CN105769795B - A kind of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet and preparation method thereof - Google Patents
A kind of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
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Abstract
The invention discloses a kind of Chinese holly Desloratadines, and oral instant-dissolving tablet and preparation method thereof is lyophilized, and belongs to the preparation field of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet.The present invention discloses a kind of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet, including following each component first:Chinese holly Desloratadine, framework material, cyclodextrin, suspending agent, corrigent, pH adjusting agent and colorant;The parts by weight of each component are:0.001-0.01 parts of 5-20 parts of Chinese holly Desloratadine, 10-30 parts of cyclodextrin, 30-80 parts of framework material, 1-10 parts of suspending agent, 0.1-5 parts of corrigent, 0.1-2 parts of pH adjusting agent and colorant.Chinese holly Desloratadine of the present invention freeze-drying oral instant-dissolving tablet appearance is good, and friability is small, good mouthfeel, and it is short to dissolve the time limit, works rapid, easy to carry, Compliance is good.
Description
Technical field
The present invention relates to oral quick disintegrating tablets, and the invention further relates to the preparations that oral instant-dissolving tablet is lyophilized in the Chinese holly Desloratadine
Method belongs to the preparation field of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet.
Technical background
Nettle rash is " one group of different substantiality disease with unique and identical cutaneous manifestations ", is a kind of common anaphylaxis skin
Skin disease such as has protracted course time long, recurrent exerbation and is difficult to cure be embodied as skin at Clinical symptoms, the clinical manifestation
Skin convulsion itches, the wheal of show pale asphyxia, cerise either skin-color.Some cases will appear edemous erythema, and every
The wheal shape and wheal size of example patient time for breaking out and is not fixed all there is difference.It often can not find the disease of the cause of disease
Disease, there are about 1/3 chronic urticaria patients there are the exception of autoimmune function, patient's not timing with, on the face or four
Limb sends out the fash block that one piece of block is red and swollen and itches very much, usually itches more grabbing, the more grabs the more swollen.Attack times are from daily for several times to a couple of days
Once differ.Nettle rash there is no specific short at present, mostly use based on antihistamine drug for oral administration.
Clinical application at present it is more be that he determines class drug, Chinese holly Desloratadine is in Desloratadine
(Desloratadine) on the basis of, by a kind of noval chemical compound of structural modification formation.Compared with former compound, noval chemical compound
It has the characteristics that:(1) under the premise of not influencing drug effect, the amino of easy oxidation discoloration in Desloratadine structure is carried out
Protection, improves medicine stability, especially improves the compatibility with auxiliary material.(2) solubility is Desloratadine in water
100 times or more, dissolubility is more preferable, haves laid a good foundation for the quick release of drug.
Be lyophilized oral instant-dissolving tablet can under the conditions of anhydrous (or the only a small amount of water presence) fater disintegration in oral cavity, with gulping down
Pharynx action enters alimentary canal, and without mucosa absorption in oral cavity, body absorption, metabolic process are consistent with conventional tablet.Facilitate part
Crowd's medication, such as patient's medication under old man, children, dysphagia or particular surroundings.ODT takes compared with ordinary preparation
The advantages that convenient, absorption is soon, bioavilability is high, small to alimentary canal mucous membrane irritation, receives significant attention.Therefore, one is developed
Oral instant-dissolving tablet is lyophilized in kind Chinese holly Desloratadine, will be with important market value and social benefit.
Invention content
Technical problem to be solved by the invention is to provide a kind of Chinese holly Desloratadines, and oral instant-dissolving tablet is lyophilized, when dissolving
Between it is short, release drug is rapid, and without being swallowed with water, good mouthfeel;
Another technical problem to be solved by this invention is to provide a kind of Chinese holly Desloratadine freeze-drying oral instant
The preparation method of piece, this method technique is simple, and obtained oral quick disintegrating tablet has higher mechanical strength.
In order to solve the above technical problems, the technical solution used in the present invention is:
The present invention discloses a kind of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet first, which is characterized in that including following
Component:Chinese holly Desloratadine, framework material, suspending agent, corrigent and pH adjusting agent.
The present invention discloses a kind of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet, including following each component first:Chinese holly ground chlorine
Lei Tading, framework material, suspending agent, corrigent, pH adjusting agent and colorant.
The parts by weight of each component are:5-20 parts of Chinese holly Desloratadine, 30-80 parts of framework material, helps 10-30 parts of cyclodextrin
0.001-0.05 parts of 1-10 parts of suspension, 0.1-5 parts of corrigent, 0.1-2 parts of pH adjusting agent and colorant;
Preferably, Chinese holly Desloratadine 5-10 parts, 15-30 parts of cyclodextrin, 50-70 parts of framework material, 1-5 parts of suspending agent,
0.001-0.01 parts of 0.2-2 parts of corrigent, 0.3-1 parts of pH adjusting agent and colorant;
Most preferably, 8.8 parts of Chinese holly Desloratadine, 30 parts of cyclodextrin, 57.2 parts of framework material, 3 parts of suspending agent, corrigent
0.01 part of 0.5 part, 0.49 part of pH adjusting agent and colorant.
Wherein the cyclodextrin is selected from alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, carboxymethyl-beta-cyclodextrin, hydroxypropyl
Any one in group-beta-cyclodextrin or sulfobutyl ether-beta-cyclodextrin or arbitrary a variety of mixtures formed according to arbitrary proportion;
Preferably hydroxypropyl-β-cyclodextrin or sulfobutyl ether-beta-cyclodextrin;Most preferably sulfobutyl ether-beta-cyclodextrin.
The framework material is selected from any one of mannitol, sorbierite, lactose, dextran, glucan, starch or appoints
Two kinds of mixtures formed according to arbitrary proportion of meaning;Preferably mannitol and lactose are according to weight ratio 2:1 composition mixture or
Mannitol and lactose are according to weight ratio 1:The mixture of 1 composition;Most preferably mannitol and lactose are according to weight ratio 2:1 composition
Mixture.
The suspending agent is xanthans, polyvinyl alcohol, tragacanth, sodium alginate, gelatin, shellac, Arabic gum, methyl
In cellulose, ethyl cellulose, agar or hydroxypropyl methylcellulose any one or it is arbitrary two kinds according to arbitrary proportion composition
Mixture;Preferably xanthans and gelatin are according to weight ratio 4:1 or xanthans and gelatin according to weight ratio 3:The mixing of 1 composition
Object;Most preferably xanthans and gelatin are according to weight ratio 4:The mixture of 1 composition.
The pH adjusting agent in citric acid, tartaric acid, malic acid, maleic acid, sodium dihydrogen phosphate any one or
Two kinds of mixtures formed according to arbitrary proportion;Preferably citric acid or tartaric acid, most preferably citric acid.
The present invention further discloses the preparation methods that oral instant-dissolving tablet is lyophilized in a kind of Chinese holly Desloratadine, including with
Lower step:
(1) cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is heated under stirring
To 45 DEG C, it is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) framework material, the corrigent of recipe quantity are weighed, is added into step (1) solution.
(3) suspending agent for weighing recipe quantity is dissolved in the purified water of prescription water consumption 20%, is heated to being completely dissolved;
(4) it is uniform to merge above two solution & stir, pH value is adjusted to 5.5-6.5 with pH adjusting agent, is added a small amount of
Toner;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The method of the present invention can make obtained oral quick disintegrating tablet have higher mechanical strength and wearability, it is ensured that
Medicine film packaging, transport, take when do not rupture, and keep good appearance.
In the composition of Chinese holly Desloratadine of the present invention freeze-drying oral instant-dissolving tablet, cyclodextrin, framework material, suspending agent type
Appearance, mouthfeel and the solution time for Chinese holly Desloratadine being lyophilized oral instant-dissolving tablet with dosage have apparent influence.Sulphur butyl
Ether-beta-cyclodextrin to nitrogenous class drug have special affinity and inclusion property, can be included well with drug molecule to be formed it is non-
Covalent complex reduces renal toxicity, mitigates drug hemolytic to improve the stability, water solubility, safety of drug, control
Drug release rate covers bad smell etc..Under conditions of other components and certain dosage:When cyclodextrin uses sulphur butyl
When ether-beta-cyclodextrin, Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet mouthfeel is obviously improved.Work as sulfobutyl ether-beta-cyclodextrin:Raw material
Weight ratio=8.8:30, mouthfeel is best;It is made when framework material is the mixture that mannitol and lactose form according to a certain percentage
Standby Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet friability is that single auxiliary material is obviously improved compared with framework material;When mannitol and breast
Sugar is according to 2:When 1 ratio, prepared Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet dissolves the time limit and is significantly shorter than mannitol and breast
Sugar dissolves the time limit according to the Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet prepared by other ratios, and good mouthfeel, no granular sensation,
Friability is small;When suspending agent is gelatin and xanthans according to weight ratio 4:When 1, oral cavity speed is lyophilized in prepared Chinese holly Desloratadine
Molten dissolves the time limit to be significantly shorter than suspending agent is single auxiliary material, and uniformity of dosage units is good, friability is small.
To sum up, the present invention finally determines that the group of Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet is grouped into:Chinese holly chlorine thunder he
8.8 parts fixed, 30 parts of cyclodextrin, 57.2 parts of framework material, 3 parts of suspending agent, 0.5 part of corrigent, 0.49 part of pH adjusting agent and coloring
0.01 part of agent.Wherein, cyclodextrin is sulfobutyl ether-beta-cyclodextrin, and framework material is mannitol and milk-sugar mixture, and suspending agent is
Xanthans and gelatin mixture, corrigent are Sucralose, and pH adjusting agent is citric acid;Prepared Chinese holly Desloratadine freezes
Dry oral instant-dissolving tablet appearance is good, and friability is small, no granular sensation, good mouthfeel, and it is short to dissolve the time limit, only 4s.
Amount of colorant or essence can also be added as needed in Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet of the present invention.
Technical solution of the present invention compared with prior art, has the advantages that:
Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet of the present invention is easy to carry, can be in rapid oral dissolution, and discharges medicine
Object, without being swallowed with water;Compliance is good, and the patient of particularly suitable old man and dysphagia takes, stable quality, works fast
Speed;It solves Chinese holly Desloratadine tablet and capsule works slowly, take inconvenience, oral solution is inconvenient to carry, unfavorable quantitative clothes
The shortcomings of using.Supplementary product consumption is small in Chinese holly Desloratadine freeze-drying oral instant-dissolving tablet of the present invention, and preparation process is simple, and cost is relatively low,
With considerable economic and social benefit.
Specific implementation mode
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.It should be understood that described, examples are merely exemplary, does not constitute any restrictions to the scope of the present invention.This field
Technical staff should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and
Form is modified or is replaced, but these modifications or substitutions each fall within protection scope of the present invention.
Embodiment 1
The every 8.8mg of Desloratadine containing Chinese holly, the group of 1000 Chinese holly Desloratadine freeze-drying oral instant-dissolving tablets become:
Preparation method is as follows:
(1) sulfobutyl ether-beta-cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is being stirred
It is heated to 45 DEG C under state, is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) mannitol, lactose, Sucralose of recipe quantity are weighed, is added into step (1) solution.
(3) gelatin, the xanthans for weighing recipe quantity, are dissolved in the purified water of prescription water consumption 20%, are heated to completely molten
Solution;
(4) it is uniform to merge above two solution & stir, with lemon acid for adjusting pH value to 5.5-6.5, a small amount of lemon is added
It is yellow;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The oral quick disintegrating tablet appearance is good, and friability is small, no granular sensation, good mouthfeel, and it is short to dissolve the time limit, only 4 seconds.
Embodiment 2
The every 8.8mg of Desloratadine containing Chinese holly, the group of 1000 Chinese holly Desloratadine freeze-drying oral instant-dissolving tablets become:
Preparation method is as follows:
(1) sulfobutyl ether-beta-cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is being stirred
It is heated to 45 DEG C under state, is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) mannitol, lactose, Sucralose of recipe quantity are weighed, is added into step (1) solution.
(3) gelatin, the xanthans for weighing recipe quantity, are dissolved in the purified water of prescription water consumption 20%, are heated to completely molten
Solution;
(4) it is uniform to merge above two solution & stir, with lemon acid for adjusting pH value to 5.5-6.5, a small amount of lemon is added
It is yellow;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The oral quick disintegrating tablet appearance is good, and friability is small, and no granular sensation, mouthfeel is general, and it is short to dissolve the time limit, only 5 seconds.
Embodiment 3
The every 8.8mg of Desloratadine containing Chinese holly, the group of 1000 Chinese holly Desloratadine freeze-drying oral instant-dissolving tablets become:
Preparation method is as follows:
(1) sulfobutyl ether-beta-cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is being stirred
It is heated to 45 DEG C under state, is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) mannitol, lactose, Sucralose of recipe quantity are weighed, is added into step (1) solution.
(3) gelatin, the xanthans for weighing recipe quantity, are dissolved in the purified water of prescription water consumption 20%, are heated to completely molten
Solution;
(4) it is uniform to merge above two solution & stir, with lemon acid for adjusting pH value to 5.5-6.5, a small amount of lemon is added
It is yellow;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The oral quick disintegrating tablet appearance is good, and friability is small, and no granular sensation, good mouthfeel is general when dissolving, and needs 15 seconds.
Embodiment 4
The every 8.8mg of Desloratadine containing Chinese holly, the group of 1000 Chinese holly Desloratadine freeze-drying oral instant-dissolving tablets become:
Preparation method is as follows:
(1) sulfobutyl ether-beta-cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is being stirred
It is heated to 45 DEG C under state, is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) mannitol, lactose, Sucralose of recipe quantity are weighed, is added into step (1) solution.
(3) gelatin, the xanthans for weighing recipe quantity, are dissolved in the purified water of prescription water consumption 20%, are heated to completely molten
Solution;
(4) it is uniform to merge above two solution & stir, with lemon acid for adjusting pH value to 5.5-6.5, a small amount of lemon is added
It is yellow;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The oral quick disintegrating tablet appearance is good, and friability is small, and no granular sensation, mouthfeel is general, and it is shorter to dissolve the time limit, only 8 seconds.
Embodiment 5
The every 8.8mg of Desloratadine containing Chinese holly, the group of 1000 Chinese holly Desloratadine freeze-drying oral instant-dissolving tablets become:
Preparation method is as follows:
(1) sulfobutyl ether-beta-cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, is being stirred
It is heated to 45 DEG C under state, is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) mannitol, lactose, Sucralose of recipe quantity are weighed, is added into step (1) solution.
(3) gelatin, the xanthans for weighing recipe quantity, are dissolved in the purified water of prescription water consumption 20%, are heated to completely molten
Solution;
(4) it is uniform to merge above two solution & stir, with lemon acid for adjusting pH value to 5.5-6.5, a small amount of lemon is added
It is yellow;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put
Enter vacuum freezing drying oven to be freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
The oral quick disintegrating tablet appearance is general, and friability is poor, no granular sensation, good mouthfeel, and it is short to dissolve the time limit, only 5 seconds.
Claims (1)
1. oral instant-dissolving tablet is lyophilized in a kind of Chinese holly Desloratadine, which is characterized in that including following each component Chinese holly Desloratadine 8.8
Part, 30 parts of cyclodextrin, 57.2 parts of framework material, 3 parts of suspending agent, 0.5 part of corrigent, 0.49 part of pH adjusting agent and colorant 0.01
Part;
The cyclodextrin is sulfobutyl ether-beta-cyclodextrin;
The framework material is mannitol and lactose according to weight ratio 2:The mixture of 1 composition;
The suspending agent is xanthans and gelatin according to weight ratio 4:The mixture of 1 composition;
The pH adjusting agent is citric acid;
Preparation method includes the following steps:
(1) cyclodextrin of recipe quantity is dissolved in 80% purified water of prescription water total amount, 45 is heated under stirring
DEG C, it is slowly added to the Chinese holly Desloratadine of recipe quantity, continues stirring 24 hours;
(2) framework material, the corrigent of recipe quantity are weighed, is added into step (1) solution;
(3) suspending agent for weighing recipe quantity is dissolved in the purified water of prescription water consumption 20%, is heated to being completely dissolved;
(4) it is uniform to merge above two solution & stir, adjusts pH value to 5.5-6.5 with pH adjusting agent, a small amount of colorant is added;
(5) after liquid measures Chinese holly Desloratadine content, liquid is sub-packed in drug-containing dish, and the drug-containing dish equipped with liquid is put into very
Vacuum freecing-dry case is freeze-dried;
(6) tablet being freeze-dried is carried out rapidly to double aluminium packagings, oral instant-dissolving tablet is lyophilized to get Chinese holly Desloratadine.
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CN109453127A (en) * | 2018-12-13 | 2019-03-12 | 深圳海王医药科技研究院有限公司 | A kind of the freeze-drying of ching-chieh volatile oil molten, mouth and preparation method thereof |
CN109875966B (en) * | 2019-04-09 | 2021-03-26 | 海南普利制药股份有限公司 | Dry suspension of desloratadine |
CN109846843B (en) * | 2019-04-15 | 2021-03-26 | 浙江普利药业有限公司 | Desloratadine orally disintegrating tablet |
CN113827574A (en) * | 2021-10-18 | 2021-12-24 | 沈阳药科大学 | Vonoprazan fumarate oral instant tablet and preparation method thereof |
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CN102697711A (en) * | 2012-05-24 | 2012-10-03 | 广州新济药业科技有限公司 | Desloratadine oral liquid preparation and preparation method thereof |
CN103721267A (en) * | 2013-12-16 | 2014-04-16 | 扬子江药业集团广州海瑞药业有限公司 | Composition containing desloratadine citrate disodium |
CN105168159A (en) * | 2015-09-06 | 2015-12-23 | 合肥华方医药科技有限公司 | Isradipine rapidly disintegrating oral tablet and preparation method thereof |
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