CN105796230B

CN105796230B - cold compress application

Info

Publication number: CN105796230B
Application number: CN201610401701.5A
Authority: CN
Inventors: 袁暾
Original assignee: Individual
Current assignee: Uyounge Medicanl Care Co ltd
Priority date: 2016-06-11
Filing date: 2016-06-11
Publication date: 2019-01-18
Anticipated expiration: 2036-06-11
Also published as: CN105796230A

Abstract

Cold compress application belongs to medical instruments field, is related to a kind of application for cold compress.It, which is seen, from longitudal section is divided into tissue-contacting layer, cold-storage gel layer and the laying with adhesive from inside to outside.There is mesh on tissue-contacting layer, and guarantees the attaching bonding zone area that perienchyma's contact layer is contacted with laying.Adjustment to mesh, such as shape, size, some designs of distribution, can effectively improve tissue and stick mode, provide to cold compress temperature, the more precise controls such as duration.Cold compress gelinite can directly contact tissue, and residual when can reduce removal, further improve the functional result of carrying object.In particular for emerging clinical demand, such as wound or Polluted area, laser therapy, the mesh design in the cold compress of radiation therapy etc., in comprehensive application technology scheme, the means such as heat transfer control and gelinite carrying, comfort and convenient can be constructed, contact is good, registration, function is unique, safe and reliable cold compress application.

Description

Cold compress application

Technical field

The present invention relates to a kind of medical instruments, and in particular to a kind of application for cold compress, this applies the use that can be convenient Cold compress in each position, can be used in surgery and postoperative, and also combinable functional materials are with different clinical effectiveness.

Background technique

Cold compress is one of common physical therapy modalities.By reducing local tissue temperature, the local blood of contraction can achieve Pipe, analgesia mitigate the multi-effects such as inflammatory swelling.For acute injury, the illness such as local inflammation, cold compress is widely used.Companion With the development of modern biomedical, many new applications of cold compress are also constantly found, for example, existing research prompts, dermatological laser In treatment, the generation of the discomfort and complication of patient is can be effectively reduced in postoperative cold compress in art；For another example, radiation therapy process In, perienchyma's cold compress can significantly protect these tissues, reduce non-target site tissue damage, and then widen optional dosage water It is flat, side reaction is reduced, patient compliance is promoted and better curative effect is provided.But technological progress is to the realization shape of cold compress itself Formula also proposed new requirement, including attaching and fixed, suitable cold compress temperature and duration, wound to the effective of different parts Hurt surface contact suitability, antibiotic anti-infection, functionalization and carries medicine, the noresidue removal after cold compress etc., and these problems Existing routine cold compress means are difficult to solve.

Existing cold compress medium includes external cold source cold compress, ice cube/ice crystal, salting liquid, organic phase change material and gelinite etc.. By Cold cornpressing body be fixed on the means at cold compress position then there are many.External cold source generally often needs binding-type or pressurization because there is interconnecting piece It is mechanically fixed.Ice cube/ice crystal, salting liquid, organic phase change material etc. mostly use isolation pocket packaging blend compounds cloth/band fixation, this Body surface planar tissue effect is pretty good, but for the position with curved surface, it is difficult to guarantee the consistent surface contact of Cold cornpressing body.Needle There are some designs that surrounded by edges band adhesive gasket layer has been used to carry out salting liquid flexible, organic phase change material and gelinite Fixed mode, this facilitates more preferably tissue and attaches.Even if being this fixed form, salting liquid and organic phase change material are still Closing bag body packaging is mostly used, this is unfavorable to effective heat transfer.For gelinite, sealed bag packs and barrier is not added completely, The problem of fixed form of directly tissue contact has, and simple closing packaging not only equally exists heat transfer, but also be unfavorable for Effective contact when gelinite has function；And barrier is not added completely then prevents the residual of gel component after cold compress finishes On it is still defective, and the design of barrier layer can not be passed through and control heat transfer, regulate and control cold compress temperature and duration.

Gelinite has some advantages outstanding compared with other cool storage mediums.Gelinite is generally softer, has certain Adhesiveness, can preferably be attached at tissue surface；By adjusting the concentration of gel-type vehicle ingredient, crosslinking degree, proportion etc. Can successional its physical property of adjustment include cold-storage capacity；Also, nontoxic and with good biocompatibility gel can Using the carrier as drug or other function substance, unique effect is played in special applications.But gelinite also has one A little disadvantages, for example, intensity it is high gel adhesion it is weaker and show stiff；It might have adherency after the low gel cold compress of intensity Residual, and these residuals may have certain influence to the reparation of tissue, especially wound and pollution tissue, and low strong The cold-storage capacity for spending flexible gel body is still inadequate relative to the needs of long-time cold compress.In addition, functional gels contact tissue When wet environment antibacterial problem；Wet environment and requirement when being contacted with the complicated surface of a wound to suitable attaching；Whole application body Ventilative water imbibition；The problems such as fixed comfort level of laying skin and control functional with carrying substance, to adjust merely The method of gel volume property is difficult to be fully solved, and this is obviously unfavorable for further expanding its clinical application.

In specific clinical application, the requirement to cold compress material is often various, needs to consider various limitations and needs It asks.For example, being used in laser therapy, to application integral light-transmitting requirement with higher；And because laser treatment head is Plane smooth structure, application is such as uneven, will affect the energy density of its undertissue acquisition, influences therapeutic effect.For another example, In radioprotective cold compress, for the exposure of surrounding tissue effective temperature-reducing and target area, application may need to be designed to very The shape of rule, such as concentric loop to guarantee that efficient targeting irradiates.Some gels can carry radioprotective substance in irradiation It reduces damage and promotes tissue repair, it is apparent that it should not be made excessively to contact target area and must assure that it in surrounding tissue Contact and release, this proposes requirement to the contact form of gelinite and body.Therefore, the angle of clinical application stores gelinite The demand of cryogen type cold compress material, it may be necessary to which comprehensive technological means side is possible to reach.

Summary of the invention

To solve deficiency of the prior art when being applied to gel Cold cornpressing body, the group in cold compress application of the invention Knit designed on contact layer it is mesh-structured, and guarantee the periphery of certain area by mesh tissue-contacting layer with it is straight with adhesive gasket layer Contact the attaching bonding zone of building.It is designed in this way particularly suitable for that effectively can guarantee to apply using gel as cool storage medium The accurate control that cold compress temperature, duration are carried out under the premise of pasting position appropriate contact.Tissue-contacting layer mesh is function Property cold compress gelinite directly organize contact to provide condition, and can obviously reduce the tissue residue of gelinite.To mesh such as shape The adjustment of shape, size, distribution etc., in conjunction with some designs of laying, it is possible to provide specific cold compress curve, for adapting to difference The needs of clinical application.For example, laying and tissue-contacting layer design same mesh, it is possible to provide have both water suction, ventilative entirety Effect, and improve the intensity that tissue sticks, it avoids tearing discomfort when taking, more preferable performance is provided in wound cold compress application.Entirely Transparent design and the liner thickened are suitable for the needs of light transmission in laser operation, also, thicken laying and in fact also act control Freeze and applies the effect of duration.

The technical solution adopted in the present invention includes: that application is divided into three layers, can be divided into group from inside to outside from longitudal section sight Contact layer, cold-storage gel layer and the laying with adhesive are knitted, wherein tissue-contacting layer is the polymer membrane with mesh Material.It is the marginal zone that tissue-contacting layer binds directly that laying is constituted from application antapical view cold-storage gel layer periphery, and applies Upper any edges of regions sector width is not less than 0.5cm.In such design, tissue-contacting layer in fact as separation layer, The selection of its material can be played the role of adjusting thermal conduction effect first.Meanwhile because medical gel cold-storage material is relatively preferable Biocompatibility, for tissue-contacting layer without full-closed structure, the mesh designed thereon both can provide functional gels body Tissue contact can further adjust heat transfer to realize design function on demand.And even if mesh is larger, tissue-contacting layer according to Can so have certain isolating power on the basis of adapting to gelinite modulus, gel few as far as possible is residual when with benefit removal application It stays.In addition, this is conducive to be avoided because tissue-contacting layer can extend to always marginal zone in conjunction with laying in the technical program The refrigerating loss on periphery.In the case, the adhesive that can contact tissue is distributed only at mesh, this is advantageously reduced because being bonded Firm and cause discomfort and removal inconvenience.Correspondingly, for the balance loss of the adhesive strength as it caused by, it is desirable that marginal zone must guarantee one Fixed width, namely apply upper any edges of regions sector width and be not less than 0.5cm.

Technical solution of the present invention particularly suitable for functional gels body, apply by the cold compress such as polyvinyl alcohol gel as cold-storage material Patch.A variety of method buildings can be used in polyvinyl alcohol gel with good cold-storage ability and biocompatibility, including to contain boronation Object such as boric acid and borax is closed to be crosslinked etc..Because boron-containing compound has certain disinfection, this gelinite can be Antibacterial has effect unique in terms of anti-infection.Further, it is coagulated according to wet union theory due to suitable water conservation permeability Colloid can promote the reparation of wound when contacting wound tissue.But since wound surface is often with exudation, although gelinite A certain amount of sepage can be absorbed, but gelinite tissue-contacting layer part has and loses intensity and ask with softening etc. when sepage is more Topic, and certain adhesion may occur with tissue.On the other hand, although boron compound facilitates the anti-sense of antibacterial in the release of the surface of a wound Dye, but the boron element retained for a long time can have certain sustained toxicity, also, when for some more tissues of sensitivity, boron Compound it is too fast, excessive release is possible to bring certain tissue irritation, therefore, controls such gelinite and contacts with tissue It is quite important to its validity of adjustment and safety with the process of removing.Either barrier is packed or be not added completely to totally enclosed type Directly contacted with tissue, cannot all reach effective control to the above demand, hinder such cold compress and apply in particular tissues The application on surface.And the application constructed with the technical program, the presence of tissue-contacting layer play certain buffer action, mesh It can guarantee that gel body tissue contacts, create moist repairing environment and adjust sepage absorption, the contact and release of boron compound It can be adjusted by controlling mesh.

Organizing the mesh on separation layer is significant design in technical solution.As described above, can be used for fitting to the adjustment of mesh Different heat transfer demands is answered, dynamic adjusts ventilative water permeability, controls contact surface wet environment and gelinite absorbs the speed of sepage Degree and capacity.Mesh can be used for the rate of release and local concentration of ingredient such as boron compound in control gel.Usually to mesh Adjustment be its size, small scale such as micron order mesh slows down heat conduction velocity, provide limited sepage absorbability and slowly And lasting functional mass release；There is fast heat transfer if the large scale such as mesh for reaching Centimeter Level, sufficient moist ring is provided Border and sepage absorbability, and faster functional materials release.When needing to reach comprehensive certain effects, heterogeneity Hole scale mutually to arrange in pairs or groups be relatively simple method.It, may also by the intense adjustment of device to hole scale when using uniform meshes Reach adjustment purpose, but accurately best hole scale is more difficult under certain particular demands under acquisition change condition.And heterogeneity Hole scale collocation can provide bigger adjusting range, and in the application because microenvironment condition change when by different pore size difference It works and the reply of relative dynamic is provided.Comparing extreme design is 2 of mesh diameter more than polymer film width between mesh Times.In this case, providing limited isolation only since tissue-contacting layer is in the netted of macropore completely to help to go after cold compress It removes, but provides stronger moist repairing environment, heat conduction velocity and functional materials release.There are also one kind to be designed as not only Tissue-contacting layer equally has mesh on laying, to promote the ventilative water permeability integrally applied.To guarantee to obstruct bacterium property Can, laying is designed as the isolation structure of low air-and water-permeable by conventional dressing, and in the present solution, gel cold storage agent itself can contain There is bactericidal properties functional mass to be promoted to the barrier bacterium for needing protection zone, laying is without completely isolated.It even can be by laying Mesh with tissue separation layer correspond to each other, applied when making to be attached at body more compliant and light and handy.Equally, mesh exists for Some regulative modes provide possibility.For example, protrusion can be designed on cold-storage gel layer and pass through mesh to tissue contact surface Protrusion.Its benefit is that the direct tissue contact surface product of cold-storage gel can be further controlled by protrusion, is obtained simple mesh-structured The broader contact surface range that cannot provide to heat-conductive characteristic, wet environment, in terms of it is more flexible can Modulability.

One purpose of the technical program is to adapt to novel clinical demand.In light treatment art cold compress, to guarantee that treatment is situated between The transmission of matter-tool energy light, it is extremely important to apply whole transparent design.Suitable cold-storage gelinite can guarantee that its is transparent Property, high transparency high molecular material can be used in laying and tissue-contacting layer, and influence of the mesh to light energy distribution is negligible, and has Help gel layer and the with the obvious advantage of local recovery's property microenvironment is provided.Further, thickening appropriate such as is done in laying marginal zone To offset the thickness loss of cold-storage gel layer, by the uniform ground that certifiable application is whole, to facilitate laser treatment head plane The work of smooth structure.In radiation protection cold compress, Cold cornpressing body of different shapes with guarantee ray concentrate on need therapentic part and Enough cooling protections are provided to surrounding tissue to be necessary.Because three-decker designs the convenience in industrial realization, this What technical solution can be convenient is configured to different shapes to adapt to the needs of different parts.The characteristics of Medical-use cold compress gel is It can carry different such as antibiotic property, rush repair medicine, the functional materials of boron compound and antioxidant reductase radioprotectant.But The realization of these functions and accurate adjustment all rely on the presence of mesh.For example, non-homogeneous net can be carried out in radiation protection application The design of pore structure can design small scale, the mesh of low distribution, week in the shape of concentric-ring pattern at the target area of center While protective tissue is needed then to design large scale, the mesh of height distribution, to help connecing for the gel gradient equipped with radioprotectant Touching needs cold compress position, avoids target area.Certainly, the above is only the citings that carrying uses, and do not exclude other function substance It carries and uses.

To make to be further understood that feature and technology contents of the invention, drawings and embodiments of the present invention are detailed in, however The citing of institute's drawings and the embodiments is only for reference and illustrates, is not that the present invention is limited.

Detailed description of the invention

Fig. 1 is longitudal section structure chart of the present invention；

Fig. 2 is antapical view schematic diagram of the present invention；

Fig. 3 is the improved laying of the present invention and tissue-contacting layer detail view；

In figure, tissue-contacting layer of the 1- with mesh；2- cold-storage gel layer；Laying of the 3- with adhesive；4- cold-storage gel Layer region；The marginal zone 5-.

Specific embodiment

The present invention will be further described with reference to the accompanying drawings and examples.

Embodiment 1:

As shown in Figure 1, the tissue-contacting layer of cold compress application is polyurethane film, being uniformly dispersed with diameter thereon is about 2mm Mesh and mesh between polyurethane film width be about 1mm.Cold-storage material uses the polyvinyl alcohol gel being crosslinked with boric acid, and laying is Compound nonwoven cloth material coated with adhesive of medical, the mesh for being also about thereon 2mm with equally distributed diameter.It applies whole Body is in rectangle, and cold-storage gel layer is located at application middle part, around to bind directly the marginal zone that laying is constituted by tissue-contacting layer And this sector width is 1cm.Whole application is being used for body surface routine cold compress after pre- cold-storage.

Embodiment 2:

As shown in Fig. 2, cold compress application is uniformly distributed diameter about 3mm using medical polyurethane film as tissue-contacting layer thereon Mesh, and film width about 1mm between mesh.Cold-storage gel layer uses the polyvinyl alcohol for mixing crosslinking with borax with boric acid solidifying Glue, laying are the compound nonwoven cloth material coated with adhesive of medical, and cold-storage gel layer is configured to concentric circles annular, inside and outside There are the marginal zone of width about 1cm in two sides, and marginal zone binds directly laying by tissue-contacting layer and forms, but on the inside of cold-storage gel It is reserved looping pit within marginal zone.Looping pit alignment is needed the target portion of radiation treatment after the processing of pre- cold-storage by application Position, application main body are used for the cooling protection in radiation therapy after being uniformly attached at perienchyma.

Embodiment 3:

As shown in figure 3, cold compress application is using medical polyurethane film as tissue-contacting layer, it is heterogeneous thereon to be dispersed with diameter Mesh from 50um to 0.5cm.Application is whole rounded, and the Major diameter net pore size distribution of tissue-contacting layer is in middle section cold accumulation/condensation Position where glue-line.Cold-storage gel layer is solidifying using the polyvinyl alcohol of physically crosslinking and carrying superoxide dismutase Glue, and it is prominent with mamillary at the big mesh of tissue-contacting layer.Laying is the polystyrene plastics coated with adhesive of medical, And it is thickened in the marginal zone (width about 2cm) bound directly with tissue-contacting layer, it is smooth to guarantee integrally to apply.Application is passing through It crosses after pre- cold-storage processing for neck face cold compress.

Embodiment 4:

Cold compress is applied using transparent medical polyurethane film as tissue-contacting layer, is uniform-distribution with the net of diameter about 3mm thereon Hole, and film width about 1mm between mesh.Cold-storage gel layer uses the transparent polyethylene alcogel of cross-linking radiation, and laying is to apply It is covered with the transparent medical polyethylene film of adhesive of medical and increases in the marginal zone (width about 3cm) bound directly with tissue-contacting layer Thickness, it is smooth to guarantee integrally to apply.Application after the processing of pre- cold-storage in laser skin art and postoperative cold compress.

Embodiment described above, the only citing of the specific embodiment of the invention, those skilled in the art is in this hair The usual variations and alternatives carried out in bright technical proposal scope should be all included within the scope of the present invention.

Claims

1. cold compress applies, it is characterized in that: application longitudal section is divided into tissue-contacting layer from inside to outside, cold-storage gel layer and with bonding The laying of agent, wherein tissue-contacting layer is the polymer membrane material of the mesh with diameter from 50um to 0.5cm；Application Antapical view cold-storage gel layer periphery is the marginal zone that tissue-contacting layer binds directly laying composition, and applies upper any regional edge Edge sector width is not less than 0.5cm.

2. cold compress application according to claim 1, it is characterised in that cold-storage gel layer used is boron compound crosslinking Polyvinyl alcohol gel.

3. cold compress application according to claim 1, it is characterised in that be non-homogeneous mesh on tissue-contacting layer, diameter is micro- Meter level changes into Centimeter Level scale.

4. cold compress application according to claim 1, it is characterised in that its mesh diameter is more than or equal to polymer film between mesh 2 times of slice width degree.

5. cold compress application according to claim 1, it is characterised in that it also has mesh on laying with adhesive.

6. cold compress application according to claim 1, it is characterised in that cold-storage gel layer has mamillary in tissue contact surface Protrusion, to control contact surface area and effective cold compress time.

7. cold compress according to claim 1 application, it is characterised in that its tissue-contacting layer, cold-storage gel layer and with adhesive Laying be all made of transparent material.

8. cold compress application according to claim 1, it is characterised in that there is the laying thickened in marginal zone, so that application Whole uniform ground.

9. cold compress application according to claim 1, it is characterised in that its global shape and marginal zone shape are variable, with suitable Answer the needs that different parts stick.

10. cold compress application according to claim 1, it is characterised in that include functional drug in cold-storage gel layer, to reach To better clinical application effect.