CN105853363A - Preparation method of tylosin tartrate premix - Google Patents
Preparation method of tylosin tartrate premix Download PDFInfo
- Publication number
- CN105853363A CN105853363A CN201610191418.4A CN201610191418A CN105853363A CN 105853363 A CN105853363 A CN 105853363A CN 201610191418 A CN201610191418 A CN 201610191418A CN 105853363 A CN105853363 A CN 105853363A
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- CN
- China
- Prior art keywords
- tylosin tartrate
- mixing
- rotating shaft
- batch mixing
- preparation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/23—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis
- B01F27/232—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes
- B01F27/2322—Mixers with rotary stirring devices in fixed receptacles; Kneaders characterised by the orientation or disposition of the rotor axis with two or more rotation axes with parallel axes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/60—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/60—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis
- B01F27/71—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis with propellers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of a tylosin tartrate premix. The method comprises the following steps: 1, extracting tylosin tartrate: extracting a tylosin tartrate-containing back extraction solution with trichloromethane, dehydrating the obtained trichloromethane extract solution through using anhydrous sodium sulfate, and carrying out reduced pressure distillation to completely remove trichloromethane in order to obtain tylosin tartrate; 2, drying the extracted tylosin tartrate, and processing the dried tylosin tartrate to obtain powder; and 3, preparing the tylosin tartrate premix: uniformly mixing the tylosin tartrate powder with auxiliary materials through a mixing device, and packaging the obtained premix in bags by specification. The problem of slow production speed of the tylosin tartrate premix, easily induced by present preparation technologies of the tylosin tartrate premix, is solved in the invention.
Description
Technical field
The present invention relates to medical drugs preparation technology field, be specifically related to the preparation method of tylosin tartrate pre-mixing agent.
Background technology
Tylosin tartrate Tylan Tartrate again, has specially good effect to mycoplasma, as the choice drug that anti-mycoplasma is sick.Tylosin tartrate belongs to Macrolide animal specific antibiotic, its mechanism of action mainly plays sterilization functions by hindering the synthesis of bacterium protein, and this product is the most easily absorbed, and excretion is rapidly, in tissue, thing residual, has specially good effect to gram positive bacteria, mycoplasma.Especially pig pleuritis Actinobacillus is had the highest activity, be the choice drug of the poultry chronic respiratory tract disease that treatment mycoplasma causes.
The effect and the safety that how to improve injecting drug use always are the problem that pharmaceutical producing enterprise wishes to solve, the effect of injecting drug use and the main solution in terms of two of safety, one is effect and the safety that Formulation guarantees medication, and two is effect and the safety that the process for producing of medicine guarantees medicine.The prescription of tylosin tartrate pre-mixing agent is single, it is ensured that the effect of its medicine and safe main path are through being controlled its preparation technology.
The speed of production that the preparation technology of existing tylosin tartrate pre-mixing agent is easily caused tylosin tartrate pre-mixing agent is slower.
Summary of the invention
It is an object of the invention to provide the preparation method of tylosin tartrate pre-mixing agent, solving the preparation technology of existing tylosin tartrate pre-mixing agent, to be easily caused the speed of production of tylosin tartrate pre-mixing agent slower
Problem.
The present invention is achieved through the following technical solutions:
The preparation method of tylosin tartrate pre-mixing agent, comprises the following steps:
1), the extraction of tylosin tartrate: use the chloroform extraction anti-stripping agent containing tylosin tartrate, the extract of chloroform is eliminated chloroform with anhydrous sodium sulfate dehydration, decompression distillation successively, obtains tylosin tartrate；
2), the tylosin tartrate of extraction dried and be prepared as powder；
3), the preparation technology of tylosin tartrate pre-mixing agent: after tylosin tartrate powder is uniformly mixed by mixing device with adjuvant, carry out packed by specification, described mixing device includes V-arrangement charging aperture, the discharge end of V-arrangement charging aperture connects one-level batch mixing chamber, one-level batch mixing intracavity is provided with the first rotating shaft, it is provided with projection in first rotating shaft, the discharge end in one-level batch mixing chamber connects two grades of batch mixing chambeies, two grades of batch mixing intracavity are provided with the second rotating shaft, it is provided with helical structure in second rotating shaft, the bottom in two grades of batch mixing chambeies is provided with discharging opening, valve it is provided with on discharging opening, two grades of batch mixing chambeies are arranged on support seat, described first rotating shaft and the second rotating shaft are by motor control.
Mixing drum-type the to be used mixing of existing tylosin tartrate pre-mixing agent, the mixing of existing drum-type can not be carried out continuously the former medicine of mixing, and the speed of production causing tylosin tartrate pre-mixing agent is slower.
Adjuvant of the present invention is that adjuvant is commonly used in pharmacy；Described V-arrangement charging aperture specifically refers to by the feeding structure of two feed ends, it is simple to the former medicine that two kinds different is put into one-level batch mixing intracavity simultaneously；Described helical structure specifically refers to the spirillum arranged around the second rotating shaft.
Tylosin tartrate powder of the present invention and the blending process of adjuvant: by tylosin powder, adjuvant is put into one-level batch mixing chamber by two feed ends of V-arrangement charging aperture respectively, 2 kinds of raw materials meet contact then into one-level batch mixing intracavity at the discharge end of V-arrangement charging aperture, electric machine rotation drives the first axis of rotation, make protruding stirring at the former medicine of mixing of one-level batch mixing intracavity, mix former medicine and drop into two grades of batch mixing intracavity after one-level batch mixing chamber mixes, driven by motor the second axis of rotation, helical structure stirring mixing raw material is made to realize secondary mixing, improve the uniformity of former medicine, mixed former medicine is exported endlessly by discharging opening, realize mixing tylosin tartrate powder and adjuvant continuously.
The present invention can be simultaneously introduced tylosin tartrate powder and adjuvant V-arrangement charging aperture by setting, raw material after entrance sequentially passes through one-level batch mixing chamber, two grades of batch mixing chambeies and raw material is carried out secondary mixing, former medicine after mixing is discharged by discharging opening, it is achieved mixes continuously, export former medicine；Further, the present invention uses two grades of batch mixings, improves the uniformity of batch mixing.
Further, projection is smooth conical structure, and the summit of conical structure is away from the first rotating shaft.
Smooth conical structure can be effectively prevented from former medicine and be attached in projection, affects the Blending Efficiency of Blending of raw material.
Further, helical structure is smooth tubular body.
Smooth tubular body can be effectively prevented from former medicine and be attached in projection, affects the Blending Efficiency of Blending of raw material.
Further, the bottom concave downward in two grades of batch mixing chambeies, groove is formed at middle part, described discharging opening is arranged on groove.
Discharging opening is arranged on groove be conducive to deriving mixed former medicine.
Further, the bottom supporting seat is arranged with protection set.
Arranging it can be avoided that support the abrasion in seat bottom portion of protection set.
The present invention compared with prior art, has such advantages as and beneficial effect:
The present invention can be simultaneously introduced tylosin tartrate powder and adjuvant V-arrangement charging aperture by setting, raw material after entrance sequentially passes through one-level batch mixing chamber, two grades of batch mixing chambeies and raw material is carried out secondary mixing, former medicine after mixing is discharged by discharging opening, realize mixing continuously, exporting former medicine, solve the preparation technology of existing tylosin tartrate pre-mixing agent and be easily caused the problem that the speed of production of tylosin tartrate pre-mixing agent is slower.
Accompanying drawing explanation
Accompanying drawing described herein is used for providing being further appreciated by the embodiment of the present invention, constitutes the part of the application, is not intended that the restriction to the embodiment of the present invention.In the accompanying drawings:
Fig. 1 is the structural representation of evenly mixing device.
The parts title of labelling and correspondence in accompanying drawing:
1-V shape charging aperture, 2-one-level batch mixing chamber, 3-the first rotating shaft, bis-grades of batch mixing chambeies of 4-, 5-the second rotating shaft, 6-discharging opening, 7-valve, 8-supports seat, and 9-protects set, and 31-is protruding, 51-helical structure.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearer, below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, and the exemplary embodiment of the present invention and explanation thereof are only used for explaining the present invention, not as a limitation of the invention.
Embodiment 1:
As it is shown in figure 1, the preparation method of tylosin tartrate pre-mixing agent, comprise the following steps:
1), the extraction of tylosin tartrate: use the chloroform extraction back extraction containing tylosin tartrate
Take liquid, the extract of chloroform is eliminated chloroform with anhydrous sodium sulfate dehydration, decompression distillation successively, obtains tylosin tartrate；
2), the tylosin tartrate of extraction dried and be prepared as powder；
3), the preparation technology of tylosin tartrate pre-mixing agent: tylosin tartrate powder is led to adjuvant
Cross after mixing device uniformly mixes, carry out packed by specification, described mixing device includes V-arrangement charging aperture 1, the discharge end of V-arrangement charging aperture 1 connects one-level batch mixing chamber 2, the first rotating shaft 3 it is provided with in one-level batch mixing chamber 2, protruding 31 it are provided with in first rotating shaft 3, the discharge end in one-level batch mixing chamber 2 connects two grades of batch mixing chambeies 4, the second rotating shaft 5 it is provided with in two grades of batch mixing chambeies 4, it is provided with helical structure 51 in second rotating shaft 5, the bottom in two grades of batch mixing chambeies 4 is provided with discharging opening 6, valve 7 it is provided with on discharging opening 6, two grades of batch mixing chambeies 4 are arranged on support seat 8, described first rotating shaft 3 and the second rotating shaft 5 are by motor control.
Embodiment 2:
As it is shown in figure 1, the present embodiment is based on embodiment 1, described protruding 31 is smooth conical structure, circle
The summit of wimble structure is away from the first rotating shaft 3；Described helical structure 51 is smooth tubular body.The bottom concave downward in described two grades of batch mixing chambeies 4, forms groove at middle part, and described discharging opening 6 is arranged on groove；The bottom of described support seat 8 is arranged with protection set 9.
Above-described detailed description of the invention; the purpose of the present invention, technical scheme and beneficial effect are further described; it is it should be understood that; the foregoing is only the detailed description of the invention of the present invention; the protection domain being not intended to limit the present invention; all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. done, should be included within the scope of the present invention.
Claims (5)
1. the preparation method of tylosin tartrate pre-mixing agent, it is characterised in that comprise the following steps:
1), the extraction of tylosin tartrate: use the chloroform extraction back extraction containing tylosin tartrate
Take liquid, the extract of chloroform is eliminated chloroform with anhydrous sodium sulfate dehydration, decompression distillation successively, obtains tylosin tartrate；
2), the tylosin tartrate of extraction dried and be prepared as powder；
3), the preparation technology of tylosin tartrate pre-mixing agent: tylosin tartrate powder is led to adjuvant
Cross after mixing device uniformly mixes, carry out packed by specification, described mixing device includes V-arrangement charging aperture (1), the discharge end of V-arrangement charging aperture (1) connects one-level batch mixing chamber (2), the first rotating shaft (3) it is provided with in one-level batch mixing chamber (2), projection (31) it is provided with in first rotating shaft (3), the discharge end in one-level batch mixing chamber (2) connects two grades of batch mixing chambeies (4), it is provided with the second rotating shaft (5) in two grades of batch mixing chambeies (4), helical structure (51) it is provided with in second rotating shaft (5), the bottom of two grades of batch mixing chambeies (4) is provided with discharging opening (6), valve (7) it is provided with on discharging opening (6), two grades of batch mixing chambeies (4) are arranged in support seat (8), described first rotating shaft (3) and the second rotating shaft (5) are by motor control.
The preparation method of tylosin tartrate pre-mixing agent the most according to claim 1, it is characterised in that described projection (31) is smooth conical structure, the summit of conical structure is away from the first rotating shaft (3).
The preparation method of tylosin tartrate pre-mixing agent the most according to claim 1, it is characterised in that described helical structure (51) is smooth tubular body.
The preparation method of tylosin tartrate pre-mixing agent the most according to claim 1, it is characterised in that the bottom concave downward of described two grades of batch mixing chambeies (4), forms groove at middle part, and described discharging opening (6) is arranged on groove.
The preparation method of tylosin tartrate pre-mixing agent the most according to claim 1, it is characterised in that the bottom of described support seat (8) is arranged with protection set (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191418.4A CN105853363A (en) | 2016-03-30 | 2016-03-30 | Preparation method of tylosin tartrate premix |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610191418.4A CN105853363A (en) | 2016-03-30 | 2016-03-30 | Preparation method of tylosin tartrate premix |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105853363A true CN105853363A (en) | 2016-08-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610191418.4A Pending CN105853363A (en) | 2016-03-30 | 2016-03-30 | Preparation method of tylosin tartrate premix |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105853363A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265711A (en) * | 2016-08-25 | 2017-01-04 | 浦城正大生化有限公司 | Tylosin phosphonate pre-mixing agent formula and preparation technology |
| CN106309409A (en) * | 2016-09-29 | 2017-01-11 | 乐山市瑞和祥动物保健药业有限公司 | Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447421A (en) * | 1980-05-08 | 1984-05-08 | American Cyanamid Company | Process for the preparation of medicated animal feed supplement |
| US6079541A (en) * | 1997-01-16 | 2000-06-27 | S.B.R S.R.L. | Container gripper, in particular for bottles |
| CN101347786A (en) * | 2008-09-11 | 2009-01-21 | 江苏星A包装机械集团有限公司 | Clip for washing bottle |
| CN202590654U (en) * | 2012-10-11 | 2012-12-12 | 成都中牧生物药业有限公司 | Simple mixer used for mixing of drug powder |
| CN103240030A (en) * | 2013-05-17 | 2013-08-14 | 成都中牧生物药业有限公司 | Liquid medicine mixing device |
| CN103588837A (en) * | 2012-08-14 | 2014-02-19 | 王玉万 | Tylosin tartrate or tylosin phosphate extraction from reextraction liquid |
| CN104892705A (en) * | 2015-05-11 | 2015-09-09 | 成都中牧生物药业有限公司 | Preparation technology of tylosin tartrate for injection |
| CN104926899A (en) * | 2015-05-11 | 2015-09-23 | 成都中牧生物药业有限公司 | Preparation process avoiding the reduction of tylosin tartrate original drug potency |
| CN105254524A (en) * | 2015-10-28 | 2016-01-20 | 成都中牧生物药业有限公司 | Preparation technology avoiding reduction of tetracycline hydrochloride technical original drug property |
-
2016
- 2016-03-30 CN CN201610191418.4A patent/CN105853363A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447421A (en) * | 1980-05-08 | 1984-05-08 | American Cyanamid Company | Process for the preparation of medicated animal feed supplement |
| US6079541A (en) * | 1997-01-16 | 2000-06-27 | S.B.R S.R.L. | Container gripper, in particular for bottles |
| CN101347786A (en) * | 2008-09-11 | 2009-01-21 | 江苏星A包装机械集团有限公司 | Clip for washing bottle |
| CN103588837A (en) * | 2012-08-14 | 2014-02-19 | 王玉万 | Tylosin tartrate or tylosin phosphate extraction from reextraction liquid |
| CN202590654U (en) * | 2012-10-11 | 2012-12-12 | 成都中牧生物药业有限公司 | Simple mixer used for mixing of drug powder |
| CN103240030A (en) * | 2013-05-17 | 2013-08-14 | 成都中牧生物药业有限公司 | Liquid medicine mixing device |
| CN104892705A (en) * | 2015-05-11 | 2015-09-09 | 成都中牧生物药业有限公司 | Preparation technology of tylosin tartrate for injection |
| CN104926899A (en) * | 2015-05-11 | 2015-09-23 | 成都中牧生物药业有限公司 | Preparation process avoiding the reduction of tylosin tartrate original drug potency |
| CN105254524A (en) * | 2015-10-28 | 2016-01-20 | 成都中牧生物药业有限公司 | Preparation technology avoiding reduction of tetracycline hydrochloride technical original drug property |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265711A (en) * | 2016-08-25 | 2017-01-04 | 浦城正大生化有限公司 | Tylosin phosphonate pre-mixing agent formula and preparation technology |
| CN106309409A (en) * | 2016-09-29 | 2017-01-11 | 乐山市瑞和祥动物保健药业有限公司 | Tylosin tartrate premix composition and preparation method of tylosin tartrate sustained-released pellets |
| CN106309409B (en) * | 2016-09-29 | 2019-05-24 | 乐山市瑞和祥动物保健药业有限公司 | A kind of sustained release pellet preparation method of Tylosin Tartrate pre-mixing agent composition |
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| PB01 | Publication | ||
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Application publication date: 20160817 |