CN105770403A

CN105770403A - Traditional Chinese medicine oral liquid for adjuvant therapy of pulmonary tuberculosis and preparation method thereof

Info

Publication number: CN105770403A
Application number: CN201610280381.2A
Authority: CN
Inventors: 衣明春
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-04-28
Filing date: 2016-04-28
Publication date: 2016-07-20

Abstract

The invention discloses traditional Chinese medicine oral liquid for adjuvant therapy of pulmonary tuberculosis and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine oral liquid comprises, by weight, 22-30 parts of Humulus Japonicus, 35-40 parts of Folium Ginkgo, 10-15 parts of Fructus Schisandra chinensis, 10-15 parts of Lily Bulb, 28-34 parts of Radix Astragali, 10-15 parts of Honeysuckle Flowers, 10-20 parts of Chinese Yam, 10-15 parts of Radix Ophiopogonis, 15-20 parts of Bitter Apricot Seed, 15-20 parts of Mongolian Dandelion Herb, 15-20 parts of Heartleaf Houttuymia Herb, 13-22 parts of Radix Geutianae, 15-20 parts of Cortex Phellodendri, 20-30 parts of Radix Glycyrrhiza, 15-22 parts of Gardenia Jasminoides Ellis and 10-15 parts of Cortex Magnoliae Officinalis. The traditional Chinese medicine oral liquid can kill germs, injury to hepatic and renal functions is reduced, meanwhile, treatment effect is improved, curative time of pulmonary tuberculosis can be effectively shortened, human body immunity is improved, capability of resisting to pulmonary tuberculosis is enhanced fundamentally, and recurrence is reduced.

Description

A kind of auxiliary treats phthisical Chinese medicine oral liquid and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, specifically the one auxiliary phthisical Chinese medicine oral liquid of existing western medicine and system thereof Preparation Method.

Background technology

Tuberculosis is also called consumptive disease and " white pestilence ", is a kind of ancient infectious disease, has just had tuberculosis since the own mankind.? In history, it was once widely current in the whole world, is once the primary killers of the harm mankind, has seized the life of several hundred million people.Tuberculosis Disease is the chronic infectious disease caused by mycobacterium tuberculosis infection.Tulase may invade the various organ of Whole Body, but mainly invades lung Dirty, referred to as pulmonary tuberculosis.Tuberculosis can be fallen ill throughout the year, and the teenager of 15 years old to 35 years old is peak occurred frequently lungy Age.Incubation period 4～8 weeks.Wherein 80% occur in pulmonary, other positions (neck lymph, meninges, peritoneum, intestinal, skin, Skeleton) also can secondary infection.Interpersonal respiratory infectious is the major way that primary disease infects.The source of infection is contact discharge of bacteria Lunger.Tuberculosis is the chronic infectious disease caused by mycobacterium tuberculosis, can invade and many internal organs, and excreter is that it is heavy The source of infection wanted.Not necessarily fall ill after human infection tulase, when resistance reduces or cell-mediated allergy increases, It is only possible to cause clinical onset.Tulase belongs to Actinomycetal, the Mycobacterium of mycobacteriaceae, for there being the acidproof of pathogenicity Bacterium.It is broadly divided into the types such as people, cattle, bird, Mus.There is pathogenic person to be mainly human-like bacterium, the rare infection of cattle type bacterium to people.Lung is tied Core symptom has closer tuberculosis contact history, and onset can suddenly can be delayed, mostly be low grade fever, night sweat, weak, poor appetite, become thin, female Property menoxenia etc.；Respiratory symptom has cough, expectoration, spitting of blood, chest pain, the most uncomfortable in chest or dyspnea.Pulmonary Sign is different and variant according to state of an illness weight, extent of disease, in early days, the tuberculosis of little scope be difficult to find positive sign, pathological changes model Enclosing wider person's percussion is voiced sound, and vocal fremitus strengthens, the low and wet sound of vesicular breathing sound.Late period, tuberculosis formed fibrosis, local contraction Pleura is made to subside and mediastinal displacement.Pleuritic rub is had in early days tuberculous pleuritis person, when forming a large amount of hydrothorax, thoracic wall Full, the turbid reality of percussion, vocal fremitus and respiratory murmur lower or disappear.

Pulmonary tuberculosis is divided into: 1. primary pulmonary tuberculosis: ooze out the dumbbell shaped of pathological changes, lymphangitis and enlargement of hilar lymph nodes in lung The primary complex changed, child is common, or is showed only as hilus pulumonis and mediastinal lymph node enlargement；2. miliary tuberculosis of lung: Including acute military tuberculosis of the lung and chronic or subacute hematogenous pulmonary tuberculosis amphitypy；Acute military tuberculosis: two lungs The shade of the foxtail millet grain size being dispersed in, equal density in the same size, the granular shade of foxtail millet being evenly distributed, it is in progress with stadium, can be mutual Merge；Chronic or subacute hematogenous pulmonary tuberculosis: two lungs occur that pathological changes not of uniform size, new and old are different, skewness, Edge blurry or sharp keen tuberosity and rope bar shade.3. secondary type pulmonary tuberculosis: this type includes that pathological changes is based on propagation, infiltration Pathological changes is multiple change main, that cheese pathological changes is main or cavity is master.Infiltrative pulmonary tuberculosis: x-ray Chang Weiyun is cotton-shaped or strip Infiltration shade, edge blurry or tuberosity, rope strip pathological changes, large stretch of consolidation or spheroid pathological changes or calcification；Chronic fibro-cavitative is exhaled Inhale road infection and belong to commonly encountered diseases and frequently-occurring disease, bigger to human health risk.

At present, clinically mainly by western medicine pulmonary tuberculosis, as used the medicine such as rifapentine, Rimactazid, but These medicines are chemotherapeutic, and while killing tulase, the harm to each internal organs of human body is also very big, especially to Liver and kidney merit The injury of energy is very big, and after healing, phthisical relapse rate is 50%, and antibiotics treatment is easily developed immunity to drugs, and once produces Raw Drug resistance, it is more likely that pasting medical help, consequence is hardly imaginable, therefore, finds the therapeutic modality of a kind of relative healths to the mankind Highly significant.

Summary of the invention

For solving the defect that prior art exists, it is desirable to provide a kind of auxiliary phthisical extract oral of existing western medicine Liquid and preparation method thereof, solves and relies primarily on the antibiotics phthisical technical problem for the treatment of, reduce antibiotics Injury to other organ function of tuberculosis patient.

To achieve these goals, the technical scheme is that

A kind of auxiliary treats phthisical Chinese medicine oral liquid, and its effective ingredient includes the raw material of following weight portion: grass 22-30 part, Folium Ginkgo 35-40 part, Fructus Schisandrae Chinensis 10-15 part, Bulbus Lilii 10-15 part, Radix Astragali 28-34 part, Flos Lonicerae 10-15 part, Rhizoma Dioscoreae 10-20 Part, 10-15 part Radix Ophiopogonis, Semen Armeniacae Amarum 15-20 part, Herba Taraxaci 15-20 part, Herba Houttuyniae 15-20 part, Radix Gentianae 13-22 part, Cortex Phellodendri 15-20 part, Radix Glycyrrhizae 20-30 part, Fructus Gardeniae 15-22 part, Cortex Magnoliae Officinalis 10-15 part.

The present invention can also have a following additional technical feature:

Preferably, its effective ingredient includes the raw material of following weight portion: grass 26 parts, Folium Ginkgo 38 parts, Fructus Schisandrae Chinensis 12 parts, Bulbus Lilii 12 parts, the Radix Astragali 30 parts, Flos Lonicerae 12 parts, Rhizoma Dioscoreae 15 parts, Radix Ophiopogonis 13 parts, Semen Armeniacae Amarum 17 parts, Herba Taraxaci 17 parts, Herba Houttuyniae 17 parts, Radix Gentianae 18 parts, Cortex Phellodendri 17 parts, 25 parts of Radix Glycyrrhizae, Fructus Gardeniae 17 parts, Cortex Magnoliae Officinalis 13 parts.

Preferably, its effective ingredient includes the raw material of following weight portion: grass 22 parts, Folium Ginkgo 40 parts, Fructus Schisandrae Chinensis 10 parts, Bulbus Lilii 10 parts, the Radix Astragali 34 parts, Flos Lonicerae 10-, Rhizoma Dioscoreae 10 parts, Radix Ophiopogonis 15 parts, Semen Armeniacae Amarum 20 parts, Herba Taraxaci 20 parts, Herba Houttuyniae 20 parts, Radix Gentianae 22 parts, Cortex Phellodendri 15 parts, 20 parts of Radix Glycyrrhizae, Fructus Gardeniae 15 parts, Cortex Magnoliae Officinalis 10 parts.

Preferably, its effective ingredient includes the raw material of following weight portion: grass 30 parts, Folium Ginkgo 35 parts, Fructus Schisandrae Chinensis 10 parts, Bulbus Lilii 15 parts, the Radix Astragali 34 parts, Flos Lonicerae 15 parts, Rhizoma Dioscoreae 10 parts, Radix Ophiopogonis 15 parts, Semen Armeniacae Amarum 20 parts, Herba Taraxaci 16 parts, Herba Houttuyniae 15 parts, Radix Gentianae 13 parts, Cortex Phellodendri 20 parts, 30 parts of Radix Glycyrrhizae, Fructus Gardeniae 22 parts, Cortex Magnoliae Officinalis 15 parts.

The present invention also provides for a kind of preparation method assisting and treating phthisical Chinese medicine oral liquid, follows the steps below:

Step 1: weighing after Fructus Schisandrae Chinensis soaks 1-2 hour by recipe quantity, slow fire decocts 2-3 hour, filters, takes filtrate, Standby；

Step 2: claim grass, Folium Ginkgo, Bulbus Lilii, the Radix Astragali, Flos Lonicerae, Rhizoma Dioscoreae, Radix Ophiopogonis, Semen Armeniacae Amarum, Pu Gong by recipe quantity After English, Herba Houttuyniae, Radix Gentianae, Cortex Phellodendri, Radix Glycyrrhizae, Fructus Gardeniae, Cortex Magnoliae Officinalis soak 1-2 hour, add 4-6 times of quality of medical material Water intense fire decoct to boiling half an hour after, filter, take for the first time filtrate, filtering residue adds the hydrology fire of 3-4 times and decocts to boiling Latter 10 minutes, filter, take second time filtrate, merge twice filtrate, standby；

Step 3: by step: the filtrate that 1, step 2 obtains merges, and being evaporated to temperature under the conditions of temperature is 50 DEG C is 50 DEG C Time relative density be the ointment of 1.2-1.3, add oral liquid conventional pharmaceutical adjuvants, make oral liquid according to common process.

Further, the drug quality concentration of described oral liquid is 8-10%.

The usage and dosage of the oral liquid of the present invention is: in lunger 1-14 year, drug level quality is that the oral liquid of 8-10% is every Day twice, each 5-10ml；More than 15 years old, every day twice, each 10-15ml, share better with Western medicine, when share, Western medicine consumption halves.Anemia of pregnant woman of the present invention disables, and avoids pungent meat or fish food.

The invention have the benefit that the medicine of the present invention has and preferably kill the effect combining pathogenic bacteria, reducing Liver and kidney merit Therapeutic effect can be improved while damage, it is possible to effectively shorten phthisical healing time, alleviate patient and be in hospital for a long time and take medicine Pain hardship, and strengthening body resistance, fundamentally improve phthisical ability of resisting, and reduces recurrence probability；The present invention's Chinese medicine has to protect the liver and protects splenic function, and formula is reasonable, and spleen be soil, earth generating metal, and gold is lung, it is possible to strengthen pulmonary function；Can be complete Substitute or part substitutes tradition western medicine antibiotics quasi drugs, it is to avoid the serious consequence brought because of Drug resistance.

The additional aspect of the present invention and advantage will part be given in the following description, and part will become apparent from the description below, Or recognized by the practice of the present invention.

Detailed description of the invention

Below in conjunction with instantiation, the present invention is described in detail.

Embodiment 1

A. following raw material is prepared:

Grass 260g, Folium Ginkgo 380g, Fructus Schisandrae Chinensis 120g, Bulbus Lilii 120g, Radix Astragali 300g, Flos Lonicerae 120g, Rhizoma Dioscoreae 150g, Radix Ophiopogonis 130g, Semen Armeniacae Amarum 170g, Herba Taraxaci 170g, Herba Houttuyniae 170g, Radix Gentianae 180g, Cortex Phellodendri 170g, Radix Glycyrrhizae 250g, Fructus Gardeniae 170g, Cortex Magnoliae Officinalis 130g；

B. following steps are used to prepare oral liquid:

Step 1: weighing after Fructus Schisandrae Chinensis soaks 1 hour by recipe quantity, slow fire decocts 2 hours, filters, takes filtrate, standby With；

Step 2: claim grass, Folium Ginkgo, Bulbus Lilii, the Radix Astragali, Flos Lonicerae, Rhizoma Dioscoreae, Radix Ophiopogonis, Semen Armeniacae Amarum, Pu Gong by recipe quantity After English, Herba Houttuyniae, Radix Gentianae, Cortex Phellodendri, Radix Glycyrrhizae, Fructus Gardeniae, Cortex Magnoliae Officinalis soak 1 hour, add the water of 4 times of quality of medical material Intense fire decocts to boiling half an hour after, filters, and takes filtrate for the first time, and filtering residue adds the hydrology fire of 3 times and decocts to latter 10 points of boiling Clock, filters, and takes second time filtrate, merges twice filtrate, standby；

: step 3: by step: the filtrate that 1, step 2 obtains merges, and being evaporated to temperature under the conditions of temperature is 50 DEG C is 50 DEG C Time relative density be the ointment of 1.22, take 10g ointment, add 0.5g sodium alginate, 1.5g xylose, 88g water stir, Filter, fill, make oral liquid.

Embodiment 2

A. following raw material is prepared:

Grass 220g, Folium Ginkgo 400g, Fructus Schisandrae Chinensis 100g, Bulbus Lilii 100g, Radix Astragali 340g, Flos Lonicerae 10-, Rhizoma Dioscoreae 100g, Radix Ophiopogonis 150g, Semen Armeniacae Amarum 200g, Herba Taraxaci 200g, Herba Houttuyniae 200g, Radix Gentianae 220g, Cortex Phellodendri 150g, Radix Glycyrrhizae 200g, Fructus Gardeniae 150g, Cortex Magnoliae Officinalis 100g；

B. following steps are used to prepare oral liquid:

Step 1: weighing after Fructus Schisandrae Chinensis soaks 1 hour by recipe quantity, slow fire decocts 3 hours, filters, takes filtrate, standby With；

Step 2: claim grass, Folium Ginkgo, Bulbus Lilii, the Radix Astragali, Flos Lonicerae, Rhizoma Dioscoreae, Radix Ophiopogonis, Semen Armeniacae Amarum, Pu Gong by recipe quantity After English, Herba Houttuyniae, Radix Gentianae, Cortex Phellodendri, Radix Glycyrrhizae, Fructus Gardeniae, Cortex Magnoliae Officinalis soak 2 hours, add the water of 6 times of quality of medical material Intense fire decocts to boiling half an hour after, filters, and takes filtrate for the first time, and filtering residue adds the hydrology fire of 4 times and decocts to latter 10 points of boiling Clock, filters, and takes second time filtrate, merges twice filtrate, standby；

: step 3: by step: the filtrate that 1, step 2 obtains merges, and being evaporated to temperature under the conditions of temperature is 50 DEG C is 50 DEG C Time relative density be the ointment of 1.25, stir, add oral liquid conventional pharmaceutical adjuvants, make oral liquid according to common process.

Embodiment 3

A. following raw material is prepared:

Grass 300g, Folium Ginkgo 350g, Fructus Schisandrae Chinensis 100g, Bulbus Lilii 150g, Radix Astragali 340g, Flos Lonicerae 150g, Rhizoma Dioscoreae 100g, Radix Ophiopogonis 150g, Semen Armeniacae Amarum 200g, Herba Taraxaci 160g, Herba Houttuyniae 150g, Radix Gentianae 130g, Cortex Phellodendri 200g, Radix Glycyrrhizae 300g, Fructus Gardeniae 220g, Cortex Magnoliae Officinalis 150g；

B. following steps are used to prepare oral liquid:

Step 1: weighing after Fructus Schisandrae Chinensis soaks 2 hours by recipe quantity, slow fire decocts 2.5 hours, filters, takes filtrate, standby With；

Step 2: claim grass, Folium Ginkgo, Bulbus Lilii, the Radix Astragali, Flos Lonicerae, Rhizoma Dioscoreae, Radix Ophiopogonis, Semen Armeniacae Amarum, Pu Gong by recipe quantity After English, Herba Houttuyniae, Radix Gentianae, Cortex Phellodendri, Radix Glycyrrhizae, Fructus Gardeniae, Cortex Magnoliae Officinalis soak 1.5 hours, add 5 times of quality of medical material Water intense fire decocts to boiling half an hour after, filters, and takes filtrate for the first time, and filtering residue adds the hydrology fire of 4 times and decocts to boiling 10 Minute, filter, take second time filtrate, merge twice filtrate, standby；

: step 3: by step: the filtrate that 1, step 2 obtains merges, and being evaporated to temperature under the conditions of temperature is 50 DEG C is 50 DEG C Time relative density be the ointment of 1.3, stir, add oral liquid conventional pharmaceutical adjuvants, make oral liquid according to common process.

Embodiment 4 toxicological study

(1) anxious poison test:

The rat oral gavage selecting body weight 200g ± 10g carries out mtd test.Every day, gavage 2ml, gave in one day at twice, Being equivalent to clinical 70 times (based on 70kg10ml/ days) intending daily dosage of being grown up, in seven days, none death of mice, puts to death mice solution Cuing open each internal organs of observation and do not find toxic reaction, administration group and control group mice are without any difference.

(2) long term toxication:

For clinical drug safety, according to country's pertinent regulations to new drug research, the rat of application body weight 200g ± 10g, by real Test medicine and be set as high, medium and low three dosage, respectively 1ml/ days, 0.5ml/ days, 0.25ml/ days.It is 70kg's by body weight People calculates, for 35 times, 17.5 times and 9 times of people's effective dose with dosage for 10ml/ days；Separately set a blank group, to reality Test group high, medium and low three continuous gastric infusions of dosage after 100 days, observe physiology every on rat, the impact of biochemical indicator. Test result indicate that: increase all without affecting to rat continuous oral 100 days, food-intake and body weight on rat by various dose. Hepatic and renal function is not all found overt toxicity effect.Routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc. are showed no obvious shadow Ring, between each group, compare no significant difference with matched group.

The clinical Composition analyzed of embodiment 5

Test method: respiratory disease hospital and specialty tuberculosis hospital in Qingdao randomly choose 150 example different age group, different journeys The patient of degree, carries out clinical trial on the basis of not abandoning western medicine, and is leaving hospital and be tracked seeing to it after drug withdrawal Examine.150 example patients are randomly divided into three groups, and complete Western medicine group combined by Western medicine group and Chinese medicine association part Western medicine group and Chinese medicine, It is administered as follows: Western medicine group is administered according to traditional antibiotic treatment prescription；Chinese medicine association part Western medicine group is by tradition antibiosis Every kind of amount of medicament of extract for treating amount halves, coordinate the embodiment of the present invention 1 Chinese medicine oral liquid, 1-14 year patient, every day twice, often Secondary 5-10ml；More than 15 years old, every day twice, each 10-15ml；Chinese medicine combine complete Western medicine group be conventional antibiotic dose not Subtracting the Chinese medicine oral liquid coordinating embodiments of the invention 1, therapeutic outcome is shown in Table 1.

Effect judgment criteria:

Recovery from illness: clinical symptom disappearance；Effective: clinical symptoms has alleviated；Invalid: clinical symptoms has no improvement；Cure time After being CT examination doctor determine can be with the treatment time of drug withdrawal；Effective time is CT examination focus and starts zooming out, and scabs, Or there is cough with asthma conditions of patients to take a turn for the better.

Table 1 therapeutic effect table

The therapeutic effect being combined complete Western medicine group from table 1, Chinese medicine association part Western medicine group and Chinese medicine is substantially better than Western medicine group, Can effectively shorten treatment time, make tuberculosis patient rehabilitation as early as possible, reduce state of an illness pain hardship, increase quality of life, and significantly drop Low relapse rate, significant to the life security of patient.Therefore, the medicine of the present invention can replace to a certain extent Part Western medicine or with Western medicine therapeutic alliance pulmonary tuberculosis, reduce the reduction immunity that causes of abuse of antibiotics, the problem such as develop immunity to drugs, Further, finding over the course for the treatment of, Western medicine group is easier to cause the diseases such as liver dysfunction, gastric injury over the course for the treatment of, and one There is liver function, stomach merit injured patient in denier, then need to stop tuberculosis medicine, and this most also develops immunity to drugs to pathogenic bacteria and adds chance, And delay healing time.And use treatment by Chinese herbs group not have liver function degree of impairment, therefore, use treatment by Chinese herbs to health Few side effects, and the formula of the present invention has to protect the liver and protects renal function, has staple market and is worth.

Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that: without departing from this These embodiments can be carried out multiple change in the case of the principle of invention and objective, revise, replace and modification, the present invention's Scope is limited by claim and equivalent thereof.

Claims

1. an auxiliary treats phthisical Chinese medicine oral liquid, it is characterized in that, its effective ingredient includes the raw material of following weight portion: grass 22-30 part, Folium Ginkgo 35-40 part, Fructus Schisandrae Chinensis 10-15 part, Bulbus Lilii 10-15 part, Radix Astragali 28-34 part, Flos Lonicerae 10-15 part, Rhizoma Dioscoreae 10-20 part, 10-15 part Radix Ophiopogonis, Semen Armeniacae Amarum 15-20 part, Herba Taraxaci 15-20 part, Herba Houttuyniae 15-20 part, Radix Gentianae 13-22 part, Cortex Phellodendri 15-20 part, Radix Glycyrrhizae 20-30 part, Fructus Gardeniae 15-22 part, Cortex Magnoliae Officinalis 10-15 part.

Auxiliary the most according to claim 1 treats phthisical Chinese medicine oral liquid, it is characterized in that, its effective ingredient includes the raw material of following weight portion: grass 26 parts, Folium Ginkgo 38 parts, Fructus Schisandrae Chinensis 12 parts, Bulbus Lilii 12 parts, the Radix Astragali 30 parts, Flos Lonicerae 12 parts, Rhizoma Dioscoreae 15 parts, Radix Ophiopogonis 13 parts, Semen Armeniacae Amarum 17 parts, Herba Taraxaci 17 parts, Herba Houttuyniae 17 parts, Radix Gentianae 18 parts, Cortex Phellodendri 17 parts, 25 parts of Radix Glycyrrhizae, Fructus Gardeniae 17 parts, Cortex Magnoliae Officinalis 13 parts.

Auxiliary the most according to claim 1 treats phthisical Chinese medicine oral liquid, it is characterized in that, its effective ingredient includes the raw material of following weight portion: grass 22 parts, Folium Ginkgo 40 parts, Fructus Schisandrae Chinensis 10 parts, Bulbus Lilii 10 parts, the Radix Astragali 34 parts, Flos Lonicerae 10-, Rhizoma Dioscoreae 10 parts, Radix Ophiopogonis 15 parts, Semen Armeniacae Amarum 20 parts, Herba Taraxaci 20 parts, Herba Houttuyniae 20 parts, Radix Gentianae 22 parts, Cortex Phellodendri 15 parts, 20 parts of Radix Glycyrrhizae, Fructus Gardeniae 15 parts, Cortex Magnoliae Officinalis 10 parts.

Auxiliary the most according to claim 1 treats phthisical Chinese medicine oral liquid, it is characterized in that, its effective ingredient includes the raw material of following weight portion: grass 30 parts, Folium Ginkgo 35 parts, Fructus Schisandrae Chinensis 10 parts, Bulbus Lilii 15 parts, the Radix Astragali 34 parts, Flos Lonicerae 15 parts, Rhizoma Dioscoreae 10 parts, Radix Ophiopogonis 15 parts, Semen Armeniacae Amarum 20 parts, Herba Taraxaci 16 parts, Herba Houttuyniae 15 parts, Radix Gentianae 13 parts, Cortex Phellodendri 20 parts, 30 parts of Radix Glycyrrhizae, Fructus Gardeniae 22 parts, Cortex Magnoliae Officinalis 15 parts.

5. the auxiliary described in claim 1 treats the preparation method of phthisical Chinese medicine oral liquid, it is characterised in that follow the steps below:

Step 2: after claiming grass, Folium Ginkgo, Bulbus Lilii, the Radix Astragali, Flos Lonicerae, Rhizoma Dioscoreae, Radix Ophiopogonis, Semen Armeniacae Amarum, Herba Taraxaci, Herba Houttuyniae, Radix Gentianae, Cortex Phellodendri, Radix Glycyrrhizae, Fructus Gardeniae, Cortex Magnoliae Officinalis to soak 1-2 hour by recipe quantity, the water intense fire adding 4-6 times of quality of medical material decocts to boiling half an hour after, filter, take filtrate for the first time, filtering residue adds the hydrology fire of 3-4 times and decocts to latter 10 minutes of boiling, filters, takes second time filtrate, merge twice filtrate, standby；

Step 3: by step: the filtrate that 1, step 2 obtains merges, and being evaporated to relative density when temperature is 50 DEG C under the conditions of temperature is 50 DEG C is the ointment of 1.2-1.3, adds oral liquid conventional pharmaceutical adjuvants, makes oral liquid according to common process.