, the data in DNA also can show in dyad, simultaneously the most also can by computing formula, data with
And result of calculation is formed in triplet, finally calculate relevant parameter.
The present invention combines forensic medicine in appraisal of material evidence practice, utilizes Yunnan population genetic data and each laboratory to commonly use
Based on the test kit of stable performance, design compilation is a simply, efficiently, software for calculation accurately, very
Solve well state one in the paternity index calculating of paternity test in medicolegal practice, full sib qualification biology
The important prudence parameters such as the calculating of the matching probability that cause property score calculation, individual identify, for the most objective more square
Just show that expert opinion provides strong help and technical support.Calculating function makes office more efficiently, soon
Victory, especially Excel, it can be produced various electrical form easily, use formula and function to data
Carry out the computing of complexity, saved the time to a great extent, made office more efficient.In daily inspection case,
For improving work efficiency, the correlation formula of paternity identification is organically combined with Excel, just have developed
The present invention.The present invention calculate paternity index, matching probability and state consistency scoring time convenient, fast,
Accurately, after only need to finding corresponding locus input allele, relevant parameter will automatically generate, and saves
Time, the mistake easily occurred during simultaneously avoiding artificial calculating so that office efficiently, result of calculation
It is protected.The present invention can the most quickly calculate parental right in the case that paternity test and individual identify and refer to
Number (PI), matching probability (PM) and state consistency scoring (IBS), improve work efficiency, make simultaneously
Obtain result of calculation accurately and reliably.Use traditional manual calculation process to calculate the fastest employee of paternity index to calculate
The paternity index of one locus is at least also required to 200 0, and [*/second calculates 15 autosomes
Locus at least needs 5 minutes, but after using the present invention, only need to input equipotential base on corresponding locus
Cause, result of calculation will automatically form.The allele of 15 locus is totally lost completely needs one point the most slowly
Half, and result of calculation is manually accurately calculated than traditional, has saved the time to a great extent,
And result of calculation is more guaranteed.
Accompanying drawing explanation
Fig. 1 is the forensic medicine in appraisal of material evidence paternity test identification parameter method individual with calculating that the embodiment of the present invention provides
Flow chart.
Detailed description of the invention
For the summary of the invention of the present invention, feature and effect can be further appreciated that, hereby enumerate following example, and
Accompanying drawing is coordinated to describe in detail as follows.
The forensic medicine in appraisal of material evidence paternity test of the embodiment of the present invention and calculating individual's identification parameter method use Excell
Form carries out the paternity index of paternity test in medicolegal practice, full sib state consistency biology is marked,
The calculating of the matching probability that individual identifies, when calculating parameter, finds corresponding test kit and computing formula,
Allele is inputted on the locus that Excel form is corresponding, generate parameter.
As it is shown in figure 1, the forensic medicine in appraisal of material evidence paternity test of the embodiment of the present invention and calculating individual's identification parameter method
Comprise the following steps:
S101: dyad is by design function operational formula, by standard triplet, dyad, DNA together
One assert that the relevant computing formula with full sib biology is programmed in function carries out computing, generates corresponding
Qualified result；
S102: when inputting allele in triplet, qualified computing formula will be in dyad
In automatically form, the data in DNA also can show in dyad, simultaneously the most also can by computing formula,
Data and result of calculation are formed in triplet, finally calculate relevant parameter.
Another object of the present invention is to a kind of forensic medicine in appraisal of material evidence paternity test is provided and calculates individual's identification parameter
System, this system uses Excel tabulating, is divided into standard triplet (parent-child-female) paternity index to calculate
Table, dyad (the parent-child or female-son) computational chart of paternity index (PI), full sib relation biology are identified
The matching probability (PM) that the computational chart of middle state consistency scoring (IBS), individual are the same for DNA in identifying
Computational chart, each computational chart comprises three Zhang Gong's tabulations, table one, data, table two；
Table one is to input allelic worksheet；
Tables of data is that the worksheet of the related gene frequency of the Yunnan population that this laboratory is added up (can basis
The difference of demographic data carries out the replacing of data)；
Table three is by the worksheet of specialty computing.
When needing to calculate parameter, only need to find corresponding test kit and computing formula, allele is inputted
On the locus that " table one " is corresponding, parameter will automatically generate；
Such as paternity test case can obtain the single paternity index of each locus, accumulation paternity index (PI)
And parental right is relative to chance (RCP)；Full sib relation identification also can automatically generate state consistency scoring
(IBS)；The matching probability (PM) in case the same with DNA and likelihood ratio (LR), meter
Calculating the index of correlation also only need to be inputted by allele on the locus that " table one " is corresponding, the index of correlation will be given birth to automatically
Become, then associated alleles Data Data and calculating parameter are copied in expert opinion report.
Cover 4 set detection kit of stable performance conventional in current laboratory: Promega company21 test kits, AB companyPlus test kit, middle dolantin
AGCU Expressmarker 22 test kit of connection, the 20A test kit of basic point company, as required can be
Increase detecting system on the basis of this and change population genetics data Bu Tong local in software.
The present invention uses Excel table to work out, and standard triplet, dyad and DNA establishing identity have three
Table, is divided into " table one ", " table two " and " data ".Biology, full sib had two tables, was divided into " table one " and " table
Two "." table one " is the worksheet of input associated alleles, and " table two " is the work carrying out relevant speciality computing
Table, " data " are the worksheets of the related gene frequency of the Yunnan population that this laboratory is added up.Between three tables
There is relatedness.Most importantly the relevant speciality computing that table two is carried out." table two " is by design
Functional operation formula, by being correlated with of standard triplet, dyad, DNA establishing identity and full sib biology
Computing formula be programmed in function and carry out computing, generate corresponding qualified result.When at " table one "
During middle input allele, qualified computing formula will automatically form in " table two ", in " table three "
Data also can show in " table two ", simultaneously also can be by computing formula, data and result of calculation at " table
One " formed in, finally calculate relevant parameter.Through checking repeatedly, the calculating knot that this invention is formed
Fruit is accurately and reliably.When calculating standard triplet and dyad, when there being the allele not meeting genetic development
During input, the printed words of " not meeting genetic development " will be generated in " table one ", occur that during these printed words, operator needs
Noting, now this allelic paternity index need to individually calculate with relevant sudden change formula.
(1) calculating of full sib biology
(2) DNA is the same
| Certified sample | Comparison sample | PM |
| PP | PP | p2 |
| PQ | PQ | 2*p*q |
The present invention combines forensic medicine in appraisal of material evidence practice, utilizes Yunnan population genetic data and each laboratory to commonly use
Based on the test kit of stable performance, design compilation is a simply, efficiently, software for calculation accurately, very
Solve well state one in the paternity index calculating of paternity test in medicolegal practice, full sib qualification biology
The important prudence parameters such as the calculating of the matching probability that cause property score calculation, individual identify, for the most objective more square
Just show that expert opinion provides strong help and technical support.
Below in conjunction with specific embodiment, the application principle of the present invention is further described.
The present invention paternity test and individual identify case in can the most quickly calculate paternity index (PI),
Matching probability (PM) and state consistency scoring (IBS), improve work efficiency, makes to calculate knot simultaneously
Fruit is accurately and reliably.Between these a few Zhang Gong's tabulations of Excel establishment, there is relatedness." table two " is by setting
Meter functional operation formula, by standard triplet, dyad, DNA establishing identity and the meter of full sib biology
Calculation formula is programmed in function and carries out computing, generates corresponding qualified result.Function fortune in " table two "
Calculate the main utilization of formula is the computing of IF function, by standard triplet, dyad, DNA establishing identity
It is programmed in IF function with the computing formula of full sib biology, then uses the connection of AND, OR to weave into letter
Number operational formula.When inputting allele in locus corresponding in " table one ", IF function will generate
The corresponding parameter of this locus and computing formula.Additionally use DGET function, carried from " data "
Take the numerical value meeting specified requirements, the data application of extraction to IF function will calculate corresponding parameter.At " table
One " finding corresponding locus in and input allele, qualified computing formula and parameter will be
" table one " automatically forms.In " table one ", the formation of computing formula and relevant parameter is mainly designed by " table two "
Functional operation formula realize.When at " table one " middle input allele, the functional operation in " table two " is public
Formula will automatically generate the qualified computing formula of institute and relevant parameter according to the allele inputted.Again
Use "=" just the clearing formula in " table two " and relevant parameter can be presented in " table one ".Such as: when at " table
When one " inputting allele on this locus of D19S433, standard triplet and the obliged gene of dyad
1, obliged gene 2, computing formula and PI value all can automatically generate, when there being the equipotential base not meeting genetic development
Also can show during because occurring.Equally, the allele 1 in DNA establishing identity, allele 2, meter
The ibs calculated in formula and PM value and biology full sib also can automatically form." table one " Plays triplet,
The calculating that dyad and DNA are the same has also been used PRODUCT function calculate accumulative paternity index and
Accumulative random fit probability.In biology full sib, the calculating of IBS is to be added by the ibs mark of each locus
Included in " data " calculated is Yunnan population genetic data, covers Promega company21 test kits, AB companyPlus test kit, Sino-German
AGCU Expressmarker 22 test kit of U.S. connection, the gene frequency of 20A test kit of basic point company.
When inputting allele on locus corresponding in " table one ", the DGET function in " table two " will
From " data ", extract qualified numerical value, and numerical value is brought into such gene paternity index or matching probability
Calculating in.
The present invention is convenient, fast, accurate when calculating paternity index, matching probability and state consistency scoring
Really, after only need to finding corresponding locus input allele, relevant parameter will automatically generate, and saves
Time, the mistake easily occurred during simultaneously avoiding artificial calculating so that efficiently, result of calculation obtains in office
To ensureing.Standard triplet, dyad and DNA establishing identity input on " table one " corresponding gene seat
Allele, by the functional operation formula designed by " table two ", will be formed this locus paternity index and
Join the computing formula of probability.Correlation values in " data " also can be brought in computing formula and be calculated parental right and refer to simultaneously
Number, matching probability.In standard triplet, dyad, input does not meets the equipotential base of Mendel's law of inheritance
Because of time, the printed words of red " not meeting law of inheritance ", now this locus parental right will occur in " table one "
The calculating of index need to be brought in corresponding sudden change formula and be calculated, and the result of calculating is the parent of this locus
Power index.Biology need not maintenance data in full sib, in " table one " during input allele, " table two "
The ibs mark of this locus is calculated by designed functional operation formula, and by "=" mark is presented on
In " table one ", finally calculate state consistency scoring.
Traditional artificial process that calculates need to determine corresponding calculating according to situation allelic on locus
Formula, and search this allelic gene frequency, bring the numerical value of gene frequency into computing formula and fall into a trap
Calculate the paternity index of this locus, matching probability, state consistency scoring.The test kit used is the most extremely
Including 15 autosomal locuses less, each locus needs repeat the above steps to calculate so that
Workload increases, and easily tape error formula or input gene frequency by mistake during calculating, and causes result of calculation
Mistake occur, result cannot be protected.In this laboratory, traditional manual calculation process is used to calculate
The fastest employee of paternity index calculates the paternity index of a locus and is at least also required to 20 seconds, calculates 15
Autosomal locus at least needs 5 minutes, but after using the present invention, only need to be on corresponding locus
Input allele, result of calculation will automatically form.The allele of 15 locus is totally lost the most completely
Slowly need one point of half, and result of calculation is manually accurately calculated than traditional, saves to a great extent
The about time, and result of calculation is more guaranteed.
As a example by the qualification case of some standard triplet by this center, the calculating using standard triplet is soft
Part calculates relevant parameter.This case is used21 test kits carry out PCR composite amplification, gene
Genotyping result is as follows:
| Locus | Yin so-and-so (suspicious father) | Yin (child) | Go into business so-and-so (mother) |
| D3S1358 | 15,16 | 15,16 | 16 |
| D1S1656 | 15 | 12,15 | 12,17 |
| D6S1043 | 18,19 | 19 | 12,19 |
| D13S317 | 8,9 | 9,11 | 8,11 |
| PentaE | 18,19 | 14,18 | 14 |
| D16S539 | 10,12 | 10,12 | 10,11 |
| D18S51 | 15,16 | 16 | 14,16 |
| D2S1338 | 19,23 | 19 | 18,19 |
| CSF1PO | 10,11 | 10,11 | 11,12 |
| Penta D | 9,12 | 9,13 | 9,13 |
| TH01 | 8,9 | 9 | 9,10 |
| vWA | 14,17 | 14,19 | 14,19 |
| D21S11 | 29,30 | 29,30 | 29,30 |
| D7S820 | 11 | 11 | 11 |
| D5S818 | 10,12 | 11,12 | 11,12 |
| TPOX | 8,9 | 8,11 | 11 |
| D8S1179 | 12,16 | 12,16 | 10,12 |
| D12S391 | 17 | 17,18 | 18 |
| D19S433 | 14.2 | 13,14.2 | 13 |
| FGA | 22,25 | 22,25 | 21,25 |
| Amelogenin | X, Y | X | X |
The software for calculation application of standard triplet is as follows:
The first step: findThe standard triplet software for calculation of 21 test kits, and open it；
Second step: on corresponding locus, the gene type of input Rhizoma Anemarrhenae；Only need to be when using software
There is input allele above in the locus of square frame；
In frame after input allele, will occur in corresponding position after the locus of lower zone
The gene type inputted, the main purpose of envisaged underneath is that people by gene type and calculate knot for convenience
Fruit pastes in verified written opinion, and writing of position paper requires that people separate with ", " between two allele,
Homozygote only need to write a gene type, this software design during with screening function, when this base
When being homozygote because of seat, just only can show a gene type, two genes will occur when for heterozygote
Typing, and separate with ", " between the two, as shown in figure Green circle, this design is to a great extent
Save the time of work.
3rd step: on corresponding locus, the gene type of input child；
4th step: on corresponding locus, inputs the gene type of suspicious father, as shown below:
Now, paternity index (PI), accumulative paternity index (CPI), parental right are relative to chance (RCP) all
Can automatically generate, required result only need to be pasted in verified written opinion by people.
Now, the paternity index of this locus should be brought in corresponding sudden change formula and manually calculate, then will
The result write respective regions calculated, replaces that numerical value that original software automatically generates, former after replacing it
First CPI value and RCP value also can change therewith；
The calculating of sudden change is referred in " paternity identification technical specification " (SF/Z JD0105001-2010)
Sudden change formula, it is also possible to list of references " calculating of euchromosome STR mutant gene seat paternity index " (Lu Hui
The tinkling of pieces of jade, Lv Dejian) in method derive.The numerical value of mutation rate refers to document, and " Chinese population parental right is reflected
The estimation of permanent str locus seat average mutation rate " (Cai Ying, Zhou Guangbiao etc.).
Use dyad, DNA the same and full sib software for calculation biology calculates the behaviour of relevant parameter
Make method the same with the operational approach of above-mentioned standard triplet, only need to input corresponding gene type in frame,
Relevant parameter will automatically generate.
Computing formula:
(1) computing formula of standard triplet:
(2) dyad computing formula
| Child's genotype | Tested father's genotype | PI value computing formula |
| PP | PP | 1/p |
| PP | PQ | 1/(2p) |
| PQ | PP | 1/(2p) |
| PQ | PQ | (p+q)/(4pq) |
| PQ | PR | 1/(4p) |
The above is only to presently preferred embodiments of the present invention, not makees the present invention any pro forma
Limiting, any simple modification made for any of the above embodiments, equivalent are become by every technical spirit according to the present invention
Change and modify, belonging in the range of technical solution of the present invention.
Claims (3)
1. a forensic medicine in appraisal of material evidence paternity test and calculating individual's identification parameter method, it is characterised in that described
Forensic medicine in appraisal of material evidence paternity test and calculate individual's identification parameter method to use Excell form to carry out prudence real
Trample the paternity index of middle paternity test, full sib state consistency biology is marked, the coupling of individual's identification is general
The calculating of rate, when calculating parameter, finds corresponding test kit and computing formula, allele is inputted Excel
On the locus that form is corresponding, generate parameter.
2. forensic medicine in appraisal of material evidence paternity test as claimed in claim 1 and calculating individual's identification parameter method, its
Being characterised by, described forensic medicine in appraisal of material evidence paternity test and calculating individual's identification parameter method use Excel table to compile
System, standard triplet, dyad and DNA establishing identity have three tables, are divided into table one, table two and data；
Biology, full sib had two tables, was divided into table one and table two；Table one is the worksheet of input associated alleles；
Table two is the worksheet carrying out relevant speciality computing, and data are the works of the related gene frequency of added up crowd
Tabulation.
3. forensic medicine in appraisal of material evidence paternity test as claimed in claim 2 and calculating individual's identification parameter method, its
Being characterised by, described dyad is by design function operational formula, by standard triplet, dyad, DNA
The same and full sib biology relevant computing formula is programmed in function and carries out computing, generates corresponding
Qualified result；
When inputting allele in triplet, qualified computing formula will in dyad automatically
Being formed, the data in DNA also can show in dyad, simultaneously the most also can by computing formula, data with
And result of calculation is formed in triplet, finally calculate relevant parameter.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107609343A (en) * | 2017-08-14 | 2018-01-19 | 广州市圣鑫生物科技有限公司 | Relationship iden- tification method, system, computer equipment and readable storage medium storing program for executing |
| CN107748837A (en) * | 2017-09-18 | 2018-03-02 | 安徽工程大学 | A kind of computational methods of the DNA identification paternity indexs comprising gene mutation |
| CN109273046A (en) * | 2018-10-19 | 2019-01-25 | 上海晶准生物医药有限公司 | A kind of biology full sibs identification method based on probability statistics model |
| CN115206424A (en) * | 2022-08-24 | 2022-10-18 | 温州医科大学 | Method, system, equipment and storage medium for identifying full sibling relationship |
| CN115273976A (en) * | 2022-08-24 | 2022-11-01 | 温州医科大学 | Method, system, equipment and storage medium for identifying half-sib relationship |
-
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- 2016-04-21 CN CN201610252205.8A patent/CN105861668A/en active Pending
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