CN105771825A - Emulsion particle generator for continuous production - Google Patents
Emulsion particle generator for continuous production Download PDFInfo
- Publication number
- CN105771825A CN105771825A CN201610306969.0A CN201610306969A CN105771825A CN 105771825 A CN105771825 A CN 105771825A CN 201610306969 A CN201610306969 A CN 201610306969A CN 105771825 A CN105771825 A CN 105771825A
- Authority
- CN
- China
- Prior art keywords
- end plug
- foreign minister
- cylindrical cavity
- inlet
- injector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides an emulsion particle generator for continuous production. The device comprises a supporting structure, a three-phase pipeline and a three-phase sample injector, wherein the supporting structure comprises three parts: an upper end plug, a cylindrical cavity and a lower end plug, and the upper end plug and the lower end plug are of a T-shaped cylindrical platform; a rectangular dumbbell-shaped through hole with two symmetric ends is formed in the center of the cylindrical cavity, and the cylindrical cavity is connected with the upper end plug and the lower end plug; a hole is formed in the center of the upper end plug, and an internal-phase pipeline is inserted into the hole for injecting samples; a hole is formed in the upper end of the cylindrical cavity at one side, and a stainless steel pipe is inserted into the hole as an intermediate-phase injection port; holes are symmetrically formed in the two sides of the lower end of the cylindrical cavity, and stainless steel pipes are inserted into the holes as an external-phase injection port I and an external-phase injection port II; an intermediate-phase pipeline is inserted into a pore in the middle of the cylindrical cavity; a hole is formed in the center of the lower end plug, and a glass external-phase pipeline is inserted into the hole for injecting samples. The device provided by the invention has the advantages of simple operation, easy cleaning, and completion of continuous production of large-size double emulsion particles.
Description
Technical field
The present invention relates to tiny balloon preparing technical field, being specifically related to one can quantity-produced breast grain generator.
Background technology
In ICF studies, generally adopt emulsion microencapsulation techniques to prepare plastic microsphere, namely firstly generate W1/O/W2Dual breast grain, then remove the organic solvent of oil phase, obtain the plastics spherical shell solidified.The conventional method preparing dual breast grain has mechanical mixing method and microfluidic control method.Dual breast particle size distribution prepared by mechanical mixing method is wide, using amount of reagent big, is not suitable for accurate control, and this kind of method is difficult to the high-quality plastic microsphere of preparing diameter more than 500 μm simultaneously.Micro-fluidic technologies is a kind of method preparing multiple breast grain of the development nineties in last century, wherein adopts parallel cut mode, increases the size of three-phase pipeline, can produce large-size dual breast grain.
Preparing in the process of dual breast grain in microfluidic control method, interior phase is close with the flow velocity of mesophase spherule, and the flow velocity of foreign minister can reach the 10 of indraft speed4About times, meanwhile, the flow velocity of three-phase is very big on diameter and the wall thickness impact of microsphere.Therefore, the stability maintaining three-phase flow velocity is the key adopting microfluidic control method to prepare dual breast grain continuously.But, adopting precise injection pump, the volume of its injector is very limited, and in traditional microfluidic control method process, foreign minister adopts single injector, frequently stops three-phase flow velocity and sucks and supplement outer phase solvent and had a strong impact on the stability of three-phase flow velocity.Therefore to prepare the dual breast grain of the equal narrowly distributing of Diameter Wall, need to repeatedly adjust three-phase flow velocity etc., cause waste greatly and inconvenience.
Summary of the invention
In order to solve microfluidic control method of the prior art prepare dual breast grain need repeatedly adjust three-phase flow velocity problem, the invention provides one can quantity-produced breast grain generator.
The present invention can quantity-produced breast grain generator, be characterized in: described device contains supporting construction, supporting construction includes upper end plug, cylindrical cavity and lower end plug；Cylindrical cavity is connected with upper end plug and lower end plug respectively；The center of upper end plug has interior phase sample holes, is used for inserting interior phase pipeline sample introduction；The one side perforate of cylindrical cavity upper end, is used for inserting mesophase spherule inlet；The lower end lateral symmetry perforate of cylindrical cavity, is respectively for insertion into foreign minister's inlet I and foreign minister's inlet II；It is provided with a pore in the middle part of cylindrical cavity, pore inserts mesophase spherule pipeline；Described lower end plug center has foreign minister's inlet opening, is used for inserting foreign minister's pipeline sample introduction；Described interior phase pipeline is connected with interior phase injector；Described mesophase spherule inlet is connected with mesophase spherule injector, and described foreign minister's inlet I and foreign minister's inlet II are connected with foreign minister's injector I and foreign minister's injector II respectively.
Described interior phase pipeline upper end is connected with the interior phase injector being placed on precise injection pump by flexible pipe, described mesophase spherule inlet is connected with the mesophase spherule injector being placed on precise injection pump by flexible pipe, and described foreign minister's inlet I is connected with the foreign minister's injector I being placed on precise injection pump and foreign minister's injector II by flexible pipe respectively with foreign minister's inlet II；The connection flexible pipe of described foreign minister's injector I and foreign minister's injector II is respectively equipped with hose clip I and hose clip II.
Described upper end plug and lower end plug are T-shaped cylinder table, and described cylindrical cavity center has the rectangle dumbbell shaped through hole that two ends are symmetrical；Described mesophase spherule inlet, foreign minister's inlet I and foreign minister's inlet II all adopt stainless steel tube；Described mesophase spherule pipeline and foreign minister's pipeline all adopt polyfluortetraethylene pipe or glass tubing；Described upper end plug, cylindrical cavity and lower end plug all adopt PTFE material.
Described upper end plug, cylindrical cavity and lower end plug centre bore are coaxial.
Described upper end plug convex surface height is less than the cylindrical cavity upper end concave surface degree of depth, and lower end plug convex surface height is less than the cylindrical cavity lower end concave surface degree of depth.
The top setting height(from bottom) of described mesophase spherule pipeline is lower than cylindrical cavity upper end concave surface, and the top setting height(from bottom) of foreign minister's pipeline is lower than lower end plug convex surface.
The present invention can have the advantage that simple to operation by quantity-produced breast grain generator, it is easy to controls, it is simple to cleans, and adopts the present invention to be capable of W1/O/W2The continuous system of dual breast grain is standby.The present invention is applicable to more than 500 μm W1/O/W2The preparation of dual breast grain.
Accompanying drawing explanation
Fig. 1 be the present invention can the structural representation of quantity-produced breast grain generator；
Fig. 2 be the present invention can the cross sectional plan view of quantity-produced breast grain generator；
Phase injector 15. mesophase spherule injector 16. foreign minister's injector I 17. foreign minister's injector II in 6. times end plug 7. mesophase spherule lead channel 8. foreign minister's lead channel 9. mesophase spherule inlet 10. foreign minister's inlet I 11. foreign minister's inlet II 12. hose clip I 13. hose clips II 14. of phase pipeline 2. mesophase spherule pipeline 3. foreign minister's pipeline 4. upper end plug 5. cylindrical cavity in 1. in figure.
Detailed description of the invention
Embodiments of the present invention are described below with reference to accompanying drawings.
Figures 1 and 2 show that the present invention can the structure of quantity-produced breast grain generator.The present invention's can contain the supporting construction that PTFE material is made by quantity-produced breast grain generator, and supporting construction includes the coaxial upper end plug of centre bore 4, cylindrical cavity 5 and lower end plug 6.Wherein upper end plug 4 and lower end plug 6 are T-shaped cylinder table, and cylindrical cavity 5 center has the rectangle dumbbell shaped through hole that two ends are symmetrical.Cylindrical cavity 5 is connected with upper end plug 4 and lower end plug 6 respectively, and upper end plug 4 convex surface height is less than the cylindrical cavity 5 upper end concave surface degree of depth, and lower end plug 6 convex surface height is less than the cylindrical cavity 5 lower end concave surface degree of depth.The center of upper end plug 4 has interior phase sample holes, is used for inserting interior phase pipeline 1 sample introduction.The one side perforate of cylindrical cavity 5 upper end, is used for inserting mesophase spherule inlet 9；The lower end lateral symmetry perforate of cylindrical cavity 5, is respectively for insertion into foreign minister's inlet I 10 and foreign minister's inlet II 11, and mesophase spherule inlet 9, foreign minister's inlet I 10 and foreign minister's inlet II 11 all adopt stainless steel tube；Being provided with a pore in the middle part of cylindrical cavity 5, insert mesophase spherule pipeline 2 in pore, the top setting height(from bottom) of mesophase spherule pipeline 2 is lower than cylindrical cavity 5 upper end concave surface.Lower end plug 6 center has foreign minister's inlet opening, is used for inserting foreign minister's pipeline 3 sample introduction, and the top setting height(from bottom) of foreign minister's pipeline 3 is lower than lower end plug 6 convex surface.Mesophase spherule pipeline 2 and foreign minister's pipeline 3 all adopt polyfluortetraethylene pipe or glass tubing.Interior phase pipeline 1 is connected with interior phase injector 14；Mesophase spherule inlet 9 is connected with mesophase spherule injector 15, and foreign minister's inlet I 10 and foreign minister's inlet II 11 are connected with foreign minister's injector I 16 and foreign minister's injector II 17 respectively.
Interior phase pipeline 1 upper end is connected with the interior phase injector 14 being placed on precise injection pump by flexible pipe, mesophase spherule inlet 9 is connected with the mesophase spherule injector 15 being placed on precise injection pump by flexible pipe, and foreign minister's inlet I 10 is connected with the foreign minister's injector I 16 being placed on precise injection pump and foreign minister's injector II 17 by flexible pipe respectively with foreign minister's inlet II 11；The connection flexible pipe of foreign minister's injector I 16 and foreign minister's injector II 17 is respectively equipped with hose clip I 12 and hose clip II 13.All connections in generator are and are tightly connected.
The present invention can the specific operation process of quantity-produced breast grain generator be: first opens the precise injection pump of phase flow velocity in controlling, it is ensured that in it mutually after smoothness；It is then turned on controlling the precise injection pump of foreign minister's flow velocity, makes external solution invade the profit whole foreign minister's pipeline 3 of circulation, to avoid interior phase drop viscous wall on foreign minister's pipeline 3, cause breast grain to crush；Finally open the precise injection pump controlling mesophase spherule flow velocity.After determining the phenomenon such as bubble-free in generator, viscous wall, close hose clip II 13 and control the precise injection pump of foreign minister's injector II 17.Regulate three-phase flow velocity according to breast grain diameter and wall thickness demand, after the stable and satisfied requirement of pump operation to be injected, dual breast grain is instilled in solidification equipment.The precise injection pump of regulable control foreign minister's injector II 17 so that it is consistent with the precise injection pump controlling foreign minister's injector I 16.When the solution in foreign minister's injector I 16 is close to zero, open the precise injection pump controlling foreign minister's injector II 17, unclamp hose clip II 13 simultaneously, close hose clip I 12 and suspend the precise injection pump controlling foreign minister's injector I 16.Supplementing the solution in foreign minister's injector I 16 in order to using, alternately this operation, until dual breast grain quantity meets demand.
Dual breast grain is first shut off controlling the precise injection pump of mesophase spherule flow velocity, turns off the precise injection pump controlling foreign minister's flow velocity, the precise injection pump of phase flow velocity in last closing control after having prepared.Adopting coordinative solvent to mesophase spherule, interior phase and foreign minister's smoothness are dry after being carried out.
Claims (6)
1. one kind can quantity-produced breast grain generator, it is characterised in that: described device contains supporting construction, and supporting construction includes upper end plug (4), cylindrical cavity (5) and lower end plug (6)；Cylindrical cavity (5) is connected with upper end plug (4) and lower end plug (6) respectively；The center of upper end plug (4) has interior phase sample holes, is used for inserting interior phase pipeline (1) sample introduction；Cylindrical cavity (5) one side, upper end perforate, is used for inserting mesophase spherule inlet (9)；The lower end lateral symmetry perforate of cylindrical cavity (5), is respectively for insertion into foreign minister's inlet I (10) and foreign minister's inlet II (11)；Cylindrical cavity (5) middle part is provided with a pore, inserts mesophase spherule pipeline (2) in pore；Described lower end plug (6) center has foreign minister's inlet opening, is used for inserting foreign minister's pipeline (3) sample introduction；Described interior phase pipeline (1) is connected with interior phase injector (14)；Described mesophase spherule inlet (9) is connected with mesophase spherule injector (15), and described foreign minister's inlet I (10) and foreign minister's inlet II (11) are connected with foreign minister's injector I (16) and foreign minister's injector II (17) respectively.
2. according to claim 1 can quantity-produced breast grain generator, it is characterized in that: described interior phase pipeline (1) upper end is connected with the interior phase injector (14) being placed on precise injection pump by flexible pipe, described mesophase spherule inlet (9) is connected with the mesophase spherule injector (15) being placed on precise injection pump by flexible pipe, and described foreign minister's inlet I (10) is connected with the foreign minister's injector I (16) being placed on precise injection pump and foreign minister's injector II (17) by flexible pipe respectively with foreign minister's inlet II (11)；The connection flexible pipe of described foreign minister's injector I (16) and foreign minister's injector II (17) is respectively equipped with hose clip I (12) and hose clip II (13).
3. according to claim 1 and 2 can quantity-produced breast grain generator, it is characterised in that: described upper end plug (4) and lower end plug (6) are T-shaped cylinder table, and described cylindrical cavity (5) center has the rectangle dumbbell shaped through hole that two ends are symmetrical；Described mesophase spherule inlet (9), foreign minister's inlet I (10) and foreign minister's inlet II (11) all adopt stainless steel tube；Described mesophase spherule pipeline (2) and foreign minister's pipeline (3) all adopt polyfluortetraethylene pipe or glass tubing；Described upper end plug (4), cylindrical cavity (5) and lower end plug (6) all adopt PTFE material to make.
4. according to claim 1 can quantity-produced breast grain generator, it is characterised in that: described upper end plug (4), cylindrical cavity (5) and lower end plug (6) centre bore are coaxial.
5. according to claim 1 can quantity-produced breast grain generator, it is characterised in that: described upper end plug (4) convex surface height is less than cylindrical cavity (5) the upper end concave surface degree of depth, and lower end plug (6) convex surface height is less than cylindrical cavity (5) the lower end concave surface degree of depth.
6. according to claim 1 can quantity-produced breast grain generator, it is characterized in that: the top setting height(from bottom) of described mesophase spherule pipeline (2) is lower than cylindrical cavity (5) upper end concave surface, and the top setting height(from bottom) of foreign minister's pipeline (3) is lower than lower end plug (6) convex surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610306969.0A CN105771825A (en) | 2016-05-11 | 2016-05-11 | Emulsion particle generator for continuous production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610306969.0A CN105771825A (en) | 2016-05-11 | 2016-05-11 | Emulsion particle generator for continuous production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105771825A true CN105771825A (en) | 2016-07-20 |
Family
ID=56402075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610306969.0A Pending CN105771825A (en) | 2016-05-11 | 2016-05-11 | Emulsion particle generator for continuous production |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105771825A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114405422A (en) * | 2022-01-19 | 2022-04-29 | 中国工程物理研究院激光聚变研究中心 | Fluid shaping device and method for preparing large-diameter polymer microspheres |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010104604A1 (en) * | 2009-03-13 | 2010-09-16 | President And Fellows Of Harvard College | Method for the controlled creation of emulsions, including multiple emulsions |
| CN102014871A (en) * | 2007-03-28 | 2011-04-13 | 哈佛大学 | Emulsions and techniques for formation |
| CN102205227A (en) * | 2011-03-20 | 2011-10-05 | 四川大学 | Micro-fluidic method for preparing monodisperse multicomponent multiple emulsion, and apparatus thereof |
| CN102574078A (en) * | 2009-09-02 | 2012-07-11 | 哈佛学院院长等 | Multiple emulsions created using jetting and other techniques |
| CN202410632U (en) * | 2012-01-05 | 2012-09-05 | 中国工程物理研究院激光聚变研究中心 | Concentric double-nozzle emulsion granule generator |
| CN104741049A (en) * | 2013-12-31 | 2015-07-01 | 财团法人金属工业研究发展中心 | Microsphere manufacturing device |
| WO2015160919A1 (en) * | 2014-04-16 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for producing droplet emulsions with relatively thin shells |
| CN205700491U (en) * | 2016-05-11 | 2016-11-23 | 中国工程物理研究院激光聚变研究中心 | One can quantity-produced breast grain generator |
-
2016
- 2016-05-11 CN CN201610306969.0A patent/CN105771825A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102014871A (en) * | 2007-03-28 | 2011-04-13 | 哈佛大学 | Emulsions and techniques for formation |
| WO2010104604A1 (en) * | 2009-03-13 | 2010-09-16 | President And Fellows Of Harvard College | Method for the controlled creation of emulsions, including multiple emulsions |
| CN102574078A (en) * | 2009-09-02 | 2012-07-11 | 哈佛学院院长等 | Multiple emulsions created using jetting and other techniques |
| CN102205227A (en) * | 2011-03-20 | 2011-10-05 | 四川大学 | Micro-fluidic method for preparing monodisperse multicomponent multiple emulsion, and apparatus thereof |
| CN202410632U (en) * | 2012-01-05 | 2012-09-05 | 中国工程物理研究院激光聚变研究中心 | Concentric double-nozzle emulsion granule generator |
| CN104741049A (en) * | 2013-12-31 | 2015-07-01 | 财团法人金属工业研究发展中心 | Microsphere manufacturing device |
| WO2015160919A1 (en) * | 2014-04-16 | 2015-10-22 | President And Fellows Of Harvard College | Systems and methods for producing droplet emulsions with relatively thin shells |
| CN205700491U (en) * | 2016-05-11 | 2016-11-23 | 中国工程物理研究院激光聚变研究中心 | One can quantity-produced breast grain generator |
Non-Patent Citations (1)
| Title |
|---|
| A. R. ABATE ET AL.: "High-Order Multiple Emulsions Formed in Poly(dimethylsiloxane) Microfluidics", 《SMALL》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114405422A (en) * | 2022-01-19 | 2022-04-29 | 中国工程物理研究院激光聚变研究中心 | Fluid shaping device and method for preparing large-diameter polymer microspheres |
| CN114405422B (en) * | 2022-01-19 | 2023-02-28 | 中国工程物理研究院激光聚变研究中心 | Fluid shaping device and method for preparing large-diameter polymer microspheres |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107488582B (en) | Rare cell and particle enrichment separation flexible micro-fluidic chip | |
| CN208711740U (en) | A kind of suction head apparatus generated for microlayer model | |
| CN108329900A (en) | A kind of displacement of reservoir oil microfoam and preparation method thereof | |
| CN105688721B (en) | For generating the micro-fluidic chip of spherical microbubble | |
| CN110639450B (en) | Device and method for preparing calcium alginate microspheres by using microreactor and application of device | |
| KR100778206B1 (en) | Petri Dish for Trapping Cell | |
| CN108927231A (en) | Multichannel drop formation device and method based on macropore perfusion microballoon | |
| CN101110278A (en) | Method for preparing fusion pallet based on micro-fluid | |
| CN113145038A (en) | Method and device for preparing oil emulsion adjuvant based on microfluidics | |
| CN108525622B (en) | Multistage reaction microfluidic device and application thereof in preparation of nano material | |
| Courrech du Pont et al. | Sink flow deforms the interface between a viscous liquid and air into a tip singularity | |
| CN105771825A (en) | Emulsion particle generator for continuous production | |
| US9725307B2 (en) | Method for producing microchannel, and microchannel | |
| CN205700491U (en) | One can quantity-produced breast grain generator | |
| CN112727416A (en) | In-situ microemulsion generation and oil displacement efficiency testing device and method | |
| CN106492716A (en) | Integral dual milk particle generating meanss and its processing method | |
| WO2020066609A1 (en) | Cell culture chip | |
| CN208949317U (en) | Digital pcr chip and digital pcr detection system | |
| CN203898835U (en) | Automatic exhausting infusion apparatus | |
| KR101959208B1 (en) | Droplet based biochip, a method for producing a tumor, and a method for deciding a metastasis tumor | |
| CN206334891U (en) | Liquid-transfering gun pipette tips cleaning box | |
| US20080032390A1 (en) | Method and Device for Control of Diffusive Transport | |
| CN101093227B (en) | Gravity drive pump of microflow controlled chip system | |
| Jeyhani et al. | Water-in-water droplet microfluidics: A design manual | |
| CN109443993A (en) | Interface changes observation system and method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160720 |
|
| WD01 | Invention patent application deemed withdrawn after publication |