CN105736328A - Device of a wearable type for dispensing a fluid, and corresponding dispensing method - Google Patents
Device of a wearable type for dispensing a fluid, and corresponding dispensing method Download PDFInfo
- Publication number
- CN105736328A CN105736328A CN201511001589.8A CN201511001589A CN105736328A CN 105736328 A CN105736328 A CN 105736328A CN 201511001589 A CN201511001589 A CN 201511001589A CN 105736328 A CN105736328 A CN 105736328A
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- China
- Prior art keywords
- micropump
- equipment
- fluid
- fixed part
- actuator
- Prior art date
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- Granted
Links
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
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- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
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- 229940125396 insulin Drugs 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
- A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
- F04B43/04—Pumps having electric drive
- F04B43/043—Micropumps
- F04B43/046—Micropumps with piezoelectric drive
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
- B05B12/08—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means
- B05B12/085—Arrangements for controlling delivery; Arrangements for controlling the spray area responsive to condition of liquid or other fluent material to be discharged, of ambient medium or of target ; responsive to condition of spray devices or of supply means, e.g. pipes, pumps or their drive means responsive to flow or pressure of liquid or other fluent material to be discharged
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14212—Pumping with an aspiration and an expulsion action
- A61M5/14224—Diaphragm type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B49/00—Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
- F04B49/06—Control using electricity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
- A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
Abstract
The invention discloses a device of a wearable type for dispensing a fluid, and a corresponding dispensing method. The device includes a fixed part (30; 70) and a replaceable part (20; 60) which is associated with the fixed part (30; 70) through fluid connection (12; 51) and includes a reservoir (21; 61) for containing the fluid to be dispensed and a micro-pump (22; 62) which is a MEMS type specifically and sends the fluid to the fixed part through the fluid connection (12; 51). The fixed part (30; 70) includes an electronic control module (31; 71) controls operation of the micro-pump (22; 62) via a pressure-sensor (23; 76). The device (10; 50) includes an actuator (25; 75; 175) which automatically operates the micro-pump (22; 62). According to the invention, the pressure-sensor (76) is configured to be inside the fixed part (70) of the fluid connection (51) in proximity to a terminal outlet of the fluid connection (51) and is associated with dispensing the fluid from a needle (74).
Description
Technical field
It relates to the equipment of the wearable for distributing fluid, it includes the fixed part dressed by object and can via fluidly connecting the replaceable portion being associated with described fixed part, described replaceable portion includes for holding the container of the fluid being assigned with and being used for fluid being sent the Micropump to described fixed part by fluidly connecting, described fixed part includes the electric control module being arranged to the operation controlling Micropump, and this equipment includes the battery actuator for operating described Micropump.
Various embodiments can be applicable to the equipment of distribution fluid, and wherein fluid comprises insulin or other drug preparation.
Background technology
Becoming known for distributing the equipment of the fluid such as comprising insulin or other drug preparation, it can be dressed by user or patient such that it is able to continuously or as required distribution fluid or, and it presents the size and cost held.
For such equipment, it is important that implement to control continuously the flowing of fluid medicament with in office why hinder (such as leakages, bubble, obturation etc.) when ensure the safety of effectiveness and the patient treated.
The system being known for this purpose is made up of two parts: fixed part, including electronic control unit, memorizer and radio frequency interface, and such as can be dressed by user;And replaceable portion, including the Micropump for the container of medicament, MEMS (MEMS) type, the actuator with correspondence and the battery powered for actuator.
In more detail, in this connection, Fig. 1 illustrates the equipment 10 for distributing fluid, and it includes replaceable portion 20, and replaceable portion 20 includes again: container 21;MEMS micropump 22, it is received from the fluid of container 21 by inlet duct 21a and is associated with pressure transducer 23;Actuator 24;And battery 25.Fixed part 30 includes electronic control module 31, and it includes again memorizer 32 and the communication interface 33 in the operation of radio frequency place.
11 signals represented between pressure transducer 23 and electronic module 31 connect, and 12 represent that beginning through fixed part 31 from Micropump 22 arrives the fluid distribution pipe of distribution pin 13, wherein distribution pin 13 is for being assigned to fluid medicament in the health of the object dressing fluid dispensing apparatus 10.
The terminal of 26 actuators 24 representing operation Micropump 22, for instance the axle of linear actuators or drift.Micropump 22 generally includes pump chamber, and its roof is made up of barrier film.The described barrier film of pump 22 is periodically applied mechanical pressure by terminal 26.
Via the pressure transducer (or sensor) 23 existed in MEMS micropump 22, by the control of the pumping pressure of MEMS micropump being performed the control of fluid.
The signal of aforementioned pressure sensor 23 is via wire bonding or by the substrate of some other kinds of connections (by the re-melting of the solder alloy of pre-deposition on MEMS or by distributing conducting resinl or the micro-knot obtained by the ultrasonic re-melting of the heat of the contact of Micropump in substrate) transmission to Micropump 22.From the substrate of Micropump, aforementioned pressure signal is connected 11 at signal and upload the electronic control part 31 transported to fixed part 30, implement signal via sliding contact or spring contact and connect 11.
As shown in Figure 1A, Micropump 22 includes the pumping chamber 22a being made up of three different silicon layers on the top being arranged on silicon base 22d, the silicon layer composition bottom 22ae of Micropump 22 that two of which is extreme and top layer or lid 22f, and determine room floor 22i between which, that dig out wherein is pump chamber 22a.Inlet duct 21a and the outlet towards fluid distribution pipe 12 must be disposed on the bottom 22e of Micropump 22, it is thus possible to it is mutual with substrate 22d, this is because the structure of two valves showed by fluid distribution pipe 12 (21b on inlet duct 21 and the 12b in outlet) makes them can not manufacture on single silicon layer, but must manufacture respectively on the contrary on different layers (bottom 22e and top layer 22f).Thus, the purpose of process is in that to obtain from pumping chamber 22a through top layer 22f, then passes through the exit circuit forming passage 22g (it seals via cap member 22h) on top layer 22f and return to bottom 22e.
The said equipment shows some defects more complicated about framework, especially replaceable portion, and layout in the MEMS micropump of the arrangement requirement circuit of above-mentioned pressure transducer and bond pad.Additionally, this layout relates on the surface of pump or is disposed therein in the layer being provided with pump itself.
Summary of the invention
The purpose that embodiment described herein is in that to improve the potential of the foregoing equipment according to prior art.
Each embodiment realizes above-mentioned purpose owing to having the equipment of the characteristic required in claims.
Each embodiment, it is envisioned that be arranged in fixed part by pressure sensor apparatus, is close to the terminal exit portion fluidly connected being associated with distribution pin.
Each embodiment is it is envisioned that fixed part includes actuator, and this equipment includes the component of the motion for transmitting the Micropump being connected in replaceable portion by the actuator in fixed part.
Each embodiment, it is envisioned that form that conveying member is thin plate or band, is especially formed from steel.
Each embodiment is it is envisioned that aforementioned thin plate is associated with Micropump with lasting manner, and is inserted in the device for engaging actuator.
Each embodiment is it is envisioned that actuator is cantilever actuator device.
Each embodiment is it is envisioned that actuator is linear actuators.
Each embodiment is it is envisioned that engagement device includes the low friction press element being pushed to the surface of thin plate by spring, and other surfaces of thin plate are positioned on actuator, especially on the end of the cantilever of actuator.
Each embodiment is it is envisioned that engagement device includes the permanent magnet being pushed to the surface of thin plate by spring, and other surfaces of thin plate are positioned on actuator, especially on the end of the cantilever of actuator.
Each embodiment is it is envisioned that the outlet fluidly connected of the Micropump being arranged in replaceable portion is connected to the hydraulic circuit of fixed part via the needle system being arranged on fixed part, and wherein needle system penetrates the fluid-tight barrier film in replaceable portion.
Each embodiment it is envisioned that (Micropump being arranged in replaceable portion) outlet conduit be positioned in by fluid fluidly connecting relative wall from container transport to Micropump.
Each embodiment is it is envisioned that method for controlling flowing in wearable device, wearable device is for distributing the fluid of described type, which provide the decline according to the pressure measured by the pressure transducer on the distribution duct downstream in replaceable portion and perform the control of fluid, the downstream being specially pipeline has outlet valve, that is, the attachment point of the contiguous fluid line with distribution pin.
Accompanying drawing explanation
Now with reference to accompanying drawing, only it is illustrated by way of example each embodiment, wherein:
Fig. 1 and Figure 1A has been previously performed description;
Fig. 2 illustrates the schematic diagram of the equipment for distributing fluid;
Fig. 2 A illustrates the schematic diagram of the embodiment of the Micropump of the equipment for distributing fluid that can be used for Fig. 2;
Fig. 3 A and Fig. 3 B is the schematic diagram of the details of the connection system of the equipment illustrating Fig. 2;
Fig. 4 is the schematic diagram of the first actuator of the equipment for Fig. 2;
Fig. 5 is the schematic diagram of the first structure of the equipment of Fig. 2, has the first system of the joint of device for transmitting motion;
Fig. 6 A to Fig. 6 D is the schematic diagram of the step of the joint of the equipment in first structure of Fig. 5 and operation;
Fig. 7 A and Fig. 7 B is the schematic diagram of the amount related in the operation of the actuator of Fig. 4;
Fig. 8 is the schematic diagram of the second structure of the equipment of the Fig. 2 with the second mating system;
Fig. 9 A to Fig. 9 D is the schematic diagram of the step of the joint of the equipment of Fig. 2 and operation;
Figure 10 is the schematic diagram of the deformation details of the equipment of Fig. 2, is used for using the second actuator and the 3rd mating system distribution fluid;
Figure 11 A to Figure 11 C and Figure 12 A to Figure 12 C is the schematic diagram of the 3rd mating system of Figure 10;
Figure 13 illustrates the equipment of the Figure 10 using the another pattern engaged;
Figure 14 illustrates the equipment using the Figure 10 for the equipment reducing motion;And
Figure 15 illustrates the schematic diagram of the alternative embodiment of the Micropump of the equipment for distributing fluid that can be used for Fig. 1.
Detailed description of the invention
In the following description, it is provided that various details are better understood when by the embodiment that example provides.Embodiment can be implemented with or without detail, or utilizes additive method, parts, material etc. to implement.In other cases, it does not have illustrate or describe known structure, material or operation so that the various aspects of embodiment are not blurred." embodiment " or " embodiment " mentioned in description refers to that the detail, structure or the characteristic that describe in conjunction with this embodiment include at least one embodiment.Therefore, each point in the description occur such as " in an embodiment " or " in one embodiment " statement be not necessary to represent one and identical embodiment.Furthermore, it is possible to combine specific feature, structure or characteristic in one or more embodiments in any convenient manner.
Reference provided herein is only for the convenience of reader rather than the scope or the implication that limit embodiment.
Figure 2 illustrates above-mentioned solution 50, wherein replaceable portion 60 includes container 61 and MEMS micropump 62.
On the contrary, fixed part 70 includes electronic module 71, and it includes memorizer 72 and at the communication interface 73 of radio frequency place operation, actuator 75 (especially piezo-activator), pressure transducer 76 and the rechargeable battery 77 for automatically powering for actuator 75.
Replaceable portion 60 is connected to fixed part 70 by being connected to fluidly connect by its outlet conduit 64, wherein fluidly connects and conveys the fluid to distribution pin 74 (that is, fluid distribution pipe 51).Additionally, the component 52 (especially sheet metal or band) for transmitting motion is preferably made up of steel, piezo-activator 75 is connected to Micropump 62 by it.Fixed part also includes audition and visual alarm and temperature sensor (not shown in fig. 2).Fluid distribution pipe 51 is arranged in fixed part 70, and the pipeline that replaceable portion 60 self is set to via having outlet valve 64 fluidly connects with fixed part 70, and outlet valve 64 is given to the outside (illustrating form referring for example to Fig. 3 A and Fig. 3 B) in replaceable portion 60 and derives from Micropump 62.
Pressure transducer 76 is arranged in fixed part 70 to measure the pressure in fluid distribution pipe 51, is the downstream towards distribution pin 74 as far as possible.This not only avoids the demand in the substrate for being connected to Micropump 62, but also be capable of the declining of pressure for measuring according to pressure transducer 76 and perform the structure of the electronic module 31 that fluid controls, the wherein downstream of the pressure transducer 76 connection between fixed part 70 and replaceable portion 60, the especially preferred downstream at the pipeline with outlet valve 64, as it has been described above, the attachment point of the contiguous fluid line 51 with pin 74.
Before being close in fluid distribution pipe 51 (transmitting the fluid from Micropump 62) via use, any leakage controlling to allow to check any point (including the hydraulic connecting between replaceable portion 60 and the fixed part 70) place between the container 61 of fluid and outlet by measuring the decline of pressure of flowing that the Stress control of absolute pressure transducer 76 on the stationary part 70 performs again is installed.
In substrate, the elimination of circuit allows to entrance (the pipeline 61a of fluid, it is additionally provided with inlet valve 61b) and outlet (being provided with the pipeline of outlet valve 64) be positioned on two opposite faces of pump 62, it is specially substrate side and barrier film side, eliminates and arrange in its surface and the passage utilizing enclosing cover to seal or embedment arrange the demand of layer interior (the passage 22g of Fig. 1 a) of pump itself.
This connection in Fig. 2 A is demonstrated by the possible embodiment of Micropump 62.
Such as the pump 22 of Fig. 1 a, aforementioned Micropump 62 includes the pump chamber 62a being made up of three different silicon layers, the extreme layer composition bottom 62e and top layer 62f of two of which, identifies room floor 62i between which, digs out pump chamber 62a in the floor 62i of room.The inlet tube 61a of inlet valve 61b with correspondence is disposed through the bottom 62e and basal layer 62d of Micropump 62, and is arranged on the top layer 62f being used as lid from the outlet conduit 63 of room 62a.This pipeline is usual and pipeline 64 fluid is continuous and can have outlet valve 63b, outlet valve 63b manufactures in top layer 62f or can share this valve with pipe 64.In cap rock, arrange passage therefore, there is no need to the situation such as Fig. 1 a then sealed.It should be noted that the Micropump 62 of Fig. 2 A has the actuator 52 being operated of the substrate 62d by inlet duct 61a, and outlet conduit 63 is positioned on opposite side.Thus, again through further pipe section towards replaceable portion 60 face send fluid.At Fig. 2 and hereinafter, Micropump 62 be schematically indicated as on the contrary with thin plate or with 52 apply the side that point is identical has the outlet for fluid.
In fig. 15 it is shown that include the Micropump 262 of the pump chamber 262a being made up of three different silicon layers, the extreme layer composition bottom 262e and top side 262f of two of which, identify room floor 262i between which, in the floor 262i of room, dig out pump chamber 262a.
The inlet tube 61a with corresponding inlet valve 61b is disposed through the top layer 262f of Micropump 262, and is arranged on top layer 262f and substrate 262d from the outlet conduit 263 of room 262a.This pipeline is usual and pipeline 64 fluid is continuous, and can have the outlet valve 263b manufactured in bottom 262e or can share this valve with pipeline 64.Additionally, in this embodiment, the situation thus without such as Fig. 1 a arranges passage in cap rock and is sealed.
The simplification of the framework of foregoing pump enables to pump and the material except silicon can also be utilized to obtain, such as moulding of plastics materials or coupled to the plastic resin of metal, pottery or substrate of glass, precision according only to pump selects material, which reflects the tolerance limit of the manufacturing process of pump.
Other than with being widely used in the abatement technique of MEMS technology by outside silicon layer manufactures, entrance and exit valve and pump members can utilize plastics molding to obtain, or obtain by including sheet metal at plastic body.
The pipeline with the outlet valve 64 of the Micropump 62 being arranged in replaceable portion 60 is connected to the hydraulic circuit of fixed part 70 via the needle system 78 (the sealing barrier film 65 in replaceable portion 60) installed on the stationary part 70, i.e. fluid distribution pipe 51, as shown in Figure 3 A and Figure 3 B, the structure after replaceable portion 60 and fixed part 70 isolating construction before coupling and coupling is respectively illustrated.Pin 78 for connecting is formed, to prevent in the obturation during barrier film 65.Barrier film 65 is arranged in the front portion of tapered protrusion, and needle system 78 includes the base 78a of correspondingly-shaped, and it holds tapered protrusion 65a in coupled structure.The material of barrier film 65 is based on silicon, thus compatible with the fluid biological distributed by pump 62.
Actuator 75 is piezo-electric type, and applies displacement S substantially along its main shaft on band 52 as shown in Figure 2, and wherein main shaft is consistent with the axle of the component being perpendicular to Micropump 62.As it was previously stated, actuator 75 is mounted on the stationary part 70.
In one embodiment, as shown in Figure 4, Figure 5 and Figure 6, above-mentioned actuator 75 can be cantilever style.As it is known, piezoelectric cantilever actuator includes base portion 75e, arm or crossbeam 75a and end 75b.Piezoelectric element between base portion and arm makes arm 75a vibrate about resting position on the V of direction.Being in resting position as in figure 2 it is shown, be perpendicular to displacement S with arm 75a and perform and this mode of vibration (referring further to Fig. 7 B) that displacement S-phase is cut, cantilever actuator device 75 is arranged in fixed part 70, and namely direction V is parallel to displacement S.In various embodiments, actuator 75 is lienar for can substitute for, for instance as shown in Figure 10.
As it has been described above, MEMS micropump 62 is volume type (volumetrictype), wherein move the volume that element changes the room of described Micropump;Specifically, it is membrane pump as shown in Figure 5.Micropump 62 includes pumping chamber 62a, and one wall is represented by silicon diaphragm 62b.The plane of barrier film 62b is perpendicular to displacement S, and the barrier film 62b of pump 62 is activated (such as by glued and welding) by metal tape 52 associated there.In Figure 5, this connects through glued 62c and obtains.
Additionally, figure 5 illustrates the component for transmitting motion, it is that band connects 52 as previously mentioned.The type of actuator 75 is depended on the connection between 52 and actuator 75.Figure 5 illustrates the connection with 52 Yu cantilever actuator device 75, it obtains via the laterally coupled system 79 of the summation fixed (specifically, the coupling of fixed part adds the length being with plus moving part), come from the fixing tolerance limit being with on Micropump that can eliminate the piezo-activator 75 come from fixed part 70.
Therefore, it should be noted that, how equipment 50 shows the band 52 (that is, via glued 62c or other modes above-mentioned) being associated with the fixed form with Micropump 62, and is inserted in the device of such as engagement device 79 (joint for actuator 75).In other words, replaceable portion 60 carrying belt 52, it was bonded on fixed part 60 in the moment coupleding to actuator 75.
The press element operated by including the spring of spring 79a and propeller 79b ensures above-mentioned laterally coupled system 79, and this press element is in the direction of the longitudinal axis of arm 75a and is perpendicular to operation on the axle of 52 and the direction of displacement S, and acts on on the end face of 52.Press element 79 and there is low-friction coefficient with the coupling between the upside of 52;Such as, propeller 79b is made up of politef, and is with 52 to be made up of steel so that the value of coefficient of friction is 0.005.Propeller 79b by with 52 by the mobile terminal 75b pressing to piezo-activator 75, mobile terminal 75b is preferably coated with copper or plastic material or is provided with the terminal being made up of plastic material on it, and this coupling between the bottom side with 52 and the mobile terminal 75b of piezo-activator is contrary has great friction coefficient.By this way, the motion of the end 75b of piezo-activator 75 is transferred to band 52, and it slides on the press element 79 of spring operation.
By example, spring 79a can utilize the metal wire of 0.5mm to make, and has the overall diameter of 5mm and the length of 15mm.Coefficient of friction between steel and copper is 1.0.Press element 79 is such as applied more than the power of 2N, and actuator 75 applies the maximum, force of 2N on the direction of displacement S.It is such as 100kPa from the pressure of the fluid of Micropump 62 outflow.
Fig. 6 illustrates the step of the coupling relative to the component (that is, with 52) for transmitting motion of fixed part 70 and replaceable portion 60 and operation.
When Fig. 6 A illustrates the beginning of the coupling between two parts 60 and 70 between end 75b and propeller 79b insert be glued to barrier film 62b with 52 step.Fig. 6 B having illustrated, press element 79 applies to be pressed into the step of the power of the end 75b of actuator 75 via the spring 79a operated by leverage (not shown) (such as can be manually close by user outside fixed part 70) in the top side with 52.Fig. 6 C has illustrated pumping step, wherein the arm of actuator 75 is showing towards the barrier film 62b movement (linearized in fig. 7) thrust from fixed part 70 on the direction of the displacement S of replaceable portion 60 orientation, it promotes band 52 in the same direction, and press element 79 slides in the opposite direction.On the contrary, Fig. 6 D has illustrated drawing step, wherein the arm 75a of actuator 75 showing the drag motion about barrier film 62b from replaceable portion 60 on the direction of the displacement S of fixed part 70 orientation, pulls band 52 in the same direction, and press element 79 slides in the opposite direction.
Fig. 7 A and Fig. 7 B has illustrated the detailed side view coupleding to the actuator 75 with 52.The drift L of arm 75a must be considerably larger than the absolute displacement of the end 75a of actuator such that it is able to the displacement of the vertical axis moved along actuator is minimized, is therefore prevented from the reduction of the power contacted with band.Such as, displacement S includes between 20 and 50 μm, and drift L includes between 5000 and 10000 μm.
With reference to Fig. 7 B, show in detail the displacement that the end 75a, the H that occur in Fig. 7 A are perpendicular to the direction of motion S, and T is the thickness of arm 75a static on the direction be parallel to the direction of motion.Therefore,
H=Tarctan (S/L) (arctan and arc tangent)
Thus, it is assumed that the value of thickness T and displacement S, length L must increase so that vertical displacement H minimize and ensure during motion with 52 contact.
Fig. 8 illustrates cantilever actuator device 75 and the various embodiments with the joint between 52, and it uses the system 89 for engaging the permanent magnet 89b supported by spring system 89a (also being controlled by leverage).Once insert the metal tape 52 can being made up of magnetic or nonmagnetic substance, magnet 89b just shifts near band 52 by acting on leverage, itself will be pressed into the end 89b (it is made up, for instance nickel) of actuator 75 of ferromagnetic material with 52.The separation with 52 is obtained by acting on leverage.Can easily replace magnet/leverage assembly.
Fig. 9 shows in detail coupling and the operating procedure of mode similar shown in Fig. 6.As it has been described above, in this case, due to magnetic couplings, system 89 is not slided on the rightabout relative to end 79b, but spring 79a bends and tilts, and follows the displacement with 52.
The following provide some reference values for magnet mating system 89.
Permanent magnet 79b such as can be made up of Nd-Fe-B (Neo-Delta-Magnet type), and associated there is energy product
The density of magnetic flux is multiplied by the power=BxH=278Kj/m in magnetic field3
Utilize the magnet 79b being of a size of 5x2.5x2m, transmitted the power of 4.5N by spring 79a, and ENERGY E is
E=278x (5x2.5x2) x10E-9kJ=6.95x10E-6kJ=6.95mJ
It can be seen that the value of ENERGY E is non-normally low.
Maximum, force on the direction of displacement S is 2.7N.
Terminating (finish) additionally, magnet 79b has towards the nickel with 52, nickel-steel coefficient is 0.6.
Magnetic field owing to being produced by permanent magnet can affect the behavior of electricity equipment, it is preferable that fixed part 70 includes steel shielding, and replaceable portion 60 does not comprise any sensing unit.
Figure 10 has illustrated linear actuators 175, it can also be piezo-electric type, and include the motor section 175e along axle S displacement linearly, displacement S direction linear translation and with the axle 175a with 52 be not associated with the barrier film 62b end being associated (especially coupling 175b via cam).
Figure 11 shows in detail and couples the 175b linear actuators 175 obtained and the connection with 52 via cam.With in 52 spaces being inserted between two jaw shape part 175d shaped, and can sliding along the vertical axis parallel with displacement S, inner cam contoured shaft 175c is applied to it.Figure 11 A illustrates not have and couples 175b (being perpendicular to the plane in the direction of displacement S) with the cam in the front view of 52, Figure 11 B illustrates the cam coupling 175b that band is inserted between jaw shape part 175d, and Figure 11 C illustrates the clamping with 52: by acting on lever, main shaft 175c rotates and moves two jaw shape part 175d, thus blocks thin plate or band 52.Once main shaft rotates to home position, spring can make jaw shape part 175d open and discharge thin plate.Figure 12 illustrates the structure identical with Figure 11 in cross-section.
Additionally, when linear actuators, it is possible to use optional connection system 189, it uses the spring 189a moved freely along the axle permanent magnet 189b supported, to compensate the reciprocating motion with 52.Mating system 189 is shown on the end of axle 175a in fig. 13 and is inserted in supporter 185, and corresponds essentially to the system 89 being previously shown.
Figure 14 illustrates the linear actuators 175 being associated with the cantilevered mechanism 190 that operation is rocking bar, to obtain with 52 from the reduction scope of the displacement S ' of the linear actuators 175 displacement S started, has thus increased power.Cantilevered mechanism 190 includes vertical wall 190b and horizontal wall 190a (it is rotatably associated with upright arm 190b) via pin 190c.Axle 175a is similarly connected to the upright arm 190d of cantilever 190 via pin 190b.Substantially along identical trunnion axis, band 52 is fixed on horizontal arm 190a, thus cantilever 190 provides the transmission of the displacement range reducing linear actuators 175.Cantilever mechanism 190 with 52 couple and be similar to cantilever actuator device 75, use press element 79 and similar coefficient of friction.In this way it is possible to use the linear piezoelectric actuator with low force and reduced size.The connection with pump can be carried out via the mechanically or magnetically sexual system having been directed towards the operation of linear actuators 175 and illustrate.
When mechanical alignment between fixed part 70 and replaceable portion 60 is by replaceable portion 60, the cone pin of casting ensures, it couples with the corresponding aperture in fixed part 70.
The metal hook of casting in the body of fixed part 70 is utilized to obtain the joint between two parts 60 and 70.These hooks coupled to the corresponding eyelet in replaceable portion 60.Preferably, to need this mode applying the replaceable portion 60 of pulling force removal to configure hook and eyelet, this causes the fault of eyelet.By this way, it is therefore prevented that reusing of replaceable portion once had been installed.
The battery 77 being arranged on fixed part is AA type.
Therefore, the advantage of described solution can from the description above in clearly obtain.
Described equipment and corresponding method can simplify the manufacture of MEMS micropump, eliminate the integrated pressure sensor transferring on fixed part.This element that can eliminate such as bond pad and internal connection, it is thus eliminated that the passage exposed, up to the present, the entrance and exit for fluid can be located at the opposite face of pump.Fluid can pass through MEMS micropump to be drawn on side, and pumps from opposite side, therefore simplifies the manufacture of pump.
Additionally, described equipment and method can simplify the replaceable portion of equipment, eliminate actuator and internal electrical connection (wire bonding) and external connection pads, producing and becoming present aspect to have obvious advantage.The MEMS structure of Micropump is directly anchored in structure.
In addition, it is contemplated that eliminate spring contact, so simplifying fixing control part.
In addition, it is contemplated that pressure transducer edge on fixed part fluidly connects movement, so described equipment can use standard MEMS to be used for measuring pressure.
Certainly, without departing substantially from principles of the invention, relative to only by described by example, details and embodiment even can significantly change, and are defined by the following claims protection domain.
As the Micropump being made up of silicon an alternative it is possible to install the Micropump that is made of plastics, even if the latter generally demonstrates relatively low performance.
Claims (12)
1. for distributing an equipment for the wearable of fluid, including: fixed part (30;70), described fixed part can be dressed by object;And replaceable portion (20;60), described replaceable portion can via fluidly connecting (12;51) with described fixed part (30;70) it is associated,
Described replaceable portion (20;60) include for holding the container (21 of the fluid being assigned with;61) and Micropump (22;62), described Micropump (22;62) it is specially MEMS-type and fluidly connects (12 described in passing through;51) described fluid is sent to described fixed part (30;70), described fixed part (30;70) electric control module (31 is included;71), described electric control module is arranged to via pressure sensor apparatus (23;76) described Micropump (22 is controlled;62) operation, described equipment (10;50) actuator (25 is included;75;175), described actuator is set to automatically operate described Micropump (22;62),
Described equipment is characterised by:
Described pressure sensor apparatus (76) be disposed in described in fluidly connect in (51) described fixed part (70) in, fluidly connect (51) described in concrete contiguous be used for distributing the terminal exit portion that the pin (74) of described fluid is associated.
2. equipment according to claim 1, it is characterised in that described fixed part (70) includes described actuator (75;175), and described equipment (50) includes the component for transmitting motion (52) wherein, and described motion is by the described actuator (75 in described fixed part (70);175) it is connected to the described Micropump (62) in described replaceable portion (60), is specially the mobile element (62b) of the volume being connected to the room (62a) for changing described Micropump (62).
3. equipment according to claim 2, it is characterised in that described conveying member (52) is the form of thin plate or band, is specifically formed from steel.
4. equipment according to claim 3, it is characterised in that described thin plate (52) is associated with described Micropump (62) in a position-stable manner, and be inserted into for engaging described actuator (75;175) device (79;89;189;190) in.
5. according to equipment in any one of the preceding claims wherein, it is characterised in that described actuator (75) is cantilever actuator device.
6. according to equipment in any one of the preceding claims wherein, it is characterised in that described actuator (175) is linear actuators.
7. according to equipment in any one of the preceding claims wherein, it is characterized in that described engagement device (79) includes being pushed to the low friction press element on the surface of described thin plate (52) by spring (79a), another surface of described thin plate (52) is positioned on described actuator (75).
8. according to equipment in any one of the preceding claims wherein, it is characterized in that described engagement device (89) includes being pushed to the permanent magnet (89b) on the surface of described thin plate (52) by spring (89a), another surface of described thin plate (52) is positioned on described actuator (75).
9. according to equipment in any one of the preceding claims wherein, it is characterized in that the outlet conduit (63 of the described Micropump (62) being arranged on described replaceable portion (60), 64) it is positioned on wall (62), the wall (62f) that described wall (62) fluidly connects (61a) with location is relative, fluid is transmitted to described Micropump (62) by described outlet conduit (63,64) from described container (61).
10. according to equipment in any one of the preceding claims wherein, it is characterized in that the outlet conduit (64) of the described Micropump (62) being arranged on described replaceable portion (60) is connected to the hydraulic circuit (51) of described fixed part (70) via the needle system (78) being arranged on described fixed part (70), described needle system (78) penetrates the fluid-tight barrier film (65) on described replaceable portion (60).
11. the method for controlling the flowing in the equipment of the wearable for distributing fluid, it is characterised in that use equipment according to any one of claim 1 to 10.
12. method according to claim 11, it is characterized in that the decline according to the pressure measured by described pressure sensor apparatus (76) performs the control of described fluid, described pressure sensor apparatus is positioned at the downstream fluidly connecting (51) described in described replaceable portion (60), it is specially the downstream of the outlet conduit (64) of described Micropump (62), is specially the attachment point fluidly connecting (51) and the described pin (74) for distributing described in vicinity.
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ITTO20141114 | 2014-12-29 | ||
ITTO2014A001114 | 2014-12-29 |
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CN201521108848.2U Withdrawn - After Issue CN205592112U (en) | 2014-12-29 | 2015-12-28 | A equipment for distributing wearable type of fluidic |
CN201511001589.8A Active CN105736328B (en) | 2014-12-29 | 2015-12-28 | For distributing the equipment and corresponding distribution method of the wearable of fluid |
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Cited By (2)
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CN114522298A (en) * | 2022-01-07 | 2022-05-24 | 王奇剑 | Micro-injection pump |
CN114828914A (en) * | 2019-12-19 | 2022-07-29 | 詹森生物科技公司 | Pump with orientation independent liquid drug accessibility |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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ITUB20151866A1 (en) * | 2014-12-29 | 2017-01-02 | St Microelectronics Srl | DEVICE TO EXPECT A FLUID OF A WEARABLE TYPE AND ITS PROCEDURE |
US10639661B2 (en) | 2014-12-29 | 2020-05-05 | Stmicroelectronics S.R.L. | Device of a wearable type for dispensing a fluid, and corresponding dispensing method |
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- 2015-12-28 CN CN201521108848.2U patent/CN205592112U/en not_active Withdrawn - After Issue
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JP2008232099A (en) * | 2007-03-23 | 2008-10-02 | Aisan Ind Co Ltd | Fluid pump control device |
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CN114828914A (en) * | 2019-12-19 | 2022-07-29 | 詹森生物科技公司 | Pump with orientation independent liquid drug accessibility |
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Also Published As
Publication number | Publication date |
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CN205592112U (en) | 2016-09-21 |
ITUB20151866A1 (en) | 2017-01-02 |
CN105736328B (en) | 2019-03-19 |
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Effective date of registration: 20221220 Address after: Geneva, Switzerland Patentee after: STMicroelectronics International N.V. Address before: Agrabrianza Patentee before: STMicroelectronics S.R.L. |