CN105709264A - Antibacterial medical absorbable suture line and preparation method thereof - Google Patents
Antibacterial medical absorbable suture line and preparation method thereof Download PDFInfo
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- CN105709264A CN105709264A CN201610132698.1A CN201610132698A CN105709264A CN 105709264 A CN105709264 A CN 105709264A CN 201610132698 A CN201610132698 A CN 201610132698A CN 105709264 A CN105709264 A CN 105709264A
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- Prior art keywords
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- absorbable suture
- biocidal property
- antibacterial
- surgical absorbable
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D1/00—Treatment of filament-forming or like material
- D01D1/04—Melting filament-forming substances
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/12—Stretch-spinning methods
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Textile Engineering (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention provides an antibacterial medical absorbable suture line and a preparation method thereof. The suture line is prepared from polyvinyl alcohol, tocopheryl acetate, coconut oil-based dimethyl ammonium hydroxypropyl hydrolyzed collagen, procyanidine, amodimethicone, chitosan, a cross-linking agent, a stabilizing agent and an antibacterial agent. The preparation method comprises the steps that the components are weighed according to the weight parts; the components are added into a reaction kettle, heated, stirred and mixed to obtain a mixture; the mixture is fed into a two-screw extruder to be extruded, and an extruded sample strip is subjected to water cooling, air drying and grain-sized dicing to obtain master batch; the master batch is heated to be molten, is defoamed and passes through a spinneret plate to form primary fiber; the primary fiber is subjected to secondary drawing in a water bath, and therefore the suture line is obtained. The raw materials of the suture line have no stimulation on the tissue and have no toxic or side effect, and no obvious stitch mark is left after a wound is healed; the coconut oil-based dimethyl ammonium hydroxypropyl hydrolyzed collagen is added to promote healing of the wound; the mechanical performance is good, and clinical requirements can be met.
Description
Technical field
The present invention relates to suture field, be specifically related to a kind of biocidal property Surgical Absorbable Suture and preparation method thereof.
Background technology
Stitching thread is one of material most basic in surgical operation, most important, is mainly used in various tissue sewing hemostasis, residual cavity locking and tissue apposition.Surgical sutures is broadly divided into non-absorbing stitching thread and the big class of absorbable suture two.Compared with non-absorbing stitching thread, absorbable suture have the main advantage that (1) no antigen while absorbing (only produce slight tissue reaction)；(2) without pyrogenicity；(3) wound healing is complete；(4) need not take out stitches, alleviate patient's misery, decrease the chance bringing out infection.Thus, absorbable suture is the trend of surgical sutures development.Dividing from making raw material, the absorbable suture of clinical practice mainly has natural material, chemical synthetic material and the complex of natural material and chemical synthetic material.Wherein, the surgical sutures of natural material manufacture meets the consumption concept of environmental protection and the social current of back to nature, is more affected by the support of national policy.
Summary of the invention
Goal of the invention: it is an object of the invention to provide a kind of biocidal property Surgical Absorbable Suture and preparation method thereof, this stitching thread has biodegradability, and human body can absorb, and the feature such as mechanical performance is strong.
Technical scheme:
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 40～50 parts, tocopherol acetas 20～25 parts, cocodimonium hydroxypropyl base hydrolytic collagen 10～15 parts, procyanidin 1～5 part, ammonia end polydimethylsiloxane 1～5 part, chitosan 1～5 part, cross-linking agent 3～5 parts, stabilizer 1～3 part and antibacterial 2～4 parts.
Preferably, by weight, including following component: polyvinyl alcohol 43～46 parts, tocopherol acetas 22～24 parts, cocodimonium hydroxypropyl base hydrolytic collagen 12～14 parts, procyanidin 2～4 parts, ammonia end polydimethylsiloxane 2～4 parts, chitosan 2～4 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
It is highly preferred that by weight, including following component: polyvinyl alcohol 44 parts, tocopherol acetas 23 parts, cocodimonium hydroxypropyl base hydrolytic collagen 13 parts, procyanidin 3 parts, ammonia end polydimethylsiloxane 3 parts, chitosan 3 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
Described deacetylating degree of chitosan is more than 85%, and ash is less than 1%, and viscosity is more than 1000Mpa.
Described cross-linking agent is vanillin.
Described stabilizer is citric acid.
Described antibacterial is cinnamic aldehyde or acetaminol.
The preparation method of a kind of biocidal property Surgical Absorbable Suture, comprises the steps:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 100～120 DEG C, is stirred continuously under the rotating speed of 500～800r/min, blended 2～3h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 220～240 DEG C, screw speed 36～54Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 120～140 DEG C, deaeration, is 1～20mm spinneret by aperture, forms primary filament, again by primary filament succeeding stretch in the water-bath of 20～40 DEG C, obtain the biocidal property Surgical Absorbable Suture of different size.
Beneficial effect:
Compared with prior art:
(1) suture materials of the present invention is non-stimulated to tissue, has no side effect, and without obvious stitch vestige after wound healing.
(2) add cocodimonium hydroxypropyl base hydrolytic collagen, promote the healing of wound；
(3) the biocidal property Surgical Absorbable Suture body satisfactory mechanical property that the present invention prepares, it is possible to meet clinical needs.
Detailed description of the invention
Hereinafter the specific embodiment of the present invention is described in detail.
Embodiment 1
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 40 parts, tocopherol acetas 20 parts, cocodimonium hydroxypropyl base hydrolytic collagen 10 parts, procyanidin 1 part, ammonia end polydimethylsiloxane 1 part, chitosan 1 part, cross-linking agent 3 parts, stabilizer 1 part and antibacterial 2 parts.
Preparation method is as follows:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 120 DEG C, is stirred continuously under the rotating speed of 800r/min, blended 3h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 240 DEG C, screw speed 54Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 120 DEG C, and deaeration, is 20mm spinneret by aperture, forms primary filament, then by primary filament succeeding stretch in the water-bath of 20 DEG C, obtains biocidal property Surgical Absorbable Suture.
Embodiment 2
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 43 parts, tocopherol acetas 22 parts, cocodimonium hydroxypropyl base hydrolytic collagen 12 parts, procyanidin 2 parts, ammonia end polydimethylsiloxane 2 parts, chitosan 2 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
Preparation method is as follows:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 115 DEG C, is stirred continuously under the rotating speed of 700r/min, blended 3h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 225 DEG C, screw speed 48Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 125 DEG C, and deaeration, is 15mm spinneret by aperture, forms primary filament, then by primary filament succeeding stretch in the water-bath of 25 DEG C, obtains biocidal property Surgical Absorbable Suture.
Embodiment 3
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 44 parts, tocopherol acetas 23 parts, cocodimonium hydroxypropyl base hydrolytic collagen 13 parts, procyanidin 3 parts, ammonia end polydimethylsiloxane 3 parts, chitosan 3 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
Preparation method is as follows:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 110 DEG C, is stirred continuously under the rotating speed of 700r/min, blended 3h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 230 DEG C, screw speed 44Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 130 DEG C, and deaeration, is 10mm spinneret by aperture, forms primary filament, then by primary filament succeeding stretch in the water-bath of 30 DEG C, obtains biocidal property Surgical Absorbable Suture.
Embodiment 4
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 46 parts, tocopherol acetas 24 parts, cocodimonium hydroxypropyl base hydrolytic collagen 14 parts, procyanidin 4 parts, ammonia end polydimethylsiloxane 4 parts, chitosan 4 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
Preparation method is as follows:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 105 DEG C, is stirred continuously under the rotating speed of 600r/min, blended 2h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 235 DEG C, screw speed 40Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 135 DEG C, and deaeration, is 5mm spinneret by aperture, forms primary filament, then by primary filament succeeding stretch in the water-bath of 35 DEG C, obtains biocidal property Surgical Absorbable Suture.
Embodiment 5
A kind of biocidal property Surgical Absorbable Suture, by weight, including following component: polyvinyl alcohol 50 parts, tocopherol acetas 25 parts, cocodimonium hydroxypropyl base hydrolytic collagen 15 parts, procyanidin 5 parts, ammonia end polydimethylsiloxane 5 parts, chitosan 5 parts, cross-linking agent 5 parts, stabilizer 3 parts and antibacterial 4 parts.
Preparation method is as follows:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 100 DEG C, is stirred continuously under the rotating speed of 500r/min, blended 2h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 220 DEG C, screw speed 36Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 120 DEG C, and deaeration, is 1mm spinneret by aperture, forms primary filament, then by primary filament succeeding stretch in the water-bath of 20 DEG C, obtains biocidal property Surgical Absorbable Suture.
Performance test:
The stitching thread of embodiment 1～5 carries out the test of fiber number, fracture strength, elongation at break and biocidal property (maximum antibacterial width), and result is in Table 1.
Table 1
As shown in Table 1, the stitching thread satisfactory mechanical property of the present invention, and there is obvious fungistatic effect.
Although embodiment of the present invention are disclosed as above, but listed utilization that it is not restricted in description and embodiment, it can be applied to various applicable the field of the invention completely, for those skilled in the art, it is easily achieved other amendment, therefore, under the general concept limited without departing substantially from claim and equivalency range, the present invention is not limited to specific details.
Claims (8)
1. a biocidal property Surgical Absorbable Suture, it is characterized in that, by weight, including following component: polyvinyl alcohol 40 ~ 50 parts, tocopherol acetas 20 ~ 25 parts, cocodimonium hydroxypropyl base hydrolytic collagen 10 ~ 15 parts, procyanidin 1 ~ 5 part, ammonia end polydimethylsiloxane 1 ~ 5 part, chitosan 1 ~ 5 part, cross-linking agent 3 ~ 5 parts, stabilizer 1 ~ 3 part and antibacterial 2 ~ 4 parts.
2. biocidal property Surgical Absorbable Suture according to claim 1, it is characterized in that, by weight, including following component: polyvinyl alcohol 43 ~ 46 parts, tocopherol acetas 22 ~ 24 parts, cocodimonium hydroxypropyl base hydrolytic collagen 12 ~ 14 parts, procyanidin 2 ~ 4 parts, ammonia end polydimethylsiloxane 2 ~ 4 parts, chitosan 2 ~ 4 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
3. biocidal property Surgical Absorbable Suture according to claim 1, it is characterized in that, by weight, including following component: polyvinyl alcohol 44 parts, tocopherol acetas 23 parts, cocodimonium hydroxypropyl base hydrolytic collagen 13 parts, procyanidin 3 parts, ammonia end polydimethylsiloxane 3 parts, chitosan 3 parts, cross-linking agent 4 parts, stabilizer 2 parts and antibacterial 3 parts.
4. the biocidal property Surgical Absorbable Suture according to any one of claim 1 ~ 3, it is characterised in that described deacetylating degree of chitosan is more than 85%, and ash is less than 1%, and viscosity is more than 1000Mpa.
5. the biocidal property Surgical Absorbable Suture according to any one of claim 1 ~ 3, it is characterised in that described cross-linking agent is vanillin.
6. the biocidal property Surgical Absorbable Suture according to any one of claim 1 ~ 3, it is characterised in that described stabilizer is citric acid.
7. the biocidal property Surgical Absorbable Suture according to any one of claim 1 ~ 3, it is characterised in that described antibacterial is cinnamic aldehyde or acetaminol.
8. the preparation method of biocidal property Surgical Absorbable Suture described in a claim 1, it is characterised in that comprise the steps:
(1) each component is weighed by weight；
(2) adding in reactor by each component, heating, to 100 ~ 120 DEG C, is stirred continuously under the rotating speed of 500 ~ 800r/min, blended 2 ~ 3h, obtains blend；
(3) blend that step (2) prepares being sent into double screw extruder, extrusion temperature 220 ~ 240 DEG C, screw speed 36 ~ 54Hz, twin-screw extrusion batten is water cooled, air-dry, pelletizing, obtains master batch；
(4) master batch heating step (3) prepared makes it melt to 120 ~ 140 DEG C, deaeration, is 1 ~ 20mm spinneret by aperture, forms primary filament, again by primary filament succeeding stretch in the water-bath of 20 ~ 40 DEG C, obtain the biocidal property Surgical Absorbable Suture of different size.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610132698.1A CN105709264A (en) | 2016-03-09 | 2016-03-09 | Antibacterial medical absorbable suture line and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610132698.1A CN105709264A (en) | 2016-03-09 | 2016-03-09 | Antibacterial medical absorbable suture line and preparation method thereof |
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| CN105709264A true CN105709264A (en) | 2016-06-29 |
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| CN201610132698.1A Pending CN105709264A (en) | 2016-03-09 | 2016-03-09 | Antibacterial medical absorbable suture line and preparation method thereof |
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2016
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Application publication date: 20160629 |
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