CN105727348A - Antibacterial film, preparing method and antibacterial repairing dressing - Google Patents
Antibacterial film, preparing method and antibacterial repairing dressing Download PDFInfo
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- CN105727348A CN105727348A CN201610221440.9A CN201610221440A CN105727348A CN 105727348 A CN105727348 A CN 105727348A CN 201610221440 A CN201610221440 A CN 201610221440A CN 105727348 A CN105727348 A CN 105727348A
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- antibacterial film
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses an antibacterial film and an antibacterial repairing dressing using the antibacterial film.According to formula matching, the antibacterial film is prepared from, by weight, 5-20% of chitosan-iodide composition, 5-20% of gelatin, 5-20% of a medical polymer material, 0.1-1% of glycerol, 0.1-1% of citric acid and 40-70% of deionized water.The antibacterial repairing dressing can effectively kill pathogenic bacteria within a large range, stop bleeding fast, repair damaged tissue and absorb seepage in quantity and is safe and convenient to use clinically.
Description
Technical field
The invention belongs to pharmaceutical technology field, especially relate to a kind of antibacterial reparation dressing.
Background technology
Medical dressing can substitute impaired skin and play the effect of temporary protection, it is to avoid or control wound sense
Dye, it is provided that be conducive to the condition of wound healing.Along with aged tendency of population is aggravated, and diabetes
Number is incremented by, and chronic ulcerative wound gets more and more, and Wound dressing is more and more important, but existing doctor
There are problems with dressing, such as antibiotic property is unstable, and repair of damaged tissues is relatively slow, and haemostatic effect is not
Good, sepage absorbs the shortcomings such as poor, and urgent need to be improved.Iodine is that a kind of broad-spectrum high efficacy is antibacterial, antiviral material
Material, but iodine is insoluble in water, iodine and iodide poor stability, heat, sees light or the most volatile liter of alkalescence
China, thus it is limited to use comparison.Chitosan is a kind of natural biological medical polymer material, is
With the chitin in Crustacean, insecticide and other invertebrates shell through deacetylated and prepared.
Chitosan-phospholipid complex not only have infection, antitumor, prevent and treat hypertension, strengthen immunologic function,
The functions such as broad-spectrum antiseptic (antibacterial, fungus) property.Be combined with iodine by chitosan derivatives and prepare shell iodine
Complex, is blended this material and the raw materials such as gelatin the one prepared antibacterial reparation dressing and has and efficiently hold
Long stability and antibiotic property and there is antiviral, quick-acting haemostatic powder, reparation damaged tissues, absorb in a large number
The features such as sepage and Clinical practice safe ready.
Summary of the invention
Present invention aim at providing a kind of antibacterial film, and prepare the method for this antibacterial film and utilize this antibacterial
The antibacterial reparation dressing of film.
The technical solution used in the present invention is as follows,
A kind of antibacterial film, by weight, its composition of raw materials proportioning is as follows for described antibacterial film:
Shell Surgidine 5-20%；
Gelatin 5-20%；
Medical macromolecular materials 5-20%；
Glycerol 0.1%-1%；
Citric acid 0.1%-1%；
Deionized water 40%-70%.
Described antibacterial film air penetrability is 111, and moisture retention is 111.
Described shell Surgidine is that chitosan-based derivant forms with iodine complexation.
Described chitosan-based derivant prioritizing selection be Quaternary Ammonium Salt of Chitosan, carboxymethyl chitosan, shell gather
One or more in sugar grafted polyethylene ketopyrrolidine, chitosan graft NVP etc..
Described medical macromolecular materials be preferably selected from Chitosan-phospholipid complex, cellulose and its derivates,
Melon glue and derivant, polyvinyl alcohol, Polyethylene Glycol, polyethylene, polypropylene, polyurethane, PET.
The method preparing above-mentioned a kind of antibacterial film, comprises the steps,
1) weighing；
2) sterilized water is utilized to be completely dissolved gelatin；
3) medical macromolecular materials are added to dissolving；
4) then, it is sequentially added into citric acid, glycerol, is eventually adding the stirring of shell Surgidine；
5) shaping and demoulding.
On the other hand, the invention still further relates to a kind of antibacterial reparation dressing, by above-mentioned antibacterial film, sponge,
Adhesive plaster and abrasive paper composition.
Described sponge uses nano-porous structure, and aperture is 10-100 micron.
A kind of method preparing above-mentioned antibacterial reparation dressing, its technique is as follows, prepares antibacterial film；By prepare
Antibacterial film is combined with sponge；The material being combined is combined with adhesive plaster, separate paper；Packaging, sterilizing.
The antibacterial reparation dressing that the invention of this reality provides can kill pathogenic bacteria the most on a large scale, quick-acting haemostatic powder,
Repair damaged tissues, absorb sepage, Clinical practice safe ready in a large number.
Accompanying drawing explanation
Fig. 1 is antibacterial reparation dressing structure schematic diagram: A is separate paper；B is antibacterial film；C is sponge；
D is adhesive plaster.
Fig. 2 is the SEM figure of embodiment 2 antibacterial film.
Fig. 3 is the water absorbing properties figure of embodiment 1-4 antibacterial film.The antibacterial film that case 1-embodiment 1 prepares；
The antibacterial film that case 2-embodiment 2 prepares；The antibacterial film that case 3-embodiment 3 prepares；Case 4-embodiment
4 antibacterial films prepared.
Fig. 4 is embodiment 1-4 antibacterial reparation dressing biocidal property experimental result；1-is without antibacterial film dressing；2-
The antibacterial reparation dressing of embodiment 1 preparation；The antibacterial reparation dressing of 3-embodiment 2 preparation；4-embodiment 3
The antibacterial reparation dressing of preparation；The antibacterial reparation dressing of 5-embodiment 4 preparation.
Detailed description of the invention
Being specifically described the present invention below in conjunction with the accompanying drawings, Fig. 1 is the structural representation of antibacterial reparation dressing
Figure.
The specifically used shell Surgidine of embodiment is that chitosan-based derivant forms with iodine complexation.Wherein,
Chitosan-based derivant can be but be not limited to Quaternary Ammonium Salt of Chitosan, carboxymethyl chitosan, chitosan graft
One or more in polyvinylpyrrolidone, chitosan graft NVP etc..Use
Medical macromolecular materials can be but be not limited to Chitosan-phospholipid complex, cellulose and its derivates, melon
Youngster's glue and derivant, polyvinyl alcohol, Polyethylene Glycol, polyethylene, polypropylene, polyurethane, PET.Its
In, used sponge uses nano-porous structure, and aperture is 10-100 micron.
The antibacterial reparation dressing of embodiment 1 one kinds
1) gelatin 5% is joined in reactor, importing deionized water 70%, homoiothermic to 30 DEG C-60 DEG C,
To being completely dissolved, joining in above-mentioned reactor by medical macromolecular materials 10%, stirring, will to dissolving
Glycerol 0.2% adds in above-mentioned reactor, in addition citric acid 0.6% to above-mentioned reactor, stirs 5 minutes
After, adding shell Surgidine 10%, stir 45 minutes, proceed to abrasive tool moulding, it is antibacterial that the demoulding prepares porous
Film.
2) become 20mm left with sponge by flat board thermal pressure machine punch forming the porous antibacterial film prepared
Right thickness, is pasted on adhesive plaster, covers anti-glued membrane, sealing packaging, r ray sterilizing.
The antibacterial reparation dressing of embodiment 2 one kinds
1) gelatin 10% is joined in reactor, importing deionized water 70%, homoiothermic to 30 DEG C-60 DEG C,
To being completely dissolved, joining in above-mentioned reactor by medical macromolecular materials 15%, stirring is to dissolving, by sweet
Oil 0.2% adds in above-mentioned reactor, in addition citric acid 0.6% to above-mentioned reactor, after stirring 5 minutes,
Adding shell Surgidine 15%, stir 50 minutes, proceed to abrasive tool moulding, the demoulding prepares porous antibacterial film.
2) become 20mm left with sponge by flat board thermal pressure machine punch forming the porous antibacterial film prepared
Right thickness, is pasted on adhesive plaster, covers anti-glued membrane, sealing packaging, r ray sterilizing.
The antibacterial reparation dressing of embodiment 3 one kinds
1) gelatin 5% is joined in reactor, importing deionized water 70%, homoiothermic to 30 DEG C-60 DEG C,
To being completely dissolved, joining in above-mentioned reactor by medical macromolecular materials 10%, stirring is to dissolving, by sweet
Oil 0.2% adds in above-mentioned reactor, in addition citric acid 0.6% to above-mentioned reactor, after stirring 5 minutes,
Adding shell Surgidine 5%, stir 40 minutes, proceed to abrasive tool moulding, the demoulding prepares porous antibacterial film.
2) become 20mm left with sponge by flat board thermal pressure machine punch forming the porous antibacterial film prepared
Right thickness, is pasted on adhesive plaster, covers anti-glued membrane, sealing packaging, r ray sterilizing.
The antibacterial reparation dressing of embodiment 4 one kinds
1) gelatin 10% is joined in reactor, importing deionized water 70%, homoiothermic to 30 DEG C-60 DEG C,
To being completely dissolved, joining in above-mentioned reactor by medical macromolecular materials 20%, stirring, will to dissolving
Glycerol 0.2% adds in above-mentioned reactor, in addition citric acid 0.6% to above-mentioned reactor, stirs 5 minutes
After, adding shell Surgidine 15%, stir 60 minutes, proceed to abrasive tool moulding, it is antibacterial that the demoulding prepares porous
Film.
2) become 20mm left with sponge by flat board thermal pressure machine punch forming the porous antibacterial film prepared
Right thickness, is pasted on adhesive plaster, covers anti-glued membrane, sealing packaging, r ray sterilizing.
Experimental performance detects
Example 1 sample is cut into a thin slice by above-mentioned reality, is affixed on aluminum platform with conducting resinl, do metal spraying and process
After, scan sample with model JSM-6360LV (JEOL, Japan) field emission scanning electron microscope.
As in figure 2 it is shown, fenestra is evenly distributed.
The antibacterial film that embodiment 1-4 prepares is cut into 40mm × 40mm size, is dried before water suction and weighs,
It is designated as W1；The film cut is immersed room temperature in the beaker of Sheng distilled water and stands 24h, carefully take out diaphragm,
Suck the moisture on surface with filter paper, weigh and be designated as W2.The computing formula of water absorption rate A (%) is:
In formula: A-water absorption rate, %；The quality of W1-water suction cephacoria；The quality of W2-water suction caudacoria.Each sample
Survey 5 times, average.As it is shown on figure 3, the water absorbing properties of antibacterial film that embodiment 1-4 prepares is maintained at
Between 1500-2000, there is outstanding water absorbing properties.
By escherichia coli picking individual colonies from solid medium, it is inoculated in fluid medium breeding and is formed
Bacteria suspension, dipping concentration with sterile cotton tweezers is that 5 × 105cfu/mL, 5 × 106cfu/mL test organisms hangs
Liquid, suitable culture medium flat plate surface uniform application 3 times.Build to drying at room temperature 300sec, will be real
Example 1-4 sample is cut into 1cm diameter circular dressing and is positioned over culture medium flat plate surface, builds, and is placed in 37 DEG C
Constant incubator, cultivates 16h-20h observed result, with the diameter of the antibacterial ring of vernier caliper measurement
As shown in Figure 4, colibacillary inhibition zone diameter is both greater than 7mm, and what embodiment 1-4 prepared antibacterial repaiies
Multiple dressing fungistatic effect reaches 99%
Although the present invention is open as above with preferred embodiment, but it is not for limiting the present invention, appoints
What those skilled in the art without departing from the spirit and scope of the present invention, may be by the disclosure above
Technical solution of the present invention is made possible variation and amendment by method and technology contents, therefore, every does not takes off
From the content of technical solution of the present invention, it is any that above example is made by the technical spirit of the foundation present invention
Simple modification, equivalent variations and modification, belong to the protection domain of technical solution of the present invention.
Claims (8)
1. an antibacterial film, it is characterised in that by weight, its composition of raw materials proportioning is as follows for described antibacterial film:
Shell Surgidine 5-20%；
Gelatin 5-20%；
Medical macromolecular materials 5-20%；
Glycerol 0.1%-1%；
Citric acid 0.1%-1%；
Deionized water 40%-70%.
2. a kind of antibacterial film as claimed in claim 1, it is characterised in that described shell Surgidine is that shell gathers
Glycosyl derivatives forms with iodine complexation.
3. a kind of antibacterial film as claimed in claim 2, it is characterised in that described chitosan-based derivant is excellent
First it is chosen as Quaternary Ammonium Salt of Chitosan, carboxymethyl chitosan, chitosan graft polyvinylpyrrolidone, shell
One or more in polysaccharide graft N-vinyl pyrrolidone etc..
4. a kind of antibacterial film as claimed in claim 1, it is characterised in that described medical macromolecular materials are excellent
First selected from Chitosan-phospholipid complex, cellulose and its derivates, melon glue and derivant, poly-second
Enol, Polyethylene Glycol, polyethylene, polypropylene, polyurethane, PET.
5. the method for the preparation a kind of antibacterial film described in claim 1, it is characterised in that comprise the steps,
1) weighing；
2) sterilized water is utilized to be completely dissolved gelatin；
3) medical macromolecular materials are added to dissolving；
4) then, it is sequentially added into citric acid, glycerol, is eventually adding the stirring of shell Surgidine；
5) shaping and demoulding.
6. an antibacterial reparation dressing, it is characterised in that by the antibacterial film described in claim 1-5, sponge,
Adhesive plaster and abrasive paper composition.
A kind of antibacterial reparation dressing the most as claimed in claim 6, it is characterised in that described sponge uses and receives
Rice loose structure, aperture is 10-100 micron.
8. preparing an a kind of method for antibacterial reparation dressing described in claim 6-7, its preparation technology is as follows: 1)
Prepare antibacterial film；2) antibacterial film prepared is combined with sponge；3) by the material being combined and glue
Cloth, separate paper are compound；4) packaging, sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221440.9A CN105727348A (en) | 2016-04-11 | 2016-04-11 | Antibacterial film, preparing method and antibacterial repairing dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610221440.9A CN105727348A (en) | 2016-04-11 | 2016-04-11 | Antibacterial film, preparing method and antibacterial repairing dressing |
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| Publication Number | Publication Date |
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| CN105727348A true CN105727348A (en) | 2016-07-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610221440.9A Pending CN105727348A (en) | 2016-04-11 | 2016-04-11 | Antibacterial film, preparing method and antibacterial repairing dressing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753997A (en) * | 2017-10-23 | 2018-03-06 | 贵州九立德生物制药有限公司 | A kind of antibacterial maintenance film and its preparation technology containing Oxsodrol |
Citations (5)
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|---|---|---|---|---|
| US20020119205A1 (en) * | 2000-12-22 | 2002-08-29 | Hassan Emadeldin M. | Ionic chitosan -iodine complexes : antiseptic hydrogels and wound healing promoters |
| CN101543658A (en) * | 2009-04-29 | 2009-09-30 | 上海市计划生育科学研究所 | Cervical cap for preventing and treating cervical erosion and preparation method thereof |
| CN102144988A (en) * | 2011-03-16 | 2011-08-10 | 贵州扬生医用器材有限公司 | Chitosan cervix uteri anti-microbial membrane and preparation method thereof |
| CN104524619A (en) * | 2014-12-30 | 2015-04-22 | 东莞市鸿元医药科技有限公司 | Chitosan dressing and production process thereof |
| CN104738782A (en) * | 2015-04-23 | 2015-07-01 | 杜卫卫 | Beautifying and health preserving juice |
-
2016
- 2016-04-11 CN CN201610221440.9A patent/CN105727348A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020119205A1 (en) * | 2000-12-22 | 2002-08-29 | Hassan Emadeldin M. | Ionic chitosan -iodine complexes : antiseptic hydrogels and wound healing promoters |
| CN101543658A (en) * | 2009-04-29 | 2009-09-30 | 上海市计划生育科学研究所 | Cervical cap for preventing and treating cervical erosion and preparation method thereof |
| CN102144988A (en) * | 2011-03-16 | 2011-08-10 | 贵州扬生医用器材有限公司 | Chitosan cervix uteri anti-microbial membrane and preparation method thereof |
| CN104524619A (en) * | 2014-12-30 | 2015-04-22 | 东莞市鸿元医药科技有限公司 | Chitosan dressing and production process thereof |
| CN104738782A (en) * | 2015-04-23 | 2015-07-01 | 杜卫卫 | Beautifying and health preserving juice |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107753997A (en) * | 2017-10-23 | 2018-03-06 | 贵州九立德生物制药有限公司 | A kind of antibacterial maintenance film and its preparation technology containing Oxsodrol |
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Application publication date: 20160706 |