CN105769146A - Anesthesia depth monitor adopting multiple monitoring indexes - Google Patents

Anesthesia depth monitor adopting multiple monitoring indexes Download PDF

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Publication number
CN105769146A
CN105769146A CN201610171360.7A CN201610171360A CN105769146A CN 105769146 A CN105769146 A CN 105769146A CN 201610171360 A CN201610171360 A CN 201610171360A CN 105769146 A CN105769146 A CN 105769146A
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module
input
outfan
depth monitor
acquisition
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CN201610171360.7A
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Inventor
韩立军
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MAYHAP INDUSTRIAL (SUZHOU) Co Ltd
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MAYHAP INDUSTRIAL (SUZHOU) Co Ltd
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Priority to CN201610171360.7A priority Critical patent/CN105769146A/en
Publication of CN105769146A publication Critical patent/CN105769146A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/01Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055Simultaneously evaluating both cardiovascular condition and temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021Measuring pressure in heart or blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • A61B5/377Electroencephalography [EEG] using evoked responses
    • A61B5/38Acoustic or auditory stimuli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4821Determining level or depth of anaesthesia

Abstract

The invention discloses an anesthesia depth monitor adopting multiple monitoring indexes. The anesthesia depth monitor is characterized by comprising an acquisition module, wherein an output end of the acquisition module is connected with an input end of an amplification module, an output end of the amplification module is connected with an input end of a denoising module, an output end of the denoising module is connected with an input end of a conversion module, an output end of the conversion module is connected with an input end of an MCU (microprogrammed control unit), the input end of the MCU is further connected with an output end of an analogue simulation module, an input end of the analogue simulation module is connected with an individual difference parameter input module, and an output end of the MCU is connected with a display module and an injection module. According to the anesthesia depth monitor adopting multiple monitoring indexes, multiple monitoring indexes are adopted, the individual parameter difference can be corrected, different acquisition modules can be selected according to actual demands of different patients, monitoring results of the acquisition modules can be mutually verified, and accordingly, the dosage of infused anesthetic is ensured to be adapted to different individuals.

Description

A kind of anaesthesia depth monitor of many monitoring indexes
Technical field
The present invention relates to the anaesthesia depth monitor of a kind of many monitoring indexes, belong to technical field of medical instruments.
Background technology
In art, depth of anesthesia accurately monitors and judges that having become clinical anesthesia doctor shows great attention to and urgently to be resolved hurrily difficult problem.General anesthesia is a kind of special and the state of complexity, including tranquilizing soporific, amnesia, analgesia, stress suppress and the many factors such as of flaccid muscles, and the overall process gone through general anesthesia induction, maintain and revive, each through using anaesthetic to control in whole process.Different modus operandis, different crowd and art moderate stimulation in various degree are also different to anaesthetic reactivity.The depth of anesthesia that anaesthetic consumption deficiency causes is excessively shallow, it is easy to causes the untoward reaction such as hemodynamics fluctuation, intraoperative diagnosis and body move, makes operation to be smoothed out;Anaesthetic is excessive, and anaesthetizing of causing is deep then in interior vital organ function, respiratory system, blood circulation is occurred serious suppression, and hypoxic-ischemic, serious may result in patient's injury of brain function, threat to life.Therefore, in art, anesthesia depth monitoring not only improves control anesthesia quality, and available minimum anaesthetic reaches the anaesthetic effect of the best again, shortens postoperative recovery time.
Presently the most successfully depth of anesthesia monitoring method is BIS(BIS Propofol-targeted, bispectralindex), this method designs according to human nerve's physiological characteristics, it is possible to reaction patient realizes disappearance and recovery situation rapidly, has good advantage as anesthesia depth monitoring index.
But shortcoming the most prominent for BIS is its threshold value to be not individually present when anaesthetic use in conjunction, during different drug combination, BIS value is identical, and not represent depth of anesthesia identical, and different patients all can change at different anesthesia stage BIS value.Furthermore, BIS value, by the impact of many factors, as esmolol, ectogenic epinephrine can make BIS value raise, affects the actual value of depth of anesthesia, and nonetheless, BIS value still be can yet be regarded as one and reflected cerebral cortex function, reflects the good index of depth of anesthesia.But, BIS value is still not clear in situation of change and the mechanism thereof of the different anaesthetic of Different Individual application, and BIS is not suitable for those patients that can not make a response, therefore be presently required and take multiple means combined monitoring depth of anesthesia, each means monitoring result can be mutually authenticated, it is ensured that the anesthetis consumption of input is applicable to the required metering of Different Individual.
Summary of the invention
The technical problem to be solved is, there is provided a kind of monitoring index many, individual parameter differences can be revised, different acquisition module can be selected according to the actual demand of different patients, the monitoring result of each acquisition module can be mutually authenticated, it is ensured that the anesthetis consumption of input is applicable to the anaesthesia depth monitor of the required metering of Different Individual.
For solving above-mentioned technical problem, the technical solution used in the present invention is:
A kind of anaesthesia depth monitor of many monitoring indexes, it is characterized in that, including acquisition module, the outfan of described acquisition module is connected with the input of amplification module, the outfan of described amplification module is connected with the input of denoising module, the described outfan of denoising module is connected with the input of modular converter, the outfan of described modular converter is connected with the input of MCU, the input of described MCU is also connected with the outfan of analogue simulation module, the input of described analogue simulation module is connected with individual variation parameter input module, the outfan of described MCU is connected with display module and injection module respectively;Described acquisition module includes at least two in the dynamic monitoring modular of brain electric data collecting electrode slice, auditory evoked potential acquisition electrode sheet, electrocardio-data collection electrode slice, non-invasive blood pressure acquisition module, body temperature acquisition module, pulse collection module, oxygen saturation monitor module, monitoring of respiration module and eye.
Described injection module is microsyringe, and the heap(ed) capacity of described microsyringe is 10 μ L.
The dynamic monitoring modular of described eye includes eye tracker.
Described brain electric data collecting electrode slice is bilateral cerebral electricity double frequency acquisition electrode sheet.
Described analogue simulation module includes individual variation correcting module.
Described display module includes LED display.
Individual variation parameter input module includes anesthetis kind input submodule, operation selection submodule, patient age input submodule, weight in patients input submodule and patient's premedicate input submodule.
Described anesthetis kind input submodule, operation selection submodule, patient age input submodule, weight in patients input submodule and patient's premedicate input submodule all include keyboard.
Analogue simulation module is single-chip microcomputer.
The setting of individual variation parameter input module, it is simple to judge the actually required anesthetis consumption of patient more accurately, as brain electric data collecting electrode slice is used for exporting BIS value, BIS value 100, waking state;BIS value 0, entirely without brain electrical acti state (cerebral cortex suppression), it is considered that BIS value is normal condition 85 ~ 100;65 ~ 85 is sedation;40 ~ 65 is narcotism;< 40 is likely to present outburst to be suppressed.And BIS value is by the impact of many factors, as esmolol, ectogenic epinephrine can make BIS value raise, affect the actual value of depth of anesthesia, therefore patient's premedicate input submodule need to be set, it is considered to the premedicate impact on BIS value.
The degree of association of anesthetis kind is also differed by different acquisition module, and the sedation depth produced such as BIS and most of anaesthetics has dependency.In intravenous anesthetics, the depth of anesthesia of propofol is fabulous with BIS value dependency, can the simple propofol degree of depth of accurate measurements.BIS is good with the inhaled concentration dependency of sevoflurane, desflurane, and when using Sevoflurane, BIS Depth of Anesthesia is reliable.But the research of isoflurane is found, BIS and isoflurane inhaled concentration non-correlation, it is impossible to the depth of anesthesia that monitoring isoflurane sucks, therefore different acquisition modules need to be selected to be monitored according to different anesthetis kinds.
Patient's all ages and classes, different body constitution, different sexes, different weight and the anesthetis consumption needed for different modus operandi are all different, therefore need each influence factor of comprehensive consideration.
BIS is relevant with the tranquilizing soporific degree in anesthesia, and it is the good index that a monitoring is calm;And AEP(auditory evoked potential, auditoryevokedpotentials) it is provided that many-sided information such as operation stimulation, analgesia, tranquilizing soporific.When, after a large amount of use analgesic, BIS is difficult to predictor and moves, and in this case, only AEP could reflect depth of anesthesia, it was predicted that body moves and intraoperative diagnosis comprehensively.But the inapplicable deafness patient of AEP.
The dynamic monitoring modular of eye can monitor the depth of anesthesia of patient according to rapid eye movement and SEM, but the dynamic monitoring modular of eye is not suitable for schizophrenia, depression, mania, bipolar disorders, obsession, anxiety neurosis, all kinds of neurosis such as neurasthenia and somatization disorder, cerebral organic psychosis, psychoactive drug substance (such as ethanol) caused by mental disorder, and stress-related disorder etc..
The anaesthesia depth monitor of a kind of many monitoring indexes provided by the invention, the setting of various monitoring measures, applicable at least two acquisition module can be selected according to the Different Individual situation of patient, the monitoring result of at least two acquisition module selected can be mutually authenticated, make monitoring result accurate, the depth of anesthesia of patient can be guarded, it is ensured that anesthetis consumption is accurate;The setting of analogue simulation module and individual variation parameter input module, it is achieved that individual parameter differences can be revised, and according to individual instances, the error of monitoring result Yu actual value can be modified, it is ensured that anesthetis consumption is accurate;The setting of the dynamic monitoring modular of eye, can the depth of anesthesia of patient anyway directly perceived, the evaluation for patient's depth of anesthesia has clinical meaning.
Accompanying drawing explanation
Fig. 1 is the structural representation of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is further described.
As shown in Figure 1, a kind of anaesthesia depth monitor of many monitoring indexes, it is characterized in that, including acquisition module, the outfan of described acquisition module is connected with the input of amplification module, the outfan of described amplification module is connected with the input of denoising module, the described outfan of denoising module is connected with the input of modular converter, the outfan of described modular converter is connected with the input of MCU, the input of described MCU is also connected with the outfan of analogue simulation module, the input of described analogue simulation module is connected with individual variation parameter input module, the outfan of described MCU is connected with display module and injection module respectively;Described acquisition module includes at least two in the dynamic monitoring modular of brain electric data collecting electrode slice, auditory evoked potential acquisition electrode sheet, electrocardio-data collection electrode slice, non-invasive blood pressure acquisition module, body temperature acquisition module, pulse collection module, oxygen saturation monitor module, monitoring of respiration module and eye.
Described injection module is microsyringe, and the heap(ed) capacity of described microsyringe is 10 μ L.
The dynamic monitoring modular of described eye includes eye tracker.
Described brain electric data collecting electrode slice is bilateral cerebral electricity double frequency acquisition electrode sheet.
Described analogue simulation module includes individual variation correcting module.
Described display module includes LED display.
The above is only the preferred embodiment of the present invention; it is noted that, for those skilled in the art; under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should be regarded as protection scope of the present invention.

Claims (6)

1. the anaesthesia depth monitor of monitoring index more than a kind, it is characterized in that, including acquisition module, the outfan of described acquisition module is connected with the input of amplification module, the outfan of described amplification module is connected with the input of denoising module, the described outfan of denoising module is connected with the input of modular converter, the outfan of described modular converter is connected with the input of MCU, the input of described MCU is also connected with the outfan of analogue simulation module, the input of described analogue simulation module is connected with individual variation parameter input module, the outfan of described MCU is connected with display module and injection module respectively;Described acquisition module includes at least two in the dynamic monitoring modular of brain electric data collecting electrode slice, auditory evoked potential acquisition electrode sheet, electrocardio-data collection electrode slice, non-invasive blood pressure acquisition module, body temperature acquisition module, pulse collection module, oxygen saturation monitor module, monitoring of respiration module and eye.
2. the anaesthesia depth monitor of a kind of many monitoring indexes according to claim 1, it is characterised in that: described injection module is microsyringe, and the heap(ed) capacity of described microsyringe is 10 μ L.
3. the anaesthesia depth monitor of a kind of many monitoring indexes according to claim 1, it is characterised in that: the dynamic monitoring modular of described eye includes eye tracker.
4. the anaesthesia depth monitor of a kind of many monitoring indexes according to claim 1, it is characterised in that: described brain electric data collecting electrode slice is bilateral cerebral electricity double frequency acquisition electrode sheet.
5. the anaesthesia depth monitor of a kind of many monitoring indexes according to claim 1, it is characterised in that: described analogue simulation module includes individual variation correcting module.
6. the anaesthesia depth monitor of a kind of many monitoring indexes according to claim 1, it is characterised in that: described display module includes LED display.
CN201610171360.7A 2016-03-24 2016-03-24 Anesthesia depth monitor adopting multiple monitoring indexes Pending CN105769146A (en)

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CN106730110A (en) * 2016-12-01 2017-05-31 谢言虎 A kind of patient-controlled sedation target-controlled infusion system based on anesthesia depth monitoring
CN109157195A (en) * 2018-08-22 2019-01-08 唐丽 A kind of department of anesthesia's anesthesia depth monitor
CN109394210A (en) * 2018-12-14 2019-03-01 张维维 A kind of department of anesthesia's anesthesia depth monitor
CN109431464A (en) * 2018-10-25 2019-03-08 惠良图 A kind of Multifunctional anesthesia section anesthesia depth monitor
CN110755051A (en) * 2019-11-19 2020-02-07 杨红晓 Anesthesia depth monitoring device for anesthesia department
CN112075945A (en) * 2020-09-17 2020-12-15 浙江大学 Consciousness detection method based on electro-oculogram signals under voice stimulation
WO2021109601A1 (en) * 2019-12-06 2021-06-10 深圳市德力凯医疗设备股份有限公司 Method for measuring depth of anesthesia, storage medium, and electronic device
CN113133744A (en) * 2021-04-30 2021-07-20 鹤壁市人民医院 Multifunctional anesthesia depth monitoring device for anesthesia department

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106730110A (en) * 2016-12-01 2017-05-31 谢言虎 A kind of patient-controlled sedation target-controlled infusion system based on anesthesia depth monitoring
CN109157195A (en) * 2018-08-22 2019-01-08 唐丽 A kind of department of anesthesia's anesthesia depth monitor
CN109431464A (en) * 2018-10-25 2019-03-08 惠良图 A kind of Multifunctional anesthesia section anesthesia depth monitor
CN109431464B (en) * 2018-10-25 2021-05-18 惠良图 Multifunctional anesthesia depth monitoring device for anesthesia department
CN109394210A (en) * 2018-12-14 2019-03-01 张维维 A kind of department of anesthesia's anesthesia depth monitor
CN110755051A (en) * 2019-11-19 2020-02-07 杨红晓 Anesthesia depth monitoring device for anesthesia department
WO2021109601A1 (en) * 2019-12-06 2021-06-10 深圳市德力凯医疗设备股份有限公司 Method for measuring depth of anesthesia, storage medium, and electronic device
CN112075945A (en) * 2020-09-17 2020-12-15 浙江大学 Consciousness detection method based on electro-oculogram signals under voice stimulation
CN113133744A (en) * 2021-04-30 2021-07-20 鹤壁市人民医院 Multifunctional anesthesia depth monitoring device for anesthesia department

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Application publication date: 20160720