CN105859670B - A kind of preparation method of high purity butylene phthalide - Google Patents
A kind of preparation method of high purity butylene phthalide Download PDFInfo
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- CN105859670B CN105859670B CN201610267875.7A CN201610267875A CN105859670B CN 105859670 B CN105859670 B CN 105859670B CN 201610267875 A CN201610267875 A CN 201610267875A CN 105859670 B CN105859670 B CN 105859670B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Abstract
The present invention provides a kind of preparation method of high purity butylene phthalide, including reaction flask is added in dl-3-n-Butylphthalidle crude product by A., and being decompressed to system vacuum degree is 1-2mbar；Heating collects 130-140 DEG C of fraction and obtains dl-3-n-Butylphthalidle fraction；B. it by dl-3-n-Butylphthalidle fraction and methanol, is added in reaction flask, the methanol solution of inorganic base is added in stirring and dissolving, it is heated to back flow reaction, is filtered, concentration removes methanol, and methylene chloride is added, solid, filtering, dry 1- hydroxyl amyl -2- benzoate is precipitated in stirring；C. 1- hydroxyl amyl -2- benzoate is added to the water stirring and dissolving, is then added in the reaction flask equipped with hydrochloric acid solution, is stirred to react in 35-45 DEG C of temperature, stratification, oil mutually successively use sodium bicarbonate solution, washing, it dries, filters to obtain dl-3-n-Butylphthalidle sterling.
Description
Technical field
The present invention relates to field of medicinal chemistry, and in particular to the refining methd of butylphenyl phthaleine.
Background technique
Butylphenyl phthaleine is artificial synthesized racemization n butylphthalide, identical as the natural structure of left-handed Butylphthalide.It is clinical
Result of study shows that butylphenyl phthaleine has improvement result to the damage of patients with acute ischemic cerebral stroke central functions, can promote
The improvement of neurologic impairment.Clinic is mainly used for treating the improvement of patients with acute ischemic cerebral stroke neurologic impairment.
It, cannot be using conventional recrystallization method purifying since butylphenyl phthaleine is liquid volatile oil.Existing butylphenyl phthaleine system
Mainly butylphenyl phthaleine crude product is prepared by various synthetic routes in Preparation Method, obtains finished product using rectification under vacuum, purity is most
The number that height is only capable of reaching 98% or so, HPLC checked for impurities is on the high side, and color is poor.Or individually use column chromatography for separation
Method purify butylphenyl phthaleine crude product, obtained butylphenyl phthaleine product colour be it is faint yellow, have the presence of more suspension insoluble matter, and
HPLC is shown containing multiple impurity peaks.
Chinese patent CN101962374 discloses a kind of butylphenyl phthaleine bulk pharmaceutical chemicals product and preparation method thereof, preparation method with
Phthalic acid acid anhydrides is raw material, obtains intermediate neighbour's valeryl yl benzoic acid by the Grignard Reagent addition with butyl halide, then
Butylphenyl phthaleine is obtained through sodium borohydride reduction, acidification cyclization.It is increased to about using the butylphthalide content that this method is prepared
97%, impurity content is reduced to about 3.0%, but the bulk pharmaceutical chemicals product stability is still poor, in placement process, bulk pharmaceutical chemicals product
Content be substantially reduced, impurity is significantly raised, therefore the bulk pharmaceutical chemicals product cannot be directly used to the research of preparation, especially cannot
Applied to directly applying to injection type.
Chinese patent CN105130934 discloses the preparation method of another butylphenyl phthaleine bulk pharmaceutical chemicals product, using the party
The butylphenyl phthaleine purity that method is prepared is improved to 99.0% or more.But there are still following deficiencies for this method: 1) product colour compared with
It is deep, for yellow to buff oily liquids；2) using the rectification step of high temperature as final step, product has the wind degraded
Danger；3) reaction process has used a large amount of inflammable and explosive solvent ether and methyl-isobutyl ether, is unfavorable for keeping the safety in production；4) it reacts
Time-consuming, and technique is cumbersome, the energy consumption and cost control being unfavorable in production；5) it under partial picture, needs secondary or even subtracts three times
Pressure rectifying can be only achieved purity requirement.
Based on above-mentioned the deficiencies in the prior art, present invention is primarily directed to develop, a kind of purity is high, stability is good and technique
Simply, it is advantageous to the butylphenyl phthaleine refining methd of industrial production application.
Summary of the invention
The present invention provides a kind of preparation method of high purity butylene phthalide, comprising the following steps:
The purification of butylphenyl phthaleine crude product:
A., dl-3-n-Butylphthalidle crude product is added to the reaction flask for being connected with rectifying separator, is decompressed to system vacuum
Degree is 1-2mbar；Heating,
It collects 130-140 DEG C of fraction and obtains dl-3-n-Butylphthalidle fraction.
B. obtained dl-3-n-Butylphthalidle fraction and methanol is above walked, is added in reaction flask, stirring and dissolving, nothing is added
The methanol solution of machine alkali is heated to back flow reaction, and filtering, concentration removes methanol, and methylene chloride is added, and solid, mistake is precipitated in stirring
Filter, dry 1- hydroxyl amyl -2- benzoate.
C. 1- hydroxyl amyl -2- benzoate is added to the water stirring and dissolving, be then added dropwise to the solution molten equipped with hydrochloric acid
In the reaction flask of liquid, it is stirred to react in 35-45 DEG C of temperature, stratification, oil mutually successively uses sodium bicarbonate solution, it washes,
It is dry, dl-3-n-Butylphthalidle sterling is finally obtained by filtration.
Above-mentioned reaction route is as follows:
Preparation method as described above, it is characterised in that in step B, the methylene chloride and racemization -3- n-butylbenzene of addition
The envelope-bulk to weight ratio of phthalein is 2: 1 to 8: 1.Preferably 2: 1 to 4: 1.
Preparation method as described above, it is characterised in that step B is added in the methanol solution of inorganic base, and inorganic base is hydrogen-oxygen
Change one of sodium, potassium hydroxide, lithium hydroxide.Preferably one of potassium hydroxide, lithium hydroxide.
Preparation method as described above, it is characterised in that in step C, whipping temp is 40-45 DEG C.
Preparation method as described above, it is characterised in that in step C, the preferred 2.0-2.5 of pH.
Butylphenyl phthaleine crude product is passed through rectifying-soap by the crystallinity for applying 1- hydroxyl amyl -2- benzoate of this law novelty
It is available colourless to light yellow that chemical conversion salt refining or column chromatograph-are saponified into salt refining, and purity is greater than 99.90%, singly miscellaneous small
In 0.1% butylphenyl phthaleine finished product.
It is thick that the present invention using 2-carboxybenzaldehyde and normal-butyl magnesium halide Grignard Reagent as raw material single step reaction obtains butylphenyl phthaleine
Product after the rectifying of butylphenyl phthaleine crude product or column chromatography for separation, will then be saponified into 1- hydroxyl amyl -2- benzoate, then through recrystallizing
Or the solid salt that mashing is purified, the last acidified purity that obtains is greater than 99.90%, and colourless to light yellow racemization -3- is just
Butylphthalide butylphenyl phthaleine finished product.
Specific embodiment
Embodiment 1: the preparation of butylphenyl phthaleine crude product:
Under nitrogen protection, reactor is added in 90Kg n-butylmagnesium chloride magnesium tetrahydrofuran solution, by 10Kg neighbour's carboxyl benzene first
Aldehyde adds 50L anhydrous tetrahydro furan wiring solution-forming and is added dropwise to Grignard Reagent, temperature control be no more than 55 DEG C, drop finish after react 2h, first plus
Enter 100L saturated ammonium chloride quenching reaction, adding 50LHCl (4M) solution regulation system pH is about 2.0, continues stirring standing point
Layer, organic phase vacuum distillation removing solvent, is added the dilution of 50L methylene chloride, and the washing of 50L saturated sodium bicarbonate solution stands and divides
Dl-3-n-Butylphthalidle crude product 12.3Kg is concentrated under reduced pressure to obtain in layer, organic phase.
Embodiment 2: the purification (sylvite) of butylphenyl phthaleine crude product:
A., 1.23Kg dl-3-n-Butylphthalidle crude product is added to the reaction flask for being connected with rectifying separator, is decompressed to body
Be vacuum degree be 1-2mbar；It is warming up to 150-160 DEG C, collects front-end volatiles, finally then heats to 220 DEG C, collects 130-140
DEG C fraction obtains 0.99kg dl-3-n-Butylphthalidle fraction；HPLC purity is 99.4%.
B. by 0.99Kg dl-3-n-Butylphthalidle fraction, single port bottle is added in 2.2L methanol, and stirring and dissolving is added
The solution that 0.31Kg potassium hydroxide and 1.33L methanol are made into advance is heated to 65 DEG C of reaction 1h, and concentration removes methanol, and 25L is added
Methylene chloride, stirring are precipitated a large amount of solids, filtering, dry 1.19Kg solid.
C. 1.19Kg 1- hydroxyl amyl -2- Potassium Benzoate and 2.4L water are added in reaction flask, then stirring and dissolving should
Solution is added dropwise in the reaction flask equipped with 8.9L hydrochloric acid (4M), and 40 DEG C are stirred to react 1.5h, and stratification, oil is mutually successively with saturation
Sodium bicarbonate solution is washed, dry, and dl-3-n-Butylphthalidle sterling 0.79Kg, HPLC purity is finally obtained by filtration and is greater than
99.90%.
The synthesis of embodiment 3:1- hydroxyl amyl -2- sodium benzoate
By 9g dl-3-n-Butylphthalidle fraction, single port bottle is added in 25mL methanol, and sodium hydroxide first is added in stirring and dissolving
Alcoholic solution (3.3g/12mL), is heated to 65 DEG C of reaction 1h, and heating is evaporated to obtain white solid.
The synthesis of embodiment 4:1- hydroxyl amyl -2- Potassium Benzoate
By 9g dl-3-n-Butylphthalidle fraction, single port bottle is added in 25mL methanol, and potassium hydroxide first is added in stirring and dissolving
Alcoholic solution (3.3g/12mL) is heated to 65 DEG C of reaction 1h, and concentration removes methanol, and 22.5mL DCM is added, and stirring is precipitated a large amount of solid
Body, filtering, dry solid 10.3g.
The synthesis of embodiment 5:1- hydroxyl amyl -2- lithium benzoate
By 9g dl-3-n-Butylphthalidle fraction, single port bottle is added in 25mL methanol, and lithium hydroxide first is added in stirring and dissolving
Alcoholic solution (1.4g/12mL) is heated to 65 DEG C of reaction 1h, and concentration removes methanol, and 22.5mL DCM is added, and stirring is precipitated a large amount of solid
Body, filtering, dry solid 9.0g.
Embodiment 6: the purification (lithium salts) of butylphenyl phthaleine crude product
A., 1.24Kg dl-3-n-Butylphthalidle crude product is added to the reaction flask for being connected with rectifying separator, is decompressed to body
Be vacuum degree be 1-2mbar；It is warming up to 150-160 DEG C, collects front-end volatiles, finally then heats to 220 DEG C, collects 130-140
DEG C fraction obtains 1.01kg dl-3-n-Butylphthalidle fraction；HPLC purity is 99.4%.
B. by butylphenyl phthaleine after 1.01Kg rectifying, single port bottle is added in 2.5L methanol, and 0.18Kg lithium hydroxide is added in stirring and dissolving
With 1.36L methanol, 65 DEG C of reaction 1h are heated to, concentration removes methanol, and 2.6L methylene chloride is added, and a large amount of solids are precipitated in stirring,
Filtering, dry 1.02Kg solid.
C. 1.02Kg 1- hydroxyl amyl -2- lithium benzoate and 2L water are added in reaction flask, stirring and dissolving is then molten by this
Drop is added in the reaction flask equipped with 7.8L hydrochloric acid (4M), and 40 DEG C are stirred to react 1.5h, stratification, and oil mutually successively uses saturated carbon
Sour hydrogen sodium solution is washed, dry, and dl-3-n-Butylphthalidle sterling 0.75Kg, HPLC purity is finally obtained by filtration and is greater than
99.90%
Embodiment 7: the selection of way of purification in step A
In research process of the invention, inventor to crude product butylphenyl phthaleine rectificating method carried out series experiment grope and
Compare, be exemplified below two kinds:
(1) rectification under vacuum
180g butylphenyl phthaleine crude product is added to the reaction flask for being connected with rectifying separator, being decompressed to system vacuum degree is 1-
2mbar steams front-end volatiles in 120-150 DEG C first, then proceedes to heating 130-140 DEG C of dl-3-n-Butylphthalidle of collection and evaporates
Point, 142.8g yellow is collected altogether to buff grease, and the number of HPLC checked for impurities is few, and HPLC purity is 99.5%.Yield
It is 79.3%.
(2) column purification is crossed
50g crude product containing butylphenyl phthaleine is subjected to silica gel column chromatography, eluant, eluent ratio is petroleum ether: ethyl acetate=15: 1, it obtains
The butylphenyl phthaleine 29.2g of impurity phthalide qualified (≤0.1%), yield 58.4%, product colour be it is faint yellow, have more suspension not
Molten object exists, and HPLC shows the impurity peaks containing multiple contents less than 0.1%.HPLC purity is 97.9%.
Conclusion: from above-mentioned experimental data it is found that rectification under vacuum products obtained therefrom amount of impurities is few, product purity and yield compared with
Column purification height is crossed, and crosses column purification and expends a large amount of organic solvents, pollution environment is unfavorable for mass production operation again；So obtaining decompression
Rectificating method is more excellent compared with column purification is crossed.
Embodiment 8: application of the dichloromethane solvent in recrystallization in step B
By dl-3-n-Butylphthalidle after 9g rectifying, single port bottle is added in 25mL methanol, and potassium hydroxide is added in stirring and dissolving
Methanol solution (3.3g/12mL) is heated to 65 DEG C of reaction 1.5h, and concentration removes methanol, and organic solvent A is added, and stirring is precipitated solid
Body, filtering, dry solid product.
Influence of the 1 different organic solvents A of table to experimental result
Conclusion: can be seen that from the experimental result of table 1, and when only methylene chloride is as reaction dissolvent, the yield of experiment can reach
To 76% or more, other solvents are selected, yield is lower, does not meet the demand of production；And when selecting methanol as solvent, then
The failure of an experiment, no product are precipitated.When the methylene chloride of addition and the envelope-bulk to weight ratio of dl-3-n-Butylphthalidle are 2: 1 to 8:
When 1, preferably 2: 1 to 4: 1, experiment is well on, and yield is higher, and product purity is up to 99.90% or more, is more preferably to select.
Embodiment 9: dl-3-n-Butylphthalidle sterling synthesis condition research
In order to further increase the yield and purity and problem of solvent residual of dl-3-n-Butylphthalidle sterling, we
The reaction condition for preparing dl-3-n-Butylphthalidle to 1- hydroxyl amyl -2- Potassium Benzoate is investigated, and experimentation is as follows:
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at T, adjust pH, is stirred to react 1h30min, stratification, oil phase is successively
With 15mL saturation NaHCO3 solution, washing, dl-3-n-Butylphthalidle sterling, HPLC inspection is finally obtained by filtration in decompressing and extracting
Survey purity.
Experimental result such as table 2:
| Experiment numbers | Reaction temperature T | pH | Dl-3-n-Butylphthalidle sterling weight | HPLC purity |
| 1) | 40-45℃ | 2.0-2.5 | 21.2g | 99.99% |
| 2) | 40-45℃ | 0.8-1.0 | 16.3g | 99.75% |
| 3) | 40-45℃ | 3.0-3.5 | 15.2g | 99.67% |
| 4) | 40-45℃ | 3.5-4.0 | 13.2g | 98.62% |
| 5) | 10-20℃ | 2.0-2.5 | 13.5g | 99.77% |
| 6) | 20-30℃ | 2.0-2.5 | 16.9g | 99.86% |
| 7) | 50-60℃ | 2.0-2.5 | 19.2g | 98.76% |
| 8) | 60-70℃ | 2.0-2.5 | 19.7g | 98.26% |
1) reaction temperature is 40-45 DEG C, pH=2.0-2.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 40-45 DEG C, pH 2.0-2.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 21.2g, HPLC purity 99.99%.
2) reaction temperature is 40-45 DEG C, pH=0.8-1.0
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 40-45 DEG C, pH 0.8-1.0, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 16.3g, HPLC purity 99.75%.
3) reaction temperature is 40-45 DEG C, pH=3.0-3.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 40-45 DEG C, pH 3.0-3.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 15.2g, HPLC purity 99.67%.
4) reaction temperature is 40-45 DEG C, pH=3.5-4.0
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 40-45 DEG C, pH 3.5-4.0, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 13.2g, HPLC purity 98.62%.
5) reaction temperature is 10-20 DEG C, pH=2.0-2.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 10-20 DEG C, pH 2.0-2.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 13.5g, HPLC purity 99.77%.
6) reaction temperature is 20-30 DEG C, pH=2.0-2.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 20-30 DEG C, pH 2.0-2.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 16.9g, HPLC purity 99.86%.
7) reaction temperature is 50-60 DEG C, pH=2.0-2.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 50-60 DEG C, pH 2.0-2.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 19.2g, HPLC purity 98.76%.
8) reaction temperature is 60-70 DEG C, pH=2.0-2.5
30g1- hydroxyl amyl -2- Potassium Benzoate, 60mL water are added in single port bottle, then stirring and dissolving the solution is added dropwise
Enter in the reaction flask equipped with HCl (4M), controlled at 60-70 DEG C, pH 2.0-2.5, is stirred to react 1h30min, stands and divide
Layer, oil is mutually successively with 15mL saturation NaHCO3 solution, washing, decompressing and extracting, finally through dl-3-n-Butylphthalidle is obtained by filtration
Sterling 19.7g, HPLC purity 98.26%.
Experiment conclusion: by 1), 2), 3), 4) four experiments to the investigation experimental result of pH it is found that as pH=2.0-2.5,
Dl-3-n-Butylphthalidle yield and purity reach highest.
It 1), 5), 6), 7), 8) can be obtained by experiment, when reaction temperature is 40-45 DEG C, dl-3-n-Butylphthalidle yield
And purity reaches highest, when temperature is lower, product yield is lower, and when temperature is higher, yield increases compared with low temperature, but under purity
Drop is obvious, is 40-45 DEG C it is advantageous to temperature.
In conclusion being 40-45 by the Optimal Temperature range for testing preferably synthetic dl-3-n-Butylphthalidle sterling
DEG C, pH range is 2.0-2.5, and with this condition, product yield and purity all reach highest.
Embodiment 10: compared with 9 technique of CN105130934 embodiment
Method (1) is produced by 9 method of [0098] section embodiment preparation in CN105130934 patent disclosure specification
Product A.
Method (2) obtains product B by 1,3,5 method of embodiment preparation in this specification.
The comparison of two methods such as table 3:
The experimentation of 3 two methods of table compares
Claims (4)
1. a kind of preparation method of high purity butylene phthalide, it is characterised in that the following steps are included:
A., dl-3-n-Butylphthalidle crude product is added to the reaction flask for being connected with rectifying separator, the system vacuum degree of being decompressed to is
1-2mbar；Heating collects 130-140 DEG C of fraction and obtains dl-3-n-Butylphthalidle fraction；
B. it by dl-3-n-Butylphthalidle fraction and methanol obtained in step A, is added in reaction flask, stirring and dissolving, nothing is added
The methanol solution of machine alkali is heated to back flow reaction, and filtering, concentration removes methanol, and methylene chloride is added, and solid, mistake is precipitated in stirring
Filter, dry 1- hydroxyl amyl -2- benzoate, wherein the volume weight of the methylene chloride and dl-3-n-Butylphthalidle that are added
Than for 2:1 to 8:1；
C. 1- hydroxyl amyl -2- benzoate is added to the water stirring and dissolving, then the solution is added dropwise to equipped with hydrochloric acid solution
In reaction flask, make pH 2.0-2.5, be stirred to react in 40-45 DEG C of temperature, stratification, oil mutually successively uses sodium bicarbonate
Solution is washed, dry, and dl-3-n-Butylphthalidle sterling is finally obtained by filtration.
2. preparation method according to claim 1, it is characterised in that in step B, the methylene chloride and racemization -3- of addition are just
The envelope-bulk to weight ratio of butylphthalide is 2: 1 to 4: 1.
3. preparation method according to claim 1, it is characterised in that step B is added in the methanol solution of inorganic base, inorganic
Alkali is one of sodium hydroxide, potassium hydroxide, lithium hydroxide.
4. preparation method according to claim 3, it is characterised in that step B is added in the methanol solution of inorganic base, inorganic
Alkali is one of potassium hydroxide, lithium hydroxide.
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| CN106674171B (en) * | 2016-12-22 | 2018-11-13 | 南京理工大学 | A kind of preparation method of 3- trifluoromethyls phthalide |
| CN107235943B (en) * | 2017-07-24 | 2020-04-21 | 北京科莱博医药开发有限责任公司 | Preparation method of high-purity butylphthalide |
| CN111377894B (en) * | 2018-12-29 | 2023-10-20 | 江苏先声药业有限公司 | Purification method of 3-n-butyl-l (3H) -isobenzofuranone |
| CN111943921A (en) * | 2019-05-17 | 2020-11-17 | 扬子江药业集团有限公司 | Preparation method of butylphthalide |
| CN113024495A (en) * | 2019-12-25 | 2021-06-25 | 上海奥博生物医药技术有限公司 | Novel method for purifying butylphthalide |
| CN114262313A (en) * | 2021-12-23 | 2022-04-01 | 乐普药业股份有限公司 | Method for purifying butylphthalide |
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| CN1382682A (en) * | 2002-05-09 | 2002-12-04 | 中国医学科学院药物研究所 | 2-(alpha-hydroxypentyl) benzoate and its preparing process and usage |
| CN101337955A (en) * | 2008-08-13 | 2009-01-07 | 中国科学院上海有机化学研究所 | Method for preparing high optical purity 3-substituted chiral phthalide compounds |
| CN105418564A (en) * | 2015-08-21 | 2016-03-23 | 石药集团恩必普药业有限公司 | New pretreatment method for butylphthalide |
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