CN105854070A - Method for preparing biomedical metal material - Google Patents

Method for preparing biomedical metal material Download PDF

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Publication number
CN105854070A
CN105854070A CN201610202141.0A CN201610202141A CN105854070A CN 105854070 A CN105854070 A CN 105854070A CN 201610202141 A CN201610202141 A CN 201610202141A CN 105854070 A CN105854070 A CN 105854070A
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parts
metallic material
preparation
fine powder
oxide fine
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不公告发明人
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Qingdao Bairuiji Biological Engineering Co Ltd
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Qingdao Bairuiji Biological Engineering Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

The present invention provides a method for preparing a biomedical metal material. The method is as below: first mixing zinc oxide fine powder, magnesium oxide fine powder, sodium hexametaphosphate, polymethylacrylic acid, terpineol, butyl acetate, castor oil, a silane coupling agent and rosin glycerol esters, reacting at 70-90 DEG C, then adding gelatin, soy lecithin, polypropylene and sodium starch to the obtained reaction products, dropwise adding a solution of potassium permanganate at 8-15 DEG C, stirring well, heating for reaction, cooling to room temperature, and finally filtering off the reaction products, washing with water and drying. The biomedical metal material has hardness of 263, friction coefficient of 0.59, pitting point of 1.509V, anti-Staphylococcus aureus rate of higher than 90%, good mechanical and tribological properties, corrosion resistance and resistance to S. aureus.

Description

A kind of preparation method of biomedical metallic material
Technical field
The invention belongs to biology medical material technical field, be specifically related to the preparation method of a kind of biomedical metallic material.
Background technology
After medical biodegradable material has referred to medical functions, can be decomposed by the lyase in organism and absorb, it is desirable to peace Entirely, nontoxic, nonirritant, good with the human-body biological compatibility.Along with medical science and the development of material science, biological fall Solve material obtained swift and violent development, be widely used in suture, fracture fixation, treatment of cancer, family planning, The fields such as the repairing of drug delivery system, organ and organizational project.
The kind of Biodegradable material is a lot, mainly high-molecular biologic degradable material, additionally include bioceramic class, The hybrid material class etc. that biologically-derived species, bioactive substance and abiotic material are combined into.But current various life Biodegradable material the most all also exist such as Biostrength not to such an extent as to fix unsuccessfully, locally nonspecific inflammation, degrading can The deficiencies such as control property difference, these all character with material itself have much relations.Although oneself has tens kinds of degradable biological materials at present Material, but really go through to be applied to the most several of clinic, mainly PGA and PLA.
Compared with bioceramic and bioabsorbable polymer material, biomedical metallic material, as rustless steel, cobalt-base alloy, titanium and Titanium alloy and noble metal etc. have high intensity, good toughness and counter-bending fatigue strength, excellent processing characteristics etc. and are permitted Many irreplaceable premium properties of other medical material.The subject matter that biomedical metallic material faces in the application, be by The metal ion caused in the corrosion of physiological environment spreads and the regression of embedded material self property to surrounding tissue, the former May cause toxic and side effects, the latter may cause implanting lost efficacy.Therefore performance is more excellent, biocompatibility is more preferable in research and development New bio medical metal material be still that material supplier author and the problem of medical personnel's common concern.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art to provide the preparation method of a kind of biomedical metallic material, gained Material has good mechanics and frictional behaviour, corrosion resisting property and anti-S. aureus L-forms performance.
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 5～15 parts, magnesium oxide powder 7～12 parts, sodium hexameta phosphate 2～ 6 parts, polymethylacrylic acid 1～7 parts, terpineol 3～6 parts, butyl acetate 2～5 parts, Oleum Ricini 1～4 parts, silane are occasionally Connection agent 3～6 parts and rosin glyceride 1～5 parts of mixing, react 1～2h under the conditions of 70～90 DEG C, obtain reactant A；
Step 2, in parts by weight, by gelatin 4～9 parts, soybean lecithin 2～6 parts, polypropylene 1～5 parts and Starch Sodium 3～9 parts add in step 1 gained reactant, drip potassium permanganate solution 5～10 parts, drip under the conditions of 8～15 DEG C Bi Hou, stirring all, is warming up to 40～50 DEG C, reacts 4～6h, is down to room temperature, obtains reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Further, in step 1, the granularity of zinc oxide fine powder is 200～400 mesh, and the granularity of magnesium oxide powder is 200～400 Mesh.
Further, silane coupler described in step 1 is KH-550 or KH-792.
Further, in step 2, the mass concentration of potassium permanganate solution is 1～3%.
Further, drying temperature in step 3 is 120～130 DEG C, and the time is 10～12h.
Further, zinc oxide fine powder described in step 1 is to obtain through acrylic resin modification.
The step of pretreatment is: the sodium hydroxide solution of 80 DEG C of 10wt% that Zinc oxide powder is placed in 5 times of weight soaks 2 Hour, it is dehydrated after taking-up, is placed in the acrylic resin of 40 DEG C 5 times of the Zinc oxide powder weight before not soaking (weight be), Keep 1 hour, by the peace and quiet post-drying of ethanol water of 30vol.% after taking-up.
The biomedical metallic material microhardness of the present invention is 263, and coefficient of friction is 0.59, and some pitting position is 1.509V, Anti-S. aureus L-forms rate, up to more than 90%, has good mechanics and frictional behaviour, corrosion resisting property and anti-S. aureus L-forms performance.
Detailed description of the invention
Embodiment 1
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 5 parts, magnesium oxide powder 7 parts, sodium hexameta phosphate 2 parts, poly-methyl 1 part of acrylic acid, terpineol 3 parts, butyl acetate 2 parts, Oleum Ricini 1 part, silane coupler 3 parts and rosin glyceride 1 Part mixing, reacts 2h under the conditions of 70 DEG C, obtains reactant A；
Step 2, in parts by weight, adds to step by 4 parts of gelatin, soybean lecithin 2 parts, polypropylene 1 part and Starch Sodium 3 parts In rapid 1 gained reactant, dripping potassium permanganate solution 5 parts under the conditions of 8 DEG C, after dropping, stirring all, is warming up to 40 DEG C, react 6h, be down to room temperature, obtain reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Wherein, in step 1, the granularity of zinc oxide fine powder is 200 mesh, and the granularity of magnesium oxide powder is 200 mesh, silane coupled Agent is KH-550；In step 2, the mass concentration of potassium permanganate solution is 1%；Drying temperature in step 3 is 120 DEG C, the time For 12h.
Embodiment 2
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 9 parts, magnesium oxide powder 11 parts, sodium hexameta phosphate 4 parts, poly-first 2 parts of base acrylic acid, terpineol 4 parts, butyl acetate 3 parts, Oleum Ricini 3 parts, silane coupler 5 parts and rosin glyceride 4 Part mixing, reacts 1h under the conditions of 80 DEG C, obtains reactant A；
Step 2, in parts by weight, adds to step by 8 parts of gelatin, soybean lecithin 4 parts, polypropylene 3 parts and starch 8 parts In 1 gained reactant, dripping potassium permanganate solution 9 parts under the conditions of 12 DEG C, after dropping, stirring all, is warming up to 50 DEG C, react 4h, be down to room temperature, obtain reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Wherein, in step 1, the granularity of zinc oxide fine powder is 300 mesh, and the granularity of magnesium oxide powder is 400 mesh, silane coupled Agent is KH-792；In step 2, the mass concentration of potassium permanganate solution is 2%；Drying temperature in step 3 is 125 DEG C, the time For 11h.
Embodiment 3
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 14 parts, magnesium oxide powder 9 parts, sodium hexameta phosphate 3 parts, poly-first 5 parts of base acrylic acid, terpineol 4 parts, butyl acetate 3 parts, Oleum Ricini 2 parts, silane coupler 5 parts and rosin glyceride 4 Part mixing, reacts 2h under the conditions of 90 DEG C, obtains reactant A；
Step 2, in parts by weight, adds to step by 8 parts of gelatin, soybean lecithin 5 parts, polypropylene 4 parts and Starch Sodium 4 parts In rapid 1 gained reactant, dripping potassium permanganate solution 8 parts under the conditions of 12 DEG C, after dropping, stirring all, is warming up to 50 DEG C, react 4h, be down to room temperature, obtain reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Wherein, in step 1, the granularity of zinc oxide fine powder is 400 mesh, and the granularity of magnesium oxide powder is 200 mesh, silane coupled Agent is KH-550；In step 2, the mass concentration of potassium permanganate solution is 3%；Drying temperature in step 3 is 130 DEG C, the time For 10h.
Embodiment 4
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 15 parts, magnesium oxide powder 12 parts, sodium hexameta phosphate 6 parts, poly-first 7 parts of base acrylic acid, terpineol 6 parts, butyl acetate 5 parts, Oleum Ricini 4 parts, silane coupler 6 parts and rosin glyceride 5 Part mixing, reacts 1h under the conditions of 90 DEG C, obtains reactant A；
Step 2, in parts by weight, adds to step by 9 parts of gelatin, soybean lecithin 6 parts, polypropylene 5 parts and Starch Sodium 9 parts In rapid 1 gained reactant, dripping potassium permanganate solution 10 parts under the conditions of 15 DEG C, after dropping, stirring all, is warming up to 40 DEG C, react 6h, be down to room temperature, obtain reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Wherein, in step 1, the granularity of zinc oxide fine powder is 200 mesh, and the granularity of magnesium oxide powder is 200 mesh, silane coupled Agent is KH-550；In step 2, the mass concentration of potassium permanganate solution is 1%；Drying temperature in step 3 is 120 DEG C, the time For 12h.
Embodiment 5
The present embodiment is with the difference of embodiment 3: zinc oxide fine powder described in step 1 is modified through acrylic resin Arrive.Modified concrete grammar is: the sodium hydroxide solution of 80 DEG C of 10wt% that Zinc oxide powder is placed in 5 times of weight soaks 2 hours, it is dehydrated after taking-up, is placed in the acrylic resin of 40 DEG C that (weight is 5 of the Zinc oxide powder weight before not soaking Times), keep 1 hour, by the peace and quiet post-drying of ethanol water of 30vol.% after taking-up.
The preparation method of a kind of biomedical metallic material, comprises the following steps:
Step 1, in parts by weight, by modified zinc oxide fine powder 14 parts, magnesium oxide powder 9 parts, sodium hexameta phosphate 3 parts, Polymethylacrylic acid 5 parts, terpineol 4 parts, butyl acetate 3 parts, Oleum Ricini 2 parts, silane coupler 5 parts and Colophonium are sweet Grease 4 parts mixing, reacts 2h under the conditions of 90 DEG C, obtains reactant A；
Step 2, in parts by weight, adds to step by 8 parts of gelatin, soybean lecithin 5 parts, polypropylene 4 parts and Starch Sodium 4 parts In rapid 1 gained reactant, dripping potassium permanganate solution 8 parts under the conditions of 12 DEG C, after dropping, stirring all, is warming up to 50 DEG C, react 4h, be down to room temperature, obtain reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
Wherein, in step 1, the granularity of zinc oxide fine powder is 400 mesh, and the granularity of magnesium oxide powder is 200 mesh, silane coupled Agent is KH-550；In step 2, the mass concentration of potassium permanganate solution is 3%；Drying temperature in step 3 is 130 DEG C, the time For 10h.
Embodiment 1 to 5 resulting materials is carried out performance test, and result is as follows:
Microhardness Coefficient of friction Point pitting position/V Anti-S. aureus L-forms rate/%
Embodiment 1 275 0.65 1.524 90
Embodiment 2 269 0.59 1.519 92
Embodiment 3 271 0.61 1.509 91
Embodiment 4 263 0.52 1.515 93
Embodiment 5 327 0.87 1.874 99
From result above, the material microhardness of the present invention is 263, and coefficient of friction is 0.59, and some pitting position is 1.509V, Anti-S. aureus L-forms rate, up to more than 90%, has good mechanics and frictional behaviour, corrosion resisting property and anti-S. aureus L-forms performance.Implement The zinc oxide fine powder of example 5 is modified through acrylic resin, and the properties of material is all improved, and this is possibly due to change Property zinc oxide on the one hand can contact with S. aureus L-forms, thus destroy the respiratory system of cell and substance delivery system makes cell loss divide Split fertility and dead, on the other hand can cause material surface hardened, enhance the plastic deformation resistance on surface.

Claims (6)

1. the preparation method of a biomedical metallic material, it is characterised in that: comprise the following steps:
Step 1, in parts by weight, by zinc oxide fine powder 5～15 parts, magnesium oxide powder 7～12 parts, sodium hexameta phosphate 2～6 parts, polymethylacrylic acid 1～7 parts, terpineol 3～6 parts, butyl acetate 2～5 parts, Oleum Ricini 1～4 parts, silane coupler 3～6 parts and rosin glyceride 1～5 parts of mixing, under the conditions of 70～90 DEG C, react 1～2h, obtain reactant A；
Step 2, in parts by weight, gelatin 4～9 parts, soybean lecithin 2～6 parts, polypropylene 1～5 parts and Starch Sodium 3～9 parts are added in step 1 gained reactant, dripping potassium permanganate solution 5～10 parts under the conditions of 8～15 DEG C, after dropping, stirring is all, it is warming up to 40～50 DEG C, reaction 4～6h, is down to room temperature, obtains reactant B；
Step 3, leaches step 2 gained reactant B, cleans with water, after drying, to obtain final product.
The preparation method of biomedical metallic material the most according to claim 1, it is characterised in that: in step 1, the granularity of zinc oxide fine powder is 200～400 mesh, and the granularity of magnesium oxide powder is 200～400 mesh.
The preparation method of biomedical metallic material the most according to claim 1, it is characterised in that: silane coupler described in step 1 is KH-550 or KH-792.
The preparation method of biomedical metallic material the most according to claim 1, it is characterised in that: in step 2, the mass concentration of potassium permanganate solution is 1～3%.
The preparation method of biomedical metallic material the most according to claim 1, it is characterised in that: drying temperature in step 3 is 120～130 DEG C, and the time is 10～12h.
The preparation method of biomedical metallic material the most according to claim 1, it is characterised in that: zinc oxide fine powder described in step 1 is to obtain through acrylic resin modification.
CN201610202141.0A 2016-03-31 2016-03-31 Method for preparing biomedical metal material Pending CN105854070A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823690A (en) * 2016-09-14 2018-03-23 东洋铝株式会社 The manufacture method of the fixed material of surgery
CN113510990A (en) * 2020-09-29 2021-10-19 东莞市元普塑胶科技有限公司 Artificial leather with artificial leather produced and prepared by supercritical nitrogen foaming technology

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077256A1 (en) * 2005-01-24 2006-07-27 Cinvention Ag Metal containing composite materials
CN103724565A (en) * 2013-11-26 2014-04-16 沃太能源南通有限公司 Preparation method of composite water absorbent material taking cyperus alternifolius as base material
CN104212103A (en) * 2014-09-28 2014-12-17 无锡康柏斯机械科技有限公司 Preparation method of heat-resisting PVC (polyvinyl chloride)/ABS (acrylonitrile butadiene styrene)/PMMA (polymethyl methacrylate) alloy material
CN104436310A (en) * 2014-11-07 2015-03-25 苏州维泰生物技术有限公司 Biomedical metal material and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077256A1 (en) * 2005-01-24 2006-07-27 Cinvention Ag Metal containing composite materials
CN103724565A (en) * 2013-11-26 2014-04-16 沃太能源南通有限公司 Preparation method of composite water absorbent material taking cyperus alternifolius as base material
CN104212103A (en) * 2014-09-28 2014-12-17 无锡康柏斯机械科技有限公司 Preparation method of heat-resisting PVC (polyvinyl chloride)/ABS (acrylonitrile butadiene styrene)/PMMA (polymethyl methacrylate) alloy material
CN104436310A (en) * 2014-11-07 2015-03-25 苏州维泰生物技术有限公司 Biomedical metal material and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107823690A (en) * 2016-09-14 2018-03-23 东洋铝株式会社 The manufacture method of the fixed material of surgery
CN113510990A (en) * 2020-09-29 2021-10-19 东莞市元普塑胶科技有限公司 Artificial leather with artificial leather produced and prepared by supercritical nitrogen foaming technology

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