CN105726159A - Method and device for manufacturing artificial soft tissue compositely molded through extruding and photocuring - Google Patents
Method and device for manufacturing artificial soft tissue compositely molded through extruding and photocuring Download PDFInfo
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- CN105726159A CN105726159A CN201610061141.3A CN201610061141A CN105726159A CN 105726159 A CN105726159 A CN 105726159A CN 201610061141 A CN201610061141 A CN 201610061141A CN 105726159 A CN105726159 A CN 105726159A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
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Abstract
The invention discloses a method for manufacturing artificial soft tissue compositely molded through extruding and photocuring. The method comprises the steps that modeling is firstly carried out on the artificial soft tissue, then contour information of each layer in the artificial soft tissue model is calculated through 3D printing layering software, and codes needed for hydraulic extruding molding and codes needed for visible photocuring molding are generated from the contour information; a hydraulic extruding head is controlled to extrude a photocuring composite solution on a work platform according to the codes, and a liquid state layer is formed; the liquid state layer is photocured according to the codes, and a cured layer is obtained; the process is repeated many times, and the artificial soft tissue is obtained. The invention further discloses a device for manufacturing the artificial soft tissue compositely molded through extruding and photocuring. Waste of materials is greatly reduced, and manufacturing efficiency is improved.
Description
Technical field
The preparation method that the present invention relates to artificial soft tissue, particularly to artificial soft tissue's preparation method and the preparation facilities of a kind of extrusion and photocuring composite molding.
Background technology
Along with the continuous progress of economic development and science and technology, the development for 3D printing technique provides strong technology and financial resources pillar, thus accelerating the developing steps of 3D printing technique.
It is known that 3D printing technique is widely used in the middle of all trades and professions, and in the preparation industry of artificial soft tissue, also it be unable to do without the application of 3D printing technique.
At present, existing 3D printing technique has multiple in the method for molding artificial soft tissue.As being the manufacture method of artificial soft tissue's body of a kind of subsidiary vasoganglion runner disclosed in 201410280450.0 in Chinese Patent Application No., it first designs the soft tissue stent model with blood vessel structure, is equidistantly layered one by one by model, manufactures the photomask blank of each layer；Then, photocuring composite solution is expelled on workbench, covers photomask blank, use face exposure technique to solidify photocuring composite solution, then solidify cumulative layer by layer, it is thus achieved that with the photocuring hydrogel soft organization bracket of blood vessel structure；In the blood vessel structure of support, plant vascular endothelial cell, make vascular endothelial cell be attached to vascular canal surface, carry out static culture and dynamic cultivation in vitro, obtain artificial soft tissue's body of subsidiary vasoganglion runner.
But, in the manufacture method of artificial soft tissue's body disclosed above, use photocuring technology and photomask blank etc. to go to prepare the artificial soft tissue's body with cell, therefore the manufacture method of existing artificial soft tissue's body exists, and effect is low and the defect of waste material, when the number of plies of artificial soft tissue is more many, need the photomask blank made more many, therefore waste material.Meanwhile, the manufacture method of existing artificial soft tissue's body can only create the relatively simple artificial soft tissue's body of structure, and the precision of artificial soft tissue's body is not high.
Therefore, it is necessary to provide a kind of waste being substantially reduced material and be greatly improved biological activity and manufacture the extrusion of efficiency and artificial soft tissue's preparation method of photocuring composite molding to overcome above-mentioned defect.
Summary of the invention
In order to overcome disadvantages mentioned above and the deficiency of prior art, it is an object of the invention to provide a kind of extrusion and artificial soft tissue's preparation method of photocuring composite molding, be substantially reduced the waste of material, improve manufacture efficiency.
Another object of the present invention is to the artificial soft tissue's preparation facilities providing a kind of extrusion with photocuring composite molding.
The purpose of the present invention is achieved through the following technical solutions:
A kind of extrusion and artificial soft tissue's preparation method of photocuring composite molding, comprise the following steps:
(1) artificial soft tissue is modeled, obtain artificial soft tissue's model；
(2) profile of each layer in artificial soft tissue's model is processed: print delamination software with 3D and calculate the profile information of each layer in described artificial soft tissue's model, and this profile information is generated the code needed for hydraulic pressure extrusion molding and the code needed for visible-light curing molding；
(3) photocuring composite solution is prepared: first make active somatic cell, somatomedin and collagen solution three mix to obtain mixed liquor, photocuring hydrogel is injected again in described mixed liquor, then add visible light photo initiators, obtain described photocuring composite solution；
(4) the photocuring composite solution prepared with step (3) is for raw material, adopts the preparation carrying out artificial soft tissue of 3D printer:
(4-1) control hydraulic pressure extruder head according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on work platforms, extrude photocuring composite solution, form layer liquid；
(4-2) according to the code control photocuring head needed for the visible-light curing molding obtained in step (2), step (4-1) is obtained layer liquid and carry out photocuring, obtain cured layer；
(4-3) control hydraulic pressure extruder head according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on the cured layer that previous step obtains, extrude photocuring composite solution, form layer liquid；
(4-4) layer liquid previous step obtained according to the code control photocuring head needed for the visible-light curing molding obtained in step (2) carries out photocuring, obtains cured layer；
(4-5) repeat step (4-3) and step (4-4) repeatedly, obtain artificial soft tissue.
Further, when hydraulic pressure extruder head is in running order, photocuring head is closed；When movement locus when hydraulic pressure extruder head is by work resets, hydraulic pressure extruder head is closed, and photocuring head is in running order.
Specifically, the code needed for described hydraulic pressure extrusion molding comprises the movement locus of the hydraulic pressure extruder head of 3D printer and the information of extrusion capacity；
Code needed for described visible-light curing molding comprises movement locus and the switching signal information of the photocuring head of 3D printer.
Further, before carrying out photocuring, control work platforms and move down a predeterminable range；In step (4-4), before carrying out photocuring, control work platforms and move down a predeterminable range.
Preferably, described predeterminable range is the distance of a layer liquid thickness.
Preferably, described layer liquid is half curdled appearance.
Preferably, described visible light photo initiators is blue visible light light trigger；Described photocuring head is that blue light solidifies head.
For realizing above-mentioned purpose, the preparation facilities of the artificial soft tissue of the extrusion of the present invention and photocuring composite molding includes 3D printer, and the hydraulic pressure extruder head of 3D printer is fixing with photocuring head to be connected；When hydraulic pressure extruder head is in running order, photocuring head is closed；When movement locus when hydraulic press is lifted one's head by work resets, hydraulic pressure extruder head is closed, and photocuring head is in running order.
Further, the work platforms of the described 3D printer movement locus when hydraulic pressure extruder head is by work moves down a predeterminable range before resetting.
Compared with prior art, the present invention has the following advantages and beneficial effect:
(1) present invention is blended with the photocuring composite solution extrusion of active somatic cell to form layer liquid, layer liquid quickly carries out photocuring again process to form cured layer, so that artificial soft tissue's preparation method of the present invention can while extruding layer liquid, another side energy this layer liquid rapid photocuring, the waste of material can be substantially reduced so on the one hand, the biological activity of artificial soft tissue can be greatly improved on the other hand and manufacture efficiency.
(2) present invention adopts blue light blue visible light consolidation liquid state layer, owing to active somatic cell is not had adverse effect by blue visible light, therefore is effectively improved the biological activity of the artificial soft tissue formed out.
(3) present invention can be used for preparing baroque artificial soft tissue's body, and preparation precision is high.
Accompanying drawing explanation
Fig. 1 is the extrusion schematic diagram with the hydraulic pressure extruder head of artificial soft tissue's preparation facilities of photocuring composite molding, work platforms and blue light solidification head of embodiments of the invention.
Fig. 2 is that the extrusion of embodiments of the invention performs schematic diagram during step (4-2) with artificial soft tissue's preparation method of photocuring composite molding.
Fig. 3 is that the extrusion of embodiments of the invention performs schematic diagram during step (4-4) with artificial soft tissue's preparation method of photocuring composite molding.
Fig. 4 is that the extrusion of embodiments of the invention performs the schematic diagram after step (4-5) with artificial soft tissue's preparation method of photocuring composite molding.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment
Artificial soft tissue's preparation facilities of the extrusion of the present embodiment and photocuring composite molding includes 3D printer, is connected as it is shown in figure 1, the hydraulic pressure extruder head 10 of 3D printer is fixing with photocuring head 20, it is preferably, in the present embodiment, photocuring head 20 solidifies head for blue light, but is not limited；When hydraulic pressure extruder head 10 is in running order, blue light solidifies 20 closedown；Movement locus when hydraulic pressure extruder head 10 is by work reset (in Fig. 2 double-head arrow direction) time, hydraulic pressure extruder head 10 is closed, and it is in running order that blue light solidifies 20；Preferably, as in figure 2 it is shown, the movement locus that the work platforms 30 of 3D printer is when hydraulic pressure extruder head 10 is by work moves down a predeterminable range before resetting, this projected distance is the distance of the layer liquid thickness that the following describes.
The extrusion of the present embodiment and artificial soft tissue's preparation method of photocuring composite molding, comprise the following steps:
(1) artificial soft tissue is modeled, obtain artificial soft tissue's model；
(2) profile of each layer in artificial soft tissue's model is processed: print delamination software with 3D and calculate the profile information of each layer in described artificial soft tissue's model, and this profile information is generated the code needed for hydraulic pressure extrusion molding, this code contains the information of movement locus and extrusion capacity；And the code needed for visible-light curing molding, this code contains movement locus and switching signal information；
(3) photocuring composite solution is prepared: first make active somatic cell 220, somatomedin and collagen solution three mix to obtain mixed liquor, specifically, active somatic cell 220, somatomedin and collagen solution three mix in ratio needed for different soft tissues, as 1:2:3 equal proportion mixes, but it is not limited；Injecting photocuring hydrogel again in described mixed liquor, then add visible light photo initiators, more excellent is blue visible light light trigger for being visible light initiator, obtains described photocuring composite solution.
(4) the photocuring composite solution prepared with step (3) is for raw material, adopts the preparation carrying out artificial soft tissue of 3D printer:
(4-1) control hydraulic pressure extruder head 10 according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on work platforms 30, extrude photocuring composite solution, form layer liquid, preferably, described layer liquid is half curdled appearance before non-photocuring；
In this step, hydraulic pressure extruder head 10 is in running order, and photocuring head 20 is closed；
(4-2) control work platforms and move down the distance of a layer liquid thickness；Movement locus when controlling hydraulic pressure extruder head 10 by work according to the code needed for the visible-light curing molding obtained in step (2) resets, and now hydraulic pressure extruder head 10 is closed, and blue light solidification 20 is in running order；Blue light solidification 20 pairs of steps (4-1) obtain layer liquid and carry out photocuring, obtain cured layer 210, as shown in Figure 2；
(4-3) control hydraulic pressure extruder head 10 according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on the cured layer 210 that previous step obtains, extrude photocuring composite solution, form layer liquid；
(4-4) control work platforms 30 and move down the distance of a layer liquid thickness, photocuring is carried out according to the layer liquid that previous step is obtained by the code control blue light solidification head needed for the visible-light curing molding obtained in step (2), obtain cured layer 210, as shown in Figure 3；
(4-5) repeat step (4-3) and step (4-4) repeatedly, obtain artificial soft tissue 200, as shown in Figure 4.
Due to the method that artificial soft tissue's preparation method of the present invention adopts extrusion and photocuring composite molding, the photocuring composite solution being blended with active somatic cell 220 is extruded to form layer liquid, layer liquid quickly carries out photocuring again process to form cured layer 210, so that artificial soft tissue's preparation method of the present invention can while extruding layer liquid, another side energy this layer liquid rapid photocuring, the waste of material can be substantially reduced so on the one hand, the biological activity of artificial soft tissue can be greatly improved on the other hand and manufacture efficiency.
Above-described embodiment is the present invention preferably embodiment; but embodiments of the present invention are also not restricted by the embodiments; the change made under other any spirit without departing from the present invention and principle, modification, replacement, combination, simplification; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (9)
1. artificial soft tissue's preparation method of an extrusion and photocuring composite molding, it is characterised in that comprise the following steps:
(1) artificial soft tissue is modeled, obtain artificial soft tissue's model；
(2) profile of each layer in artificial soft tissue's model is processed: print delamination software with 3D and calculate the profile information of each layer in described artificial soft tissue's model, and this profile information is generated the code needed for hydraulic pressure extrusion molding and the code needed for visible-light curing molding；
(3) photocuring composite solution is prepared: first make active somatic cell, somatomedin and collagen solution three mix to obtain mixed liquor, photocuring hydrogel is injected again in described mixed liquor, then add visible light photo initiators, obtain described photocuring composite solution；
(4) the photocuring composite solution prepared with step (3) is for raw material, adopts the preparation carrying out artificial soft tissue of 3D printer:
(4-1) control hydraulic pressure extruder head according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on work platforms, extrude photocuring composite solution, form layer liquid；
(4-2) according to the code control photocuring head needed for the visible-light curing molding obtained in step (2), step (4-1) is obtained layer liquid and carry out photocuring, obtain cured layer；
(4-3) control hydraulic pressure extruder head according to the code needed for the hydraulic pressure extrusion molding obtained in step (2) on the cured layer that previous step obtains, extrude photocuring composite solution, form layer liquid；
(4-4) layer liquid previous step obtained according to the code control photocuring head needed for the visible-light curing molding obtained in step (2) carries out photocuring, obtains cured layer；
(4-5) repeat step (4-3) and step (4-4) repeatedly, obtain artificial soft tissue.
2. artificial soft tissue's preparation method of extrusion according to claim 1 and photocuring composite molding, it is characterised in that described hydraulic pressure extruder head is fixing with photocuring head to be connected；When hydraulic pressure extruder head is in running order, photocuring head is closed；When movement locus when hydraulic pressure extruder head is by work resets, hydraulic pressure extruder head is closed, and photocuring head is in running order.
3. artificial soft tissue's preparation method of extrusion according to claim 1 and photocuring composite molding, it is characterised in that the code needed for described hydraulic pressure extrusion molding comprises the movement locus of the hydraulic pressure extruder head of 3D printer and the information of extrusion capacity；
Code needed for described visible-light curing molding comprises movement locus and the switching signal information of the photocuring head of 3D printer.
4. artificial soft tissue's preparation method of extrusion according to claim 1 and photocuring composite molding, it is characterised in that in step (4-2), before carrying out photocuring, controls work platforms and moves down a predeterminable range；In step (4-4), before carrying out photocuring, control work platforms and move down a predeterminable range.
5. artificial soft tissue's preparation method of extrusion according to claim 3 and photocuring composite molding, it is characterised in that described predeterminable range is the distance of a layer liquid thickness.
6. artificial soft tissue's preparation method of extrusion according to claim 1 and photocuring composite molding, it is characterised in that described layer liquid is half curdled appearance.
7. artificial soft tissue's preparation method of extrusion according to claim 1 and photocuring composite molding, it is characterised in that described visible light photo initiators is blue visible light light trigger；Described photocuring head is that blue light solidifies head.
8. realize the preparation facilities of the extrusion with artificial soft tissue's preparation method of photocuring composite molding of the extrusion described in claim 1 and the artificial soft tissue of photocuring composite molding, including 3D printer, it is characterized in that, the hydraulic pressure extruder head of 3D printer is fixing with photocuring head to be connected；When hydraulic pressure extruder head is in running order, photocuring head is closed；When movement locus when hydraulic pressure extruder head is by work resets, hydraulic pressure extruder head is closed, and photocuring head is in running order.
9. the preparation facilities of the artificial soft tissue of extrusion according to claim 8 and photocuring composite molding, it is characterised in that the work platforms of the described 3D printer movement locus when hydraulic pressure extruder head is by work moves down a predeterminable range before resetting.
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| CN201610061141.3A CN105726159A (en) | 2016-01-28 | 2016-01-28 | Method and device for manufacturing artificial soft tissue compositely molded through extruding and photocuring |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109571940A (en) * | 2018-12-10 | 2019-04-05 | 中国科学技术大学 | A kind of UV photocuring hemoglobin particle preparation Photobiology imitates the 3 D-printing system and method for body |
| CN110435136A (en) * | 2019-08-06 | 2019-11-12 | 武汉卫亚汽车零部件有限公司 | A kind of integrally formed technique of automotive seat connecting rod |
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| CN109571940A (en) * | 2018-12-10 | 2019-04-05 | 中国科学技术大学 | A kind of UV photocuring hemoglobin particle preparation Photobiology imitates the 3 D-printing system and method for body |
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